NG25_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.170322
VIM vimentin 0.110298
PTMA prothymosin, alpha 0.087959
RPS18 ribosomal protein S18 0.0755189
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0750959
PCBP2 poly(rC) binding protein 2 0.0640436
ERRFI1 ERBB receptor feedback inhibitor 1 0.0609703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0500998
BIRC3 baculoviral IAP repeat containing 3 0.0445097
TPM3 tropomyosin 3 0.0438357
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0434655
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.043412
KLF6 Kruppel-like factor 6 0.0433847
ANGPTL4 angiopoietin-like 4 0.0426846
TMSB10 thymosin beta 10 0.0419498
TXNIP thioredoxin interacting protein 0.0398262
MCL1 myeloid cell leukemia 1 0.0390445
HMGA1 high mobility group AT-hook 1 0.0382854
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0381564
POTEF POTE ankyrin domain family, member F 0.037592
SOX9 SRY (sex determining region Y)-box 9 0.0358077
UBC ubiquitin C 0.0357321
EZR ezrin 0.0328601
EEF2 eukaryotic translation elongation factor 2 0.0325049
RPS12 ribosomal protein S12 0.0304119
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0300949
RPL3 ribosomal protein L3 0.0295716
S100A6 S100 calcium binding protein A6 0.0292835
CALR calreticulin 0.0279768
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027682
MT1X metallothionein 1X 0.0265859
EREG epiregulin 0.0265532
RPS2 ribosomal protein S2 0.0247546
RPL23 ribosomal protein L23 0.0246605
YBX1 Y box binding protein 1 0.0245993
APLP2 amyloid beta (A4) precursor-like protein 2 0.0244548
RPL12 ribosomal protein L12 0.0242215
BCAR3 breast cancer anti-estrogen resistance 3 0.0235935
IFITM1 interferon induced transmembrane protein 1 0.0232067
EIF4A1 eukaryotic translation initiation factor 4A1 0.0226386
MYH9 myosin, heavy chain 9, non-muscle 0.0226314
JUN jun proto-oncogene 0.0224179
LOC112694756 uncharaterized LOC112694756 0.021948
EIF5 eukaryotic translation initiation factor 5 0.0216332
SPAG9 sperm associated antigen 9 0.0214573
DDIT4 DNA-damage-inducible transcript 4 0.0210356
RPS4X ribosomal protein S4, X-linked 0.0210224
KRT18 keratin 18, type I 0.0206886
TXNRD1 thioredoxin reductase 1 0.0204514
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0200956
SQSTM1 sequestosome 1 0.0200559
PGK1 phosphoglycerate kinase 1 0.0199388
RPS13 ribosomal protein S13 0.0195359
EIF1 eukaryotic translation initiation factor 1 0.0190903
MT1E metallothionein 1E 0.0190199
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0189934
EMP1 epithelial membrane protein 1 0.0188108
PLEC plectin 0.0186827
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0185346
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0184349
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0184183
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0183592
UBA1 ubiquitin-like modifier activating enzyme 1 0.0181802
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0181677
FOS FBJ murine osteosarcoma viral oncogene homolog 0.01752
AKAP12 A kinase (PRKA) anchor protein 12 0.017489
RERE arginine-glutamic acid dipeptide (RE) repeats 0.017431
SP100 SP100 nuclear antigen 0.0171884
EGR1 early growth response 1 0.0171065
ADM adrenomedullin 0.0170614
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0166168
DIAPH1 diaphanous-related formin 1 0.0165171
NAP1L1 nucleosome assembly protein 1-like 1 0.0165046
TPI1 triosephosphate isomerase 1 0.0164381
B2M beta-2-microglobulin 0.0164084
ZEB1 zinc finger E-box binding homeobox 1 0.0163744
OSBPL8 oxysterol binding protein-like 8 0.0163252
ASPH aspartate beta-hydroxylase 0.0162303
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0162028
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0161979
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0161692
SEPTIN7 septin 7 0.0160132
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0159381
ENO1 enolase 1, (alpha) 0.0158732
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.015845
RPS27 ribosomal protein S27 0.0158219
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.015813
IFITM3 interferon induced transmembrane protein 3 0.0157751
SON SON DNA binding protein 0.0155835
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0155492
ZSWIM6 zinc finger, SWIM-type containing 6 0.0152705
CAPRIN2 caprin family member 2 0.0152639
MATR3 matrin 3 0.0152549
KMT2E lysine (K)-specific methyltransferase 2E 0.0152457
RSRC2 arginine/serine-rich coiled-coil 2 0.0152387
LDHA lactate dehydrogenase A 0.0151016
LOC102724023 ES1 protein homolog, mitochondrial 0.0150771
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0149254
PDE4D phosphodiesterase 4D, cAMP-specific 0.0147828
PRDX1 peroxiredoxin 1 0.0147745

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.20891
TP63 tumor protein p63 -0.143334
CD44 CD44 molecule (Indian blood group) -0.136736
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.133341
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.118694
CADM2 cell adhesion molecule 2 -0.0990547
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0932846
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0921602
PSD3 pleckstrin and Sec7 domain containing 3 -0.0863196
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0837009
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0824752
DST dystonin -0.0752611
DLG1 discs, large homolog 1 (Drosophila) -0.0743692
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0740934
EHBP1 EH domain binding protein 1 -0.0737972
EPHA4 EPH receptor A4 -0.0728218
EFNA5 ephrin-A5 -0.0705249
TNS3 tensin 3 -0.0701131
SLC38A2 solute carrier family 38, member 2 -0.0655409
DPYD dihydropyrimidine dehydrogenase -0.064034
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0620081
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0584428
TSC22D1 TSC22 domain family, member 1 -0.0543974
COL5A2 collagen, type V, alpha 2 -0.0515877
MYOF myoferlin -0.0438424
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427061
RUNX1 runt-related transcription factor 1 -0.0414538
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0409414
CSMD3 CUB and Sushi multiple domains 3 -0.0402288
FNIP1 folliculin interacting protein 1 -0.0399338
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0391692
EGFR epidermal growth factor receptor -0.0381744
EXOC4 exocyst complex component 4 -0.0381374
PIAS2 protein inhibitor of activated STAT, 2 -0.0366047
WSB1 WD repeat and SOCS box containing 1 -0.0345499
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0345492
DENND1A DENN/MADD domain containing 1A -0.0339578
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0339561
MBNL2 muscleblind-like splicing regulator 2 -0.0339528
DOCK11 dedicator of cytokinesis 11 -0.0326198
ZNF217 zinc finger protein 217 -0.0321624
TMEM123 transmembrane protein 123 -0.0316275
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0310135
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0304784
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0304504
ADGRG6 adhesion G protein-coupled receptor G6 -0.0292979
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.028882
CAVIN1 caveolae associated protein 1 -0.0286107
DENND5B DENN/MADD domain containing 5B -0.0281954
FAF1 Fas (TNFRSF6) associated factor 1 -0.0273591
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0270483
MBD5 methyl-CpG binding domain protein 5 -0.0263091
PRELID2 PRELI domain containing 2 -0.0261159
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0255701
FBXO11 F-box protein 11 -0.0254759
CFAP299 cilia and flagella associated protein 299 -0.025365
TRIO trio Rho guanine nucleotide exchange factor -0.0253412
CLIP2 CAP-GLY domain containing linker protein 2 -0.0249784
KDM4C lysine (K)-specific demethylase 4C -0.0245838
LPP LIM domain containing preferred translocation partner in lipoma -0.0245456
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0245105
EPB41 erythrocyte membrane protein band 4.1 -0.0242193
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0240536
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0240068
LYST lysosomal trafficking regulator -0.0227594
PDIA3 protein disulfide isomerase family A, member 3 -0.022381
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0222518
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0222012
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0221043
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0219989
PDE10A phosphodiesterase 10A -0.0219455
ZNF292 zinc finger protein 292 -0.0218671
RASAL2 RAS protein activator like 2 -0.0218166
TAS2R14 taste receptor, type 2, member 14 -0.0217903
PTPRF protein tyrosine phosphatase, receptor type, F -0.0217321
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0216945
ZMYND8 zinc finger, MYND-type containing 8 -0.0211623
AHNAK AHNAK nucleoprotein -0.0207412
ANXA1 annexin A1 -0.0205454
APOLD1 apolipoprotein L domain containing 1 -0.0203795
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0203167
LRRC49 leucine rich repeat containing 49 -0.020197
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0200521
CENPF centromere protein F, 350/400kDa -0.0194644
NPAS2 neuronal PAS domain protein 2 -0.0192963
HLA-B major histocompatibility complex, class I, B -0.0192811
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.019164
TTC3 tetratricopeptide repeat domain 3 -0.0191182
TTC28 tetratricopeptide repeat domain 28 -0.0190949
PDGFC platelet derived growth factor C -0.0189845
BICD1 bicaudal D homolog 1 (Drosophila) -0.0187609
MAP4 microtubule-associated protein 4 -0.0187334
HDLBP high density lipoprotein binding protein -0.0186517
VCL vinculin -0.01858
CUX1 cut-like homeobox 1 -0.0184906
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0184593
CMIP c-Maf inducing protein -0.0183966
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0182191
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0180986
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0180703