NG25_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.425217
FN1 fibronectin 1 0.234114
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.194154
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.128621
VIM vimentin 0.126051
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.125567
NDRG1 N-myc downstream regulated 1 0.122505
CDH13 cadherin 13 0.117261
ENO1 enolase 1, (alpha) 0.111906
VEGFA vascular endothelial growth factor A 0.105129
CALR calreticulin 0.100372
LOXL2 lysyl oxidase-like 2 0.0960485
COL6A3 collagen, type VI, alpha 3 0.09552
LDHA lactate dehydrogenase A 0.0901699
STC1 stanniocalcin 1 0.0724888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0700937
COL5A1 collagen, type V, alpha 1 0.0672608
MYH9 myosin, heavy chain 9, non-muscle 0.0663685
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0636794
ASPH aspartate beta-hydroxylase 0.0618287
NAV1 neuron navigator 1 0.0609943
FBN1 fibrillin 1 0.0597337
EEF2 eukaryotic translation elongation factor 2 0.0557537
GOLGB1 golgin B1 0.0546452
ERRFI1 ERBB receptor feedback inhibitor 1 0.0533363
TGFBI transforming growth factor, beta-induced, 68kDa 0.0499079
COL1A2 collagen, type I, alpha 2 0.0498716
PLEC plectin 0.0474244
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0462854
EXT1 exostosin glycosyltransferase 1 0.0459756
ZSWIM6 zinc finger, SWIM-type containing 6 0.0434212
HLA-A major histocompatibility complex, class I, A 0.0427897
MYO10 myosin X 0.0427331
COL3A1 collagen, type III, alpha 1 0.0425827
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0425478
APP amyloid beta (A4) precursor protein 0.0424918
PSD3 pleckstrin and Sec7 domain containing 3 0.0423915
FNDC3B fibronectin type III domain containing 3B 0.0418516
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0410879
HMGA2 high mobility group AT-hook 2 0.0406939
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0403005
EFNA5 ephrin-A5 0.0391564
CXCL8 chemokine (C-X-C motif) ligand 8 0.0390671
TIMP1 TIMP metallopeptidase inhibitor 1 0.0369304
PCBP2 poly(rC) binding protein 2 0.0368307
MACF1 microtubule-actin crosslinking factor 1 0.0359979
SQSTM1 sequestosome 1 0.0359594
RPL3 ribosomal protein L3 0.0358943
EGFR epidermal growth factor receptor 0.0351858
HYOU1 hypoxia up-regulated 1 0.0346256
IFI6 interferon, alpha-inducible protein 6 0.0343562
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0342831
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0341751
ECE1 endothelin converting enzyme 1 0.0341598
RPS18 ribosomal protein S18 0.0327744
MAP1B microtubule-associated protein 1B 0.0321451
LGALS1 lectin, galactoside-binding, soluble, 1 0.0320969
JARID2 jumonji, AT rich interactive domain 2 0.0320232
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0317502
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303919
LIMS1 LIM and senescent cell antigen-like domains 1 0.0303227
PGM3 phosphoglucomutase 3 0.0302789
ATXN1 ataxin 1 0.028934
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0287045
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.028595
MT2A metallothionein 2A 0.0280169
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0279013
NFE2L1 nuclear factor, erythroid 2-like 1 0.0276587
IGFBP7 insulin-like growth factor binding protein 7 0.0276319
FAT1 FAT atypical cadherin 1 0.0272487
B2M beta-2-microglobulin 0.0270135
NALF1 NALCN channel auxiliary factor 1 0.0267129
PDLIM5 PDZ and LIM domain 5 0.0266687
PDIA6 protein disulfide isomerase family A, member 6 0.026668
ACTN1 actinin, alpha 1 0.0264151
VCAN versican 0.0261012
HDAC9 histone deacetylase 9 0.0258934
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0256396
SON SON DNA binding protein 0.0252263
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0252239
GLIS3 GLIS family zinc finger 3 0.0251104
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0248695
WWTR1 WW domain containing transcription regulator 1 0.0247814
MCL1 myeloid cell leukemia 1 0.024524
F3 coagulation factor III (thromboplastin, tissue factor) 0.0241411
RAB2A RAB2A, member RAS oncogene family 0.0239648
CLMP CXADR-like membrane protein 0.0238423
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0237912
RND3 Rho family GTPase 3 0.0237048
SDC2 syndecan 2 0.0237014
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230606
ATF4 activating transcription factor 4 0.0230305
SP100 SP100 nuclear antigen 0.0228475
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0226955
DST dystonin 0.0226614
CTSB cathepsin B 0.0226092
TPM3 tropomyosin 3 0.0225876
SRRM2 serine/arginine repetitive matrix 2 0.0224453
CANX calnexin 0.0222773

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.0825095
CADM1 cell adhesion molecule 1 -0.0745375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0654243
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0651452
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0616288
NAMPT nicotinamide phosphoribosyltransferase -0.0490584
MT1X metallothionein 1X -0.0478259
ATP13A3 ATPase type 13A3 -0.044644
ZNF292 zinc finger protein 292 -0.0438436
IER3 immediate early response 3 -0.037283
QKI QKI, KH domain containing, RNA binding -0.0367608
SPAG9 sperm associated antigen 9 -0.0363423
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0361693
PTMA prothymosin, alpha -0.0347518
WSB1 WD repeat and SOCS box containing 1 -0.0342488
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0341903
TOP2A topoisomerase (DNA) II alpha 170kDa -0.033393
USP3 ubiquitin specific peptidase 3 -0.0332231
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.033163
TFG TRK-fused gene -0.0329801
RASA2 RAS p21 protein activator 2 -0.0306424
RPL35A ribosomal protein L35a -0.0297061
TM4SF1 transmembrane 4 L six family member 1 -0.0280088
RHEB Ras homolog enriched in brain -0.0274333
NPEPPS aminopeptidase puromycin sensitive -0.0262636
OGA O-GlcNAcase -0.0255487
KMT2E lysine (K)-specific methyltransferase 2E -0.0252007
MARCHF6 membrane associated ring-CH-type finger 6 -0.0242809
TRIO trio Rho guanine nucleotide exchange factor -0.0238124
RLF rearranged L-myc fusion -0.0237057
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0234772
ZFAND3 zinc finger, AN1-type domain 3 -0.0229903
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0228073
KDM3A lysine (K)-specific demethylase 3A -0.0224007
CAVIN1 caveolae associated protein 1 -0.0218182
PTK2 protein tyrosine kinase 2 -0.0217549
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0215467
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0214263
DLG1 discs, large homolog 1 (Drosophila) -0.0212605
PRRC1 proline-rich coiled-coil 1 -0.0211043
CAV1 caveolin 1, caveolae protein, 22kDa -0.0208644
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201712
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0198662
H1-0 H1.0 linker histone -0.0194045
ADAM17 ADAM metallopeptidase domain 17 -0.0192219
APOLD1 apolipoprotein L domain containing 1 -0.0191615
ANKRD10 ankyrin repeat domain 10 -0.0191071
RNF145 ring finger protein 145 -0.0190744
RAB1A RAB1A, member RAS oncogene family -0.0190457
PDE8A phosphodiesterase 8A -0.018892
SOD2 superoxide dismutase 2, mitochondrial -0.0184183
ELL2 elongation factor, RNA polymerase II, 2 -0.0183322
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0182912
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0181702
AZIN1 antizyme inhibitor 1 -0.0181047
TSC22D2 TSC22 domain family, member 2 -0.0180727
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0180416
RPS24 ribosomal protein S24 -0.0179034
MTF2 metal response element binding transcription factor 2 -0.0178669
RAB6A RAB6A, member RAS oncogene family -0.0177391
FTL ferritin, light polypeptide -0.0175063
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0174371
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0173874
CLINT1 clathrin interactor 1 -0.0173457
THY1 Thy-1 cell surface antigen -0.0173269
RPLP0 ribosomal protein, large, P0 -0.0172205
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0170905
FOXJ3 forkhead box J3 -0.0168936
HMGB2 high mobility group box 2 -0.0168356
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0167259
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0164081
HELZ helicase with zinc finger -0.0162686
PXDN peroxidasin -0.0162269
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0162069
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0161394
WTAP Wilms tumor 1 associated protein -0.0160935
ECT2 epithelial cell transforming 2 -0.0159291
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0158133
RYBP RING1 and YY1 binding protein -0.015803
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0157435
ADAM9 ADAM metallopeptidase domain 9 -0.0157121
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0154647
BHLHE40 basic helix-loop-helix family, member e40 -0.0153809
MEF2A myocyte enhancer factor 2A -0.0152725
SKIC3 SKI3 subunit of superkiller complex -0.015198
ARRDC3 arrestin domain containing 3 -0.0150187
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0149757
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0148466
TPT1 tumor protein, translationally-controlled 1 -0.0147779
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0146497
SMC4 structural maintenance of chromosomes 4 -0.0145649
HIP1 huntingtin interacting protein 1 -0.014558
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0145201
TMEM263 transmembrane protein 263 -0.014383
RPS6 ribosomal protein S6 -0.0143612
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0143405
RPL34 ribosomal protein L34 -0.0142721
NKTR natural killer cell triggering receptor -0.014266
FCHSD2 FCH and double SH3 domains 2 -0.0142309
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0141581