NFAT5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor of activated T-cells 5, tonicity-responsive|The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10725)
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Genes

328 genes differentially expressed following the NFAT5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOXD1 forkhead box D1 2.82024
ADGRE3 adhesion G protein-coupled receptor E3 2.82024
KNG1 kininogen 1 2.82024
IGFL3 IGF-like family member 3 2.82024
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.82024
TMEM176A transmembrane protein 176A 2.82024
GFRA3 GDNF family receptor alpha 3 2.82024
RAX retina and anterior neural fold homeobox 2.82024
LRRC14B leucine rich repeat containing 14B 2.82024
CSTL1 cystatin-like 1 2.82024
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.82024
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.82024
HDC histidine decarboxylase 2.82024
NRN1 neuritin 1 2.82024
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.82024
RHOXF2B Rhox homeobox family, member 2B 2.82024
CD6 CD6 molecule 2.82024
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.82024
ZC3H11A zinc finger CCCH-type containing 11A 2.82024
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.82024
CDH5 cadherin 5, type 2 (vascular endothelium) 2.82024
PAX9 paired box 9 2.82024
PAX2 paired box 2 2.82024
BMP8B bone morphogenetic protein 8b 2.82024
CLEC5A C-type lectin domain family 5, member A 2.82024
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.82024
LONRF2 LON peptidase N-terminal domain and ring finger 2 2.82024
NPIPA3 nuclear pore complex interacting protein family, member A3 2.82024
GNRHR gonadotropin-releasing hormone receptor 2.82024
LBX2 ladybird homeobox 2 2.82024
ATOH7 atonal homolog 7 (Drosophila) 2.82024
AIRE autoimmune regulator 2.82024
HAND1 heart and neural crest derivatives expressed 1 2.82024
FOXC1 forkhead box C1 2.82024
RGPD4 RANBP2-like and GRIP domain containing 4 2.82024
FETUB fetuin B 2.82024
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.82024
LRG1 leucine-rich alpha-2-glycoprotein 1 2.82024
ASB12 ankyrin repeat and SOCS box containing 12 2.82024
MYCT1 myc target 1 2.82024
REN renin 2.82024
GCKR glucokinase (hexokinase 4) regulator 2.82024
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.82024
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.82024
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.82024
LOC107986837 uncharacterized LOC107986837 2.82024
HBG2 hemoglobin, gamma G 2.82024
ALX4 ALX homeobox 4 2.82024
PNLIPRP2 pancreatic lipase-related protein 2 2.82024
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.82024
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 2.82024
TMPRSS4 transmembrane protease, serine 4 2.82024
TMEM40 transmembrane protein 40 2.82024
SMTNL1 smoothelin-like 1 2.82024
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.82024
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.82024
UNC93A unc-93 homolog A (C. elegans) 2.82024
LRTM3 leucine rich repeat transmembrane protein 3 2.82024
CATSPERT catsper channel auxiliary subunit tau 2.82024
CIMAP1D CIMAP1 family member D 2.82024
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.82024
SPACDR sperm acrosome developmental regulator 2.82024
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.82024
SMIM38 small integral membrane protein 38 2.82024
CFAP65 cilia and flagella associated protein 65 2.82024
OTOF otoferlin 2.82024
GATA2 GATA binding protein 2 2.82024
LRRN4CL LRRN4 C-terminal like 2.82024
COX8C cytochrome c oxidase subunit VIIIC 2.82024
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.82024
SCRT2 scratch family zinc finger 2 2.82024
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.82024
MEOX1 mesenchyme homeobox 1 2.82024
OR8D1 olfactory receptor, family 8, subfamily D, member 1 2.82024
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.82024
BIK BCL2-interacting killer (apoptosis-inducing) 2.82024
CLDN9 claudin 9 2.82024
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.82024
