NFATC2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2|This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 4773)
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Genes

345 genes differentially expressed following the NFATC2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.42591
PSCA prostate stem cell antigen 3.42591
WDR64 WD repeat domain 64 3.42591
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.42591
TMPRSS3 transmembrane protease, serine 3 3.42591
TMPRSS4 transmembrane protease, serine 4 3.42591
TMEM121 transmembrane protein 121 3.42591
SETSIP SET-like protein 3.42591
BFSP2 beaded filament structural protein 2, phakinin 3.42591
FCMR Fc fragment of IgM receptor 3.42591
ARPP21 cAMP-regulated phosphoprotein, 21kDa 3.42591
TDRD6 tudor domain containing 6 3.42591
HCRTR2 hypocretin (orexin) receptor 2 3.42591
TRIM74 tripartite motif containing 74 3.42591
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.42591
OSTN osteocrin 3.42591
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.42591
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.42591
FAM228A family with sequence similarity 228, member A 3.42591
ZNF556 zinc finger protein 556 3.42591
FOXN4 forkhead box N4 3.42591
KRT86 keratin 86, type II 3.42591
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.42591
IRX1 iroquois homeobox 1 3.42591
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.42591
CCER2 coiled-coil glutamate-rich protein 2 3.42591
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.42591
OTOF otoferlin 3.42591
C5ORF46 chromosome 5 open reading frame 46 3.42591
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.42591
CDCP2 CUB domain containing protein 2 3.42591
WNK4 WNK lysine deficient protein kinase 4 3.42591
GPR35 G protein-coupled receptor 35 3.42591
AMIGO3 adhesion molecule with Ig-like domain 3 3.42591
THEMIS thymocyte selection associated 3.42591
LVRN laeverin 3.42591
FAM9B family with sequence similarity 9, member B 3.42591
PMCH pro-melanin-concentrating hormone 3.42591
AMY1A amylase, alpha 1A (salivary) 3.42591
GPR78 G protein-coupled receptor 78 3.42591
NRSN1 neurensin 1 3.42591
SPI1 Spi-1 proto-oncogene 3.42591
MT4 metallothionein 4 3.42591
ASB10 ankyrin repeat and SOCS box containing 10 3.42591
C10ORF67 chromosome 10 open reading frame 67 3.42591
CELA2A chymotrypsin-like elastase family, member 2A 3.42591
CPNE6 copine VI (neuronal) 3.42591
TBX20 T-box 20 3.42591
HBA2 hemoglobin, alpha 2 3.42591
USH1G Usher syndrome 1G (autosomal recessive) 3.42591
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.42591
RGS21 regulator of G-protein signaling 21 3.42591
PLB1 phospholipase B1 3.42591
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.42591
PCDHA8 protocadherin alpha 8 3.42591
CCIN calicin 3.42591
CATSPER3 cation channel, sperm associated 3 3.42591
CBLN3 cerebellin 3 precursor 3.42591
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.42591
VSX2 visual system homeobox 2 3.42591
CHRD chordin 3.42591
TUBA3E tubulin, alpha 3e 3.42591
MYH15 myosin, heavy chain 15 3.42591
REG4 regenerating islet-derived family, member 4 3.42591
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.42591
OOSP1 oocyte secreted protein 1, pseudogene 3.42591
HLF hepatic leukemia factor 3.42591
PCDHB6 protocadherin beta 6 3.42591
LTF lactotransferrin 3.42591
GLYAT glycine-N-acyltransferase 3.42591
PGBDF plakoglobin binding and degradation factor 3.42591
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.42591
SH2D7 SH2 domain containing 7 3.42591
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.42591
MROH5 maestro heat-like repeat family member 5 3.42591
TRIM15 tripartite motif containing 15 3.42591
PGAM4 phosphoglycerate mutase family member 4 3.42591
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.42591
ELF5 E74-like factor 5 (ets domain transcription factor) 3.42591
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.42591
ASB15 ankyrin repeat and SOCS box containing 15 3.42591
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.42591
FAM167A family with sequence similarity 167, member A 3.42591
