NEUROD2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neuronal differentiation 2|This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4761)
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Genes

319 genes differentially expressed following the NEUROD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD274 CD274 molecule 3.32131
C8ORF48 chromosome 8 open reading frame 48 3.32131
SH2D7 SH2 domain containing 7 3.32131
SKOR2 SKI family transcriptional corepressor 2 3.32131
CCL5 chemokine (C-C motif) ligand 5 3.32131
LRRC56 leucine rich repeat containing 56 3.32131
MTTP microsomal triglyceride transfer protein 3.32131
ARHGAP36 Rho GTPase activating protein 36 3.32131
OLIG3 oligodendrocyte transcription factor 3 3.32131
MUSK muscle, skeletal, receptor tyrosine kinase 3.32131
DDN dendrin 3.32131
PRODH2 proline dehydrogenase (oxidase) 2 3.32131
IL11RA interleukin 11 receptor, alpha 3.32131
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.32131
MAP3K7CL MAP3K7 C-terminal like 3.32131
FAM180A family with sequence similarity 180, member A 3.32131
ALOX15 arachidonate 15-lipoxygenase 3.32131
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.32131
PGAM4 phosphoglycerate mutase family member 4 3.32131
TSGA13 testis specific, 13 3.32131
PCDHB7 protocadherin beta 7 3.32131
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.32131
ADAD2 adenosine deaminase domain containing 2 3.32131
BMP3 bone morphogenetic protein 3 3.32131
MYO1A myosin IA 3.32131
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 3.32131
HES2 hes family bHLH transcription factor 2 3.32131
NWD1 NACHT and WD repeat domain containing 1 3.32131
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.32131
CAMK1G calcium/calmodulin-dependent protein kinase IG 3.32131
FGF7 fibroblast growth factor 7 3.32131
CCDC83 coiled-coil domain containing 83 3.32131
ACOT12 acyl-CoA thioesterase 12 3.32131
TAS2R10 taste receptor, type 2, member 10 3.32131
TAL2 T-cell acute lymphocytic leukemia 2 3.32131
GIMAP4 GTPase, IMAP family member 4 3.32131
TCAF2 TRPM8 channel-associated factor 2 3.32131
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.32131
ADAMTSL5 ADAMTS-like 5 3.32131
TMEM217 transmembrane protein 217 3.32131
GLRA3 glycine receptor, alpha 3 3.32131
PSCA prostate stem cell antigen 3.32131
CD68 CD68 molecule 3.32131
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 3.32131
LOC107986837 uncharacterized LOC107986837 3.32131
SMIM38 small integral membrane protein 38 3.32131
MISP3 MISP family member 3 3.32131
GBP6 guanylate binding protein family, member 6 3.32131
C3AR1 complement component 3a receptor 1 3.32131
OTOR otoraplin 3.32131
PDC phosducin 3.32131
PLCZ1 phospholipase C, zeta 1 3.32131
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.32131
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.32131
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.32131
KASH5 KASH domain containing 5 3.32131
ACKR5 atypical chemokine receptor 5 3.32131
DRC5 dynein regulatory complex subunit 5 3.32131
SPATA31F1 SPATA31 subfamily F member 1 3.32131
OOSP4B oocyte secreted protein family member 4B 3.32131
ZNF593OS ZNF593 opposite strand 3.32131
PEAK3 PEAK family member 3 3.32131
ACP4 acid phosphatase 4 3.32131
MEIOSIN meiosis initiator 3.32131
CFAP206 cilia and flagella associated protein 206 3.32131
PAPOLB poly(A) polymerase beta (testis specific) 3.32131
ASB9 ankyrin repeat and SOCS box containing 9 3.32131
TMEM236 transmembrane protein 236 3.32131
FAM78A family with sequence similarity 78, member A 3.32131
VSX2 visual system homeobox 2 3.32131
CLDN9 claudin 9 3.32131
PCDHB13 protocadherin beta 13 3.32131
IL12RB1 interleukin 12 receptor, beta 1 3.32131
GRXCR1 glutaredoxin, cysteine rich 1 3.32131
FPR1 formyl peptide receptor 1 3.32131
KLHL34 kelch-like family member 34 3.32131
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.32131
