NFE2L1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor, erythroid 2-like 1|This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4779)
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Genes

344 genes differentially expressed following the NFE2L1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SOX1 SRY (sex determining region Y)-box 1 3.01562
MYBPC3 myosin binding protein C, cardiac 3.01562
CLEC19A C-type lectin domain family 19, member A 3.01562
PDZD9 PDZ domain containing 9 3.01562
SH2D7 SH2 domain containing 7 3.01562
PAX6 paired box 6 3.01562
OLIG1 oligodendrocyte transcription factor 1 3.01562
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.01562
SSTR5 somatostatin receptor 5 3.01562
SFXN3 sideroflexin 3 3.01562
TBX15 T-box 15 3.01562
OSGIN1 oxidative stress induced growth inhibitor 1 3.01562
PCDHB9 protocadherin beta 9 3.01562
MYO7A myosin VIIA 3.01562
ZNF492 zinc finger protein 492 3.01562
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.01562
DUXB double homeobox B 3.01562
IZUMO3 IZUMO family member 3 3.01562
SLC46A3 solute carrier family 46, member 3 3.01562
PLIN1 perilipin 1 3.01562
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.01562
TSGA13 testis specific, 13 3.01562
MFAP4 microfibrillar-associated protein 4 3.01562
REN renin 3.01562
BMP3 bone morphogenetic protein 3 3.01562
TMC8 transmembrane channel-like 8 3.01562
SP6 Sp6 transcription factor 3.01562
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.01562
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.01562
THEMIS thymocyte selection associated 3.01562
PRR22 proline rich 22 3.01562
FGF6 fibroblast growth factor 6 3.01562
IL23A interleukin 23, alpha subunit p19 3.01562
LBX2 ladybird homeobox 2 3.01562
LRRC66 leucine rich repeat containing 66 3.01562
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.01562
GFI1 growth factor independent 1 transcription repressor 3.01562
ADGB androglobin 3.01562
ADAMTSL5 ADAMTS-like 5 3.01562
GMFG glia maturation factor, gamma 3.01562
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.01562
FOXO3B forkhead box O3B pseudogene 3.01562
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.01562
TMEM89 transmembrane protein 89 3.01562
CCDC38 coiled-coil domain containing 38 3.01562
TPRX1 tetra-peptide repeat homeobox 1 3.01562
SPMIP7 sperm microtubule inner protein 7 3.01562
ARX aristaless related homeobox 3.01562
PNLIPRP1 pancreatic lipase-related protein 1 3.01562
VN1R2 vomeronasal 1 receptor 2 3.01562
TMPRSS3 transmembrane protease, serine 3 3.01562
SPMIP1 sperm microtubule inner protein 1 3.01562
ASB5 ankyrin repeat and SOCS box containing 5 3.01562
TSPAN1 tetraspanin 1 3.01562
LY6K lymphocyte antigen 6 complex, locus K 3.01562
SMTNL1 smoothelin-like 1 3.01562
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.01562
TMEM275 transmembrane protein 275 3.01562
FAM240B family with sequence similarity 240 member B 3.01562
FAM240A family with sequence similarity 240 member A 3.01562
LINC02268 long intergenic non-protein coding RNA 2268 3.01562
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.01562
DEFB109B defensin beta 109B 3.01562
LOC124906010 uncharacterized LOC124906010 3.01562
C20ORF204 chromosome 20 open reading frame 204 3.01562
DUSP29 dual specificity phosphatase 29 3.01562
PLAAT2 phospholipase A and acyltransferase 2 3.01562
PLAAT4 phospholipase A and acyltransferase 4 3.01562
OR8G5 olfactory receptor, family 8, subfamily G, member 5 3.01562
C15ORF62 chromosome 15 open reading frame 62 3.01562
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.01562
EDAR ectodysplasin A receptor 3.01562
CLDN9 claudin 9 3.01562
TLE6 transducin-like enhancer of split 6 3.01562
GDA guanine deaminase 3.01562
PCDHA3 protocadherin alpha 3 3.01562
HHEX hematopoietically expressed homeobox 3.01562
FPR1 formyl peptide receptor 1 3.01562
FAM3D family with sequence similarity 3, member D 3.01562
GOLGA7B golgin A7 family, member B 3.01562
S1PR1 sphingosine-1-phosphate receptor 1 3.01562
TLR7 toll-like receptor 7 3.01562
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.01562
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.01562
PXDC1 PX domain containing 1 3.01562
VCX3A variable charge, X-linked 3A 3.01562
