NEIL3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nei endonuclease VIII-like 3 (E. coli)|NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 55247)
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Genes

346 genes differentially expressed following the NEIL3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SFTA2 surfactant associated 2 3.16101
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.16101
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.16101
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.16101
CLEC19A C-type lectin domain family 19, member A 3.16101
FZD1 frizzled class receptor 1 3.16101
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.16101
ANKRD53 ankyrin repeat domain 53 3.16101
PTH parathyroid hormone 3.16101
PCDHGB3 protocadherin gamma subfamily B, 3 3.16101
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.16101
TNNI1 troponin I type 1 (skeletal, slow) 3.16101
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.16101
PRR18 proline rich 18 3.16101
COL17A1 collagen, type XVII, alpha 1 3.16101
SSTR5 somatostatin receptor 5 3.16101
TMPRSS11F transmembrane protease, serine 11F 3.16101
POTEF POTE ankyrin domain family, member F 3.16101
ERVW-1 endogenous retrovirus group W, member 1 3.16101
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.16101
DCST2 DC-STAMP domain containing 2 3.16101
PCDHB12 protocadherin beta 12 3.16101
TMEM150B transmembrane protein 150B 3.16101
MYOZ2 myozenin 2 3.16101
CXORF65 chromosome X open reading frame 65 3.16101
SYCP2 synaptonemal complex protein 2 3.16101
NRN1 neuritin 1 3.16101
CNR1 cannabinoid receptor 1 (brain) 3.14379
ASB12 ankyrin repeat and SOCS box containing 12 3.06388
FOLR3 folate receptor 3 (gamma) 3.06388
GPR85 G protein-coupled receptor 85 3.06388
TUBB1 tubulin, beta 1 class VI 3.06388
MUSK muscle, skeletal, receptor tyrosine kinase 3.06388
NEU4 sialidase 4 3.06388
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.06388
LIM2 lens intrinsic membrane protein 2, 19kDa 3.06388
IQCF1 IQ motif containing F1 3.06388
MPL MPL proto-oncogene, thrombopoietin receptor 3.06388
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.06388
ETV2 ets variant 2 3.06388
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 3.06388
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.06388
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.06388
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.06388
BFSP2 beaded filament structural protein 2, phakinin 3.06388
KRT72 keratin 72, type II 3.06388
OR52E8 olfactory receptor, family 52, subfamily E, member 8 3.06388
CXCL2 chemokine (C-X-C motif) ligand 2 3.06388
GADL1 glutamate decarboxylase-like 1 3.06388
OSTN osteocrin 3.06388
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.06388
DYNLRB2 dynein, light chain, roadblock-type 2 3.06388
BDKRB2 bradykinin receptor B2 3.06388
MUC22 mucin 22 3.06388
STEAP4 STEAP family member 4 3.06388
CEP295NL CEP295 N-terminal like 3.06388
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.06388
CDH9 cadherin 9, type 2 (T1-cadherin) 3.06388
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.06388
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.06388
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.06388
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.06388
GDF10 growth differentiation factor 10 3.06388
HNF4A hepatocyte nuclear factor 4, alpha 3.06388
TAS2R5 taste receptor, type 2, member 5 3.06388
FAM153A family with sequence similarity 153, member A 3.06388
KLF17 Kruppel-like factor 17 3.06388
TMEM229A transmembrane protein 229A 3.06388
CLDN9 claudin 9 3.06388
MAGEB3 melanoma antigen family B3 3.06388
PANX3 pannexin 3 3.06388
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.06388
GOLGA7B golgin A7 family, member B 3.06388
PI16 peptidase inhibitor 16 3.06388
HPCAL4 hippocalcin like 4 3.06388
GNLY granulysin 3.06388
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.06388
DSG3 desmoglein 3 3.06388
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.06388
TMEM191B transmembrane protein 191B 3.06388
DNASE2B deoxyribonuclease II beta 3.06388
LRRC73 leucine rich repeat containing 73 3.06388
UMOD uromodulin 3.06388
HAL histidine ammonia-lyase 3.06388