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.32131
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 3.32131
C10ORF53 chromosome 10 open reading frame 53 3.32131
KHDC1L KH homology domain containing 1-like 3.32131
LGSN lengsin, lens protein with glutamine synthetase domain 3.32131
ZAR1L zygote arrest 1-like 3.32131
VCX3A variable charge, X-linked 3A 3.32131
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.32131
NPFF neuropeptide FF-amide peptide precursor 3.32131
C6ORF118 chromosome 6 open reading frame 118 3.32131
CFHR4 complement factor H-related 4 3.32131
PCDHGA11 protocadherin gamma subfamily A, 11 3.32131
DRD2 dopamine receptor D2 3.32131
EBF3 early B-cell factor 3 3.32131
PCDHGB5 protocadherin gamma subfamily B, 5 3.32131
ZNF366 zinc finger protein 366 3.32131
TEKT2 tektin 2 (testicular) 3.32131
CTXN2 cortexin 2 3.32131
FGR FGR proto-oncogene, Src family tyrosine kinase 3.32131
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.32131
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.32131
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.32131
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.32131
TG thyroglobulin 3.32131
ANKRD55 ankyrin repeat domain 55 3.32131
G0S2 G0/G1 switch 2 3.32131
SPATA32 spermatogenesis associated 32 3.32131
PRND prion protein 2 (dublet) 3.32131
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.32131
FNDC9 fibronectin type III domain containing 9 3.32131
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.32131
PCDHGA2 protocadherin gamma subfamily A, 2 3.32131
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.32131
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.32131
ADAM7 ADAM metallopeptidase domain 7 3.32131
WFDC6 WAP four-disulfide core domain 6 3.32131
HCLS1 hematopoietic cell-specific Lyn substrate 1 3.32131
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.32131
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.32131
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.32131
FOXE3 forkhead box E3 3.32131
SHOX2 short stature homeobox 2 3.32131
AGXT2 alanine--glyoxylate aminotransferase 2 3.32131
COX7B2 cytochrome c oxidase subunit VIIb2 3.32131
ZSCAN4 zinc finger and SCAN domain containing 4 3.32131
MUC17 mucin 17, cell surface associated 3.32131
DLX2 distal-less homeobox 2 3.32131
EBI3 Epstein-Barr virus induced 3 3.32131
C4BPA complement component 4 binding protein, alpha 3.32131
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.32131
RAB6C RAB6C, member RAS oncogene family 3.32131
PLA2G5 phospholipase A2, group V 3.32131
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.32131
SDSL serine dehydratase-like 3.32131
STRC stereocilin 3.32131
PF4V1 platelet factor 4 variant 1 3.32131
KCTD4 potassium channel tetramerization domain containing 4 3.32131
GOLGA8O golgin A8 family, member O 3.32131
OXER1 oxoeicosanoid (OXE) receptor 1 3.32131
KIF12 kinesin family member 12 3.32131
ART1 ADP-ribosyltransferase 1 3.32131
BTBD16 BTB (POZ) domain containing 16 3.32131
NFE2 nuclear factor, erythroid 2 3.32131
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.32131
TMPPE transmembrane protein with metallophosphoesterase domain 3.32131
AMER3 APC membrane recruitment protein 3 3.32131
DLX6 distal-less homeobox 6 3.32131
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.32131
MAPK11 mitogen-activated protein kinase 11 3.32131
ECM1 extracellular matrix protein 1 3.32131
ZNF534 zinc finger protein 534 3.32131
NCR3 natural cytotoxicity triggering receptor 3 3.32131
PRAP1 proline-rich acidic protein 1 3.32131
APOL1 apolipoprotein L, 1 3.32131
GCM1 glial cells missing homolog 1 (Drosophila) 3.32131
MTCH1 mitochondrial carrier 1 3.30308
NCF2 neutrophil cytosolic factor 2 3.19801
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 3.13045
KLHL22 kelch-like family member 22 3.05303
AGFG2 ArfGAP with FG repeats 2 3.04458
JMJD6 jumonji domain containing 6 3.03269