CELA2A chymotrypsin-like elastase family, member 2A 3.01562
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.01562
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.01562
CCDC120 coiled-coil domain containing 120 3.01562
GZMM granzyme M (lymphocyte met-ase 1) 3.01562
AGTR1 angiotensin II receptor, type 1 3.01562
NANOGNB NANOG neighbor homeobox 3.01562
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.01562
IRGM immunity-related GTPase family, M 3.01562
EMP1 epithelial membrane protein 1 3.01562
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.01562
PCDHGA4 protocadherin gamma subfamily A, 4 3.01562
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.01562
SMYD1 SET and MYND domain containing 1 3.01562
SHISA8 shisa family member 8 3.01562
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.01562
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.01562
MC5R melanocortin 5 receptor 3.01562
MAEL maelstrom spermatogenic transposon silencer 3.01562
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.01562
ZFP92 ZFP92 zinc finger protein 3.01562
NUTM2D NUT family member 2D 3.01562
ALAS2 5'-aminolevulinate synthase 2 3.01562
PCDHGB4 protocadherin gamma subfamily B, 4 3.01562
CTAGE9 CTAGE family, member 9 3.01562
CALHM3 calcium homeostasis modulator 3 3.01562
CTAGE4 CTAGE family, member 4 3.01562
TDRD10 tudor domain containing 10 3.01562
CXCR5 chemokine (C-X-C motif) receptor 5 3.01562
AQP7 aquaporin 7 3.01562
AKNAD1 AKNA domain containing 1 3.01562
HKDC1 hexokinase domain containing 1 3.01562
MEFV Mediterranean fever 3.01562
LCNL1 lipocalin-like 1 3.01562
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.01562
TMEM132E transmembrane protein 132E 3.01562
PAGE4 P antigen family, member 4 (prostate associated) 3.01562
ERCC8 excision repair cross-complementation group 8 3.01562
KRT222 keratin 222, type II 3.01562
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.01562
SP100 SP100 nuclear antigen 3.01562
ZC3H11D zinc finger CCCH-type containing 11D 3.01562
CRHBP corticotropin releasing hormone binding protein 3.01562
RBBP8NL RBBP8 N-terminal like 3.01562
NLRP4 NLR family, pyrin domain containing 4 3.01562
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.01562
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.01562
DCST1 DC-STAMP domain containing 1 3.01562
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.01562
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.01562
MEPE matrix extracellular phosphoglycoprotein 3.01562
SFTA2 surfactant associated 2 3.01562
NR2F1 nuclear receptor subfamily 2, group F, member 1 3.01562
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.01562
SCN3A sodium channel, voltage gated, type III alpha subunit 3.01562
TRAF3IP3 TRAF3 interacting protein 3 3.01562
GLT6D1 glycosyltransferase 6 domain containing 1 3.01562
ZNF534 zinc finger protein 534 3.01562
C7ORF33 chromosome 7 open reading frame 33 3.01562
PXT1 peroxisomal, testis specific 1 3.01562
GPBAR1 G protein-coupled bile acid receptor 1 3.01562
GSTA1 glutathione S-transferase alpha 1 3.01562
FITM1 fat storage-inducing transmembrane protein 1 3.01562
PAQR6 progestin and adipoQ receptor family member VI 3.01562
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.01562
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 3.01562
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.01562
LYZL4 lysozyme-like 4 3.01562
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.01562
TG thyroglobulin 3.01562
UBAC1 UBA domain containing 1 2.95606
RTL8C retrotransposon Gag like 8C 2.74259
MPG N-methylpurine-DNA glycosylase 2.74259
SCYL3 SCY1-like 3 (S. cerevisiae) 2.72537
FGFBP3 fibroblast growth factor binding protein 3 2.71874
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.65072
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.62028
SNX15 sorting nexin 15 2.61039
VENTX VENT homeobox 2.59442
KLHL13 kelch-like family member 13 2.53333
H2BC12 H2B clustered histone 12 2.53201
PURB purine-rich element binding protein B 2.53109
DCAF17 DDB1 and CUL4 associated factor 17 2.51881
SETD2 SET domain containing 2 2.48055
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.47658
