NFATC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1|The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 4772)
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Genes

314 genes differentially expressed following the NFATC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DYDC1 DPY30 domain containing 1 3.19475
MPO myeloperoxidase 3.19475
IL2RA interleukin 2 receptor, alpha 3.19475
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.19475
IL16 interleukin 16 3.19475
TTR transthyretin 3.19475
BHLHE40 basic helix-loop-helix family, member e40 3.19475
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.19475
FAM186A family with sequence similarity 186, member A 3.19475
PRR18 proline rich 18 3.19475
CARD9 caspase recruitment domain family, member 9 3.19475
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 3.19475
OASL 2'-5'-oligoadenylate synthetase-like 3.19475
GFAP glial fibrillary acidic protein 3.19475
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.19475
GALR3 galanin receptor 3 3.19475
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.19475
IGFL4 IGF-like family member 4 3.19475
GARIN6 golgi associated RAB2 interactor family member 6 3.19475
LMX1A LIM homeobox transcription factor 1, alpha 3.19475
MRC1 mannose receptor, C type 1 3.19475
ANXA8 annexin A8 3.19475
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.19475
ZNF467 zinc finger protein 467 3.10041
SSMEM1 serine-rich single-pass membrane protein 1 3.10041
FAM9C family with sequence similarity 9, member C 3.10041
ERAP2 endoplasmic reticulum aminopeptidase 2 3.10041
APOA2 apolipoprotein A-II 3.10041
FGL1 fibrinogen-like 1 3.10041
AADACL4 arylacetamide deacetylase-like 4 3.10041
TMEM191B transmembrane protein 191B 3.10041
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.10041
SLC35G3 solute carrier family 35, member G3 3.10041
CCDC89 coiled-coil domain containing 89 3.10041
LOC105378220 macrophage receptor MARCO-like 3.10041
HGD homogentisate 1,2-dioxygenase 3.10041
LGALS2 lectin, galactoside-binding, soluble, 2 3.10041
NEU4 sialidase 4 3.10041
RPE65 retinal pigment epithelium-specific protein 65kDa 3.10041
TMOD4 tropomodulin 4 (muscle) 3.10041
MYO1G myosin IG 3.10041
TAS2R19 taste receptor, type 2, member 19 3.10041
ANXA2R annexin A2 receptor 3.10041
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.10041
LBX2 ladybird homeobox 2 3.10041
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.10041
BIRC3 baculoviral IAP repeat containing 3 3.10041
TEX35 testis expressed 35 3.10041
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.10041
HES2 hes family bHLH transcription factor 2 3.10041
ANKRD34A ankyrin repeat domain 34A 3.10041
GYPB glycophorin B (MNS blood group) 3.10041
SSTR5 somatostatin receptor 5 3.10041
TM4SF1 transmembrane 4 L six family member 1 3.10041
PRICKLE4 prickle homolog 4 (Drosophila) 3.10041
SPMIP1 sperm microtubule inner protein 1 3.10041
GBP4 guanylate binding protein 4 3.10041
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.10041
PNLIPRP1 pancreatic lipase-related protein 1 3.10041
FRG2C FSHD region gene 2 family, member C 3.10041
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.10041
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 3.10041
SPATA25 spermatogenesis associated 25 3.10041
OSTN osteocrin 3.10041
ALDOB aldolase B, fructose-bisphosphate 3.10041
H2BC1 H2B clustered histone 1 3.10041
LY6S lymphocyte antigen 6 family member S 3.10041
PNMA6F PNMA family member 6F 3.10041
EXOC1L exocyst complex component 1 like 3.10041
AGA-DT AGA divergent transcript 3.10041
C8ORF90 chromosome 8 open reading frame 90 3.10041
SMIM31 small integral membrane protein 31 3.10041
H3C3 H3 clustered histone 3 3.10041
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.10041
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.10041
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.10041