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.06388
PGLYRP2 peptidoglycan recognition protein 2 3.06388
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.06388
PDIA2 protein disulfide isomerase family A, member 2 3.06388
TSGA13 testis specific, 13 3.06388
MAGEA6 melanoma antigen family A6 3.06388
NPFF neuropeptide FF-amide peptide precursor 3.06388
HEATR9 HEAT repeat containing 9 3.06388
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.06388
NHLRC4 NHL repeat containing 4 3.06388
ALX1 ALX homeobox 1 3.06388
ART1 ADP-ribosyltransferase 1 3.06388
CTXN2 cortexin 2 3.06388
MYEOV myeloma overexpressed 3.06388
FSHR follicle stimulating hormone receptor 3.06388
PRPH peripherin 3.06388
EGR2 early growth response 2 3.06388
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.06388
ZCCHC12 zinc finger, CCHC domain containing 12 3.06388
CHI3L2 chitinase 3-like 2 3.06388
ANGPTL8 angiopoietin like 8 3.06388
MUC16 mucin 16, cell surface associated 3.06388
LMOD2 leiomodin 2 (cardiac) 3.06388
AGXT2 alanine--glyoxylate aminotransferase 2 3.06388
WNT7B wingless-type MMTV integration site family, member 7B 3.06388
CGB2 chorionic gonadotropin, beta polypeptide 2 3.06388
H3-5 H3.5 histone 3.06388
CPA2 carboxypeptidase A2 (pancreatic) 3.06388
FGB fibrinogen beta chain 3.06388
GFRAL GDNF family receptor alpha like 3.06388
PHOX2A paired-like homeobox 2a 3.06388
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.06388
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.06388
GOLGA8R golgin A8 family, member R 3.06388
SPMIP10 sperm microtubule inner protein 10 3.06388
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 3.06388
OR56B2 olfactory receptor family 56 subfamily B member 2 3.06388
DRC1 dynein regulatory complex subunit 1 3.06388
LAMB3 laminin, beta 3 3.06388
RAB6C RAB6C, member RAS oncogene family 3.06388
NKX6-2 NK6 homeobox 2 3.06388
GNG5B G protein subunit gamma 5B 3.06388
TUBB8B tubulin beta 8B 3.06388
QRFP pyroglutamylated RFamide peptide 3.06388
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.06388
LYZ lysozyme 3.06388
SPINK9 serine peptidase inhibitor, Kazal type 9 3.06388
PRM1 protamine 1 3.06388
GBP4 guanylate binding protein 4 3.06388
PADI1 peptidyl arginine deiminase, type I 3.06388
SLC38A11 solute carrier family 38, member 11 3.06388
RHAG Rh-associated glycoprotein 3.06388
TMEM86A transmembrane protein 86A 3.06388
DLEU7 deleted in lymphocytic leukemia, 7 3.06388
HBG2 hemoglobin, gamma G 3.06388
ANKRD30A ankyrin repeat domain 30A 3.06388
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.06388
GRAPL GRB2-related adaptor protein-like 3.06388
FOXP3 forkhead box P3 3.06388
LRRC31 leucine rich repeat containing 31 3.06388
IFNE interferon, epsilon 3.06388
BEND2 BEN domain containing 2 3.06388
TEX26 testis expressed 26 3.06388
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.06388
FGF10 fibroblast growth factor 10 3.06388
SLC7A4 solute carrier family 7, member 4 3.06388
PCDHGA9 protocadherin gamma subfamily A, 9 3.06388
CTAGE9 CTAGE family, member 9 3.06388
FATE1 fetal and adult testis expressed 1 3.06388
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.06388
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.06388
YIPF7 Yip1 domain family, member 7 3.06388
GPR35 G protein-coupled receptor 35 3.06388
HHIP hedgehog interacting protein 3.06388
CIDEA cell death-inducing DFFA-like effector a 3.06388
SPRN shadow of prion protein homolog (zebrafish) 3.06388
SNAI2 snail family zinc finger 2 3.06388
TBC1D21 TBC1 domain family, member 21 3.06388
NUTM2D NUT family member 2D 3.06388
IFITM10 interferon induced transmembrane protein 10 3.06388
TAS2R31 taste receptor, type 2, member 31 2.97703
SLC35D4 solute carrier family 35 member D4 2.9573
EDNRB endothelin receptor type B 2.81558
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.80048
PPOX protoporphyrinogen oxidase 2.7506
PUM1 pumilio RNA-binding family member 1 2.70618
CDK11B cyclin-dependent kinase 11B 2.66424
BLTP2 bridge-like lipid transfer protein family member 2 2.66181
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.62812
TBC1D31 TBC1 domain family, member 31 2.61355
GDF11 growth differentiation factor 11 2.59891
INSYN1 inhibitory synaptic factor 1 2.58753
USP6NL USP6 N-terminal like 2.5725