ZSCAN5B zinc finger and SCAN domain containing 5B 3.42591
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.42591
BEST3 bestrophin 3 3.42591
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.42591
AHSG alpha-2-HS-glycoprotein 3.42591
APOC2 apolipoprotein C-II 3.42591
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 3.42591
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.42591
MYZAP myocardial zonula adherens protein 3.42591
ANKRD55 ankyrin repeat domain 55 3.42591
MORN5 MORN repeat containing 5 3.42591
SIGLEC11 sialic acid binding Ig-like lectin 11 3.42591
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.42591
UBXN10 UBX domain protein 10 3.42591
KLK4 kallikrein-related peptidase 4 3.42591
C20ORF144 chromosome 20 open reading frame 144 3.42591
PEAK3 PEAK family member 3 3.42591
CLEC4G C-type lectin domain family 4, member G 3.42591
CPHXL cytoplasmic polyadenylated homeobox like 3.42591
AKR1C8 aldo-keto reductase family 1 member C8 3.42591
CYS1 cystin 1 3.42591
EMP1 epithelial membrane protein 1 3.42591
CLEC20A C-type lectin domain containing 20A 3.42591
RPS26 ribosomal protein S26 3.42591
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.42591
SYT15B synaptotagmin 15B 3.42591
SMIM32 small integral membrane protein 32 3.42591
LYPD5 LY6/PLAUR domain containing 5 3.42591
SYT5 synaptotagmin V 3.42591
SLC17A2 solute carrier family 17, member 2 3.42591
STRC stereocilin 3.42591
BHLHA15 basic helix-loop-helix family, member a15 3.42591
GOLGA8T golgin A8 family, member T 3.42591
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.42591
SPMIP1 sperm microtubule inner protein 1 3.42591
ART1 ADP-ribosyltransferase 1 3.42591
RBM24 RNA binding motif protein 24 3.42591
ETV3L ets variant 3-like 3.42591
ARHGAP40 Rho GTPase activating protein 40 3.42591
SH2D1A SH2 domain containing 1A 3.42591
PNMA6F PNMA family member 6F 3.42591
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.42591
LGALS14 lectin, galactoside-binding, soluble, 14 3.42591
IGIP IgA-inducing protein 3.42591
FAIM2 Fas apoptotic inhibitory molecule 2 3.42591
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 3.42591
IL26 interleukin 26 3.42591
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.42591
CPA2 carboxypeptidase A2 (pancreatic) 3.42591
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 3.42591
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.42591
CLDN34 claudin 34 3.42591
ADAM29 ADAM metallopeptidase domain 29 3.42591
NELL1 NEL-like 1 (chicken) 3.42591
CCDC187 coiled-coil domain containing 187 3.42591
PLAAT2 phospholipase A and acyltransferase 2 3.42591
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.42591
APOL2 apolipoprotein L, 2 3.42591
KRT15 keratin 15, type I 3.42591
H1-6 H1.6 linker histone, cluster member 3.42591
DBX2 developing brain homeobox 2 3.42591
SQOR sulfide quinone oxidoreductase 3.42591
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.42591
PRRX1 paired related homeobox 1 3.42591
CARNS1 carnosine synthase 1 3.42591
BTNL2 butyrophilin-like 2 3.42591
AQP8 aquaporin 8 3.42591
SLITRK6 SLIT and NTRK-like family, member 6 3.42591
FAM177B family with sequence similarity 177, member B 3.42591
PLET1 placenta expressed transcript 1 3.42591
CALHM3 calcium homeostasis modulator 3 3.42591
EMX2 empty spiracles homeobox 2 3.42591
C4BPA complement component 4 binding protein, alpha 3.42591
TRADD TNFRSF1A-associated via death domain 3.42591
CFAP107 cilia and flagella associated protein 107 3.42591
TUBA8 tubulin, alpha 8 3.42591
LCN1 lipocalin 1 3.42591
CENPVL3 centromere protein V like 3 3.42591
SFTPA1 surfactant protein A1 3.42591
TAS2R46 taste receptor, type 2, member 46 3.42591
ZW10 zw10 kinetochore protein 3.42083
SCRG1 stimulator of chondrogenesis 1 3.1653
TTC23 tetratricopeptide repeat domain 23 3.1063
FAM117A family with sequence similarity 117, member A 2.99269
ZDHHC2 zinc finger, DHHC-type containing 2 2.92868
RINT1 RAD50 interactor 1 2.92095
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.79729
IRF2BPL interferon regulatory factor 2 binding protein-like 2.77587
DCTN5 dynactin 5 (p25) 2.75845
FASN fatty acid synthase 2.73036
