NG25_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.241349
MCL1 myeloid cell leukemia 1 0.0906207
GRAMD1B GRAM domain containing 1B 0.077058
ERRFI1 ERBB receptor feedback inhibitor 1 0.072923
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0698532
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0631268
TPM3 tropomyosin 3 0.0605509
KTN1 kinectin 1 (kinesin receptor) 0.0564887
THSD4 thrombospondin, type I, domain containing 4 0.0489449
YBX3 Y box binding protein 3 0.0448864
KRT18 keratin 18, type I 0.0437792
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436954
TFPI2 tissue factor pathway inhibitor 2 0.0420815
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0415846
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0415028
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0414266
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0393162
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.036745
FMNL2 formin-like 2 0.0363462
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0359676
TXNRD1 thioredoxin reductase 1 0.0339276
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0327775
MYH9 myosin, heavy chain 9, non-muscle 0.0326407
POTEF POTE ankyrin domain family, member F 0.0318129
INTS6 integrator complex subunit 6 0.029996
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0296243
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0291679
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0289523
ADAR adenosine deaminase, RNA-specific 0.0286109
DOCK5 dedicator of cytokinesis 5 0.0285351
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0285334
IFI6 interferon, alpha-inducible protein 6 0.0273933
PDLIM5 PDZ and LIM domain 5 0.0271498
STC1 stanniocalcin 1 0.0269925
MACF1 microtubule-actin crosslinking factor 1 0.026856
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0265155
HOMER1 homer scaffolding protein 1 0.0262195
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0261767
NFE2L2 nuclear factor, erythroid 2-like 2 0.0259174
RPL3 ribosomal protein L3 0.0258553
TRIP12 thyroid hormone receptor interactor 12 0.0257672
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.025736
PRKCE protein kinase C, epsilon 0.0252386
EXT1 exostosin glycosyltransferase 1 0.024566
SFPQ splicing factor proline/glutamine-rich 0.024516
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0243139
VCL vinculin 0.022946
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0229364
ELL2 elongation factor, RNA polymerase II, 2 0.0228152
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.022764
OSMR oncostatin M receptor 0.022691
WNK1 WNK lysine deficient protein kinase 1 0.0225262
SMAD3 SMAD family member 3 0.022308
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0220352
PCBP2 poly(rC) binding protein 2 0.0218042
ATP11A ATPase, class VI, type 11A 0.0216767
RPS18 ribosomal protein S18 0.0215506
ICAM1 intercellular adhesion molecule 1 0.0214214
IGF1R insulin-like growth factor 1 receptor 0.0212548
IPO7 importin 7 0.0210677
TRIO trio Rho guanine nucleotide exchange factor 0.0210602
RAB7A RAB7A, member RAS oncogene family 0.0209186
RUNX1 runt-related transcription factor 1 0.0206836
ANO6 anoctamin 6 0.0206817
DST dystonin 0.0204284
STK4 serine/threonine kinase 4 0.0203099
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0200325
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019968
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0195914
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0195492
WNT2B wingless-type MMTV integration site family, member 2B 0.0195289
BZW1 basic leucine zipper and W2 domains 1 0.019486
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0194414
WWOX WW domain containing oxidoreductase 0.0194077
RRM2 ribonucleotide reductase M2 0.0189816
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0188412
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187465
AEBP2 AE binding protein 2 0.0185143
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0182853
ATP13A3 ATPase type 13A3 0.0180145
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0179831
PFDN2 prefoldin subunit 2 0.0179185
LOXL2 lysyl oxidase-like 2 0.0176476
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0174603
NEK10 NIMA-related kinase 10 0.017459
PLEC plectin 0.017413
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0173427
TM4SF1 transmembrane 4 L six family member 1 0.01733
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0172817
UBC ubiquitin C 0.0172404
SVIL supervillin 0.0171525
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0166708
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.016571
DOCK1 dedicator of cytokinesis 1 0.0165135
ACTG1 actin gamma 1 0.0164806
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0164596
