NF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neurofibromin 1|This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4763)
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Genes

321 genes differentially expressed following the NF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DMBX1 diencephalon/mesencephalon homeobox 1 3.86499
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 3.86499
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.86499
PCDHB8 protocadherin beta 8 3.86499
FOXA2 forkhead box A2 3.86499
SLC35G5 solute carrier family 35, member G5 3.86499
PKP1 plakophilin 1 3.86499
SOX18 SRY (sex determining region Y)-box 18 3.86499
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.86499
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.86499
MAGEA3 melanoma antigen family A3 3.86499
XAF1 XIAP associated factor 1 3.86499
TACSTD2 tumor-associated calcium signal transducer 2 3.86499
CXCL14 chemokine (C-X-C motif) ligand 14 3.86499
HPR haptoglobin-related protein 3.86499
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.86499
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.86499
CLDN2 claudin 2 3.86499
ACOT1 acyl-CoA thioesterase 1 3.86499
RS1 retinoschisin 1 3.86499
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.86499
SH2D6 SH2 domain containing 6 3.86499
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.86499
TAS2R10 taste receptor, type 2, member 10 3.86499
AVP arginine vasopressin 3.86499
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.86499
MYL1 myosin, light chain 1, alkali; skeletal, fast 3.86499
SPAG6 sperm associated antigen 6 3.86499
TPRX1 tetra-peptide repeat homeobox 1 3.86499
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.86499
DSPP dentin sialophosphoprotein 3.86499
PSD2 pleckstrin and Sec7 domain containing 2 3.86499
VSX1 visual system homeobox 1 3.86499
DIO1 deiodinase, iodothyronine, type I 3.86499
OLFM4 olfactomedin 4 3.86499
SSTR5 somatostatin receptor 5 3.86499
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.86499
RFPL2 ret finger protein-like 2 3.86499
CRH corticotropin releasing hormone 3.86499
ACVRL1 activin A receptor type II-like 1 3.86499
OCSTAMP osteoclast stimulatory transmembrane protein 3.86499
CRYGA crystallin, gamma A 3.86499
IL2RA interleukin 2 receptor, alpha 3.86499
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.86499
IL5 interleukin 5 3.86499
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.86499
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.86499
RTL9 retrotransposon Gag like 9 3.86499
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.86499
HTD2 hydroxyacyl-thioester dehydratase type 2 3.86499
H3-5 H3.5 histone 3.86499
ZAR1 zygote arrest 1 3.86499
ROPN1B rhophilin associated tail protein 1B 3.86499
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.86499
HBG2 hemoglobin, gamma G 3.86499
RNF227 ring finger protein 227 3.86499
CFAP141 cilia and flagella associated protein 141 3.86499
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.86499
CIMIP2B ciliary microtubule inner protein 2B 3.86499
TEX53 testis expressed 53 3.86499
THSD8 thrombospondin type 1 domain containing 8 3.86499
PRR20G proline rich 20G 3.86499
TBC1D3I TBC1 domain family member 3I 3.86499
DEFB109B defensin beta 109B 3.86499
PNMA8C PNMA family member 8C 3.86499
SERTM2 serine rich and transmembrane domain containing 2 3.86499
MGAT4D MGAT4 family, member D 3.86499
RD3 retinal degeneration 3 3.86499
ZG16B zymogen granule protein 16B 3.86499
DLK2 delta-like 2 homolog (Drosophila) 3.86499
TAS1R2 taste receptor, type 1, member 2 3.86499
OOSP1 oocyte secreted protein 1, pseudogene 3.86499
VCX3B variable charge, X-linked 3B 3.86499
KRABD1 KRAB domain containing 1 3.86499
GJD2 gap junction protein, delta 2, 36kDa 3.86499
GJD4 gap junction protein, delta 4, 40.1kDa 3.86499
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.86499
RNF183 ring finger protein 183 3.86499
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.86499