SEC11A SEC11 homolog A (S. cerevisiae) 2.67812
TIGD5 tigger transposable element derived 5 2.64682
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.64408
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.62712
NTPCR nucleoside-triphosphatase, cancer-related 2.60998
MRPS23 mitochondrial ribosomal protein S23 2.5964
PNMA6A paraneoplastic Ma antigen family member 6A 2.59501
PARP10 poly (ADP-ribose) polymerase family, member 10 2.51188
HMBOX1 homeobox containing 1 2.50672
PCDHB13 protocadherin beta 13 2.46459
SRSF9 serine/arginine-rich splicing factor 9 2.46459
LDHC lactate dehydrogenase C 2.46459
ESD esterase D 2.46177
TMEM236 transmembrane protein 236 2.4597
HES2 hes family bHLH transcription factor 2 2.4597
AGXT2 alanine--glyoxylate aminotransferase 2 2.4597
SLC15A5 solute carrier family 15, member 5 2.42616
SNPH syntaphilin 2.42616
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.42616
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.42616
DNAAF2 dynein, axonemal, assembly factor 2 2.38233
ARHGAP45 Rho GTPase activating protein 45 2.38214
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.35424
RPS20 ribosomal protein S20 2.35424
EXOSC8 exosome component 8 2.2732
PITX2 paired-like homeodomain 2 2.26986
ERICH6 glutamate-rich 6 2.26986
E2F6 E2F transcription factor 6 2.25967
TSPAN3 tetraspanin 3 2.25237
DPH2 DPH2 homolog (S. cerevisiae) 2.25237
SDK2 sidekick cell adhesion molecule 2 2.25237
UEVLD UEV and lactate/malate dehyrogenase domains 2.22288
LSM1 LSM1, U6 small nuclear RNA associated 2.22288
CSNK1G2 casein kinase 1, gamma 2 2.22209
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.19905
ITGA6 integrin, alpha 6 2.19429
GOSR1 golgi SNAP receptor complex member 1 2.19215
MRPL16 mitochondrial ribosomal protein L16 2.18879
LPIN1 lipin 1 2.18879
TAS2R4 taste receptor, type 2, member 4 2.18664
MTMR1 myotubularin related protein 1 2.1813
SIDT2 SID1 transmembrane family, member 2 2.17952
IGF2R insulin-like growth factor 2 receptor 2.14916
MRPS16 mitochondrial ribosomal protein S16 2.13662
ZNF280B zinc finger protein 280B 2.13662
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.13395
SKIC2 SKI2 subunit of superkiller complex 2.1306
DTNB dystrobrevin, beta 2.12254
SFTPD surfactant protein D 2.12032
ACOT2 acyl-CoA thioesterase 2 2.11492
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.09938
NEFM neurofilament, medium polypeptide 2.09466
B4GAT1-DT B4GAT1 divergent transcript 2.06864
CFAP92 cilia and flagella associated protein 92 (putative) 2.04646
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.02875
ATP11A ATPase, class VI, type 11A 2.02363
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.02287
RPL37 ribosomal protein L37 2.02287
RPS15 ribosomal protein S15 2.02287
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.02287
SRF serum response factor (c-fos serum response element-binding transcription factor) 2.02074
ABHD18 abhydrolase domain containing 18 2.01816
TSC22D4 TSC22 domain family, member 4 2.01584
NMRK2 nicotinamide riboside kinase 2 2.00996
ZNF670 zinc finger protein 670 2.00996
METTL22 methyltransferase like 22 2.00996
STRADB STE20-related kinase adaptor beta 2.00996
KLF3 Kruppel-like factor 3 (basic) 2.00918
TMEM147 transmembrane protein 147 2.00399

decreased expression

Symbol Name Standardized Value
TINCR tissue differentiation-inducing non-protein coding RNA -3.42591
GOLM1 golgi membrane protein 1 -3.42591
SHANK1 SH3 and multiple ankyrin repeat domains 1 -3.42591
LDHD lactate dehydrogenase D -3.42591
SHBG sex hormone-binding globulin -3.42591
SYCE3 synaptonemal complex central element protein 3 -3.42083
ACTL8 actin-like 8 -3.42083
ZCCHC18 zinc finger, CCHC domain containing 18 -3.42083
PCDH12 protocadherin 12 -3.42083
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -3.42083
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.42083
TRIM55 tripartite motif containing 55 -3.42083
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -3.42083
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -3.42083
TMEM204 transmembrane protein 204 -3.42083
MBLAC1 metallo-beta-lactamase domain containing 1 -3.42083
