NFIL3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear factor, interleukin 3 regulated|The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 4783)
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Genes

295 genes differentially expressed following the NFIL3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CES3 carboxylesterase 3 2.57125
CAMP cathelicidin antimicrobial peptide 2.57125
PRSS48 protease, serine, 48 2.57125
PCDHB6 protocadherin beta 6 2.57125
PCDHB9 protocadherin beta 9 2.57125
FOXA2 forkhead box A2 2.57125
HES3 hes family bHLH transcription factor 3 2.57125
SSTR1 somatostatin receptor 1 2.57125
CNTNAP4 contactin associated protein-like 4 2.57125
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.57125
PLIN1 perilipin 1 2.57125
IL22RA1 interleukin 22 receptor, alpha 1 2.57125
CFHR3 complement factor H-related 3 2.57125
ALB albumin 2.57125
ASB15 ankyrin repeat and SOCS box containing 15 2.57125
FAM167A family with sequence similarity 167, member A 2.57125
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.57125
CTRC chymotrypsin C (caldecrin) 2.57125
ADGRE1 adhesion G protein-coupled receptor E1 2.57125
KNG1 kininogen 1 2.57125
CLEC19A C-type lectin domain family 19, member A 2.57125
GJA10 gap junction protein, alpha 10, 62kDa 2.57125
HMX3 H6 family homeobox 3 2.57125
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.57125
FAM9C family with sequence similarity 9, member C 2.57125
KIAA1755 KIAA1755 2.57125
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.57125
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.57125
PSD2 pleckstrin and Sec7 domain containing 2 2.57125
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.57125
PRDM13 PR domain containing 13 2.57125
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.57125
TBATA thymus, brain and testes associated 2.57125
TRIM77 tripartite motif containing 77 2.57125
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.57125
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 2.57125
DLX4 distal-less homeobox 4 2.57125
S100A3 S100 calcium binding protein A3 2.57125
S100A5 S100 calcium binding protein A5 2.57125
GNRH2 gonadotropin-releasing hormone 2 2.57125
LRRC61 leucine rich repeat containing 61 2.57125
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.57125
RLBP1 retinaldehyde binding protein 1 2.57125
FAM240A family with sequence similarity 240 member A 2.57125
PNLIPRP3 pancreatic lipase-related protein 3 2.57125
ACER1 alkaline ceramidase 1 2.57125
ZNF229 zinc finger protein 229 2.57125
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.57125
FRG2C FSHD region gene 2 family, member C 2.57125
KRT82 keratin 82, type II 2.57125
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.57125
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.57125
PNLIPRP2 pancreatic lipase-related protein 2 2.57125
CD300LF CD300 molecule-like family member f 2.57125
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.57125
ZNF593OS ZNF593 opposite strand 2.57125
CD8B2 CD8b2 molecule 2.57125
RHEX regulator of hemoglobinization and erythroid cell expansion 2.57125
H2AC1 H2A clustered histone 1 2.57125
H2BC3 H2B clustered histone 3 2.57125
DIPK1C divergent protein kinase domain 1C 2.57125
ALPG alkaline phosphatase, germ cell 2.57125
H1-6 H1.6 linker histone, cluster member 2.57125
OR52K2 olfactory receptor, family 52, subfamily K, member 2 2.57125
ASB9 ankyrin repeat and SOCS box containing 9 2.57125
ANXA13 annexin A13 2.57125
MAG myelin associated glycoprotein 2.57125
TEX101 testis expressed 101 2.57125
PTPRH protein tyrosine phosphatase, receptor type, H 2.57125
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.57125
RHOXF2 Rhox homeobox family, member 2 2.57125
PRB4 proline-rich protein BstNI subfamily 4 2.57125
RAB41 RAB41, member RAS oncogene family 2.57125
S1PR5 sphingosine-1-phosphate receptor 5 2.57125
SPMIP11 sperm microtubule inner protein 11 2.57125
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.57125
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.57125
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.57125
ACE2 angiotensin I converting enzyme 2 2.57125
IL1RN interleukin 1 receptor antagonist 2.57125
CCR4 chemokine (C-C motif) receptor 4 2.57125
PRR18 proline rich 18 2.57125
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.57125
C1QL2 complement component 1, q subcomponent-like 2 2.57125
IL12RB1 interleukin 12 receptor, beta 1 2.57125
EGR3 early growth response 3 2.57125
SLC38A8 solute carrier family 38, member 8 2.57125
SERINC2 serine incorporator 2 2.57125
DCT dopachrome tautomerase 2.57125
GOLGA6A golgin A6 family, member A 2.57125
MKRN3 makorin ring finger protein 3 2.57125
LCN9 lipocalin 9 2.57125
DCK deoxycytidine kinase 2.57125
C9ORF64 chromosome 9 open reading frame 64 2.57125
CRYBB2 crystallin, beta B2 2.57125
