NF-kappaB Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells 1|This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 4790)
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Genes

376 target genes of the NF-kappaB transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADGRF5 adhesion G protein-coupled receptor F5
ADRBK2 adrenergic, beta, receptor kinase 2
ADTRP androgen-dependent TFPI-regulating protein
AGO1 argonaute RISC catalytic component 1
AHDC1 AT hook, DNA binding motif, containing 1
AKAP13 A kinase (PRKA) anchor protein 13
AKAP6 A kinase (PRKA) anchor protein 6
ALCAM activated leukocyte cell adhesion molecule
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1
ANKHD1 ankyrin repeat and KH domain containing 1
ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough
ANKRD24 ankyrin repeat domain 24
APLF aprataxin and PNKP like factor
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP26-AS1 ARHGAP26 antisense RNA 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARID5A AT rich interactive domain 5A (MRF1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASH1L-AS1 ASH1L antisense RNA 1
ASXL1 additional sex combs like transcriptional regulator 1
ATG16L2 autophagy related 16-like 2 (S. cerevisiae)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
B2M beta-2-microglobulin
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
BATF basic leucine zipper transcription factor, ATF-like
BCL3 B-cell CLL/lymphoma 3
BCL6B B-cell CLL/lymphoma 6, member B
BICC1 BicC family RNA binding protein 1
BIRC3 baculoviral IAP repeat containing 3
BMP2K BMP2 inducible kinase
BMP5 bone morphogenetic protein 5
C10ORF25 chromosome 10 open reading frame 25
C10ORF55 chromosome 10 open reading frame 55
C11ORF30 chromosome 11 open reading frame 30
C11ORF68 chromosome 11 open reading frame 68
C17ORF112 chromosome 17 open reading frame 112
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1QTNF7 C1q and tumor necrosis factor related protein 7
C4ORF32 chromosome 4 open reading frame 32
C6ORF136 chromosome 6 open reading frame 136
CACHD1 cache domain containing 1
CAMTA1 calmodulin binding transcription activator 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CBX2 chromobox homolog 2
CCDC155 coiled-coil domain containing 155
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2 cyclin-dependent kinase 2
CDK8 cyclin-dependent kinase 8
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHD2 chromodomain helicase DNA binding protein 2
CHGA chromogranin A
CHI3L2 chitinase 3-like 2
CLCN1 chloride channel, voltage-sensitive 1
CLIC5 chloride intracellular channel 5
CLPTM1 cleft lip and palate associated transmembrane protein 1
COMMD3 COMM domain containing 3
COMMD3-BMI1 COMMD3-BMI1 readthrough
COPS7B COP9 signalosome subunit 7B
CORO6 coronin 6
CRB2 crumbs family member 2
CREB1 cAMP responsive element binding protein 1
CSF1 colony stimulating factor 1 (macrophage)
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
DDR1 discoidin domain receptor tyrosine kinase 1
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DIO3OS DIO3 opposite strand/antisense RNA (head to head)
DMD dystrophin
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSP desmoplakin
DTX4 deltex 4, E3 ubiquitin ligase
EGF epidermal growth factor
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EGR2 early growth response 2
EHF ets homologous factor
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EML2 echinoderm microtubule associated protein like 2
EMX1 empty spiracles homeobox 1
ENO3 enolase 3 (beta, muscle)
ERCC3 excision repair cross-complementation group 3
ETV3L ets variant 3-like
FADS2 fatty acid desaturase 2
FAM160B2 family with sequence similarity 160, member B2
FAM187A family with sequence similarity 187, member A
FAM189A2 family with sequence similarity 189, member A2
FAM65A family with sequence similarity 65, member A
FANCI Fanconi anemia, complementation group I
FBRS fibrosin
FBXL8 F-box and leucine-rich repeat protein 8
FCAMR Fc receptor, IgA, IgM, high affinity
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FERMT3 fermitin family member 3
FFAR2 free fatty acid receptor 2
FGF13-AS1 FGF13 antisense RNA 1
FGF17 fibroblast growth factor 17
FLJ20021 uncharacterized LOC90024
FLJ31104 uncharacterized LOC441072
