NG25_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.177643
PDLIM5 PDZ and LIM domain 5 0.129416
PALM2AKAP2 PALM2 and AKAP2 fusion 0.107761
MTSS1 metastasis suppressor 1 0.101248
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0968875
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0799744
RASAL2 RAS protein activator like 2 0.0765805
TIMP3 TIMP metallopeptidase inhibitor 3 0.0760626
MACF1 microtubule-actin crosslinking factor 1 0.0756152
PDE4D phosphodiesterase 4D, cAMP-specific 0.0754839
ENO1 enolase 1, (alpha) 0.0748093
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0703493
INTS6 integrator complex subunit 6 0.0669438
LDHA lactate dehydrogenase A 0.0645492
EFNA5 ephrin-A5 0.0621194
IFITM1 interferon induced transmembrane protein 1 0.0603941
ZSWIM6 zinc finger, SWIM-type containing 6 0.0599159
POTEF POTE ankyrin domain family, member F 0.0580038
MBNL1 muscleblind-like splicing regulator 1 0.0578396
MT2A metallothionein 2A 0.0572125
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0549586
PLEC plectin 0.0548596
B2M beta-2-microglobulin 0.0538527
SQSTM1 sequestosome 1 0.0535282
EXT1 exostosin glycosyltransferase 1 0.0534351
TXNIP thioredoxin interacting protein 0.0529473
MSN moesin 0.0514382
SLC35F3 solute carrier family 35, member F3 0.0513704
TGM2 transglutaminase 2 0.0512225
APLP2 amyloid beta (A4) precursor-like protein 2 0.0509566
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0508194
HMGA2 high mobility group AT-hook 2 0.0505477
PCBP2 poly(rC) binding protein 2 0.0495227
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0490572
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0468081
TPM3 tropomyosin 3 0.046344
ALCAM activated leukocyte cell adhesion molecule 0.0448511
LAMC2 laminin, gamma 2 0.0445242
FTH1 ferritin, heavy polypeptide 1 0.0440909
DIAPH1 diaphanous-related formin 1 0.043344
KLF5 Kruppel-like factor 5 (intestinal) 0.0433174
RAI14 retinoic acid induced 14 0.0426262
ANO1 anoctamin 1, calcium activated chloride channel 0.0420298
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0418574
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0412151
MYH9 myosin, heavy chain 9, non-muscle 0.0410047
EEF2 eukaryotic translation elongation factor 2 0.0403936
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0403147
RPS12 ribosomal protein S12 0.0399921
TSC22D1 TSC22 domain family, member 1 0.0399133
PICALM phosphatidylinositol binding clathrin assembly protein 0.0398765
FNDC3B fibronectin type III domain containing 3B 0.0393564
CDK6 cyclin-dependent kinase 6 0.0390394
PALLD palladin, cytoskeletal associated protein 0.0389325
PLS3 plastin 3 0.0378789
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.037826
PODXL podocalyxin-like 0.0378126
RPL37 ribosomal protein L37 0.0370253
GOLGB1 golgin B1 0.0365795
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0364416
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0364353
MCL1 myeloid cell leukemia 1 0.0360809
BCAR3 breast cancer anti-estrogen resistance 3 0.0358605
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0354274
SMAD3 SMAD family member 3 0.0353421
HLA-E major histocompatibility complex, class I, E 0.034805
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0346955
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0343589
SIK3 SIK family kinase 3 0.0342015
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0340776
RPS18 ribosomal protein S18 0.0339859
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0337669
LOC112694756 uncharaterized LOC112694756 0.0335355
IFITM3 interferon induced transmembrane protein 3 0.033114
RIGI RNA sensor RIG-I 0.032549
ECE1 endothelin converting enzyme 1 0.0325472
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0319312
PSD3 pleckstrin and Sec7 domain containing 3 0.031715
RNF217 ring finger protein 217 0.0316128
CD44 CD44 molecule (Indian blood group) 0.0315541
APP amyloid beta (A4) precursor protein 0.0314623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310358
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0308861
RACK1 receptor for activated C kinase 1 0.0308165
IFI44L interferon-induced protein 44-like 0.0297226
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0293077
DOCK5 dedicator of cytokinesis 5 0.0289669
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0287558
PLXNA2 plexin A2 0.0286347
ACTN1 actinin, alpha 1 0.0286201
RPL3 ribosomal protein L3 0.0284843
DOK5 docking protein 5 0.0283691
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0281443
AMOTL1 angiomotin like 1 0.0280141
CSMD2 CUB and Sushi multiple domains 2 0.0278569
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0277395
ENO2 enolase 2 (gamma, neuronal) 0.027514
AGO2 argonaute RISC catalytic component 2 0.0271418
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0269937
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0269725

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.0955058
MEF2A myocyte enhancer factor 2A -0.0920779