TBX5 T-box 5 2.82024
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.82024
PTH parathyroid hormone 2.82024
UTS2 urotensin 2 2.82024
TACR2 tachykinin receptor 2 2.82024
GSC goosecoid homeobox 2.82024
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.82024
ARMS2 age-related maculopathy susceptibility 2 2.82024
SPDYC speedy/RINGO cell cycle regulator family member C 2.82024
FAM186A family with sequence similarity 186, member A 2.82024
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.82024
PCDHA7 protocadherin alpha 7 2.82024
LEP leptin 2.82024
CHRM1 cholinergic receptor, muscarinic 1 2.82024
MAGEA2B melanoma antigen family A2B 2.82024
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.82024
APLNR apelin receptor 2.82024
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2.82024
FAM163A family with sequence similarity 163, member A 2.82024
KLF2 Kruppel-like factor 2 2.82024
ERICH6B glutamate-rich 6B 2.82024
ADAM7 ADAM metallopeptidase domain 7 2.82024
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.82024
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.82024
PCDHGB2 protocadherin gamma subfamily B, 2 2.82024
ROM1 retinal outer segment membrane protein 1 2.82024
AMER2 APC membrane recruitment protein 2 2.82024
C9ORF50 chromosome 9 open reading frame 50 2.82024
SHOX short stature homeobox 2.82024
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.82024
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.82024
KRT15 keratin 15, type I 2.82024
MAGEA11 melanoma antigen family A11 2.82024
VAX2 ventral anterior homeobox 2 2.82024
HAVCR1 hepatitis A virus cellular receptor 1 2.82024
MAB21L2 mab-21-like 2 (C. elegans) 2.82024
MUCL1 mucin-like 1 2.82024
OTOP1 otopetrin 1 2.82024
RGS4 regulator of G-protein signaling 4 2.82024
CAPSL calcyphosine-like 2.82024
MSMP microseminoprotein, prostate associated 2.82024
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.82024
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.82024
NPY2R neuropeptide Y receptor Y2 2.82024
TTC24 tetratricopeptide repeat domain 24 2.82024
LRRC24 leucine rich repeat containing 24 2.82024
PRSS33 protease, serine, 33 2.82024
VAV1 vav 1 guanine nucleotide exchange factor 2.82024
CDK20 cyclin-dependent kinase 20 2.82024
COL17A1 collagen, type XVII, alpha 1 2.82024
KLK7 kallikrein-related peptidase 7 2.82024
PRPH peripherin 2.82024
PDCD1LG2 programmed cell death 1 ligand 2 2.82024
FCRL1 Fc receptor-like 1 2.82024
GSTA1 glutathione S-transferase alpha 1 2.82024
NTN5 netrin 5 2.82024
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.82024
NLRP14 NLR family, pyrin domain containing 14 2.82024
RERGL RERG/RAS-like 2.82024
CGA glycoprotein hormones, alpha polypeptide 2.82024
FABP12 fatty acid binding protein 12 2.82024
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 2.82024
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.82024
TUBAL3 tubulin, alpha-like 3 2.82024
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.82024
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.82024
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.82024
PSG11 pregnancy specific beta-1-glycoprotein 11 2.82024
AREG amphiregulin 2.82024
MAGEA12 melanoma antigen family A12 2.82024
CCDC166 coiled-coil domain containing 166 2.82024
FGF7 fibroblast growth factor 7 2.82024
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.82024
FAM81B family with sequence similarity 81, member B 2.82024
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.82024
KRTAP4-1 keratin associated protein 4-1 2.82024
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.82024
ITPKA inositol-trisphosphate 3-kinase A 2.82024
TSHZ3 teashirt zinc finger homeobox 3 2.74013
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 2.72935
FGF18 fibroblast growth factor 18 2.70369
PRLR prolactin receptor 2.67235
TUFT1 tuftelin 1 2.63378
PXMP4 peroxisomal membrane protein 4, 24kDa 2.60696
CGN cingulin 2.58616
A1BG alpha-1-B glycoprotein 2.53302
MTMR4 myotubularin related protein 4 2.50872
RPAIN RPA interacting protein 2.50284