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.45627
PRMT9 protein arginine methyltransferase 9 2.45627
CLSTN3 calsyntenin 3 2.43422
RNF17 ring finger protein 17 2.42846
KRTAP13-4 keratin associated protein 13-4 2.42846
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2.36297
TMEM171 transmembrane protein 171 2.36143
EBF1 early B-cell factor 1 2.35932
TLL1 tolloid-like 1 2.34441
COMMD8 COMM domain containing 8 2.33294
TCL1A T-cell leukemia/lymphoma 1A 2.31294
CBX5 chromobox homolog 5 2.31294
SDC2 syndecan 2 2.29025
FAM162B family with sequence similarity 162, member B 2.2545
MRPS12 mitochondrial ribosomal protein S12 2.24919
NNT nicotinamide nucleotide transhydrogenase 2.24871
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.24402
MATN4 matrilin 4 2.2282
EEF1AKMT4 EEF1A lysine methyltransferase 4 2.21982
PRKCQ protein kinase C, theta 2.19634
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.19623
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.1892
CCNJ cyclin J 2.1626
RNF152 ring finger protein 152 2.13096
RAB36 RAB36, member RAS oncogene family 2.11195
CCDC122 coiled-coil domain containing 122 2.11195
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.11195
ZNF597 zinc finger protein 597 2.11195
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.11195
ZNF804A zinc finger protein 804A 2.11195
PRB3 proline-rich protein BstNI subfamily 3 2.11195
IRF4 interferon regulatory factor 4 2.11195
PWWP2A PWWP domain containing 2A 2.11195
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.11195
CSPG4 chondroitin sulfate proteoglycan 4 2.11195
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.11195
LDB3 LIM domain binding 3 2.11195
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 2.11195
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.08331
RHD Rh blood group, D antigen 2.08331
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.08331
THAP9 THAP domain containing 9 2.08101
GLRX2 glutaredoxin 2 2.05957
NIPAL3 NIPA-like domain containing 3 2.05225
RPL24 ribosomal protein L24 2.04867
PCDHB3 protocadherin beta 3 2.04613
FAM20A family with sequence similarity 20, member A 2.03762
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 2.03039
IRF2BPL interferon regulatory factor 2 binding protein-like 2.01258
ZNF875 zinc finger protein 875 2.00314
IP6K1 inositol hexakisphosphate kinase 1 2.00218

decreased expression

Symbol Name Standardized Value
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.01562
TOGARAM2 TOG array regulator of axonemal microtubules 2 -3.01562
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -3.01562
PCP4 Purkinje cell protein 4 -3.01562
ADPRHL1 ADP-ribosylhydrolase like 1 -3.01562
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -3.01562
LGI4 leucine-rich repeat LGI family, member 4 -3.01562
RBM34 RNA binding motif protein 34 -3.01562
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like -3.01562
CER1 cerberus 1, DAN family BMP antagonist -3.01562
DNAAF3 dynein, axonemal, assembly factor 3 -3.01562
FTH1 ferritin, heavy polypeptide 1 -3.00315
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.92171
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.9158
GPR150 G protein-coupled receptor 150 -2.9158
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.9158
SLA Src-like-adaptor -2.9158
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.9158
CTF1 cardiotrophin 1 -2.9158
WBP2NL WBP2 N-terminal like -2.9158
SPATA16 spermatogenesis associated 16 -2.9158
CATSPERD catsper channel auxiliary subunit delta -2.9158
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.9158
PLB1 phospholipase B1 -2.9158
MIB1 mindbomb E3 ubiquitin protein ligase 1 -2.9158
LHX8 LIM homeobox 8 -2.9158
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.9158
EPN3 epsin 3 -2.9158
GOLGA6C golgin A6 family, member C -2.9158
ETV3L ets variant 3-like -2.9158
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.9158
PRCD progressive rod-cone degeneration -2.9158
ARSI arylsulfatase family, member I -2.9158
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -2.9158
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.9158
RUMY3 RUMY family member 3 -2.9158
RNF227 ring finger protein 227 -2.9158