H1-0 H1.0 linker histone -0.0842667
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0799698
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0782284
ANLN anillin, actin binding protein -0.070426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.066628
OGA O-GlcNAcase -0.0664245
PTMA prothymosin, alpha -0.0566012
NPEPPS aminopeptidase puromycin sensitive -0.0557119
KDM3A lysine (K)-specific demethylase 3A -0.0546007
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0510335
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.04712
KIAA1217 KIAA1217 -0.0465563
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.046131
TPT1 tumor protein, translationally-controlled 1 -0.045418
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0447678
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.044359
WSB1 WD repeat and SOCS box containing 1 -0.0429514
RPS21 ribosomal protein S21 -0.0424097
ZNF292 zinc finger protein 292 -0.0399272
GOLGA4 golgin A4 -0.0392361
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392066
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0384718
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0380027
SPAG9 sperm associated antigen 9 -0.03746
EMP1 epithelial membrane protein 1 -0.0373718
DLG1 discs, large homolog 1 (Drosophila) -0.0369038
DENND4C DENN/MADD domain containing 4C -0.0365107
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0364705
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0363464
USP3 ubiquitin specific peptidase 3 -0.0361696
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0359757
CLU clusterin -0.0359014
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0357167
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0356462
RBM39 RNA binding motif protein 39 -0.0355429
RAB6A RAB6A, member RAS oncogene family -0.0353651
RLF rearranged L-myc fusion -0.0353581
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0346115
ITCH itchy E3 ubiquitin protein ligase -0.0342257
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0340033
KDM6A lysine (K)-specific demethylase 6A -0.033889
KDM5B lysine (K)-specific demethylase 5B -0.0329864
NT5C2 5'-nucleotidase, cytosolic II -0.0327805
BRWD3 bromodomain and WD repeat domain containing 3 -0.0321921
RPS24 ribosomal protein S24 -0.0319633
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0318801
AHNAK AHNAK nucleoprotein -0.0315698
MARCHF6 membrane associated ring-CH-type finger 6 -0.0314293
SKIC3 SKI3 subunit of superkiller complex -0.0313778
HELZ helicase with zinc finger -0.030935
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0302481
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0298334
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0293719
NUP58 nucleoporin 58 -0.0291279
NF1 neurofibromin 1 -0.0291033
VDAC1 voltage-dependent anion channel 1 -0.0290727
RAB1A RAB1A, member RAS oncogene family -0.0290633
FOSL1 FOS-like antigen 1 -0.028987
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0289134
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0288744
ARHGAP12 Rho GTPase activating protein 12 -0.0280124
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0279865
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0275906
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0275129
ANKRD10 ankyrin repeat domain 10 -0.0273831
ZMYM2 zinc finger, MYM-type 2 -0.0273298
GARS1 glycyl-tRNA synthetase 1 -0.0271919
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265159
STC1 stanniocalcin 1 -0.0262241
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0261987
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.026071
RNF145 ring finger protein 145 -0.0259716
TRA2A transformer 2 alpha homolog (Drosophila) -0.0258998
KCMF1 potassium channel modulatory factor 1 -0.0258324
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0257613
FNDC3A fibronectin type III domain containing 3A -0.0252431
COG5 component of oligomeric golgi complex 5 -0.0251352
CD47 CD47 molecule -0.0251215
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0251206
PNISR PNN-interacting serine/arginine-rich protein -0.0248571
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.024421
TFG TRK-fused gene -0.0244069
PRELID2 PRELI domain containing 2 -0.0237299
ITGA6 integrin, alpha 6 -0.023714
QKI QKI, KH domain containing, RNA binding -0.0236863
CUL4B cullin 4B -0.0235088
NFIA nuclear factor I/A -0.023502
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0234606
IGF2 insulin-like growth factor 2 -0.0232848
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0232319
CENPF centromere protein F, 350/400kDa -0.0232288
SUCO SUN domain containing ossification factor -0.0231274
FAM13A family with sequence similarity 13, member A -0.0228111
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0227106
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0226206
YBX3 Y box binding protein 3 -0.0225721
ABI3BP ABI family, member 3 (NESH) binding protein -0.0224948
SBF2 SET binding factor 2 -0.0224405