ACP6 acid phosphatase 6, lysophosphatidic 2.9151
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.8766
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.81805
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.77393
LHFPL6 LHFPL tetraspan subfamily member 6 2.77393
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.74732
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.74102
ZNF408 zinc finger protein 408 2.69326
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.69168
ZFP62 ZFP62 zinc finger protein 2.68753
SOGA3 SOGA family member 3 2.66547
DENND4A DENN/MADD domain containing 4A 2.61875
HPF1 histone PARylation factor 1 2.61776
RANBP3 RAN binding protein 3 2.61665
SHISAL1 shisa like 1 2.60288
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.48731
FBXO36 F-box protein 36 2.46583
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.45951
DSP desmoplakin 2.4535
LATS2 large tumor suppressor kinase 2 2.4375
GNL1 guanine nucleotide binding protein-like 1 2.42138
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.41872
RPS29 ribosomal protein S29 2.40089
H2BC14 H2B clustered histone 14 2.39826
TMEM61 transmembrane protein 61 2.39666
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.39666
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.38224
DNM1 dynamin 1 2.35184
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 2.34053
MMP11 matrix metallopeptidase 11 2.3293
GFRA3 GDNF family receptor alpha 3 2.31331
SEC23IP SEC23 interacting protein 2.30801
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.29145
KRTCAP2 keratinocyte associated protein 2 2.2804
COL11A2 collagen, type XI, alpha 2 2.2804
TMEM196 transmembrane protein 196 2.2804
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.27727
ADIRF adipogenesis regulatory factor 2.24277
CNTNAP4 contactin associated protein-like 4 2.24277
S100A4 S100 calcium binding protein A4 2.24277
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.24277
PRSS50 protease, serine, 50 2.24277
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.20753
REXO5 RNA exonuclease 5 2.20753
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.20685
ANO7 anoctamin 7 2.16141
PRPF38B pre-mRNA processing factor 38B 2.16141
MCMDC2 minichromosome maintenance domain containing 2 2.15044
TGM2 transglutaminase 2 2.15044
CGN cingulin 2.15044
SYNPO2L synaptopodin 2-like 2.15044
SMC6 structural maintenance of chromosomes 6 2.14025
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 2.13117
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 2.13036
TATDN2 TatD DNase domain containing 2 2.1256
JAZF1 JAZF zinc finger 1 2.11783
SELENOO selenoprotein O 2.10894
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.08461
GAK cyclin G associated kinase 2.03246
RFTN2 raftlin family member 2 2.02464
MFAP2 microfibrillar-associated protein 2 2.02464

decreased expression

Symbol Name Standardized Value
TRMT9B tRNA methyltransferase 9B (putative) -3.39736
LRRC61 leucine rich repeat containing 61 -3.32131
ANKRD61 ankyrin repeat domain 61 -3.32131
TMIE transmembrane inner ear -3.32131
ATP13A4 ATPase type 13A4 -3.32131
FPR3 formyl peptide receptor 3 -3.32131
IER5L immediate early response 5-like -3.32131
CD8B CD8b molecule -3.32131
SGPP2 sphingosine-1-phosphate phosphatase 2 -3.32131
LAG3 lymphocyte-activation gene 3 -3.32131
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.32131
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -3.32131
SSTR5 somatostatin receptor 5 -3.32131
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -3.32131
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -3.32131
CCR10 chemokine (C-C motif) receptor 10 -3.32131
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -3.32131
C1ORF167 chromosome 1 open reading frame 167 -3.32131
SPMIP10 sperm microtubule inner protein 10 -3.32131
IDI2 isopentenyl-diphosphate delta isomerase 2 -3.32131