PYGL phosphorylase, glycogen, liver 0.0160365
YAP1 Yes-associated protein 1 0.0158979
VCP valosin containing protein 0.0156657
APLP2 amyloid beta (A4) precursor-like protein 2 0.0155806

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130366
RPS3 ribosomal protein S3 -0.0785156
TOP2A topoisomerase (DNA) II alpha 170kDa -0.078049
RPL37A ribosomal protein L37a -0.0593684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0568531
CENPF centromere protein F, 350/400kDa -0.0567387
RPL35A ribosomal protein L35a -0.0533605
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.050472
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0491221
RPL26 ribosomal protein L26 -0.0468424
RPL11 ribosomal protein L11 -0.0463083
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0458486
WSB1 WD repeat and SOCS box containing 1 -0.0432749
RPL37 ribosomal protein L37 -0.0386808
RPS12 ribosomal protein S12 -0.0381668
RPS21 ribosomal protein S21 -0.0380737
RPS8 ribosomal protein S8 -0.0371332
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0358456
VIM vimentin -0.0357739
RPS6 ribosomal protein S6 -0.0355081
TMSB10 thymosin beta 10 -0.0352304
RSF1 remodeling and spacing factor 1 -0.0347349
PTMA prothymosin, alpha -0.0345961
RPS29 ribosomal protein S29 -0.0339489
RPL12 ribosomal protein L12 -0.0339318
RPL23 ribosomal protein L23 -0.0324836
RPL34 ribosomal protein L34 -0.0323496
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0319693
ZMYND8 zinc finger, MYND-type containing 8 -0.0318699
FTL ferritin, light polypeptide -0.0315876
RPS27 ribosomal protein S27 -0.0314639
RPL31 ribosomal protein L31 -0.0309075
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0308461
BBX bobby sox homolog (Drosophila) -0.0305318
RPL19 ribosomal protein L19 -0.0303367
RPS19 ribosomal protein S19 -0.0302282
DENND5B DENN/MADD domain containing 5B -0.030048
RPLP1 ribosomal protein, large, P1 -0.0296606
RPL9 ribosomal protein L9 -0.0295078
HSPA1A heat shock 70kDa protein 1A -0.0283154
SRSF11 serine/arginine-rich splicing factor 11 -0.0275156
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0270459
DCAF7 DDB1 and CUL4 associated factor 7 -0.0259693
KDM2A lysine (K)-specific demethylase 2A -0.0257914
RPL36 ribosomal protein L36 -0.0254393
ATP5F1B ATP synthase F1 subunit beta -0.0253368
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0252451
TPX2 TPX2, microtubule-associated -0.0249093
ZBTB20 zinc finger and BTB domain containing 20 -0.0244257
ANKRD12 ankyrin repeat domain 12 -0.024208
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.024197
MKI67 marker of proliferation Ki-67 -0.024152
CENPE centromere protein E, 312kDa -0.0241295
TAS2R14 taste receptor, type 2, member 14 -0.0238159
RBM25 RNA binding motif protein 25 -0.0236417
PHF21A PHD finger protein 21A -0.0234325
RPS10 ribosomal protein S10 -0.0234188
SMC4 structural maintenance of chromosomes 4 -0.0233565
RPL13A ribosomal protein L13a -0.0232309
PFN1 profilin 1 -0.0230184
ZNF292 zinc finger protein 292 -0.022757
FAM13A family with sequence similarity 13, member A -0.0227463
KIF4A kinesin family member 4A -0.0218647
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0218425
IGF2 insulin-like growth factor 2 -0.0215201
RPS27A ribosomal protein S27a -0.0214467
PHIP pleckstrin homology domain interacting protein -0.0212756
RPL32 ribosomal protein L32 -0.0211561
GOLGA4 golgin A4 -0.0209031
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0206552
THOC2 THO complex 2 -0.0203913
RPL35 ribosomal protein L35 -0.0203744
MIS18BP1 MIS18 binding protein 1 -0.0202883
KMT2A lysine (K)-specific methyltransferase 2A -0.0202713
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0197534
RPS14 ribosomal protein S14 -0.0197312
RACK1 receptor for activated C kinase 1 -0.0197173
RPL5 ribosomal protein L5 -0.019715
RPS15 ribosomal protein S15 -0.0196207
WASF2 WAS protein family, member 2 -0.0190676
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0190265
RPS24 ribosomal protein S24 -0.0187091
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0186162
CCDC88A coiled-coil domain containing 88A -0.0186027
NPEPPS aminopeptidase puromycin sensitive -0.0185724
ZNF148 zinc finger protein 148 -0.0185419
ZNF638 zinc finger protein 638 -0.0184688
PNISR PNN-interacting serine/arginine-rich protein -0.0183377
ZMYM2 zinc finger, MYM-type 2 -0.018334
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0183016
LMNA lamin A/C -0.0182844
TNRC6B trinucleotide repeat containing 6B -0.0181116
NBEAL1 neurobeachin-like 1 -0.0181066
SEPTIN7 septin 7 -0.0179863
RPLP2 ribosomal protein, large, P2 -0.0179401
GNAS GNAS complex locus -0.0178232
ANKRD36B ankyrin repeat domain 36B -0.0177166
CSDE1 cold shock domain containing E1, RNA-binding -0.0174506
RPS17 ribosomal protein S17 -0.0172863
SBF2 SET binding factor 2 -0.0172364