TRIM7 tripartite motif containing 7 2.57125
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.57125
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 2.57125
EDN3 endothelin 3 2.57125
MR1 major histocompatibility complex, class I-related 2.57125
AKR1B15 aldo-keto reductase family 1, member B15 2.57125
NIPAL4 NIPA-like domain containing 4 2.57125
PRTN3 proteinase 3 2.57125
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.57125
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.57125
IGF2 insulin-like growth factor 2 2.57125
DHH desert hedgehog 2.57125
TEX19 testis expressed 19 2.57125
TEKT2 tektin 2 (testicular) 2.57125
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.57125
WNT7A wingless-type MMTV integration site family, member 7A 2.57125
KLK7 kallikrein-related peptidase 7 2.57125
CAGE1 cancer antigen 1 2.57125
KLK3 kallikrein-related peptidase 3 2.57125
RANBP3L RAN binding protein 3-like 2.57125
IL9R interleukin 9 receptor 2.57125
AMN amnion associated transmembrane protein 2.57125
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.57125
CLEC4C C-type lectin domain family 4, member C 2.57125
CCL27 chemokine (C-C motif) ligand 27 2.57125
ASCL3 achaete-scute family bHLH transcription factor 3 2.57125
GH2 growth hormone 2 2.57125
CHRM4 cholinergic receptor, muscarinic 4 2.57125
CNR2 cannabinoid receptor 2 (macrophage) 2.57125
TRIM50 tripartite motif containing 50 2.57125
PATE1 prostate and testis expressed 1 2.57125
CLCA2 chloride channel accessory 2 2.57125
NNMT nicotinamide N-methyltransferase 2.57125
C22ORF31 chromosome 22 open reading frame 31 2.57125
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.57125
LHB luteinizing hormone beta polypeptide 2.57125
SLC36A3 solute carrier family 36, member 3 2.57125
ADRA1B adrenoceptor alpha 1B 2.57125
AMDHD1 amidohydrolase domain containing 1 2.57125
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.57125
CHRDL2 chordin-like 2 2.57125
POTEF POTE ankyrin domain family, member F 2.57125
CLINT1 clathrin interactor 1 2.57125
TSPAN16 tetraspanin 16 2.57125
IGIP IgA-inducing protein 2.57125
CALML5 calmodulin-like 5 2.57125
LIMS3 LIM and senescent cell antigen-like domains 3 2.57125
MSMP microseminoprotein, prostate associated 2.57125
DEFB136 defensin, beta 136 2.57125
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.57125
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.57125
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.57125
MC5R melanocortin 5 receptor 2.57125
ESPNL espin-like 2.57125
ADCY4 adenylate cyclase 4 2.57125
MLH3 mutL homolog 3 2.55925
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 2.55098
AFAP1L1 actin filament associated protein 1-like 1 2.54713
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.52746
RNF214 ring finger protein 214 2.52323
CCNT2 cyclin T2 2.51635
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.51635
FBP1 fructose-1,6-bisphosphatase 1 2.51635
TMEM229A transmembrane protein 229A 2.51635
LMO1 LIM domain only 1 (rhombotin 1) 2.51635
NTNG2 netrin G2 2.51635
MMP26 matrix metallopeptidase 26 2.50294
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.4536
DENND3 DENN/MADD domain containing 3 2.4536
WDR6 WD repeat domain 6 2.4536
ANKRD65 ankyrin repeat domain 65 2.4536
KLHL28 kelch-like family member 28 2.4536
OVGP1 oviductal glycoprotein 1, 120kDa 2.4536
UNC93A unc-93 homolog A (C. elegans) 2.4536
ABRACL ABRA C-terminal like 2.39668
IFT46 intraflagellar transport 46 2.34383
HRH4 histamine receptor H4 2.32798
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.32798
CCDC13 coiled-coil domain containing 13 2.306
LCTL lactase-like 2.29379
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.28606
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 2.28415
PYDC1 PYD (pyrin domain) containing 1 2.24788
RARS2 arginyl-tRNA synthetase 2, mitochondrial 2.23134
UQCC6 ubiquinol-cytochrome c reductase complex assembly factor 6 2.23134
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.21736
SCRN1 secernin 1 2.19433
MAPK14 mitogen-activated protein kinase 14 2.18917
TRIM52 tripartite motif containing 52 2.17651
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.16861
SART3 squamous cell carcinoma antigen recognized by T cells 3 2.16291
CNOT3 CCR4-NOT transcription complex, subunit 3 2.15649
BCAN brevican 2.13512
DYNLT2B dynein light chain Tctex-type 2B 2.13277
CAAP1 caspase activity and apoptosis inhibitor 1 2.1108
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.10855
FAS Fas cell surface death receptor 2.10855
NLK nemo-like kinase 2.10855
NCKIPSD NCK interacting protein with SH3 domain 2.07919
GPI glucose-6-phosphate isomerase 2.06854
KAZN kazrin, periplakin interacting protein 2.06352
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.06173
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 2.05563