TTC22 tetratricopeptide repeat domain 22 -3.42083
TTR transthyretin -3.42083
UPK1B uroplakin 1B -3.42083
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.42083
CCDC170 coiled-coil domain containing 170 -3.42083
DNAI7 dynein axonemal intermediate chain 7 -3.42083
NIBAN3 niban apoptosis regulator 3 -3.42083
ADRA2A adrenoceptor alpha 2A -3.42083
LRRC63 leucine rich repeat containing 63 -3.42083
ADAD2 adenosine deaminase domain containing 2 -3.42083
FETUB fetuin B -3.42083
CELA1 chymotrypsin-like elastase family, member 1 -3.42083
PRSS36 protease, serine, 36 -3.42083
DUSP8 dual specificity phosphatase 8 -3.42083
AADACL3 arylacetamide deacetylase-like 3 -3.42083
LRRN4CL LRRN4 C-terminal like -3.42083
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -3.15679
CDH26 cadherin 26 -3.06631
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -3.04454
ERCC5 excision repair cross-complementation group 5 -2.89687
APC2 adenomatosis polyposis coli 2 -2.85601
CD109 CD109 molecule -2.77087
NNAT neuronatin -2.76152
ABHD3 abhydrolase domain containing 3 -2.74578
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.71707
USP39 ubiquitin specific peptidase 39 -2.63757
IGFLR1 IGF-like family receptor 1 -2.6361
ZNF276 zinc finger protein 276 -2.62712
KIAA0753 KIAA0753 -2.59016
NLGN3 neuroligin 3 -2.5852
SUMF2 sulfatase modifying factor 2 -2.57162
FGFBP3 fibroblast growth factor binding protein 3 -2.51875
OXR1 oxidation resistance 1 -2.50672
POLM polymerase (DNA directed), mu -2.50672
RAB19 RAB19, member RAS oncogene family -2.50003
AP3B1 adaptor-related protein complex 3, beta 1 subunit -2.49977
UGT8 UDP glycosyltransferase 8 -2.497
MMP16 matrix metallopeptidase 16 (membrane-inserted) -2.47969
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.47748
SCLY selenocysteine lyase -2.47397
USP9X ubiquitin specific peptidase 9, X-linked -2.4597
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.44002
KCTD19 potassium channel tetramerization domain containing 19 -2.41516
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.41297
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.40661
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.40661
CCNP cyclin P -2.38233
RSPO2 R-spondin 2 -2.38233
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -2.35424
PTCD2 pentatricopeptide repeat domain 2 -2.35424
CIBAR1 CBY1 interacting BAR domain containing 1 -2.34795
LONRF1 LON peptidase N-terminal domain and ring finger 1 -2.31566
CARD14 caspase recruitment domain family, member 14 -2.2914
CAPN11 calpain 11 -2.2914
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -2.2914
RAB33A RAB33A, member RAS oncogene family -2.27504
HSPB11 heat shock protein family B (small), member 11 -2.2732
NOAZFP nucleolar atypical zinc finger -2.26982
FOXK2 forkhead box K2 -2.26982
PLCB2 phospholipase C, beta 2 -2.25558
WSCD2 WSC domain containing 2 -2.24228
LCN15 lipocalin 15 -2.24228
TMPRSS11E transmembrane protease, serine 11E -2.24228
LKAAEAR1 LKAAEAR motif containing 1 -2.24228
CD70 CD70 molecule -2.24228
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.19165
BCL2L1 BCL2-like 1 -2.16397
KLHL11 kelch-like family member 11 -2.16397
ADAMTSL3 ADAMTS-like 3 -2.1574
ZNF776 zinc finger protein 776 -2.1421
ATG4D autophagy related 4D, cysteine peptidase -2.14172
CFAP95 cilia and flagella associated protein 95 -2.13662
ADNP activity-dependent neuroprotector homeobox -2.13595
CLUH clustered mitochondria (cluA/CLU1) homolog -2.12032
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.11096
C1ORF50 chromosome 1 open reading frame 50 -2.11096
PDCD2L programmed cell death 2-like -2.10275
LNX2 ligand of numb-protein X 2 -2.05844
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.03854
QRFPR pyroglutamylated RFamide peptide receptor -2.03838
PHACTR4 phosphatase and actin regulator 4 -2.03368
MEIOB meiosis specific with OB domains -2.02875
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.02875
TUBD1 tubulin, delta 1 -2.02875
NDE1 nudE neurodevelopment protein 1 -2.02875
LCAT lecithin-cholesterol acyltransferase -2.02287
CGGBP1 CGG triplet repeat binding protein 1 -2.01816