NFATC2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2|This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 4773)
External Link http://www.ncbi.nlm.nih.gov/gene/4773
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259 interacting proteins for NFATC2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CATSPER3 cation channel, sperm associated 3
CATSPER4 cation channel, sperm associated 4
CATSPERB catsper channel auxiliary subunit beta
CATSPERD catsper channel auxiliary subunit delta
CATSPERG catsper channel auxiliary subunit gamma
CCL11 chemokine (C-C motif) ligand 11
CD247 CD247 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CDC42 cell division cycle 42
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CLIC2 chloride intracellular channel 2
CLOCK clock circadian regulator
CNGA1 cyclic nucleotide gated channel alpha 1
CNGA3 cyclic nucleotide gated channel alpha 3
CNGB1 cyclic nucleotide gated channel beta 1
CNGB3 cyclic nucleotide gated channel beta 3
CREBBP CREB binding protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CSNK1G3 casein kinase 1, gamma 3
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
DCC DCC netrin 1 receptor
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
EGR1 early growth response 1
EGR4 early growth response 4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESRRA estrogen-related receptor alpha
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP1 forkhead box P1
FOXP2 forkhead box P2
FOXP3 forkhead box P3
FZD2 frizzled class receptor 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHE immunoglobulin heavy constant epsilon
INO80E INO80 complex subunit E
IQGAP1 IQ motif containing GTPase activating protein 1
IRF2BP2 interferon regulatory factor 2 binding protein 2
IRF4 interferon regulatory factor 4
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KPNB1 karyopherin (importin) beta 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LRRK2 leucine-rich repeat kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MBD2 methyl-CpG binding domain protein 2
MCOLN1 mucolipin 1
MCOLN2 mucolipin 2
MCOLN3 mucolipin 3
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED31 mediator complex subunit 31
MEF2D myocyte enhancer factor 2D
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTA3 metastasis associated 1 family, member 3
NAV3 neuron navigator 3
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRG1 neuregulin 1
NTN1 netrin 1
NTN3 netrin 3
NTN4 netrin 4
NTNG1 netrin G1
NTNG2 netrin G2
NUP214 nucleoporin 214kDa
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PF4 platelet factor 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKNOX1 PBX/knotted 1 homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDM16 PR domain containing 16
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD50 RAD50 homolog (S. cerevisiae)
RAN RAN, member RAS oncogene family
RIPK2 receptor-interacting serine-threonine kinase 2
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SH3BP2 SH3-domain binding protein 2
SIN3B SIN3 transcription regulator family member B
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOGA3 SOGA family member 3
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRI sorcin
STIM1 stromal interaction molecule 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THYN1 thymocyte nuclear protein 1
TNPO1 transportin 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TPCN1 two pore segment channel 1
TPCN2 two pore segment channel 2
TRDN triadin
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTF2 transcription termination factor, RNA polymerase II
TUBA1A tubulin, alpha 1a
UBC ubiquitin C
UBP1 upstream binding protein 1 (LBP-1a)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USF2 upstream transcription factor 2, c-fos interacting
USP22 ubiquitin specific peptidase 22
VIM vimentin
VRK1 vaccinia related kinase 1
VRK2 vaccinia related kinase 2
WIZ widely interspaced zinc finger motifs
WNT5A wingless-type MMTV integration site family, member 5A
XPO1 exportin 1
YEATS2 YEATS domain containing 2
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZZZ3 zinc finger, ZZ-type containing 3