NFIC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor I/C (CCAAT-binding transcription factor)|The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 4782)
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Genes

334 genes differentially expressed following the NFIC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLX H2.0-like homeobox 3.63357
HCRTR1 hypocretin (orexin) receptor 1 3.63357
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.63357
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.63357
SIRPB1 signal-regulatory protein beta 1 3.63357
ADTRP androgen-dependent TFPI-regulating protein 3.63357
SKOR2 SKI family transcriptional corepressor 2 3.63357
GJB3 gap junction protein, beta 3, 31kDa 3.63357
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 3.63357
ARHGAP36 Rho GTPase activating protein 36 3.63357
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.63357
TMEM176B transmembrane protein 176B 3.63357
CD19 CD19 molecule 3.63357
AGTR1 angiotensin II receptor, type 1 3.63357
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.63357
ALB albumin 3.63357
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.63357
PLEK pleckstrin 3.63357
ASB15 ankyrin repeat and SOCS box containing 15 3.63357
MAP3K7CL MAP3K7 C-terminal like 3.63357
FAM167B family with sequence similarity 167, member B 3.63357
SLC26A7 solute carrier family 26 (anion exchanger), member 7 3.63357
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.63357
ASB10 ankyrin repeat and SOCS box containing 10 3.63357
MUSK muscle, skeletal, receptor tyrosine kinase 3.63357
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.63357
VSX1 visual system homeobox 1 3.63357
LGALS4 lectin, galactoside-binding, soluble, 4 3.63357
LGALS9 lectin, galactoside-binding, soluble, 9 3.63357
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.63357
IL18R1 interleukin 18 receptor 1 3.63357
SPAG6 sperm associated antigen 6 3.63357
CCDC83 coiled-coil domain containing 83 3.63357
HRG histidine-rich glycoprotein 3.63357
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.63357
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.63357
TREML1 triggering receptor expressed on myeloid cells-like 1 3.63357
S100A1 S100 calcium binding protein A1 3.63357
GFI1 growth factor independent 1 transcription repressor 3.63357
GUCY2F guanylate cyclase 2F, retinal 3.63357
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 3.63357
DEFB124 defensin, beta 124 3.63357
C1ORF141 chromosome 1 open reading frame 141 3.63357
TDRD9 tudor domain containing 9 3.63357
LCN12 lipocalin 12 3.63357
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.63357
PSCA prostate stem cell antigen 3.63357
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.63357
WFDC11 WAP four-disulfide core domain 11 3.63357
SIX3 SIX homeobox 3 3.63357
FAM90A12 family with sequence similarity 90 member A12 3.63357
C3AR1 complement component 3a receptor 1 3.63357
CAPN9 calpain 9 3.63357
PNLIPRP1 pancreatic lipase-related protein 1 3.63357
CXCL13 chemokine (C-X-C motif) ligand 13 3.63357
DNAAF1 dynein, axonemal, assembly factor 1 3.63357
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.63357
FMO2 flavin containing monooxygenase 2 (non-functional) 3.63357
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.63357
KLB klotho beta 3.63357
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.63357
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.63357
TLE7 TLE family member 7 3.63357
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.63357
CIMIP2A ciliary microtubule inner protein 2A 3.63357
CIMIP7 ciliary microtubule inner protein 7 3.63357
GNG5B G protein subunit gamma 5B 3.63357
MAJIN membrane anchored junction protein 3.63357
TENT5D terminal nucleotidyltransferase 5D 3.63357
CFAP141 cilia and flagella associated protein 141 3.63357
FLACC1 flagellum associated containing coiled-coil domains 1 3.63357
CCN5 cellular communication network factor 5 3.63357
PLAAT4 phospholipase A and acyltransferase 4 3.63357
DOK7 docking protein 7 3.63357
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.63357
LY6H lymphocyte antigen 6 complex, locus H 3.63357
