NEK6 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description NIMA-related kinase 6|The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 10783)
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Genes

100 substrates of the kinase NEK6 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HAUS6 HAUS augmin-like complex, subunit 6
OFD1 oral-facial-digital syndrome 1
EIF5B eukaryotic translation initiation factor 5B
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
TRAFD1 TRAF-type zinc finger domain containing 1
AVEN apoptosis, caspase activation inhibitor
MED7 mediator complex subunit 7
EHBP1 EH domain binding protein 1
UGP2 UDP-glucose pyrophosphorylase 2
ATXN2L ataxin 2-like
TRAT1 T cell receptor associated transmembrane adaptor 1
TBC1D5 TBC1 domain family, member 5
CDK16 cyclin-dependent kinase 16
RCN2 reticulocalbin 2, EF-hand calcium binding domain
CABIN1 calcineurin binding protein 1
INTS3 integrator complex subunit 3
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
SPN sialophorin
FAM134C family with sequence similarity 134, member C
AFTPH aftiphilin
TSHZ3 teashirt zinc finger homeobox 3
TSHZ1 teashirt zinc finger homeobox 1
PRDM16 PR domain containing 16
PLIN2 perilipin 2
CRTC3 CREB regulated transcription coactivator 3
MYO18A myosin XVIIIA
SHROOM1 shroom family member 1
USP48 ubiquitin specific peptidase 48
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
RTTN rotatin
GORAB golgin, RAB6-interacting
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
NIN ninein (GSK3B interacting protein)
KNOP1 lysine-rich nucleolar protein 1
ZNF79 zinc finger protein 79
SFPQ splicing factor proline/glutamine-rich
C2CD5 C2 calcium-dependent domain containing 5
CTNNBL1 catenin, beta like 1
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
AKAP8 A kinase (PRKA) anchor protein 8
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
TUBA3E tubulin, alpha 3e
TUBA3D tubulin, alpha 3d
IRF4 interferon regulatory factor 4
CENPC centromere protein C
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
ZMYND8 zinc finger, MYND-type containing 8
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
CDCA2 cell division cycle associated 2
COPS8 COP9 signalosome subunit 8
INF2 inverted formin, FH2 and WH2 domain containing
WAPAL wings apart-like homolog (Drosophila)
BMS1 BMS1 ribosome biogenesis factor
FAM219A family with sequence similarity 219, member A
OCIAD1 OCIA domain containing 1
PHF6 PHD finger protein 6
CEP192 centrosomal protein 192kDa
ITGB4 integrin, beta 4
KCMF1 potassium channel modulatory factor 1
VAV2 vav 2 guanine nucleotide exchange factor
BCLAF1 BCL2-associated transcription factor 1
PCNT pericentrin
ADSL adenylosuccinate lyase
TUBA1C tubulin, alpha 1c
TUBA1B tubulin, alpha 1b
TUBA1A tubulin, alpha 1a
DCX doublecortin
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
EEA1 early endosome antigen 1
CARD11 caspase recruitment domain family, member 11
NOS3 nitric oxide synthase 3 (endothelial cell)
TGM1 transglutaminase 1
TARDBP TAR DNA binding protein
JMJD1C jumonji domain containing 1C
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae)
DIRC2 disrupted in renal carcinoma 2
BOD1L1 biorientation of chromosomes in cell division 1-like 1
NUMB numb homolog (Drosophila)
NELFE negative elongation factor complex member E
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
PDCD11 programmed cell death 11
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
CNOT12 CCR4-NOT transcription complex subunit 12
TP53BP1 tumor protein p53 binding protein 1
SYNM synemin, intermediate filament protein
PNP purine nucleoside phosphorylase
DTWD1 DTW domain containing 1
CLK3 CDC-like kinase 3
CYBB cytochrome b-245, beta polypeptide
HMHA1 histocompatibility (minor) HA-1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
IQSEC1 IQ motif and Sec7 domain 1