STMN4 stathmin-like 4 3.86499
KRT80 keratin 80, type II 3.86499
TREX2 three prime repair exonuclease 2 3.86499
MYEOV myeloma overexpressed 3.86499
FOXC1 forkhead box C1 3.86499
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.86499
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.86499
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.86499
CSAG1 chondrosarcoma associated gene 1 3.86499
MIA melanoma inhibitory activity 3.86499
NEUROD1 neuronal differentiation 1 3.86499
PRM1 protamine 1 3.86499
GLYATL3 glycine-N-acyltransferase-like 3 3.86499
SAMD5 sterile alpha motif domain containing 5 3.86499
GFI1B growth factor independent 1B transcription repressor 3.86499
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.86499
PLA2G12B phospholipase A2, group XIIB 3.86499
PRH2 proline-rich protein HaeIII subfamily 2 3.86499
OTOP3 otopetrin 3 3.86499
PCDHGB4 protocadherin gamma subfamily B, 4 3.86499
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.86499
PRSS54 protease, serine, 54 3.86499
IBSP integrin-binding sialoprotein 3.86499
RGS4 regulator of G-protein signaling 4 3.86499
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.86499
SLC7A4 solute carrier family 7, member 4 3.86499
ADGRF1 adhesion G protein-coupled receptor F1 3.86499
PSD pleckstrin and Sec7 domain containing 3.86499
ASTL astacin-like metallo-endopeptidase (M12 family) 3.86499
CLIC3 chloride intracellular channel 3 3.86499
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.86499
SPINK9 serine peptidase inhibitor, Kazal type 9 3.86499
C2CD4B C2 calcium-dependent domain containing 4B 3.86499
PCDHGA4 protocadherin gamma subfamily A, 4 3.86499
SPATA31E1 SPATA31 subfamily E, member 1 3.86499
NUPR1 nuclear protein, transcriptional regulator, 1 3.86499
OTC ornithine carbamoyltransferase 3.86499
KISS1 KiSS-1 metastasis-suppressor 3.86499
EGR2 early growth response 2 3.86499
CST1 cystatin SN 3.86499
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.86499
CTRB1 chymotrypsinogen B1 3.86499
KLK2 kallikrein-related peptidase 2 3.86499
CNTF ciliary neurotrophic factor 3.86499
HAMP hepcidin antimicrobial peptide 3.86499
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.86499
AMDHD1 amidohydrolase domain containing 1 3.86499
SYT5 synaptotagmin V 3.86499
ST18 suppression of tumorigenicity 18, zinc finger 3.86499
ADRA1B adrenoceptor alpha 1B 3.86499
GOLGA8T golgin A8 family, member T 3.86499
GREM1 gremlin 1, DAN family BMP antagonist 3.86499
PF4V1 platelet factor 4 variant 1 3.86499
ANGPTL6 angiopoietin-like 6 3.86499
MMP13 matrix metallopeptidase 13 3.86499
AHSG alpha-2-HS-glycoprotein 3.86499
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.86499
NLRP14 NLR family, pyrin domain containing 14 3.86499
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.86499
RAB7B RAB7B, member RAS oncogene family 3.86499
CYBB cytochrome b-245, beta polypeptide 3.86499
MROH2A maestro heat-like repeat family member 2A 3.86499
ASCL5 achaete-scute family bHLH transcription factor 5 3.86499
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.86499
CNGB1 cyclic nucleotide gated channel beta 1 3.86499
ADAM18 ADAM metallopeptidase domain 18 3.86499
RTN4RL1 reticulon 4 receptor-like 1 3.86499
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.86499
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.86499
GPR150 G protein-coupled receptor 150 3.86499
NXF2B nuclear RNA export factor 2B 3.86499
PXT1 peroxisomal, testis specific 1 3.86499
SCN3B sodium channel, voltage gated, type III beta subunit 3.78748
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 3.67528
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 3.63585
MLXIP MLX interacting protein 3.19264
NUMA1 nuclear mitotic apparatus protein 1 3.03969
ACE2 angiotensin I converting enzyme 2 2.96996
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.96996
SERTAD1 SERTA domain containing 1 2.77753
PTCD2 pentatricopeptide repeat domain 2 2.73726
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.73419