MIS12 MIS12 kinetochore complex component 2.57114
ZSCAN23 zinc finger and SCAN domain containing 23 2.55377
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.5337
WDR59 WD repeat domain 59 2.52894
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.51795
RWDD3 RWD domain containing 3 2.47434
RAB5IF RAB5 interacting factor 2.45561
ATP5F1D ATP synthase F1 subunit delta 2.45249
DSTYK dual serine/threonine and tyrosine protein kinase 2.44145
CPB2 carboxypeptidase B2 (plasma) 2.40179
CSP2 CS pseudogene 2 2.40179
CCDC171 coiled-coil domain containing 171 2.36711
TTC39A tetratricopeptide repeat domain 39A 2.36711
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 2.36711
WFDC13 WAP four-disulfide core domain 13 2.36543
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.3363
GJC1 gap junction protein, gamma 1, 45kDa 2.3363
ADTRP androgen-dependent TFPI-regulating protein 2.33613
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 2.31991
NAAA N-acylethanolamine acid amidase 2.29681
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2.28046
UNC79 unc-79 homolog (C. elegans) 2.28046
TMC7 transmembrane channel-like 7 2.26295
ENOX2 ecto-NOX disulfide-thiol exchanger 2 2.19779
FAAP24 FA core complex associated protein 24 2.1794
FAM149A family with sequence similarity 149, member A 2.17842
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.16801
SMN2 survival of motor neuron 2, centromeric 2.15863
ZBTB46 zinc finger and BTB domain containing 46 2.15291
IQCE IQ motif containing E 2.13791
APTX aprataxin 2.12593
GJA9 gap junction protein, alpha 9, 59kDa 2.11629
SPINK1 serine peptidase inhibitor, Kazal type 1 2.11629
LSAMP limbic system-associated membrane protein 2.11629
SIDT1 SID1 transmembrane family, member 1 2.11629
BMX BMX non-receptor tyrosine kinase 2.11629
RTBDN retbindin 2.11629
ERMARD ER membrane-associated RNA degradation 2.08542
SLC16A12 solute carrier family 16, member 12 2.07978
CDK14 cyclin-dependent kinase 14 2.07728
RBM39 RNA binding motif protein 39 2.07275
SCAMP1 secretory carrier membrane protein 1 2.0529
UNC80 unc-80 homolog (C. elegans) 2.0529
SNX18 sorting nexin 18 2.04593
CTC1 CTS telomere maintenance complex component 1 2.03779
PTPN23 protein tyrosine phosphatase, non-receptor type 23 2.02899
RGS20 regulator of G-protein signaling 20 2.01483
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.01429
GPATCH2 G patch domain containing 2 2.00718
COMMD10 COMM domain containing 10 2.00381

decreased expression

Symbol Name Standardized Value
CSDC2 cold shock domain containing C2, RNA binding -3.14379
BIN2 bridging integrator 2 -3.14379
NIPSNAP3B nipsnap homolog 3B (C. elegans) -3.14379
TSLP thymic stromal lymphopoietin -3.14379
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -3.14379
SDSL serine dehydratase-like -3.06388
CRYGN crystallin, gamma N -3.06388
MMP10 matrix metallopeptidase 10 -3.06388
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -3.06388
LECT2 leukocyte cell-derived chemotaxin 2 -3.06388
ECEL1 endothelin converting enzyme-like 1 -3.06388
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -3.06388
LPA lipoprotein, Lp(a) -3.06388
CARNS1 carnosine synthase 1 -3.06388
IER5L immediate early response 5-like -3.06388
AHSG alpha-2-HS-glycoprotein -3.06388
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) -3.06388
SP6 Sp6 transcription factor -3.06388
TM4SF20 transmembrane 4 L six family member 20 -3.06388
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.06388
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -3.06388
CD160 CD160 molecule -3.06388
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -3.06388
PROKR1 prokineticin receptor 1 -3.06388
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -3.06388
AKAP6 A kinase (PRKA) anchor protein 6 -3.06388
SYCE3 synaptonemal complex central element protein 3 -3.06388
FAM228A family with sequence similarity 228, member A -3.06388
PVRIG poliovirus receptor related immunoglobulin domain containing -3.06388
TAS2R10 taste receptor, type 2, member 10 -3.06388
LRRC71 leucine rich repeat containing 71 -3.06388
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -3.06388
TMEM255A transmembrane protein 255A -3.06388
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -3.06388
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.06388
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -3.06388
PNLIPRP1 pancreatic lipase-related protein 1 -3.06388
CRYBA1 crystallin, beta A1 -3.06388
TMEM139 transmembrane protein 139 -3.06388
OTOF otoferlin -3.06388
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.06388
TM4SF19 transmembrane 4 L six family member 19 -3.06388
TEX29 testis expressed 29 -3.06388
XKR3 XK, Kell blood group complex subunit-related family, member 3 -3.06388
CRTAC1 cartilage acidic protein 1 -3.06388
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -3.06388
PCDHGC3 protocadherin gamma subfamily C, 3 -3.06388
CNGA4 cyclic nucleotide gated channel alpha 4 -3.06388
CST1 cystatin SN -3.06388
BTNL8 butyrophilin-like 8 -3.06388
ARHGAP20 Rho GTPase activating protein 20 -3.06388
CXCR4 chemokine (C-X-C motif) receptor 4 -3.06388
SEC16A SEC16 homolog A (S. cerevisiae) -3.02776
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.02447
SPDYE3 speedy/RINGO cell cycle regulator family member E3 -2.95939
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.95573
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.95573
KDM6B lysine (K)-specific demethylase 6B -2.95573
MRPL34 mitochondrial ribosomal protein L34 -2.89537
LIMS2 LIM and senescent cell antigen-like domains 2 -2.87405
LTC4S leukotriene C4 synthase -2.77581
PSD pleckstrin and Sec7 domain containing -2.75629
PKM pyruvate kinase, muscle -2.7331
STOM stomatin -2.71398
FTH1 ferritin, heavy polypeptide 1 -2.66323
MOB3A MOB kinase activator 3A -2.62812
INO80D INO80 complex subunit D -2.61355
UBE2T ubiquitin-conjugating enzyme E2T -2.57971
C1ORF210 chromosome 1 open reading frame 210 -2.56157
ADH6 alcohol dehydrogenase 6 (class V) -2.55377
REC114 REC114 meiotic recombination protein -2.55377
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.55377
ZNF525 zinc finger protein 525 -2.51622
SAP18 Sin3A-associated protein, 18kDa -2.50165
TIPRL TOR signaling pathway regulator -2.48991
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.48006
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.48006
ZNF223 zinc finger protein 223 -2.4393
OSBPL2 oxysterol binding protein-like 2 -2.40171
METTL23 methyltransferase like 23 -2.38954
SIRT5 sirtuin 5 -2.37336
TFPI2 tissue factor pathway inhibitor 2 -2.36001
EIF3J eukaryotic translation initiation factor 3, subunit J -2.32794
UFL1 UFM1-specific ligase 1 -2.32645
EHD2 EH-domain containing 2 -2.28046
SMC1B structural maintenance of chromosomes 1B -2.22231
DMRTA1 DMRT-like family A1 -2.21947
SKA1 spindle and kinetochore associated complex subunit 1 -2.21298
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.19878
PHLDB3 pleckstrin homology-like domain, family B, member 3 -2.19808
MSRB1 methionine sulfoxide reductase B1 -2.1794
RPL21 ribosomal protein L21 -2.1794
GNMT glycine N-methyltransferase -2.1794
PEX12 peroxisomal biogenesis factor 12 -2.1794
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.16801
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.16801
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.15291
RBM20 RNA binding motif protein 20 -2.15291
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.1482
LIME1 Lck interacting transmembrane adaptor 1 -2.14369
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.11161
IL3RA interleukin 3 receptor, alpha (low affinity) -2.09964
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.09964
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -2.08722
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -2.08542
ZNF623 zinc finger protein 623 -2.08088
TYW2 tRNA wybutosine-synthesizing protein 2 -2.06641
NMD3 NMD3 ribosome export adaptor -2.04729
AMPD3 adenosine monophosphate deaminase 3 -2.04112
SNRPF small nuclear ribonucleoprotein polypeptide F -2.04112
ANXA6 annexin A6 -2.04112
SLC44A5 solute carrier family 44, member 5 -2.03801
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -2.02814
CD63 CD63 molecule -2.00503
BRCA2 breast cancer 2, early onset -2.00503
SV2C synaptic vesicle glycoprotein 2C -2.00503
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.00503
GOLGA6L10 golgin A6 family-like 10 -2.00503
BARX1 BARX homeobox 1 -2.00454