NF2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description neurofibromin 2 (merlin)|This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4771)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_NF2
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Genes

300 co-expressed genes for NF2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABHD16A abhydrolase domain containing 16A
ACAD11 acyl-CoA dehydrogenase family, member 11
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ADPRHL2 ADP-ribosylhydrolase like 2
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ALKBH5 AlkB family member 5, RNA demethylase
AMMECR1L AMMECR1-like
ANAPC5 anaphase promoting complex subunit 5
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD10 ankyrin repeat domain 10
ANKRD40 ankyrin repeat domain 40
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
APMAP adipocyte plasma membrane associated protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASB3 ankyrin repeat and SOCS box containing 3
ASB6 ankyrin repeat and SOCS box containing 6
ASB7 ankyrin repeat and SOCS box containing 7
ASCC1 activating signal cointegrator 1 complex subunit 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG2B autophagy related 2B
ATG4B autophagy related 4B, cysteine peptidase
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATXN7L3 ataxin 7-like 3
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAHD1 bromo adjacent homology domain containing 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L1 BCL2-like 1
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRD9 bromodomain containing 9
C14ORF1 chromosome 14 open reading frame 1
C1ORF52 chromosome 1 open reading frame 52
C21ORF33 chromosome 21 open reading frame 33
C21ORF59 chromosome 21 open reading frame 59
C2CD5 C2 calcium-dependent domain containing 5
C5ORF51 chromosome 5 open reading frame 51
C7ORF43 chromosome 7 open reading frame 43
CAND1 cullin-associated and neddylation-dissociated 1
CENPO centromere protein O
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHD9 chromodomain helicase DNA binding protein 9
CHTOP chromatin target of PRMT1
CHUK conserved helix-loop-helix ubiquitous kinase
CIAPIN1 cytokine induced apoptosis inhibitor 1
CIZ1 CDKN1A interacting zinc finger protein 1
CLEC16A C-type lectin domain family 16, member A
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COG5 component of oligomeric golgi complex 5
COMMD9 COMM domain containing 9
COPS6 COP9 signalosome subunit 6
COQ10A coenzyme Q10 homolog A (S. cerevisiae)
CRAMP1L Crm, cramped-like (Drosophila)
CS citrate synthase
CSRNP2 cysteine-serine-rich nuclear protein 2
DBNL drebrin-like
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DENND4A DENN/MADD domain containing 4A
DENR density-regulated protein
DHCR7 7-dehydrocholesterol reductase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
EDNRA endothelin receptor type A
EHBP1 EH domain binding protein 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EMC8 ER membrane protein complex subunit 8
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
EPT1 ethanolaminephosphotransferase 1
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
EVI5L ecotropic viral integration site 5-like
EXOSC6 exosome component 6
FAM104B family with sequence similarity 104, member B
FAM134A family with sequence similarity 134, member A
FAM168B family with sequence similarity 168, member B
FAM192A family with sequence similarity 192, member A
FAM195B family with sequence similarity 195, member B
FAM213A family with sequence similarity 213, member A
FAM65A family with sequence similarity 65, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FBXL20 F-box and leucine-rich repeat protein 20
FBXO9 F-box protein 9
FN3KRP fructosamine 3 kinase related protein
FNTB farnesyltransferase, CAAX box, beta
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GFM2 G elongation factor, mitochondrial 2
GGT7 gamma-glutamyltransferase 7
GLT8D1 glycosyltransferase 8 domain containing 1
GMEB2 glucocorticoid modulatory element binding protein 2
GOLGA7 golgin A7
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPBP1 GC-rich promoter binding protein 1
GSPT1 G1 to S phase transition 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H2AFV H2A histone family, member V
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNRNPR heterogeneous nuclear ribonucleoprotein R
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFT52 intraflagellar transport 52
IMPAD1 inositol monophosphatase domain containing 1
ING1 inhibitor of growth family, member 1
INTS5 integrator complex subunit 5
IPO5 importin 5
IQCK IQ motif containing K
ISCA1 iron-sulfur cluster assembly 1
JKAMP JNK1/MAPK8-associated membrane protein
KDM3B lysine (K)-specific demethylase 3B
KIAA1191 KIAA1191
KIAA2013 KIAA2013
KLF12 Kruppel-like factor 12
KLHL11 kelch-like family member 11
KLHL12 kelch-like family member 12
KLHL17 kelch-like family member 17
KLHL18 kelch-like family member 18
KMT2A lysine (K)-specific methyltransferase 2A
KPNA6 karyopherin alpha 6 (importin alpha 7)
LEMD3 LEM domain containing 3
LIG3 ligase III, DNA, ATP-dependent
LOC652276 potassium channel tetramerization domain containing 5 pseudogene
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAP6 microtubule-associated protein 6
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBD3 methyl-CpG binding domain protein 3
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
METTL17 methyltransferase like 17
MFN2 mitofusin 2
MFSD8 major facilitator superfamily domain containing 8
MKS1 Meckel syndrome, type 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MOB4 MOB family member 4, phocein