RIBC1 RIB43A domain with coiled-coils 1 -3.32131
VENTX VENT homeobox -3.32131
GOLGA8H golgin A8 family, member H -3.32131
CFAP61 cilia and flagella associated protein 61 -3.32131
FAM186A family with sequence similarity 186, member A -3.32131
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -3.32131
UPK2 uroplakin 2 -3.26106
TSNAXIP1 translin-associated factor X interacting protein 1 -3.26106
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -3.18893
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -3.18017
CCDC88A coiled-coil domain containing 88A -3.15749
HEXD hexosaminidase D -3.01828
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -3.01529
PGM5 phosphoglucomutase 5 -3.00865
AKAP6 A kinase (PRKA) anchor protein 6 -2.99623
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -2.944
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.8744
TUBGCP5 tubulin, gamma complex associated protein 5 -2.84074
NCAPD3 non-SMC condensin II complex, subunit D3 -2.8149
EVC2 Ellis van Creveld syndrome 2 -2.68294
PSEN2 presenilin 2 -2.6791
RUMY2 RUMY family member 2 -2.60725
ELMOD2 ELMO/CED-12 domain containing 2 -2.60288
ECE1 endothelin converting enzyme 1 -2.53068
ZNF100 zinc finger protein 100 -2.52188
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.52188
MRC2 mannose receptor, C type 2 -2.46441
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -2.46056
CYYR1 cysteine/tyrosine-rich 1 -2.42138
FZD9 frizzled class receptor 9 -2.40095
MCOLN3 mucolipin 3 -2.40095
KIF23 kinesin family member 23 -2.39826
CAMTA1 calmodulin binding transcription activator 1 -2.38349
RBM26 RNA binding motif protein 26 -2.38224
GTPBP10 GTP-binding protein 10 (putative) -2.36831
TEC tec protein tyrosine kinase -2.36828
MMP28 matrix metallopeptidase 28 -2.31455
NBPF14 neuroblastoma breakpoint family, member 14 -2.31455
KIRREL2 kin of IRRE like 2 (Drosophila) -2.31455
PRTFDC1 phosphoribosyl transferase domain containing 1 -2.31455
GJA4 gap junction protein, alpha 4, 37kDa -2.31455
TAGLN transgelin -2.31455
STAC2 SH3 and cysteine rich domain 2 -2.31455
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -2.31455
CTSO cathepsin O -2.31455
USP19 ubiquitin specific peptidase 19 -2.31455
TICAM2 toll-like receptor adaptor molecule 2 -2.31455
H2BC13 H2B clustered histone 13 -2.31218
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.31218
MRPL27 mitochondrial ribosomal protein L27 -2.31218
BRAT1 BRCA1-associated ATM activator 1 -2.30344
LONP1 lon peptidase 1, mitochondrial -2.2911
NMRAL1 NmrA-like family domain containing 1 -2.28888
NRG1 neuregulin 1 -2.28744
PEX11A peroxisomal biogenesis factor 11 alpha -2.24364
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.24277
ST7 suppression of tumorigenicity 7 -2.24277
CEND1 cell cycle exit and neuronal differentiation 1 -2.24277
FNBP1L formin binding protein 1-like -2.23731
TRIP10 thyroid hormone receptor interactor 10 -2.23165
DNASE1 deoxyribonuclease I -2.23124
NOSTRIN nitric oxide synthase trafficking -2.22874
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -2.21919
HID1 HID1 domain containing -2.21919
CALR calreticulin -2.2123
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B -2.20753
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.15367
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.15044
NBPF3 neuroblastoma breakpoint family, member 3 -2.15044
ARL8A ADP-ribosylation factor-like 8A -2.13501
TKFC triokinase/FMN cyclase -2.11964
NBR1 neighbor of BRCA1 gene 1 -2.11051
CDK10 cyclin-dependent kinase 10 -2.11051
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase -2.09312
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.08103
XRN2 5'-3' exoribonuclease 2 -2.06806
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.05913
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.03445
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.00444
SERINC3 serine incorporator 3 -2.00102