NEDD4L Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase|This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 23327)
External Link http://www.ncbi.nlm.nih.gov/gene/23327
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Genes

50 interacting proteins for hub protein NEDD4L from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMD1 adenosylmethionine decarboxylase 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ART5 ADP-ribosyltransferase 5
ASCL3 achaete-scute family bHLH transcription factor 3
CDC14A cell division cycle 14A
CYTH1 cytohesin 1
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
ELP2 elongator acetyltransferase complex subunit 2
ENO2 enolase 2 (gamma, neuronal)
IDI1 isopentenyl-diphosphate delta isomerase 1
KAT2A K(lysine) acetyltransferase 2A
NAP1L3 nucleosome assembly protein 1-like 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NPR1 natriuretic peptide receptor 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
PADI1 peptidyl arginine deiminase, type I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRDM9 PR domain containing 9
PTBP3 polypyrimidine tract binding protein 3
PYDC1 PYD (pyrin domain) containing 1
RIMS4 regulating synaptic membrane exocytosis 4
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SNX8 sorting nexin 8
SOX9 SRY (sex determining region Y)-box 9
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TMEM50A transmembrane protein 50A
TNK2 tyrosine kinase, non-receptor, 2
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR4 WD repeat domain 4