AKR1D1 aldo-keto reductase family 1, member D1 3.63357
FOSL2 FOS-like antigen 2 3.63357
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.63357
KLHL33 kelch-like family member 33 3.63357
RAB41 RAB41, member RAS oncogene family 3.63357
TMEM229B transmembrane protein 229B 3.63357
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.63357
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.63357
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.63357
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.63357
THPO thrombopoietin 3.63357
MAG myelin associated glycoprotein 3.63357
FAM228A family with sequence similarity 228, member A 3.63357
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 3.63357
OSTN osteocrin 3.63357
LRRC73 leucine rich repeat containing 73 3.63357
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.63357
CCR9 chemokine (C-C motif) receptor 9 3.63357
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.63357
IL6 interleukin 6 3.63357
OR2A14 olfactory receptor, family 2, subfamily A, member 14 3.63357
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.63357
COL19A1 collagen, type XIX, alpha 1 3.63357
NFE2 nuclear factor, erythroid 2 3.63357
ONECUT3 one cut homeobox 3 3.63357
DUOX2 dual oxidase 2 3.63357
RTBDN retbindin 3.63357
ADAM8 ADAM metallopeptidase domain 8 3.63357
CD244 CD244 molecule, natural killer cell receptor 2B4 3.63357
MAB21L2 mab-21-like 2 (C. elegans) 3.63357
POU2AF1 POU class 2 associating factor 1 3.63357
FOXE3 forkhead box E3 3.63357
EVPLL envoplakin-like 3.63357
COX7B2 cytochrome c oxidase subunit VIIb2 3.63357
KRT222 keratin 222, type II 3.63357
ADGRA1 adhesion G protein-coupled receptor A1 3.63357
HCRT hypocretin (orexin) neuropeptide precursor 3.63357
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.63357
CLPS colipase, pancreatic 3.63357
ACOX2 acyl-CoA oxidase 2, branched chain 3.63357
FNDC9 fibronectin type III domain containing 9 3.63357
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.63357
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.63357
EREG epiregulin 3.63357
HAMP hepcidin antimicrobial peptide 3.63357
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.63357
TAT tyrosine aminotransferase 3.63357
DHH desert hedgehog 3.63357
THBD thrombomodulin 3.63357
LGALS12 lectin, galactoside-binding, soluble, 12 3.63357
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.63357
PLA2G2C phospholipase A2, group IIC 3.63357
ADCY4 adenylate cyclase 4 3.63357
IL27 interleukin 27 3.63357
CCNA1 cyclin A1 3.63357
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.63357
GJC2 gap junction protein, gamma 2, 47kDa 3.63357
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.63357
ORM1 orosomucoid 1 3.63357
TRIM7 tripartite motif containing 7 3.63357
SLC38A3 solute carrier family 38, member 3 3.63357
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.63357
ANKRD20A1 ankyrin repeat domain 20 family, member A1 3.63357
LRRK2 leucine-rich repeat kinase 2 3.63357
CATIP ciliogenesis associated TTC17 interacting protein 3.63357
FBXO47 F-box protein 47 3.63357
KLK4 kallikrein-related peptidase 4 3.63357
ILDR2 immunoglobulin-like domain containing receptor 2 3.63357
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.63357
SIGLEC11 sialic acid binding Ig-like lectin 11 3.63357
GOLGA8O golgin A8 family, member O 3.63357
PRSS55 protease, serine, 55 3.63357
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.63357
MC5R melanocortin 5 receptor 3.63357
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.63357
GCM2 glial cells missing homolog 2 (Drosophila) 3.63357
STMND1 stathmin domain containing 1 3.63357
CARD9 caspase recruitment domain family, member 9 3.63357
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.63357
APOL1 apolipoprotein L, 1 3.63357
MYOZ2 myozenin 2 3.63357
POU3F3 POU class 3 homeobox 3 3.63357
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.63357
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.63357
LRRC31 leucine rich repeat containing 31 3.63357
PATE2 prostate and testis expressed 2 3.63357
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.63357