FLRT1 fibronectin leucine rich transmembrane protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXP4 forkhead box P4
FOXS1 forkhead box S1
FREM2 FRAS1 related extracellular matrix protein 2
FTHL17 ferritin, heavy polypeptide-like 17
FXYD7 FXYD domain containing ion transport regulator 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA4 GATA binding protein 4
GFOD1 glucose-fructose oxidoreductase domain containing 1
GGNBP2 gametogenetin binding protein 2
GLRA2 glycine receptor, alpha 2
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GPBP1 GC-rich promoter binding protein 1
GPHN gephyrin
GPR139 G protein-coupled receptor 139
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GRIK2 glutamate receptor, ionotropic, kainate 2
GRK5 G protein-coupled receptor kinase 5
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HAX1 HCLS1 associated protein X-1
HCAR2 hydroxycarboxylic acid receptor 2
HCP5 HLA complex P5 (non-protein coding)
HDAC9 histone deacetylase 9
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HES1 hes family bHLH transcription factor 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLA-B major histocompatibility complex, class I, B
HMGB1 high mobility group box 1
HOXA13 homeobox A13
HS1BP3 HCLS1 binding protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICAM1 intercellular adhesion molecule 1
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL36G interleukin 36, gamma
IL6 interleukin 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INADL InaD-like (Drosophila)
IRF8 interferon regulatory factor 8
ITGB4 integrin, beta 4
ITGB8 integrin, beta 8
ITPKC inositol-trisphosphate 3-kinase C
JRKL JRK-like
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCTD11 potassium channel tetramerization domain containing 11
KDM2A lysine (K)-specific demethylase 2A
KIAA0368 KIAA0368
KIAA1217 KIAA1217
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF5 Kruppel-like factor 5 (intestinal)
KREMEN2 kringle containing transmembrane protein 2
KRT5 keratin 5, type II
KRTAP13-1 keratin associated protein 13-1
KSR1 kinase suppressor of ras 1
KU-MEL-3 uncharacterized LOC497048
LAMP5 lysosomal-associated membrane protein family, member 5
LHX8 LIM homeobox 8
LINC00486 long intergenic non-protein coding RNA 486
LINC00570 long intergenic non-protein coding RNA 570
LIPE-AS1 LIPE antisense RNA 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC100507384 uncharacterized LOC100507384
LOC154761 family with sequence similarity 115, member C pseudogene
LOC284648 uncharacterized LOC284648
LOC285847 uncharacterized LOC285847
LOC339807 uncharacterized LOC339807
LOC441204 uncharacterized LOC441204
LOC646626 uncharacterized LOC646626
LOC729683 uncharacterized LOC729683
LOC730101 uncharacterized LOC730101
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC3B leucine rich repeat containing 3B
LRRC49 leucine rich repeat containing 49
LRTM2 leucine-rich repeats and transmembrane domains 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAG myelin associated glycoprotein
MAMLD1 mastermind-like domain containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBNL2 muscleblind-like splicing regulator 2
MIR1181 microRNA 1181
MIR1208 microRNA 1208
MIR129-2 microRNA 129-2
MIR153-2 microRNA 153-2
MIR1538 microRNA 1538
MIR17HG miR-17-92 cluster host gene
MIR3127 microRNA 3127
MIR3191 microRNA 3191
MIR4322 microRNA 4322
MIR449C microRNA 449c
MIR4505 microRNA 4505
MIR4679-1 microRNA 4679-1
MIR4734 microRNA 4734
MIR4792 microRNA 4792
MIRLET7I microRNA let-7i
MMP9 matrix metallopeptidase 9
MSL1 male-specific lethal 1 homolog (Drosophila)
MSX1 msh homeobox 1
MTMR14 myotubularin related protein 14
MYB v-myb avian myeloblastosis viral oncogene homolog
N4BP3 NEDD4 binding protein 3
NARR nine-amino acid residue-repeats
NCS1 neuronal calcium sensor 1
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NEK6 NIMA-related kinase 6
NEK8 NIMA-related kinase 8
NELFE negative elongation factor complex member E
NEO1 neogenin 1
NEURL3 neuralized E3 ubiquitin protein ligase 3
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L1 nuclear factor, erythroid 2-like 1
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NHEJ1 nonhomologous end-joining factor 1
NKX2-8 NK2 homeobox 8
NLK nemo-like kinase
NOD2 nucleotide-binding oligomerization domain containing 2
NRXN3 neurexin 3
NT5C1A 5'-nucleotidase, cytosolic IA