SLITRK1 SLIT and NTRK-like family, member 1 2.48103
ANGPTL6 angiopoietin-like 6 2.48103
LOXL4 lysyl oxidase-like 4 2.48103
TCHP trichoplein, keratin filament binding 2.47721
CYB561D1 cytochrome b561 family, member D1 2.47363
GPC4 glypican 4 2.43351
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.40064
COG3 component of oligomeric golgi complex 3 2.40064
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.36319
ZNF484 zinc finger protein 484 2.35511
FAIM Fas apoptotic inhibitory molecule 2.33265
MAF1 MAF1 homolog (S. cerevisiae) 2.33204
TRAPPC5 trafficking protein particle complex 5 2.30251
SH2D6 SH2 domain containing 6 2.29613
GTF2H2C GTF2H2 family member C 2.27634
PDE4B phosphodiesterase 4B, cAMP-specific 2.27586
ISL1 ISL LIM homeobox 1 2.2531
TOX3 TOX high mobility group box family member 3 2.23802
SMIM30 small integral membrane protein 30 2.23432
ZNF644 zinc finger protein 644 2.23362
ZNF335 zinc finger protein 335 2.22957
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.19685
MPL MPL proto-oncogene, thrombopoietin receptor 2.19685
STAG1 stromal antigen 1 2.1811
PRH1-TAS2R14 PRH1-TAS2R14 readthrough 2.17611
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.16904
LGALS3 lectin, galactoside-binding, soluble, 3 2.16617
SARAF store-operated calcium entry-associated regulatory factor 2.16144
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.14649
HSPA2 heat shock 70kDa protein 2 2.14649
BMPER BMP binding endothelial regulator 2.14649
MIF4GD MIF4G domain containing 2.14649
TMEM181 transmembrane protein 181 2.14649
SRD5A3 steroid 5 alpha-reductase 3 2.12553
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.12553
DGUOK deoxyguanosine kinase 2.12553
KIZ kizuna centrosomal protein 2.12553
RASL10A RAS-like, family 10, member A 2.12553
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.12553
SRRM5 serine/arginine repetitive matrix 5 2.08579
APELA apelin receptor early endogenous ligand 2.08492
TMEM106C transmembrane protein 106C 2.08492
H2AC25 H2A clustered histone 25 2.08428
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.071
NCAM2 neural cell adhesion molecule 2 2.0659
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.0659
ARRDC3 arrestin domain containing 3 2.0659
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.05562
RASL10B RAS-like, family 10, member B 2.0103
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.0059
PGAM5 phosphoglycerate mutase family member 5 2.00442

decreased expression

Symbol Name Standardized Value
IQCN IQ motif containing N -2.82024
MRPL53 mitochondrial ribosomal protein L53 -2.82024
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.82024
PTH2 parathyroid hormone 2 -2.82024
MANSC4 MANSC domain containing 4 -2.82024
CC2D2B coiled-coil and C2 domain containing 2B -2.82024
ALPK2 alpha-kinase 2 -2.82024
SLC9C2 solute carrier family 9, member C2 (putative) -2.82024
RFPL2 ret finger protein-like 2 -2.82024
HAS1 hyaluronan synthase 1 -2.82024
TJP1 tight junction protein 1 -2.82024
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.82024
CFAP54 cilia and flagella associated 54 -2.82024
ETF1 eukaryotic translation termination factor 1 -2.82024
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.82024
RAI2 retinoic acid induced 2 -2.82024
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -2.82024
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -2.82024
AJM1 apical junction component 1 homolog -2.82024
YPEL4 yippee-like 4 (Drosophila) -2.82024
CLDN18 claudin 18 -2.82024
FMO3 flavin containing monooxygenase 3 -2.82024
RAB36 RAB36, member RAS oncogene family -2.82024
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -2.82024
CSAG3 CSAG family, member 3 -2.82024
LTF lactotransferrin -2.82024
NPFF neuropeptide FF-amide peptide precursor -2.82024
PROX1 prospero homeobox 1 -2.82024
TLE6 transducin-like enhancer of split 6 -2.82024
PRB3 proline-rich protein BstNI subfamily 3 -2.82024
CPTP ceramide-1-phosphate transfer protein -2.82024
TPPP2 tubulin polymerization-promoting protein family member 2 -2.82024