IRX1 iroquois homeobox 1 3.63357
TTC36 tetratricopeptide repeat domain 36 3.63357
TMEM52B transmembrane protein 52B 3.63357
ZNF829 zinc finger protein 829 3.63357
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.63357
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.63357
CD177 CD177 molecule 3.63357
CLCNKA chloride channel, voltage-sensitive Ka 3.63357
CALML6 calmodulin-like 6 3.63357
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.63357
KIF19 kinesin family member 19 3.63357
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.63357
NPNT nephronectin 3.61778
MTMR14 myotubularin related protein 14 3.49623
XG Xg blood group 3.36695
MISFA mitochondrial sheath formation associated 3.2262
H1-3 H1.3 linker histone, cluster member 3.20642
PLK3 polo-like kinase 3 2.98158
C2 complement component 2 2.98158
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.83639
AMZ2 archaelysin family metallopeptidase 2 2.82062
CERT1 ceramide transporter 1 2.77724
FZD8 frizzled class receptor 8 2.68719
METTL24 methyltransferase like 24 2.6803
JPH1 junctophilin 1 2.55313
CCL5 chemokine (C-C motif) ligand 5 2.44255
IRF2-DT IRF2 divergent transcript 2.44255
NPPA natriuretic peptide A 2.44255
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.44255
HLA-DMB major histocompatibility complex, class II, DM beta 2.44255
RGPD6 RANBP2-like and GRIP domain containing 6 2.44255
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.44255
NMBR neuromedin B receptor 2.44255
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.44255
E2F8 E2F transcription factor 8 2.35894
CENPV centromere protein V 2.33631
GIPC2 GIPC PDZ domain containing family, member 2 2.33383
MAST3 microtubule associated serine/threonine kinase 3 2.29866
ISG20 interferon stimulated exonuclease gene 20kDa 2.28984
COIL coilin 2.28964
TSPAN11 tetraspanin 11 2.27127
TMEM40 transmembrane protein 40 2.27127
IFT122 intraflagellar transport 122 2.27127
MAMDC4 MAM domain containing 4 2.25965
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.25965
SETD3 SET domain containing 3 2.24352
GFM2 G elongation factor, mitochondrial 2 2.23783
TSPAN6 tetraspanin 6 2.20276
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.19494
MMUT methylmalonyl-CoA mutase 2.19164
DUSP10 dual specificity phosphatase 10 2.18468
BCL6 B-cell CLL/lymphoma 6 2.18468
EML5 echinoderm microtubule associated protein like 5 2.18468
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 2.18468
MSANTD7 Myb/SANT DNA binding domain containing 7 2.18468
TSPO translocator protein (18kDa) 2.17473
PID1 phosphotyrosine interaction domain containing 1 2.16673
TOP3B topoisomerase (DNA) III beta 2.16673
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.16269
TXNRD1 thioredoxin reductase 1 2.15854
SCAI suppressor of cancer cell invasion 2.15854
TUBB2A tubulin, beta 2A class IIa 2.14491
PHF6 PHD finger protein 6 2.14476
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.14165
LITAF lipopolysaccharide-induced TNF factor 2.13247
CTC1 CTS telomere maintenance complex component 1 2.12478
PDPN podoplanin 2.12166
MAPK6 mitogen-activated protein kinase 6 2.09644
FANCB Fanconi anemia, complementation group B 2.09095
TMSB15A thymosin beta 15a 2.08915
COCH cochlin 2.08348
NANS N-acetylneuraminic acid synthase 2.0655
CHMP6 charged multivesicular body protein 6 2.01122

decreased expression

Symbol Name Standardized Value
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.63357
IL1R1 interleukin 1 receptor, type I -3.63357
PDF peptide deformylase (mitochondrial) -3.63357
SPACDR sperm acrosome developmental regulator -3.63357
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -3.63357
BHLHE40 basic helix-loop-helix family, member e40 -3.63357
SUN3 Sad1 and UNC84 domain containing 3 -3.63357
NHLH1 nescient helix loop helix 1 -3.63357
BFSP2 beaded filament structural protein 2, phakinin -3.63357
TMPRSS6 transmembrane protease, serine 6 -3.63357
PAPOLB poly(A) polymerase beta (testis specific) -3.63357
ANXA1 annexin A1 -3.63357
GPR171 G protein-coupled receptor 171 -3.63357
WFDC13 WAP four-disulfide core domain 13 -3.63357
LPO lactoperoxidase -3.63357