CLDN22 claudin 22 3.10041
USH1G Usher syndrome 1G (autosomal recessive) 3.10041
SLC22A10 solute carrier family 22, member 10 3.10041
PLVAP plasmalemma vesicle associated protein 3.10041
SELPLG selectin P ligand 3.10041
VCX2 variable charge, X-linked 2 3.10041
ZSCAN5B zinc finger and SCAN domain containing 5B 3.10041
PI16 peptidase inhibitor 16 3.10041
ADGRE3 adhesion G protein-coupled receptor E3 3.10041
NKX2-6 NK2 homeobox 6 3.10041
MAGEB1 melanoma antigen family B1 3.10041
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.10041
INSRR insulin receptor-related receptor 3.10041
CREB3L3 cAMP responsive element binding protein 3-like 3 3.10041
TLR7 toll-like receptor 7 3.10041
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.10041
CBLN3 cerebellin 3 precursor 3.10041
ANXA10 annexin A10 3.10041
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.10041
NPPB natriuretic peptide B 3.10041
ZC3H12D zinc finger CCCH-type containing 12D 3.10041
CD244 CD244 molecule, natural killer cell receptor 2B4 3.10041
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.10041
TCP11X2 t-complex 11 family, X-linked 2 3.10041
GOLGA6A golgin A6 family, member A 3.10041
WFDC6 WAP four-disulfide core domain 6 3.10041
ARR3 arrestin 3, retinal (X-arrestin) 3.10041
KLHL6 kelch-like family member 6 3.10041
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.10041
C10ORF105 chromosome 10 open reading frame 105 3.10041
DHH desert hedgehog 3.10041
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.10041
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.10041
APOB apolipoprotein B 3.10041
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.10041
DES desmin 3.10041
TBXA2R thromboxane A2 receptor 3.10041
OTP orthopedia homeobox 3.10041
TH tyrosine hydroxylase 3.10041
C8G complement component 8, gamma polypeptide 3.10041
SMIM17 small integral membrane protein 17 3.10041
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.10041
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.10041
CA5A carbonic anhydrase VA, mitochondrial 3.10041
TEX12 testis expressed 12 3.10041
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.10041
OR5B2 olfactory receptor, family 5, subfamily B, member 2 3.10041
DNTT DNA nucleotidylexotransferase 3.10041
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.10041
SHISA8 shisa family member 8 3.10041
LGALS14 lectin, galactoside-binding, soluble, 14 3.10041
LMAN1L lectin, mannose-binding, 1 like 3.10041
C22ORF42 chromosome 22 open reading frame 42 3.10041
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.10041
FZD1 frizzled class receptor 1 3.10041
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.10041
EPO erythropoietin 3.10041
AREG amphiregulin 3.10041
LRRC31 leucine rich repeat containing 31 3.10041
ZNF831 zinc finger protein 831 3.10041
MB myoglobin 3.10041
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.10041
CFH complement factor H 3.10041
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.10041
CCNO cyclin O 3.10041
ADRA1B adrenoceptor alpha 1B 3.10041
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.10041
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.10041
KRT40 keratin 40, type I 3.10041
PLGLB2 plasminogen-like B2 3.10041
ART1 ADP-ribosyltransferase 1 3.10041
ANGPTL5 angiopoietin-like 5 3.10041
MROH2A maestro heat-like repeat family member 2A 3.10041
TBC1D21 TBC1 domain family, member 21 3.10041
CCDC78 coiled-coil domain containing 78 3.10041
PRRX1 paired related homeobox 1 3.10041
ANKRD30A ankyrin repeat domain 30A 3.10041
ALOX15B arachidonate 15-lipoxygenase, type B 3.10041
RFPL2 ret finger protein-like 2 3.09865
SPMIP10 sperm microtubule inner protein 10 3.00137
RAMP1 receptor (G protein-coupled) activity modifying protein 1 3.00137
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.86503
PGM1 phosphoglucomutase 1 2.77628
SGO1 shugoshin 1 2.77333