NCAPD2 non-SMC condensin I complex, subunit D2 2.03834
NUDT4B nudix hydrolase 4B 2.03194
KLHL2 kelch-like family member 2 2.02392
HPS4 Hermansky-Pudlak syndrome 4 2.02392
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.01261
MFAP3L microfibrillar-associated protein 3-like 2.0069
ZSWIM6 zinc finger, SWIM-type containing 6 2.00175
LOXL2 lysyl oxidase-like 2 2.00175
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.00123
CTSD cathepsin D 2.00123
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.00012
NOAZFP nucleolar atypical zinc finger 2.00002

decreased expression

Symbol Name Standardized Value
CCNQ cyclin Q -2.57125
TLR2 toll-like receptor 2 -2.57125
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.57125
FES FES proto-oncogene, tyrosine kinase -2.57125
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.57125
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.57125
ZNF597 zinc finger protein 597 -2.57125
TRIL TLR4 interactor with leucine-rich repeats -2.57125
VSTM2B V-set and transmembrane domain containing 2B -2.57125
TAS2R30 taste receptor, type 2, member 30 -2.57125
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -2.57125
NRDE2 NRDE-2, necessary for RNA interference, domain containing -2.57125
TDRD7 tudor domain containing 7 -2.57125
PLPPR2 phospholipid phosphatase related 2 -2.57125
ZNF589 zinc finger protein 589 -2.57125
ZNF582 zinc finger protein 582 -2.55925
RBM46 RNA binding motif protein 46 -2.55925
GRM2 glutamate receptor, metabotropic 2 -2.55925
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.55925
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.5413
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.51635
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) -2.51635
MGMT O-6-methylguanine-DNA methyltransferase -2.50088
FBXW2 F-box and WD repeat domain containing 2 -2.47052
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.46697
CHADL chondroadherin-like -2.4536
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.4536
CCN5 cellular communication network factor 5 -2.4536
ZNF23 zinc finger protein 23 -2.4536
SPATA32 spermatogenesis associated 32 -2.4536
BMP8A bone morphogenetic protein 8a -2.4536
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.4536
OSTN osteocrin -2.4536
MEDAG mesenteric estrogen-dependent adipogenesis -2.4536
GTSF1 gametocyte specific factor 1 -2.4536
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.4536
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.4536
IZUMO3 IZUMO family member 3 -2.4536
PCDHGC3 protocadherin gamma subfamily C, 3 -2.4536
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.4536
GPR22 G protein-coupled receptor 22 -2.4536
GAB3 GRB2-associated binding protein 3 -2.4536
EBF3 early B-cell factor 3 -2.4536
NIM1K NIM1 serine/threonine protein kinase -2.4536
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.4536
EFCAB3 EF-hand calcium binding domain 3 -2.4536
GOLGA6C golgin A6 family, member C -2.4536
ANXA1 annexin A1 -2.4536
FAM177B family with sequence similarity 177, member B -2.4536
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.4536
DLL4 delta-like 4 (Drosophila) -2.4536
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.4536
CRTAM cytotoxic and regulatory T cell molecule -2.4536
SYCE3 synaptonemal complex central element protein 3 -2.4536
LRRK2 leucine-rich repeat kinase 2 -2.4536
RAD21 RAD21 homolog (S. pombe) -2.42144
GGACT gamma-glutamylamine cyclotransferase -2.33918
TECTA tectorin alpha -2.33918
PLD6 phospholipase D family, member 6 -2.33918
SUSD6 sushi domain containing 6 -2.33264
CEP57L1 centrosomal protein 57kDa-like 1 -2.32738
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.306
GPATCH4 G patch domain containing 4 -2.19433
TERF2IP telomeric repeat binding factor 2, interacting protein -2.18288
ANG angiogenin, ribonuclease, RNase A family, 5 -2.18288
IL15RA interleukin 15 receptor, alpha -2.1648
CNOT6L CCR4-NOT transcription complex, subunit 6-like -2.13341
APOE apolipoprotein E -2.11209
ADSL adenylosuccinate lyase -2.06535
PRSS3 protease, serine, 3 -2.06173
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.06173
TIGD7 tigger transposable element derived 7 -2.06173
EPAS1 endothelial PAS domain protein 1 -2.06173
CD4 CD4 molecule -2.06173
NLRC5 NLR family, CARD domain containing 5 -2.06173
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.06173
LIMD2 LIM domain containing 2 -2.05463
ZNF195 zinc finger protein 195 -2.04313
MRPL54 mitochondrial ribosomal protein L54 -2.03834
GGCT gamma-glutamylcyclotransferase -2.02724
PLPP7 phospholipid phosphatase 7 (inactive) -2.0106
SLC66A3 solute carrier family 66 member 3 -2.00838
EIPR1 EARP complex and GARP complex interacting protein 1 -2.00175
FBXO4 F-box protein 4 -2.00175
NUTM1 NUT midline carcinoma, family member 1 -2.00002