EXTL1 exostosin-like glycosyltransferase 1 -3.63357
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.63357
MTMR11 myotubularin related protein 11 -3.63357
TACSTD2 tumor-associated calcium signal transducer 2 -3.63357
TSGA10IP testis specific, 10 interacting protein -3.63357
CHD9NB CHD9 neighbor -3.63357
VIT vitrin -3.63357
ZFP92 ZFP92 zinc finger protein -3.63357
BAHCC1 BAH domain and coiled-coil containing 1 -3.63357
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -3.63357
FBP1 fructose-1,6-bisphosphatase 1 -3.63357
SCT secretin -3.63357
BVES blood vessel epicardial substance -3.63357
WFDC1 WAP four-disulfide core domain 1 -3.63357
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -3.33236
SIRT1 sirtuin 1 -3.30435
NRK Nik related kinase -3.14387
RRBP1 ribosome binding protein 1 -3.11424
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -3.11157
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -3.09504
IVD isovaleryl-CoA dehydrogenase -3.08329
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -3.01373
MON1A MON1 secretory trafficking family member A -3.0084
BHLHE41 basic helix-loop-helix family, member e41 -2.86485
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.86485
NFU1 NFU1 iron-sulfur cluster scaffold -2.8194
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.79003
H2BC26 H2B clustered histone 26 -2.77089
BOLL boule-like RNA-binding protein -2.6893
TUBA8 tubulin, alpha 8 -2.6893
TTC29 tetratricopeptide repeat domain 29 -2.6893
PROM2 prominin 2 -2.6893
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.6893
NPM2 nucleophosmin/nucleoplasmin 2 -2.6893
PPP1R16A protein phosphatase 1, regulatory subunit 16A -2.6803
CDC23 cell division cycle 23 -2.6682
UNKL unkempt family zinc finger-like -2.66555
NCDN neurochondrin -2.53766
ANGPTL7 angiopoietin-like 7 -2.49245
ARB2A ARB2 cotranscriptional regulator A -2.49135
IFT140 intraflagellar transport 140 -2.45665
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.44604
PRR5L proline rich 5 like -2.44326
MTERF3 mitochondrial transcription termination factor 3 -2.44211
CARD14 caspase recruitment domain family, member 14 -2.41907
CHMP2B charged multivesicular body protein 2B -2.41281
VIRMA vir like m6A methyltransferase associated -2.40337
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.4001
TRHDE thyrotropin-releasing hormone degrading enzyme -2.29082
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.27906
NVL nuclear VCP-like -2.27127
H2BC15 H2B clustered histone 15 -2.26009
TTC23 tetratricopeptide repeat domain 23 -2.25965
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.25741
DMAC2 distal membrane arm assembly component 2 -2.25599
IL13RA1 interleukin 13 receptor, alpha 1 -2.25245
TERT telomerase reverse transcriptase -2.21888
NAGK N-acetylglucosamine kinase -2.2165
DUOX1 dual oxidase 1 -2.21481
DOC2B double C2-like domains, beta -2.21481
FES FES proto-oncogene, tyrosine kinase -2.21481
LINC02762 long intergenic non-protein coding RNA 2762 -2.21481
ACSS2 acyl-CoA synthetase short-chain family member 2 -2.19296
HAUS1 HAUS augmin-like complex, subunit 1 -2.19005
PPIF peptidylprolyl isomerase F -2.18638
SMTN smoothelin -2.18468
SETD6 SET domain containing 6 -2.17902
FAM156A family with sequence similarity 156, member A -2.14165
CRYL1 crystallin, lambda 1 -2.12381
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.10745
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.06552
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.0655
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.06515
MITD1 MIT, microtubule interacting and transport, domain containing 1 -2.06116
RFX8 RFX family member 8, lacking RFX DNA binding domain -2.05518
ECH1 enoyl CoA hydratase 1, peroxisomal -2.05518
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.0531
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -2.0531
CSPP1 centrosome and spindle pole associated protein 1 -2.04811
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.03386
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.01684
ZCCHC4 zinc finger, CCHC domain containing 4 -2.01166
APLP2 amyloid beta (A4) precursor-like protein 2 -2.00602