NG25_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0531723
HMGA1 high mobility group AT-hook 1 0.0272273
PLEC plectin 0.0239091
DTNA dystrobrevin, alpha 0.0230604
GRB10 growth factor receptor-bound protein 10 0.0227352
VEGFA vascular endothelial growth factor A 0.0214904
TRIO trio Rho guanine nucleotide exchange factor 0.0209938
TJP1 tight junction protein 1 0.020499
PCBP2 poly(rC) binding protein 2 0.0200514
EXT1 exostosin glycosyltransferase 1 0.0200508
POTEF POTE ankyrin domain family, member F 0.0199181
MSN moesin 0.0191283
RPS18 ribosomal protein S18 0.0189398
MACC1 metastasis associated in colon cancer 1 0.0188321
SMAD3 SMAD family member 3 0.0182157
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0180638
PGBD5 piggyBac transposable element derived 5 0.0180579
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179636
MCL1 myeloid cell leukemia 1 0.0179114
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0178945
HDAC9 histone deacetylase 9 0.0177397
SAMD4A sterile alpha motif domain containing 4A 0.0176536
MYO5B myosin VB 0.0165004
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0154181
RPL3 ribosomal protein L3 0.0147854
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.014566
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0139747
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.013917
SQSTM1 sequestosome 1 0.0130737
ZFP36L1 ZFP36 ring finger protein-like 1 0.012992
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0129642
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0128245
EGR1 early growth response 1 0.0123373
EFNA5 ephrin-A5 0.0123224
DSPP dentin sialophosphoprotein 0.0123123
PPARD peroxisome proliferator-activated receptor delta 0.0120917
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0120773
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0119918
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0117433
VGLL3 vestigial-like family member 3 0.0114004
DST dystonin 0.0112036
MACF1 microtubule-actin crosslinking factor 1 0.0109789
NAV2 neuron navigator 2 0.0108986
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0106761
GLS2 glutaminase 2 (liver, mitochondrial) 0.0106668
ZSWIM6 zinc finger, SWIM-type containing 6 0.0106343
ICAM1 intercellular adhesion molecule 1 0.0103928
FNDC3B fibronectin type III domain containing 3B 0.0103317
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0102528
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.010172
SH3RF1 SH3 domain containing ring finger 1 0.0100736
EZR ezrin 0.00986052
ANO6 anoctamin 6 0.0096893
RUNX1 runt-related transcription factor 1 0.00967095
DUSP10 dual specificity phosphatase 10 0.00948596
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00939738
ADAR adenosine deaminase, RNA-specific 0.00923594
SLTM SAFB-like, transcription modulator 0.00914128
BHLHE40 basic helix-loop-helix family, member e40 0.00908788
PTK2 protein tyrosine kinase 2 0.00892529
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.00883061
SIK3 SIK family kinase 3 0.00862826
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00862155
EEF2 eukaryotic translation elongation factor 2 0.00861533
EIF5 eukaryotic translation initiation factor 5 0.0085671
HOMER1 homer scaffolding protein 1 0.00853628
RASAL2 RAS protein activator like 2 0.00851585
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.00834211
MX1 MX dynamin-like GTPase 1 0.00833142
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00824586
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00811141
PPARG peroxisome proliferator-activated receptor gamma 0.0081001
C3ORF52 chromosome 3 open reading frame 52 0.00795691
TPM3 tropomyosin 3 0.0079388
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00780833
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.00780663
ETV6 ets variant 6 0.00778964
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00761722
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.00757173
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00756862
LAMC2 laminin, gamma 2 0.00748918
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.00747675
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.00744495
SOX9 SRY (sex determining region Y)-box 9 0.00739202
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00729843
JARID2 jumonji, AT rich interactive domain 2 0.00718007
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00717323
SON SON DNA binding protein 0.00705037
DUSP6 dual specificity phosphatase 6 0.00701872
AFDN afadin, adherens junction formation factor 0.00698155
HYOU1 hypoxia up-regulated 1 0.00692263
LYST lysosomal trafficking regulator 0.0068563
AKAP13 A kinase (PRKA) anchor protein 13 0.0067689
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00676849