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OIT3 oncoprotein induced transcript 3
OPTN optineurin
ORAI1 ORAI calcium release-activated calcium modulator 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PACS1 phosphofurin acidic cluster sorting protein 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK7 parkinson protein 7
PARP8 poly (ADP-ribose) polymerase family, member 8
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDZD2 PDZ domain containing 2
PEA15 phosphoprotein enriched in astrocytes 15
PHC2 polyhomeotic homolog 2 (Drosophila)
PHF1 PHD finger protein 1
PI3 peptidase inhibitor 3, skin-derived
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PNKD paroxysmal nonkinesigenic dyskinesia
POLG polymerase (DNA directed), gamma
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP6C protein phosphatase 6, catalytic subunit
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PSD pleckstrin and Sec7 domain containing
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTCH1 patched 1
PTPRR protein tyrosine phosphatase, receptor type, R
PTX3 pentraxin 3, long
RAB10 RAB10, member RAS oncogene family
RAB39A RAB39A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARA retinoic acid receptor, alpha
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RBP5 retinol binding protein 5, cellular
RBX1 ring-box 1, E3 ubiquitin protein ligase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELT RELT tumor necrosis factor receptor
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
RIN3 Ras and Rab interactor 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF31 ring finger protein 31
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RYR3 ryanodine receptor 3
SCAF1 SR-related CTD-associated factor 1
SEC24A SEC24 family member A
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEPT9 septin 9
SETD5 SET domain containing 5
SFTPC surfactant protein C
SGK494 uncharacterized serine/threonine-protein kinase SgK494
SH2B3 SH2B adaptor protein 3
SH3BP1 SH3-domain binding protein 1
SHISA3 shisa family member 3
SLC12A8 solute carrier family 12, member 8
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC30A2 solute carrier family 30 (zinc transporter), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SMOC1 SPARC related modular calcium binding 1
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX10 SRY (sex determining region Y)-box 10
SOX13 SRY (sex determining region Y)-box 13
SQSTM1 sequestosome 1
ST7-AS2 ST7 antisense RNA 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STX17 syntaxin 17
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SYNPO synaptopodin
SYPL2 synaptophysin-like 2
SYT1 synaptotagmin I
TBX4 T-box 4
THADA thyroid adenoma associated
THSD7B thrombospondin, type I, domain containing 7B
TMEM171 transmembrane protein 171
TMEM184B transmembrane protein 184B
TMEM91 transmembrane protein 91
TMEM92 transmembrane protein 92
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNK2 tyrosine kinase, non-receptor, 2
TOM1L1 target of myb1 (chicken)-like 1
TOP1 topoisomerase (DNA) I
TP63 tumor protein p63
TPBGL trophoblast glycoprotein-like
TRAF2 TNF receptor-associated factor 2
TRAF3IP2-AS1 TRAF3IP2 antisense RNA 1
TRAF3IP3 TRAF3 interacting protein 3
TRAIP TRAF interacting protein
TRIM69 tripartite motif containing 69
TRPT1 tRNA phosphotransferase 1
TSC22D4 TSC22 domain family, member 4
TSLP thymic stromal lymphopoietin
TSPAN1 tetraspanin 1
TULP1 tubby like protein 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBL7 ubiquitin-like 7
UNC13B unc-13 homolog B (C. elegans)
USP34 ubiquitin specific peptidase 34
USP54 ubiquitin specific peptidase 54
UVRAG UV radiation resistance associated
VANGL2 VANGL planar cell polarity protein 2
VASH2 vasohibin 2
VCAN versican
VGF VGF nerve growth factor inducible
VIM vimentin
VRTN vertebrae development associated
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZBTB1 zinc finger and BTB domain containing 1
ZBTB32 zinc finger and BTB domain containing 32
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H7B zinc finger CCCH-type containing 7B
ZHX2 zinc fingers and homeoboxes 2
ZMYND15 zinc finger, MYND-type containing 15
ZNF292 zinc finger protein 292
ZNF436-AS1 ZNF436 antisense RNA 1
ZNF609 zinc finger protein 609
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase