NG25_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.137403
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0905095
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0747635
PCBP2 poly(rC) binding protein 2 0.0659941
LOC102724023 ES1 protein homolog, mitochondrial 0.0657195
MYOF myoferlin 0.0634853
GDA guanine deaminase 0.0633498
APLP2 amyloid beta (A4) precursor-like protein 2 0.0569359
B2M beta-2-microglobulin 0.0541813
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.054095
EZR ezrin 0.0510102
MACC1 metastasis associated in colon cancer 1 0.0508128
MBNL1 muscleblind-like splicing regulator 1 0.0504724
PTPRK protein tyrosine phosphatase, receptor type, K 0.0493013
FAT1 FAT atypical cadherin 1 0.0481595
TJP1 tight junction protein 1 0.0461136
GMDS GDP-mannose 4,6-dehydratase 0.0460174
SEPTIN9 septin 9 0.0454635
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0452727
MBNL2 muscleblind-like splicing regulator 2 0.0445689
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.043673
DSTN destrin (actin depolymerizing factor) 0.0430285
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0424351
UGCG UDP-glucose ceramide glucosyltransferase 0.0418231
ZSWIM6 zinc finger, SWIM-type containing 6 0.0417278
LPP LIM domain containing preferred translocation partner in lipoma 0.0415685
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0381275
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0375839
SMAD3 SMAD family member 3 0.037002
ANXA1 annexin A1 0.0364606
RNF213 ring finger protein 213 0.0364203
CDK6 cyclin-dependent kinase 6 0.036274
MTUS1 microtubule associated tumor suppressor 1 0.0358151
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0357667
CLDN4 claudin 4 0.035346
PKM pyruvate kinase, muscle 0.0351857
MYH9 myosin, heavy chain 9, non-muscle 0.0347261
TMC5 transmembrane channel-like 5 0.0344752
POTEF POTE ankyrin domain family, member F 0.0338656
MYO1E myosin IE 0.0334519
NCEH1 neutral cholesterol ester hydrolase 1 0.033418
AKAP13 A kinase (PRKA) anchor protein 13 0.0332184
ENO1 enolase 1, (alpha) 0.0324562
RUNX1 runt-related transcription factor 1 0.031941
INTS6 integrator complex subunit 6 0.0313912
FTL ferritin, light polypeptide 0.0303979
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.029677
ASPH aspartate beta-hydroxylase 0.0294586
SIK3 SIK family kinase 3 0.0293438
LIMA1 LIM domain and actin binding 1 0.0293054
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0283653
MCU mitochondrial calcium uniporter 0.0278398
ATP11A ATPase, class VI, type 11A 0.0277847
EFNA5 ephrin-A5 0.0276231
ADGRF1 adhesion G protein-coupled receptor F1 0.0273219
CATSPERB catsper channel auxiliary subunit beta 0.0269809
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0268619
VMP1 vacuole membrane protein 1 0.0264957
MAML2 mastermind-like 2 (Drosophila) 0.026374
ANXA11 annexin A11 0.0259845
PDLIM5 PDZ and LIM domain 5 0.0246523
DST dystonin 0.0233471
EXT1 exostosin glycosyltransferase 1 0.0231065
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0231
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230719
KLF5 Kruppel-like factor 5 (intestinal) 0.0227361
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0225591
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.022347
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0223348
HDAC9 histone deacetylase 9 0.0222681
CALR calreticulin 0.021745
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0216902
FNDC3B fibronectin type III domain containing 3B 0.0216433
PLEC plectin 0.021473
SOS1 son of sevenless homolog 1 (Drosophila) 0.0214601
UBASH3B ubiquitin associated and SH3 domain containing B 0.021427
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.021283
SH3RF1 SH3 domain containing ring finger 1 0.0212261
UBAP2 ubiquitin associated protein 2 0.0210639
LCN2 lipocalin 2 0.0208353
SOX9 SRY (sex determining region Y)-box 9 0.0208046
TXNIP thioredoxin interacting protein 0.0204572
VEGFA vascular endothelial growth factor A 0.0201637
SPATA13 spermatogenesis associated 13 0.0200443
RPS18 ribosomal protein S18 0.019958
ARHGAP32 Rho GTPase activating protein 32 0.0196495
CLDN7 claudin 7 0.0196362
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0193268
RBM47 RNA binding motif protein 47 0.0192585
EIF1 eukaryotic translation initiation factor 1 0.0192337
SNX9 sorting nexin 9 0.0191425
ADAM9 ADAM metallopeptidase domain 9 0.019138
CEMIP2 cell migration inducing hyaluronidase 2 0.0190489
NFE2L2 nuclear factor, erythroid 2-like 2 0.0189931
FAM107B family with sequence similarity 107, member B 0.0189886
SLTM SAFB-like, transcription modulator 0.0189707
TPM4 tropomyosin 4 0.0188022
FHL2 four and a half LIM domains 2 0.0186876
MACF1 microtubule-actin crosslinking factor 1 0.018392
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0183606

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169696
FGFR2 fibroblast growth factor receptor 2 -0.169203
NPSR1 neuropeptide S receptor 1 -0.160036
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.155424
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0654494
TPT1 tumor protein, translationally-controlled 1 -0.0599664
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0524699
H1-0 H1.0 linker histone -0.047253
AGR2 anterior gradient 2 -0.0452627
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0442177
PDIA3 protein disulfide isomerase family A, member 3 -0.0430413
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0381257
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0374067
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0357295
KDM3A lysine (K)-specific demethylase 3A -0.0328464
RAB1A RAB1A, member RAS oncogene family -0.0295672
ANLN anillin, actin binding protein -0.0289401
AHNAK AHNAK nucleoprotein -0.0264962
RRBP1 ribosome binding protein 1 -0.0249629
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0243183
GOLGA4 golgin A4 -0.0236611
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0234736
RPS24 ribosomal protein S24 -0.0234606
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0228848
S100A6 S100 calcium binding protein A6 -0.0226736
PTMA prothymosin, alpha -0.0226661
CEP95 centrosomal protein 95kDa -0.0225182
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0222007
CANX calnexin -0.0221323
HM13 histocompatibility (minor) 13 -0.0216346
IARS1 isoleucyl-tRNA synthetase 1 -0.0209629
ACACA acetyl-CoA carboxylase alpha -0.0204788
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0202931
MON2 MON2 homolog (S. cerevisiae) -0.0200081
KRT18 keratin 18, type I -0.0198656
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0197843
CLTC clathrin, heavy chain (Hc) -0.0196933
WDR45B WD repeat domain 45B -0.0194571
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0191031
HLA-C major histocompatibility complex, class I, C -0.0189538
PRSS3 protease, serine, 3 -0.0187189
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0185519
ZMYND8 zinc finger, MYND-type containing 8 -0.0177854
PDIA4 protein disulfide isomerase family A, member 4 -0.0176601
ZNF292 zinc finger protein 292 -0.0175036
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0171112
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0171109
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0168014
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0165727
TRIM31 tripartite motif containing 31 -0.0165404
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0162528
NECTIN2 nectin cell adhesion molecule 2 -0.0160502
WARS1 tryptophanyl-tRNA synthetase 1 -0.0158816
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0158545
CLINT1 clathrin interactor 1 -0.0156234
NUP214 nucleoporin 214kDa -0.0154606
RNF43 ring finger protein 43 -0.0153232
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0152968
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0152453
ARF1 ADP-ribosylation factor 1 -0.0152103
FNDC3A fibronectin type III domain containing 3A -0.0151446
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0150496
TAS2R14 taste receptor, type 2, member 14 -0.0149794
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.014956
GOSR1 golgi SNAP receptor complex member 1 -0.0149216
ZFAND3 zinc finger, AN1-type domain 3 -0.0147227
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0146109
GOLPH3L golgi phosphoprotein 3-like -0.014541
SULF2 sulfatase 2 -0.0143745
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0142405
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0141242
TM9SF3 transmembrane 9 superfamily member 3 -0.0141077
RPN1 ribophorin I -0.0139528
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0138226
OGA O-GlcNAcase -0.0138172
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0136932
RPL26 ribosomal protein L26 -0.0136906
GARS1 glycyl-tRNA synthetase 1 -0.0135319
SEC63 SEC63 homolog (S. cerevisiae) -0.0133758
RBM39 RNA binding motif protein 39 -0.0133758
ANO1 anoctamin 1, calcium activated chloride channel -0.0132874
TMSB4X thymosin beta 4, X-linked -0.0132583
FOXK2 forkhead box K2 -0.0132066
INSIG1 insulin induced gene 1 -0.0129191
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.012662
GRB2 growth factor receptor-bound protein 2 -0.0126556
UBE4A ubiquitination factor E4A -0.0126046
RAD21 RAD21 homolog (S. pombe) -0.0125645
PRPF6 pre-mRNA processing factor 6 -0.0125174
NPC1 Niemann-Pick disease, type C1 -0.0125066
TCEA1 transcription elongation factor A (SII), 1 -0.0124016
HSPB1 heat shock 27kDa protein 1 -0.0123225
EPCAM epithelial cell adhesion molecule -0.0123194
ZFP36L2 ZFP36 ring finger protein-like 2 -0.012284
SENP5 SUMO1/sentrin specific peptidase 5 -0.0122383
LMAN1 lectin, mannose-binding, 1 -0.0122351
AVL9 AVL9 homolog (S. cerevisiase) -0.0119527
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.011944
FASN fatty acid synthase -0.0119204
IRF1 interferon regulatory factor 1 -0.011892