NEK6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NIMA-related kinase 6|The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 10783)
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Genes

338 genes differentially expressed following the NEK6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SOX1 SRY (sex determining region Y)-box 1 3.43562
SIRPB2 signal-regulatory protein beta 2 3.43562
PRL prolactin 3.43562
COL8A2 collagen, type VIII, alpha 2 3.43562
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.43562
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.43562
ASPA aspartoacylase 3.43562
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.43562
TNIP3 TNFAIP3 interacting protein 3 3.43562
SLC9C2 solute carrier family 9, member C2 (putative) 3.43562
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.43562
OSGIN1 oxidative stress induced growth inhibitor 1 3.43562
HES5 hes family bHLH transcription factor 5 3.43562
MYBPHL myosin binding protein H-like 3.43562
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.43562
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.43562
SCG2 secretogranin II 3.43562
IGFL4 IGF-like family member 4 3.43562
CELF3 CUGBP, Elav-like family member 3 3.43562
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.43562
SCGB3A1 secretoglobin, family 3A, member 1 3.43562
NXPH4 neurexophilin 4 3.43562
MBLAC1 metallo-beta-lactamase domain containing 1 3.43562
NRROS negative regulator of reactive oxygen species 3.43562
C3ORF22 chromosome 3 open reading frame 22 3.43562
ARRDC5 arrestin domain containing 5 3.43562
ARSH arylsulfatase family, member H 3.43562
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.43562
PCDHGA12 protocadherin gamma subfamily A, 12 3.43562
PITX1 paired-like homeodomain 1 3.43562
C16ORF54 chromosome 16 open reading frame 54 3.43562
AMPD1 adenosine monophosphate deaminase 1 3.43562
LKAAEAR1 LKAAEAR motif containing 1 3.43562
IRX4 iroquois homeobox 4 3.43562
CHRDL2 chordin-like 2 3.43562
CLNK cytokine-dependent hematopoietic cell linker 3.43562
LOC102724877 uncharacterized LOC102724877 3.43562
ZNF804B zinc finger protein 804B 3.43562
TTLL8 tubulin tyrosine ligase-like family member 8 3.43562
MEIKIN meiotic kinetochore factor 3.43562
TRIM40 tripartite motif containing 40 3.43562
S100A5 S100 calcium binding protein A5 3.43562
BFSP2 beaded filament structural protein 2, phakinin 3.43562
CAPS calcyphosine 3.43562
ASGR2 asialoglycoprotein receptor 2 3.43562
C2ORF78 chromosome 2 open reading frame 78 3.43562
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.43562
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.43562
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.43562
UPK3A uroplakin 3A 3.43562
SPMIP7 sperm microtubule inner protein 7 3.43562
SMIM38 small integral membrane protein 38 3.43562
H2AL3 H2A.L variant histone 3 3.43562
MYOCOS myocilin opposite strand 3.43562
H3-5 H3.5 histone 3.43562
SEPTIN14 septin 14 3.43562
CES4A carboxylesterase 4A 3.43562
HAO2 hydroxyacid oxidase 2 (long chain) 3.43562
MT3 metallothionein 3 3.43562
ROPN1B rhophilin associated tail protein 1B 3.43562
MGAT4D MGAT4 family, member D 3.43562
PLPP4 phospholipid phosphatase 4 3.43562
H2BW2 H2B.W histone 2 3.43562
CIMIP4 ciliary microtubule inner protein 4 3.43562
TEX53 testis expressed 53 3.43562
LITAFD LITAF domain containing 3.43562
REELD1 reeler domain containing 1 3.43562
H3C13 H3 clustered histone 13 3.43562
H4C12 H4 clustered histone 12 3.43562
H3C14 H3 clustered histone 14 3.43562
EZHIP EZH inhibitory protein 3.43562
ACP4 acid phosphatase 4 3.43562
CLEC20A C-type lectin domain containing 20A 3.43562
DNAAF1 dynein, axonemal, assembly factor 1 3.43562
TMPRSS3 transmembrane protease, serine 3 3.43562
ZNF705A zinc finger protein 705A 3.43562
MTNR1B melatonin receptor 1B 3.43562
PCDHA8 protocadherin alpha 8 3.43562
PCDHA7 protocadherin alpha 7 3.43562
ACOT4 acyl-CoA thioesterase 4 3.43562
LIPJ lipase, family member J 3.43562
PVRIG poliovirus receptor related immunoglobulin domain containing 3.43562
RAET1G retinoic acid early transcript 1G 3.43562