MORF4L1 mortality factor 4 like 1
MRI1 methylthioribose-1-phosphate isomerase 1
MRPL10 mitochondrial ribosomal protein L10
MRPL30 mitochondrial ribosomal protein L30
MRPS5 mitochondrial ribosomal protein S5
MRVI1 murine retrovirus integration site 1 homolog
MSL1 male-specific lethal 1 homolog (Drosophila)
MTCH2 mitochondrial carrier 2
MTMR4 myotubularin related protein 4
MTMR7 myotubularin related protein 7
MTPN myotrophin
MTRF1L mitochondrial translational release factor 1-like
MYO9A myosin IXA
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NCLN nicalin
NF2 neurofibromin 2 (merlin)
NPFF neuropeptide FF-amide peptide precursor
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUMA1 nuclear mitotic apparatus protein 1
NUP133 nucleoporin 133kDa
OCIAD1 OCIA domain containing 1
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
OSBPL2 oxysterol binding protein-like 2
OTUD6B OTU domain containing 6B
PACS2 phosphofurin acidic cluster sorting protein 2
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PEX11B peroxisomal biogenesis factor 11 beta
PHAX phosphorylated adaptor for RNA export
PHF10 PHD finger protein 10
PIGS phosphatidylinositol glycan anchor biosynthesis, class S
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
POGZ pogo transposable element with ZNF domain
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POLR2M polymerase (RNA) II (DNA directed) polypeptide M
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRDM4 PR domain containing 4
PREP prolyl endopeptidase
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRPF8 pre-mRNA processing factor 8
PRRC2B proline-rich coiled-coil 2B
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTCD3 pentatricopeptide repeat domain 3
RAB14 RAB14, member RAS oncogene family
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RABIF RAB interacting factor
RABL2B RAB, member of RAS oncogene family-like 2B
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RAN RAN, member RAS oncogene family
RANBP6 RAN binding protein 6
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RMDN3 regulator of microtubule dynamics 3
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNF216 ring finger protein 216
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPL7L1 ribosomal protein L7-like 1
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RSC1A1 regulatory solute carrier protein, family 1, member 1
RTBDN retbindin
RTN4 reticulon 4
SAFB scaffold attachment factor B
SAMD4B sterile alpha motif domain containing 4B
SAP130 Sin3A-associated protein, 130kDa
SCAMP2 secretory carrier membrane protein 2
SCG2 secretogranin II
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
SETD1A SET domain containing 1A
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SIN3A SIN3 transcription regulator family member A
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
SLC35E2 solute carrier family 35, member E2
SLC38A7 solute carrier family 38, member 7
SMG5 SMG5 nonsense mediated mRNA decay factor
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNX15 sorting nexin 15
SNX33 sorting nexin 33
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
STAMBP STAM binding protein
STRN4 striatin, calmodulin binding protein 4
SUMF2 sulfatase modifying factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TADA2B transcriptional adaptor 2B
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D10B TBC1 domain family, member 10B
TBC1D14 TBC1 domain family, member 14
TBC1D15 TBC1 domain family, member 15
TBC1D22B TBC1 domain family, member 22B
TBCK TBC1 domain containing kinase
TEX261 testis expressed 261
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM106B transmembrane protein 106B
TMEM120A transmembrane protein 120A
TMEM138 transmembrane protein 138
TMEM167B transmembrane protein 167B
TMEM199 transmembrane protein 199
TMEM245 transmembrane protein 245
TMEM55B transmembrane protein 55B
TNPO1 transportin 1
TNPO2 transportin 2
TNS2 tensin 2
TOX4 TOX high mobility group box family member 4
TP73-AS1 TP73 antisense RNA 1
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSNAX translin-associated factor X
TSPYL4 TSPY-like 4
TTC17 tetratricopeptide repeat domain 17
TUBGCP4 tubulin, gamma complex associated protein 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
U2SURP U2 snRNP-associated SURP domain containing
UBE2K ubiquitin-conjugating enzyme E2K
UBE2N ubiquitin-conjugating enzyme E2N
UBQLN4 ubiquilin 4
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
URGCP upregulator of cell proliferation
USP19 ubiquitin specific peptidase 19
USP33 ubiquitin specific peptidase 33
VCP valosin containing protein
VEZT vezatin, adherens junctions transmembrane protein
VPS26B vacuolar protein sorting 26 homolog B (S. pombe)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VRK3 vaccinia related kinase 3
WBP2 WW domain binding protein 2
WDR19 WD repeat domain 19
WDR33 WD repeat domain 33
WDR6 WD repeat domain 6
WDR70 WD repeat domain 70
WSB1 WD repeat and SOCS box containing 1
WSB2 WD repeat and SOCS box containing 2
XPO6 exportin 6
YME1L1 YME1-like 1 ATPase
ZBED1 zinc finger, BED-type containing 1
ZDHHC4 zinc finger, DHHC-type containing 4
ZER1 zyg-11 related, cell cycle regulator
ZFAND5 zinc finger, AN1-type domain 5
ZFR zinc finger RNA binding protein
ZNF12 zinc finger protein 12
ZNF133 zinc finger protein 133
ZNF275 zinc finger protein 275
ZNF292 zinc finger protein 292
ZNF512 zinc finger protein 512
ZNF529 zinc finger protein 529
ZNF559 zinc finger protein 559
ZNF644 zinc finger protein 644
ZNF710 zinc finger protein 710
ZNF84 zinc finger protein 84
ZXDB zinc finger, X-linked, duplicated B