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.73419
MXRA5 matrix-remodelling associated 5 2.73419
EBF2 early B-cell factor 2 2.73419
SACK1A scaffolding CK1 anchoring protein A 2.73419
SMIM47 small integral membrane protein 47 2.73419
SGK2 serum/glucocorticoid regulated kinase 2 2.73419
DPRX divergent-paired related homeobox 2.73419
ADAM29 ADAM metallopeptidase domain 29 2.73419
LGALS7B lectin, galactoside-binding, soluble, 7B 2.73419
FMO1 flavin containing monooxygenase 1 2.73419
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.73419
NCDN neurochondrin 2.72346
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 2.66659
RASAL1 RAS protein activator like 1 (GAP1 like) 2.6372
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.59009
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.55851
RPS7 ribosomal protein S7 2.55809
SMIM30 small integral membrane protein 30 2.55137
B2M beta-2-microglobulin 2.53974
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.53599
KIAA0232 KIAA0232 2.51975
DEAF1 DEAF1 transcription factor 2.5004
UGDH UDP-glucose 6-dehydrogenase 2.44968
DBR1 debranching RNA lariats 1 2.41762
SF3B1 splicing factor 3b, subunit 1, 155kDa 2.36065
KRT222 keratin 222, type II 2.32868
PIGBOS1 PIGB opposite strand 1 2.29356
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2.29086
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.27661
GJA3 gap junction protein, alpha 3, 46kDa 2.27661
DGCR6 DiGeorge syndrome critical region gene 6 2.27661
IFT70A intraflagellar transport 70A 2.27313
SPATA20 spermatogenesis associated 20 2.27313
MCAM melanoma cell adhesion molecule 2.26923
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.23966
UPK1A uroplakin 1A 2.23239
NTHL1 nth endonuclease III-like 1 (E. coli) 2.22055
IRF3 interferon regulatory factor 3 2.2196
TRAF2 TNF receptor-associated factor 2 2.2092
HEXD hexosaminidase D 2.19944
ZNF296 zinc finger protein 296 2.19944
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 2.19944
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.19926
CFAP43 cilia and flagella associated protein 43 2.19926
TDRD6 tudor domain containing 6 2.19347
ZNF384 zinc finger protein 384 2.18184
LDOC1 leucine zipper, down-regulated in cancer 1 2.18071
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.14906
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.13729
IL1RAP interleukin 1 receptor accessory protein 2.13729
ZDHHC16 zinc finger, DHHC-type containing 16 2.13526
SUMO4 small ubiquitin-like modifier 4 2.11968
ACP1 acid phosphatase 1, soluble 2.10482
KCTD20 potassium channel tetramerization domain containing 20 2.10017
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.08507
H2AC25 H2A clustered histone 25 2.07516
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 2.07516
CPNE5 copine V 2.06743
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.06743
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 2.06743
PCDH15 protocadherin-related 15 2.06743
LRP2 low density lipoprotein receptor-related protein 2 2.06743
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.06159
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.0409
PARP14 poly (ADP-ribose) polymerase family, member 14 2.02049
ANKRD18B ankyrin repeat domain 18B 2.00987
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 2.00075

decreased expression

Symbol Name Standardized Value
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -3.86499
IL31RA interleukin 31 receptor A -3.86499
CLEC4D C-type lectin domain family 4, member D -3.86499
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -3.86499
ADAM8 ADAM metallopeptidase domain 8 -3.86499
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound -3.86499
BTNL8 butyrophilin-like 8 -3.86499
CIROZ ciliated left-right organizer protein containing ZP-N domains -3.86499
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) -3.86499
DUSP26 dual specificity phosphatase 26 (putative) -3.86499