SLC22A10 solute carrier family 22, member 10 3.43562
SLC22A14 solute carrier family 22, member 14 3.43562
KLHL35 kelch-like family member 35 3.43562
OVOL3 ovo-like zinc finger 3 3.43562
TLR4 toll-like receptor 4 3.43562
SYT15 synaptotagmin XV 3.43562
LTK leukocyte receptor tyrosine kinase 3.43562
MYO18B myosin XVIIIB 3.43562
WNT9B wingless-type MMTV integration site family, member 9B 3.43562
PNPLA1 patatin-like phospholipase domain containing 1 3.43562
LRRC72 leucine rich repeat containing 72 3.43562
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.43562
PRR18 proline rich 18 3.43562
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.43562
PGC progastricsin (pepsinogen C) 3.43562
PLVAP plasmalemma vesicle associated protein 3.43562
KRT40 keratin 40, type I 3.43562
TSNAXIP1 translin-associated factor X interacting protein 1 3.43562
NIPAL4 NIPA-like domain containing 4 3.43562
TMED6 transmembrane emp24 protein transport domain containing 6 3.43562
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.43562
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.43562
NUPR1 nuclear protein, transcriptional regulator, 1 3.43562
MUC19 mucin 19, oligomeric 3.43562
ALOXE3 arachidonate lipoxygenase 3 3.43562
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.43562
ISL1 ISL LIM homeobox 1 3.43562
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.43562
PLET1 placenta expressed transcript 1 3.43562
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.43562
CLIC3 chloride intracellular channel 3 3.43562
SHOX2 short stature homeobox 2 3.43562
CDC20B cell division cycle 20B 3.43562
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.43562
BTNL9 butyrophilin-like 9 3.43562
CXCR6 chemokine (C-X-C motif) receptor 6 3.43562
C9ORF64 chromosome 9 open reading frame 64 3.43562
KLF2 Kruppel-like factor 2 3.43562
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 3.43562
HOPX HOP homeobox 3.43562
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.43562
ATP10B ATPase, class V, type 10B 3.43562
CSF1R colony stimulating factor 1 receptor 3.43562
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.43562
IGIP IgA-inducing protein 3.43562
ERVV-2 endogenous retrovirus group V, member 2 3.43562
IL21 interleukin 21 3.43562
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.43562
MB myoglobin 3.43562
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.43562
PENK proenkephalin 3.43562
NT5C1B 5'-nucleotidase, cytosolic IB 3.43562
SFRP4 secreted frizzled-related protein 4 3.43562
EGR2 early growth response 2 3.43562
CHIT1 chitinase 1 (chitotriosidase) 3.43562
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.43562
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.43562
TAPBPL TAP binding protein-like 3.43562
TF transferrin 3.43562
TH tyrosine hydroxylase 3.43562
TP63 tumor protein p63 3.43562
PHOX2A paired-like homeobox 2a 3.43562
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.43562
FOXP3 forkhead box P3 3.43562
FGF17 fibroblast growth factor 17 3.43562
DEFB134 defensin, beta 134 3.43562
MT1M metallothionein 1M 3.43562
NUTM2A NUT family member 2A 3.43562
PLGLB2 plasminogen-like B2 3.43562
ACKR2 atypical chemokine receptor 2 3.43562
TBC1D26 TBC1 domain family, member 26 3.43562
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.43562
FGF6 fibroblast growth factor 6 3.43562
AHSG alpha-2-HS-glycoprotein 3.43562
TGM6 transglutaminase 6 3.43562
AGBL4 ATP/GTP binding protein-like 4 3.43562
RNF148 ring finger protein 148 3.43562
TMEM45B transmembrane protein 45B 3.43562
IL10RA interleukin 10 receptor, alpha 3.43562
BIN2 bridging integrator 2 3.43562
PTCRA pre T-cell antigen receptor alpha 3.43562
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.43562
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.43562
PALMD palmdelphin 3.43562
PCDHGB4 protocadherin gamma subfamily B, 4 3.43562
APOB apolipoprotein B 3.43562
ALAS2 5'-aminolevulinate synthase 2 3.43562
LRRC32 leucine rich repeat containing 32 3.43562
CYBB cytochrome b-245, beta polypeptide 3.43562
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.43562
TCF21 transcription factor 21 3.43562
PDE10A phosphodiesterase 10A 3.23364
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 3.23245
ATG10 autophagy related 10 3.17718
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 3.16031
UBXN8 UBX domain protein 8 2.93743
ASB16 ankyrin repeat and SOCS box containing 16 2.82762
ZNF771 zinc finger protein 771 2.76407
XKR9 XK, Kell blood group complex subunit-related family, member 9 2.76407
OSER1 oxidative stress responsive serine-rich 1 2.7323
DCTN5 dynactin 5 (p25) 2.72563
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.71813
UBXN10 UBX domain protein 10 2.59004
AEBP1 AE binding protein 1 2.57972
PRNP prion protein 2.5411
EFCAB11 EF-hand calcium binding domain 11 2.53598
TMEM98 transmembrane protein 98 2.51814
EVL Enah/Vasp-like 2.51191
FEN1 flap structure-specific endonuclease 1 2.49201
RNF145 ring finger protein 145 2.46357
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.42691
HLA-A major histocompatibility complex, class I, A 2.41871
CAMSAP1 calmodulin regulated spectrin-associated protein 1 2.39844
RHBDD3 rhomboid domain containing 3 2.36764
GHR growth hormone receptor 2.34013
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.33758
ZNF680 zinc finger protein 680 2.33397
KLK7 kallikrein-related peptidase 7 2.31839
C13ORF42 chromosome 13 open reading frame 42 2.31452
MCFD2 multiple coagulation factor deficiency 2 2.29963
FGF16 fibroblast growth factor 16 2.29738
CHMP3 charged multivesicular body protein 3 2.2432
MDP1 magnesium-dependent phosphatase 1 2.23998
ZNF609 zinc finger protein 609 2.22443
STXBP1 syntaxin binding protein 1 2.21768
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 2.21668
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.16242
MAP7D3 MAP7 domain containing 3 2.15621
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.13728
CNBD2 cyclic nucleotide binding domain containing 2 2.09294
DIDO1 death inducer-obliterator 1 2.06633
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.03884
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.03809
LTC4S leukotriene C4 synthase 2.02426
SNU13 small nuclear ribonucleoprotein 13 2.0122
TSEN15 TSEN15 tRNA splicing endonuclease subunit 2.00862
SUZ12 SUZ12 polycomb repressive complex 2 subunit 2.00584
WASHC4 WASH complex subunit 4 2.00145

decreased expression

Symbol Name Standardized Value
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.43562
TDRD1 tudor domain containing 1 -3.43562
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.43562
KCNIP3 Kv channel interacting protein 3, calsenilin -3.43562
ADH6 alcohol dehydrogenase 6 (class V) -3.43562
NWD2 NACHT and WD repeat domain containing 2 -3.43562
VPREB3 pre-B lymphocyte 3 -3.43562
GPBAR1 G protein-coupled bile acid receptor 1 -3.43562
DAND5 DAN domain family member 5, BMP antagonist -3.43562
SUN3 Sad1 and UNC84 domain containing 3 -3.43562
ALOX15B arachidonate 15-lipoxygenase, type B -3.43562
PKLR pyruvate kinase, liver and RBC -3.43562
NPIPB15 nuclear pore complex interacting protein family, member B15 -3.43562
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -3.43562
LBP lipopolysaccharide binding protein -3.43562
C6ORF58 chromosome 6 open reading frame 58 -3.43562
BDKRB2 bradykinin receptor B2 -3.43562
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.43562
PARVG parvin, gamma -3.43562
CNTFR ciliary neurotrophic factor receptor -3.43562
MSX1 msh homeobox 1 -3.43562
CATSPER4 cation channel, sperm associated 4 -3.43562
LTBP3 latent transforming growth factor beta binding protein 3 -3.43562
ZNG1C Zn regulated GTPase metalloprotein activator 1C -3.43562
BTN3A3 butyrophilin, subfamily 3, member A3 -3.43562
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -3.43562
HES3 hes family bHLH transcription factor 3 -3.43562
BMP8B bone morphogenetic protein 8b -3.43562
NPPA natriuretic peptide A -3.43562
WNT7B wingless-type MMTV integration site family, member 7B -3.43562
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -3.43562
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -3.43562
ZNF547 zinc finger protein 547 -3.43562
FAM222A family with sequence similarity 222, member A -3.43562
BEAN1 brain expressed, associated with NEDD4, 1 -3.43562
MYO15A myosin XVA -3.43562
RNF112 ring finger protein 112 -3.43562
FAM151A family with sequence similarity 151, member A -3.43562
PINK1 PTEN induced putative kinase 1 -3.38131
ZNF658 zinc finger protein 658 -3.3196
PNMA6A paraneoplastic Ma antigen family member 6A -3.29599
GLYCTK glycerate kinase -3.29599
MANSC1 MANSC domain containing 1 -3.11554
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide -3.1066
TUBA8 tubulin, alpha 8 -3.00762
TECTA tectorin alpha -2.9956
PPARA peroxisome proliferator-activated receptor alpha -2.91058
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -2.88023
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.87537
MROH8 maestro heat-like repeat family member 8 -2.80777
C2ORF76 chromosome 2 open reading frame 76 -2.72841
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.724
RAB3B RAB3B, member RAS oncogene family -2.67341
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.60064
RBFA ribosome binding factor A (putative) -2.58792
ZNF85 zinc finger protein 85 -2.5411
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.52101
RUSC1 RUN and SH3 domain containing 1 -2.51492
SCRG1 stimulator of chondrogenesis 1 -2.51085
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.51085
COL21A1 collagen, type XXI, alpha 1 -2.50889
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.44335
SHTN1 shootin 1 -2.42691
DUSP26 dual specificity phosphatase 26 (putative) -2.39799
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.37986
HFE hemochromatosis -2.37494
ELOVL5 ELOVL fatty acid elongase 5 -2.37128
PEX19 peroxisomal biogenesis factor 19 -2.35557
SELENOF selenoprotein F -2.35428
MBTPS1 membrane-bound transcription factor peptidase, site 1 -2.34488
WNK4 WNK lysine deficient protein kinase 4 -2.34013
CAND1 cullin-associated and neddylation-dissociated 1 -2.34013
MAP6 microtubule-associated protein 6 -2.34013
RGPD2 RANBP2-like and GRIP domain containing 2 -2.34013
IL4I1 interleukin 4 induced 1 -2.34013
POLR1C polymerase (RNA) I polypeptide C, 30kDa -2.32912
ANKRD18B ankyrin repeat domain 18B -2.32912
AQP5 aquaporin 5 -2.31452
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.31452
HDAC11 histone deacetylase 11 -2.31452
CES3 carboxylesterase 3 -2.31452
PCDHA9 protocadherin alpha 9 -2.31452
ZDHHC20 zinc finger, DHHC-type containing 20 -2.30239
ELL elongation factor RNA polymerase II -2.27452
CPNE3 copine III -2.26476
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -2.25611
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.25274
SOCS4 suppressor of cytokine signaling 4 -2.2432
EMILIN3 elastin microfibril interfacer 3 -2.2432
PTAFR platelet-activating factor receptor -2.2432
SCARA3 scavenger receptor class A, member 3 -2.22386
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.21815
ZNF608 zinc finger protein 608 -2.21768
BLVRB biliverdin reductase B -2.21139
CCDC43 coiled-coil domain containing 43 -2.18658
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.17015
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -2.13728
PICK1 protein interacting with PRKCA 1 -2.1335
PRDX1 peroxiredoxin 1 -2.13137
PTER phosphotriesterase related -2.1274
TAS2R20 taste receptor, type 2, member 20 -2.1043
MIB2 mindbomb E3 ubiquitin protein ligase 2 -2.10262
OLA1 Obg-like ATPase 1 -2.10166
SRSF12 serine/arginine-rich splicing factor 12 -2.08062
PRPF18 pre-mRNA processing factor 18 -2.07262
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.06939
RPL7A ribosomal protein L7a -2.05785
IFNGR1 interferon gamma receptor 1 -2.05446
LACTB2 lactamase, beta 2 -2.05008
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 -2.04619
CORO1C coronin, actin binding protein, 1C -2.03884
SS18 synovial sarcoma translocation, chromosome 18 -2.03484
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.02426
CNTNAP2 contactin associated protein-like 2 -2.02426
DEPDC1B DEP domain containing 1B -2.01742
ZBTB1 zinc finger and BTB domain containing 1 -2.00862
ZRANB1 zinc finger, RAN-binding domain containing 1 -2.00145