ARHGAP26 Rho GTPase activating protein 26 2.7595
ZNF473 zinc finger protein 473 2.74465
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.67437
SYK spleen tyrosine kinase 2.66987
TEDC1 tubulin epsilon and delta complex 1 2.64022
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.63124
PCDH15 protocadherin-related 15 2.6128
C19ORF85 chromosome 19 open reading frame 85 2.55923
SUSD2 sushi domain containing 2 2.47716
ARHGAP17 Rho GTPase activating protein 17 2.46563
DMWD dystrophia myotonica, WD repeat containing 2.46563
C14ORF119 chromosome 14 open reading frame 119 2.42615
PLPPR5 phospholipid phosphatase related 5 2.42615
HDGF hepatoma-derived growth factor 2.38451
ANKRD46 ankyrin repeat domain 46 2.34766
RHOBTB2 Rho-related BTB domain containing 2 2.30504
PPCS phosphopantothenoylcysteine synthetase 2.30009
SETD4 SET domain containing 4 2.28663
CFAP126 cilia and flagella associated protein 126 2.25569
NRBP1 nuclear receptor binding protein 1 2.24712
MGST2 microsomal glutathione S-transferase 2 2.24639
GPR12 G protein-coupled receptor 12 2.24458
ADAM10 ADAM metallopeptidase domain 10 2.24432
RTRAF RNA transcription, translation and transport factor 2.22987
CNTF ciliary neurotrophic factor 2.22192
LCMT1 leucine carboxyl methyltransferase 1 2.15528
IGHMBP2 immunoglobulin mu binding protein 2 2.13414
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.12602
PCDHB12 protocadherin beta 12 2.12564
ZNF426 zinc finger protein 426 2.12564
SEC23IP SEC23 interacting protein 2.12564
SNX4 sorting nexin 4 2.11381
MITF microphthalmia-associated transcription factor 2.11381
ANKRD37 ankyrin repeat domain 37 2.11336
ICAM1 intercellular adhesion molecule 1 2.07733
LENG1 leukocyte receptor cluster (LRC) member 1 2.06437
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.0593
EGFL7 EGF-like-domain, multiple 7 2.04977
RIC8A RIC8 guanine nucleotide exchange factor A 2.04392
MRPL33 mitochondrial ribosomal protein L33 2.0341
PRSS36 protease, serine, 36 2.03078
KIF12 kinesin family member 12 2.03078
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.03078
CNOT10 CCR4-NOT transcription complex, subunit 10 2.03078
OPRK1 opioid receptor, kappa 1 2.03078
CSAG3 CSAG family, member 3 2.03078
HLA-G major histocompatibility complex, class I, G 2.03078
GJD3 gap junction protein, delta 3, 31.9kDa 2.03078
DOCK11 dedicator of cytokinesis 11 2.01512
COBL cordon-bleu WH2 repeat protein 2.01063
WDR83OS WD repeat domain 83 opposite strand 2.00912
GAMT guanidinoacetate N-methyltransferase 2.00738
S1PR5 sphingosine-1-phosphate receptor 5 2.00738
WWC1 WW and C2 domain containing 1 2.00372

decreased expression

Symbol Name Standardized Value
SCT secretin -3.19475
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.19475
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -3.19475
C1ORF202 chromosome 1 open reading frame 202 -3.19475
FBXO6 F-box protein 6 -3.10041
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.10041
TMEM176A transmembrane protein 176A -3.10041
GSG1 germ cell associated 1 -3.10041
OR2A25 olfactory receptor, family 2, subfamily A, member 25 -3.10041
TMPRSS11D transmembrane protease, serine 11D -3.10041
PLA2G4E phospholipase A2, group IVE -3.10041
HES3 hes family bHLH transcription factor 3 -3.10041
CD226 CD226 molecule -3.10041
SIKE1 suppressor of IKBKE 1 -3.10041
CIITA class II, major histocompatibility complex, transactivator -3.10041
DNAH8 dynein, axonemal, heavy chain 8 -3.10041
ZNF319 zinc finger protein 319 -3.10041
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -3.10041
ADGRD1 adhesion G protein-coupled receptor D1 -3.10041
CFAP157 cilia and flagella associated protein 157 -3.10041
LOC122526780 uncharacterized LOC122526780 -3.10041
IL6ST-DT IL6ST divergent transcript -3.10041
MYZAP myocardial zonula adherens protein -3.10041
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.10041