ANKRD53 ankyrin repeat domain 53 -2.82024
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -2.82024
GLRB glycine receptor, beta -2.82024
ZBTB7B zinc finger and BTB domain containing 7B -2.82024
FKBP1C FK506 binding protein 1C -2.82024
POU3F2 POU class 3 homeobox 2 -2.82024
CRHR2 corticotropin releasing hormone receptor 2 -2.82024
KISS1 KiSS-1 metastasis-suppressor -2.82024
CCDC22 coiled-coil domain containing 22 -2.82024
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.82024
FGF16 fibroblast growth factor 16 -2.82024
C22ORF31 chromosome 22 open reading frame 31 -2.82024
NTF4 neurotrophin 4 -2.82024
CDC20B cell division cycle 20B -2.82024
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.82024
BCL9L B-cell CLL/lymphoma 9-like -2.80591
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.77496
FBXL17 F-box and leucine-rich repeat protein 17 -2.71765
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -2.65044
ADSS2 adenylosuccinate synthase 2 -2.64242
JRK Jrk homolog (mouse) -2.62106
VAT1L vesicle amine transport 1-like -2.60795
NLRX1 NLR family member X1 -2.56256
NRIP2 nuclear receptor interacting protein 2 -2.50224
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.48103
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.48103
EPB41 erythrocyte membrane protein band 4.1 -2.48103
ZFP36L2 ZFP36 ring finger protein-like 2 -2.46363
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.46247
ANKRD16 ankyrin repeat domain 16 -2.44895
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.40204
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.40204
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -2.38236
UEVLD UEV and lactate/malate dehyrogenase domains -2.32486
MEIG1 meiosis/spermiogenesis associated 1 -2.32211
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -2.32193
HYDIN HYDIN, axonemal central pair apparatus protein -2.31387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.30895
PTS 6-pyruvoyltetrahydropterin synthase -2.29746
PCDHB5 protocadherin beta 5 -2.29337
TMED7 transmembrane emp24 protein transport domain containing 7 -2.29334
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.27634
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.27158
DHRS13 dehydrogenase/reductase (SDR family) member 13 -2.26994
ARL5A ADP-ribosylation factor-like 5A -2.26293
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -2.25952
LRRC69 leucine rich repeat containing 69 -2.25952
ENOPH1 enolase-phosphatase 1 -2.24991
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -2.22035
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -2.20045
STK26 serine/threonine protein kinase 26 -2.20045
S100A4 S100 calcium binding protein A4 -2.19413
LIPH lipase, member H -2.19004
HTRA3 HtrA serine peptidase 3 -2.18985
LTO1 LTO1 maturation factor of ABCE1 -2.16144
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.15963
NELFE negative elongation factor complex member E -2.15963
SPATS2L spermatogenesis associated, serine-rich 2-like -2.14466
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 -2.12856
KRABD4 KRAB domain containing 4 -2.12674
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -2.12553
BCL2L2 BCL2-like 2 -2.12542
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.11278
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.10295
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.08428
USP50 ubiquitin specific peptidase 50 -2.0659
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.0659
BTBD2 BTB (POZ) domain containing 2 -2.0659
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.0659
PCDHB13 protocadherin beta 13 -2.0659
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.0659
BTN1A1 butyrophilin, subfamily 1, member A1 -2.0659
CHCT1 CHD1 helical C-terminal domain containing 1 -2.0659
MCOLN3 mucolipin 3 -2.05564
GPR63 G protein-coupled receptor 63 -2.03285
XDH xanthine dehydrogenase -2.03118
ZNF219 zinc finger protein 219 -2.0122
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -2.00442
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.00225