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.9158
CREG2 cellular repressor of E1A-stimulated genes 2 -2.9158
MSC musculin -2.9158
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.9158
C2ORF80 chromosome 2 open reading frame 80 -2.9158
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.9158
AQP4 aquaporin 4 -2.9158
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.9158
AP5B1 adaptor-related protein complex 5, beta 1 subunit -2.84634
ACSF3 acyl-CoA synthetase family member 3 -2.8242
ZNF70 zinc finger protein 70 -2.76736
TMEM144 transmembrane protein 144 -2.76736
MASP2 mannan-binding lectin serine peptidase 2 -2.76736
BRME1 break repair meiotic recombinase recruitment factor 1 -2.76736
NOXO1 NADPH oxidase organizer 1 -2.76736
HBQ1 hemoglobin, theta 1 -2.76736
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.74189
CEP290 centrosomal protein 290kDa -2.62041
WDR55 WD repeat domain 55 -2.54562
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.53201
ITGA10 integrin, alpha 10 -2.53201
ADRA2B adrenoceptor alpha 2B -2.53201
MYL7 myosin, light chain 7, regulatory -2.53201
DCLK2 doublecortin-like kinase 2 -2.50876
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.49399
TAOK2 TAO kinase 2 -2.45627
DNAH12 dynein, axonemal, heavy chain 12 -2.45627
ZNHIT3 zinc finger, HIT-type containing 3 -2.45627
NLE1 notchless homolog 1 (Drosophila) -2.45538
SSH2 slingshot protein phosphatase 2 -2.45076
SCNN1A sodium channel, non voltage gated 1 alpha subunit -2.43117
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.42846
PTPRJ protein tyrosine phosphatase, receptor type, J -2.42846
ZNF622 zinc finger protein 622 -2.41841
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.38732
RTN4RL2 reticulon 4 receptor-like 2 -2.36143
TMEM250 transmembrane protein 250 -2.35206
IL6R interleukin 6 receptor -2.34441
EIF3M eukaryotic translation initiation factor 3, subunit M -2.34441
PDE8A phosphodiesterase 8A -2.31465
UTRN utrophin -2.31465
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.29525
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.28996
GARS1 glycyl-tRNA synthetase 1 -2.27072
PHPT1 phosphohistidine phosphatase 1 -2.26144
MED13L mediator complex subunit 13-like -2.25585
SRP54 signal recognition particle 54kDa -2.24871
TRABD2A TraB domain containing 2A -2.23552
GMPR guanosine monophosphate reductase -2.23552
HHIPL1 HHIP-like 1 -2.23189
PHF12 PHD finger protein 12 -2.22939
DACH2 dachshund family transcription factor 2 -2.21343
SLC44A2 solute carrier family 44 (choline transporter), member 2 -2.2083
COL5A3 collagen, type V, alpha 3 -2.20267
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.20267
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.20267
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.19634
CLIC6 chloride intracellular channel 6 -2.1881
ZNF583 zinc finger protein 583 -2.1881
NFIL3 nuclear factor, interleukin 3 regulated -2.1881
OXNAD1 oxidoreductase NAD-binding domain containing 1 -2.18673
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.18379
ZNF581 zinc finger protein 581 -2.16567
CLC Charcot-Leyden crystal galectin -2.16055
COMMD7 COMM domain containing 7 -2.15424
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.14435
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.12624
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.12327
ZNF292 zinc finger protein 292 -2.11292
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.11195
ZNF284 zinc finger protein 284 -2.11195
SH3YL1 SH3 and SYLF domain containing 1 -2.11195
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.10826
CPNE1 copine I -2.09898
PACS2 phosphofurin acidic cluster sorting protein 2 -2.09283
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.07795
CCDC144A coiled-coil domain containing 144A -2.06113
NSUN7 NOP2/Sun domain family, member 7 -2.05957
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.05848
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.0572
FSIP2 fibrous sheath interacting protein 2 -2.05682
ARGLU1 arginine and glutamate rich 1 -2.04729
GUCA1A guanylate cyclase activator 1A (retina) -2.01996
NFE2L1 nuclear factor, erythroid 2-like 1 -2.00463
IGF1R insulin-like growth factor 1 receptor -2.00218