SAFB2 scaffold attachment factor B2 -3.10041
NHLRC4 NHL repeat containing 4 -3.10041
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -3.10041
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -3.10041
ZFPL1 zinc finger protein-like 1 -3.0382
IGF1R insulin-like growth factor 1 receptor -2.95027
SLITRK3 SLIT and NTRK-like family, member 3 -2.93901
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -2.78084
ADNP2 ADNP homeobox 2 -2.77628
RABEPK Rab9 effector protein with kelch motifs -2.69713
RPTOR regulatory associated protein of MTOR, complex 1 -2.62524
SIRT5 sirtuin 5 -2.6128
FAF2 Fas associated factor family member 2 -2.5397
PCDHA9 protocadherin alpha 9 -2.52396
TCTA T-cell leukemia translocation altered -2.49849
CCDC85A coiled-coil domain containing 85A -2.46721
RNF175 ring finger protein 175 -2.44974
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.44735
ZNF384 zinc finger protein 384 -2.44735
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.42615
SFRP4 secreted frizzled-related protein 4 -2.42133
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.42133
MEIS2 Meis homeobox 2 -2.42133
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.41194
RPS29 ribosomal protein S29 -2.38593
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.32718
HOOK3 hook microtubule-tethering protein 3 -2.30253
C6ORF62 chromosome 6 open reading frame 62 -2.30253
WAS Wiskott-Aldrich syndrome -2.28808
TCP11L2 t-complex 11, testis-specific-like 2 -2.27918
MAPK3 mitogen-activated protein kinase 3 -2.27413
BAZ1A bromodomain adjacent to zinc finger domain, 1A -2.27413
FUS FUS RNA binding protein -2.27413
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.25569
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.24522
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.23466
CHD5 chromodomain helicase DNA binding protein 5 -2.22748
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -2.20969
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.20504
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.20271
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.20271
ZDBF2 zinc finger, DBF-type containing 2 -2.19373
RNF25 ring finger protein 25 -2.19373
TRIP4 thyroid hormone receptor interactor 4 -2.17751
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 -2.16801
SPICE1 spindle and centriole associated protein 1 -2.16737
DRP2 dystrophin related protein 2 -2.15393
CRYGB crystallin, gamma B -2.15393
SCN2A sodium channel, voltage gated, type II alpha subunit -2.15393
PPP4R3A protein phosphatase 4 regulatory subunit 3A -2.15364
PDCD2L programmed cell death 2-like -2.14255
ETFRF1 electron transfer flavoprotein regulatory factor 1 -2.11381
DNAAF10 dynein axonemal assembly factor 10 -2.11381
DUT deoxyuridine triphosphatase -2.09555
MADD MAP-kinase activating death domain -2.09555
ZNF469 zinc finger protein 469 -2.09036
HYKK hydroxylysine kinase -2.07941
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -2.07733
TRIM25 tripartite motif containing 25 -2.06964
DUSP6 dual specificity phosphatase 6 -2.06564
LIMK2 LIM domain kinase 2 -2.06564
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.06437
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.06437
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.06437
USP21 ubiquitin specific peptidase 21 -2.06437
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.05223
HIPK1 homeodomain interacting protein kinase 1 -2.05106
EIF3B eukaryotic translation initiation factor 3, subunit B -2.03078
USP36 ubiquitin specific peptidase 36 -2.03078
ZHX1 zinc fingers and homeoboxes 1 -2.03078
MBP myelin basic protein -2.02708
GLT8D1 glycosyltransferase 8 domain containing 1 -2.02326
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.02073
SOCS5 suppressor of cytokine signaling 5 -2.02
AFAP1 actin filament associated protein 1 -2.01984
MSI1 musashi RNA-binding protein 1 -2.01314