INTS6 integrator complex subunit 6 0.00675941
LAMB3 laminin, beta 3 0.00673164
DBN1 drebrin 1 0.0067058
AGO2 argonaute RISC catalytic component 2 0.00668058
HMGN2 high mobility group nucleosomal binding domain 2 0.00664994
LOC102724023 ES1 protein homolog, mitochondrial 0.00663821

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.272681
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157122
UBC ubiquitin C -0.0986129
TMSB10 thymosin beta 10 -0.0946221
PTMA prothymosin, alpha -0.0905531
ACTG1 actin gamma 1 -0.0615403
TPT1 tumor protein, translationally-controlled 1 -0.0523145
RPS27A ribosomal protein S27a -0.0480349
LIMCH1 LIM and calponin homology domains 1 -0.0459408
S100A6 S100 calcium binding protein A6 -0.0451804
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0436553
TM4SF1 transmembrane 4 L six family member 1 -0.0430808
RPL23 ribosomal protein L23 -0.0418125
FTL ferritin, light polypeptide -0.0391472
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0389583
AHNAK AHNAK nucleoprotein -0.0379623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0369285
RPS3 ribosomal protein S3 -0.0344139
WSB1 WD repeat and SOCS box containing 1 -0.0343982
RPL34 ribosomal protein L34 -0.0341693
EPCAM epithelial cell adhesion molecule -0.0322348
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314992
RPS8 ribosomal protein S8 -0.0293094
LPP LIM domain containing preferred translocation partner in lipoma -0.0289135
NDRG1 N-myc downstream regulated 1 -0.0287377
RPL35A ribosomal protein L35a -0.0286932
RPLP2 ribosomal protein, large, P2 -0.0283086
HMGB2 high mobility group box 2 -0.0282035
RPL37A ribosomal protein L37a -0.0280909
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0280098
RPLP1 ribosomal protein, large, P1 -0.0276376
NPEPPS aminopeptidase puromycin sensitive -0.0272311
S100A10 S100 calcium binding protein A10 -0.0269341
SLC38A1 solute carrier family 38, member 1 -0.0268254
RPL9 ribosomal protein L9 -0.0261893
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0261248
HSPB1 heat shock 27kDa protein 1 -0.0255399
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0249917
RPS23 ribosomal protein S23 -0.0240324
RPS25 ribosomal protein S25 -0.0236178
RPS24 ribosomal protein S24 -0.0235917
RPL8 ribosomal protein L8 -0.0232848
TMSB4X thymosin beta 4, X-linked -0.0229865
RHOA ras homolog family member A -0.0224388
ALCAM activated leukocyte cell adhesion molecule -0.0219836
VIM vimentin -0.0217042
CD2AP CD2-associated protein -0.0214273
IFI27 interferon, alpha-inducible protein 27 -0.020874
CENPF centromere protein F, 350/400kDa -0.0206942
GOLGA4 golgin A4 -0.0204364
ASPH aspartate beta-hydroxylase -0.0204315
MRPS6 mitochondrial ribosomal protein S6 -0.0202833
TMEM263 transmembrane protein 263 -0.0202651
RPS29 ribosomal protein S29 -0.0202466
ENO1 enolase 1, (alpha) -0.0201009
KDM3A lysine (K)-specific demethylase 3A -0.019895
RPL19 ribosomal protein L19 -0.0195418
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0194285
CCNI cyclin I -0.0193071
RAB1A RAB1A, member RAS oncogene family -0.0191942
RPS13 ribosomal protein S13 -0.0189979
RPL31 ribosomal protein L31 -0.0185704
RPS19 ribosomal protein S19 -0.0184982
RPL30 ribosomal protein L30 -0.0184855
RPL37 ribosomal protein L37 -0.0184703
OGA O-GlcNAcase -0.0184613
RPS10 ribosomal protein S10 -0.0182955
CALU calumenin -0.0182081
RPS12 ribosomal protein S12 -0.0179642
TFG TRK-fused gene -0.0177117
RPL32 ribosomal protein L32 -0.0174633
RACK1 receptor for activated C kinase 1 -0.0172541
RPLP0 ribosomal protein, large, P0 -0.0172532
RPS6 ribosomal protein S6 -0.0168817
RPL15 ribosomal protein L15 -0.0167862
HLA-B major histocompatibility complex, class I, B -0.0166147
KRT7 keratin 7, type II -0.0165986
BASP1 brain abundant, membrane attached signal protein 1 -0.0163722
PKM pyruvate kinase, muscle -0.0162238
RPS16 ribosomal protein S16 -0.0161456
RPS5 ribosomal protein S5 -0.016016
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0159961
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0159118
MDK midkine (neurite growth-promoting factor 2) -0.0158476
RPS21 ribosomal protein S21 -0.015732
RPL36 ribosomal protein L36 -0.0156754
FBXO32 F-box protein 32 -0.0156672
LY6E lymphocyte antigen 6 complex, locus E -0.0155932
MARCHF6 membrane associated ring-CH-type finger 6 -0.0155359
RPL26 ribosomal protein L26 -0.0155158
CTSD cathepsin D -0.0151412
AKAP9 A kinase (PRKA) anchor protein 9 -0.0150812
MXD1 MAX dimerization protein 1 -0.0148828
GNAS GNAS complex locus -0.0147061
H3-3B H3.3 histone B -0.0145543
PEG10 paternally expressed 10 -0.0144964
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0143129
NPC2 Niemann-Pick disease, type C2 -0.0141305
RPL28 ribosomal protein L28 -0.0139124
RPS15 ribosomal protein S15 -0.0138436