NFYA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear transcription factor Y, alpha|The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4800)
External Link http://www.ncbi.nlm.nih.gov/gene/4800
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45 interacting proteins for NFYA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF2 activating transcription factor 2
ATF6 activating transcription factor 6
ATF6B activating transcription factor 6 beta
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK2 cyclin-dependent kinase 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
ELF1 E74-like factor 1 (ets domain transcription factor)
EP300 E1A binding protein p300
HDAC1 histone deacetylase 1
HMGA1 high mobility group AT-hook 1
HNF4A hepatocyte nuclear factor 4, alpha
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KPNB1 karyopherin (importin) beta 1
NFYB nuclear transcription factor Y, beta
NFYC nuclear transcription factor Y, gamma
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRF1 nuclear respiratory factor 1
PAPOLG poly(A) polymerase gamma
PKM pyruvate kinase, muscle
POU2F1 POU class 2 homeobox 1
PWP1 PWP1 homolog (S. cerevisiae)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF1 serine/arginine-rich splicing factor 1
SUB1 SUB1 homolog (S. cerevisiae)
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TP53 tumor protein p53
TP63 tumor protein p63
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
ZHX1 zinc fingers and homeoboxes 1
ZHX2 zinc fingers and homeoboxes 2
ZHX3 zinc fingers and homeoboxes 3