IER5L immediate early response 5-like -3.86499
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.86499
EBI3 Epstein-Barr virus induced 3 -3.86499
TMPRSS6 transmembrane protease, serine 6 -3.86499
TBXA2R thromboxane A2 receptor -3.86499
C1QTNF12 C1q and TNF related 12 -3.86499
CCNA1 cyclin A1 -3.86499
SPHKAP SPHK1 interactor, AKAP domain containing -3.86499
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -3.86499
ZC3H12D zinc finger CCCH-type containing 12D -3.86499
TENT5D terminal nucleotidyltransferase 5D -3.86499
FGR FGR proto-oncogene, Src family tyrosine kinase -3.86499
MEIOSIN meiosis initiator -3.86499
DCDC2B doublecortin domain containing 2B -3.86499
CES4A carboxylesterase 4A -3.86499
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -3.63585
CNTN2 contactin 2 (axonal) -3.46098
NF1 neurofibromin 1 -3.30357
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -3.24666
ITLN2 intelectin 2 -3.13979
SORCS3 sortilin-related VPS10 domain containing receptor 3 -3.13423
FAM117A family with sequence similarity 117, member A -2.99922
STOML1 stomatin (EPB72)-like 1 -2.92725
MGARP mitochondria-localized glutamic acid-rich protein -2.90434
HSPA1L heat shock 70kDa protein 1-like -2.90434
MYT1L myelin transcription factor 1-like -2.90434
ETNPPL ethanolamine-phosphate phospho-lyase -2.90434
RAPSN receptor-associated protein of the synapse -2.90434
FBP2 fructose-1,6-bisphosphatase 2 -2.86177
PRODH proline dehydrogenase (oxidase) 1 -2.84383
TPCN2 two pore segment channel 2 -2.83822
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -2.62166
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -2.59495
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.59495
ZDHHC5 zinc finger, DHHC-type containing 5 -2.57643
ADCY5 adenylate cyclase 5 -2.57322
KLHL8 kelch-like family member 8 -2.55865
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.55851
NFASC neurofascin -2.5166
SPATC1L spermatogenesis and centriole associated 1-like -2.45621
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -2.45227
ZNF287 zinc finger protein 287 -2.41762
EXOC1 exocyst complex component 1 -2.34516
MBD5 methyl-CpG binding domain protein 5 -2.33462
DAND5 DAN domain family member 5, BMP antagonist -2.3161
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.3161
DMC1 DNA meiotic recombinase 1 -2.27661
BCL7C B-cell CLL/lymphoma 7C -2.27661
TMEM79 transmembrane protein 79 -2.27661
DCAF10 DDB1 and CUL4 associated factor 10 -2.27661
DCBLD1 discoidin, CUB and LCCL domain containing 1 -2.27313
WASF3 WAS protein family, member 3 -2.27313
IPO7 importin 7 -2.27036
STX5 syntaxin 5 -2.26172
TTC31 tetratricopeptide repeat domain 31 -2.25712
LMBRD1 LMBR1 domain containing 1 -2.2566
CKAP2 cytoskeleton associated protein 2 -2.23966
SLA2 Src-like-adaptor 2 -2.23966
TAS2R30 taste receptor, type 2, member 30 -2.23966
RBBP4 retinoblastoma binding protein 4 -2.23239
LHX1 LIM homeobox 1 -2.23239
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.23239
FBXO15 F-box protein 15 -2.23061
FRMD8 FERM domain containing 8 -2.22373
KIF5B kinesin family member 5B -2.19358
PLAA phospholipase A2-activating protein -2.19319
ABITRAM actin binding transcription modulator -2.18823
DSEL dermatan sulfate epimerase-like -2.18823
RNF145 ring finger protein 145 -2.18455
NANOGP8 Nanog homeobox pseudogene 8 -2.1778
ATF2 activating transcription factor 2 -2.1778
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -2.1676
GLYATL2 glycine-N-acyltransferase-like 2 -2.09996
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -2.07516
PIF1 PIF1 5'-to-3' DNA helicase -2.06743
AIDA axin interactor, dorsalization associated -2.05532
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.0409
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.03129
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 -2.03129
ARSB arylsulfatase B -2.01985
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.01105
CPXM2 carboxypeptidase X (M14 family), member 2 -2.00546
CNTN4 contactin 4 -2.00075