NG25_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NG25 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NG25_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.241676
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.211644
PDE4D phosphodiesterase 4D, cAMP-specific 0.195375
PKM pyruvate kinase, muscle 0.177656
EEF2 eukaryotic translation elongation factor 2 0.146226
EZR ezrin 0.109293
VCL vinculin 0.10508
HDAC9 histone deacetylase 9 0.103637
TMSB4X thymosin beta 4, X-linked 0.0995251
PDE4B phosphodiesterase 4B, cAMP-specific 0.0965042
PCBP2 poly(rC) binding protein 2 0.0817323
ANXA1 annexin A1 0.0804391
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0759345
EGFR epidermal growth factor receptor 0.0723444
LDHA lactate dehydrogenase A 0.0716099
ADAM10 ADAM metallopeptidase domain 10 0.0709887
ENO1 enolase 1, (alpha) 0.0691095
AHNAK AHNAK nucleoprotein 0.0674513
TJP1 tight junction protein 1 0.0650511
RPS8 ribosomal protein S8 0.0642818
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0639023
RPS6 ribosomal protein S6 0.0620307
FOXP1 forkhead box P1 0.0619955
RPL3 ribosomal protein L3 0.0592396
POTEF POTE ankyrin domain family, member F 0.0577856
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0560984
SQSTM1 sequestosome 1 0.0558769
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0557368
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0549391
EML4 echinoderm microtubule associated protein like 4 0.0545242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0532926
ARL4C ADP-ribosylation factor-like 4C 0.0519486
EIF1 eukaryotic translation initiation factor 1 0.0505952
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0503811
RPS18 ribosomal protein S18 0.046554
B2M beta-2-microglobulin 0.0454562
UBC ubiquitin C 0.0448581
PYGB phosphorylase, glycogen; brain 0.0446931
ANKRD11 ankyrin repeat domain 11 0.044088
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0439251
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0434353
ZEB1 zinc finger E-box binding homeobox 1 0.0429283
S100A6 S100 calcium binding protein A6 0.0415825
NBEA neurobeachin 0.0414555
CCND1 cyclin D1 0.0411851
NAP1L1 nucleosome assembly protein 1-like 1 0.041099
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0410353
PGK1 phosphoglycerate kinase 1 0.0404967
GLI2 GLI family zinc finger 2 0.0404058
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0399545
NFE2L2 nuclear factor, erythroid 2-like 2 0.0395965
ENO2 enolase 2 (gamma, neuronal) 0.0395474
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0392884
ZNF608 zinc finger protein 608 0.0390986
RTN4 reticulon 4 0.0388174
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0384557
TXNRD1 thioredoxin reductase 1 0.0379822
EFNA5 ephrin-A5 0.0375876
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0375514
TXNIP thioredoxin interacting protein 0.0371423
DUSP4 dual specificity phosphatase 4 0.0371258
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0368415
RPL5 ribosomal protein L5 0.0359964
RPS2 ribosomal protein S2 0.0354955
SOX9 SRY (sex determining region Y)-box 9 0.0351189
TACC2 transforming, acidic coiled-coil containing protein 2 0.0347013
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.034626
EBNA1BP2 EBNA1 binding protein 2 0.0344302
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.034384
RHOA ras homolog family member A 0.0343082
DUSP6 dual specificity phosphatase 6 0.0342134
KIF5B kinesin family member 5B 0.0334639
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0332919
PDGFC platelet derived growth factor C 0.0331763
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0330046
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0328582
TPM3 tropomyosin 3 0.0328144
RPL12 ribosomal protein L12 0.0326943
TGFBR3 transforming growth factor, beta receptor III 0.031828
RPS4X ribosomal protein S4, X-linked 0.0317155
RPS12 ribosomal protein S12 0.031698
ACTG1 actin gamma 1 0.0316451
CLIP1 CAP-GLY domain containing linker protein 1 0.0313992
AMOTL2 angiomotin like 2 0.030738
CSDE1 cold shock domain containing E1, RNA-binding 0.0305691
BMP10 bone morphogenetic protein 10 0.0304342
SSBP2 single-stranded DNA binding protein 2 0.0301402
ZBTB38 zinc finger and BTB domain containing 38 0.0297303
PRDX2 peroxiredoxin 2 0.0295518
EEF1G eukaryotic translation elongation factor 1 gamma 0.0294237
RPL11 ribosomal protein L11 0.0292663
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0290705
HDLBP high density lipoprotein binding protein 0.0287249
PRRC2C proline-rich coiled-coil 2C 0.0287156
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0284318
TSC22D1 TSC22 domain family, member 1 0.0281754
LOC112694756 uncharaterized LOC112694756 0.0279282
RPS13 ribosomal protein S13 0.0279223
BMP2K BMP2 inducible kinase 0.0278547
ZNF148 zinc finger protein 148 0.0278458

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.176749
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0600239
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0402862
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0391753
CENPF centromere protein F, 350/400kDa -0.0335678
FHIT fragile histidine triad -0.0311177
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0308264
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0298677
WSB1 WD repeat and SOCS box containing 1 -0.0288961
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.028119
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.020991
PDE10A phosphodiesterase 10A -0.0208103
LCORL ligand dependent nuclear receptor corepressor-like -0.0196968
NEBL nebulette -0.0190467
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0180245
PRELID2 PRELI domain containing 2 -0.0178978
FAM13A family with sequence similarity 13, member A -0.0175692
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0172911
ZMYM2 zinc finger, MYM-type 2 -0.0171493
ZNF106 zinc finger protein 106 -0.016843
COG6 component of oligomeric golgi complex 6 -0.0162508
RFC3 replication factor C (activator 1) 3, 38kDa -0.0160625
RRBP1 ribosome binding protein 1 -0.015923
HELZ helicase with zinc finger -0.0157244
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0157032
SDK1 sidekick cell adhesion molecule 1 -0.0154562
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0146061
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.014455
CAMTA1 calmodulin binding transcription activator 1 -0.0140865
RAB1A RAB1A, member RAS oncogene family -0.0140063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0139143
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0132292
RAD18 RAD18 E3 ubiquitin protein ligase -0.0128716
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0128339
MSI2 musashi RNA-binding protein 2 -0.0126911
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0126158
KDM4C lysine (K)-specific demethylase 4C -0.0124351
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0124016
HSPA4L heat shock 70kDa protein 4-like -0.0119773
ACBD6 acyl-CoA binding domain containing 6 -0.0118244
GAS2L3 growth arrest-specific 2 like 3 -0.0117783
FTL ferritin, light polypeptide -0.0117542
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.011747
MEIS2 Meis homeobox 2 -0.0116618
DIAPH3 diaphanous-related formin 3 -0.0115381
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0114604
SLC38A4 solute carrier family 38, member 4 -0.0110432
RPS21 ribosomal protein S21 -0.0109685
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0108236
OGA O-GlcNAcase -0.0108093
SMAD4 SMAD family member 4 -0.0107522
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0106754
ANKRD12 ankyrin repeat domain 12 -0.0106696
EED embryonic ectoderm development -0.0105255
NT5C2 5'-nucleotidase, cytosolic II -0.0102696
TNS3 tensin 3 -0.0101934
POGZ pogo transposable element with ZNF domain -0.0101546
FGFR2 fibroblast growth factor receptor 2 -0.0101506
HSPG2 heparan sulfate proteoglycan 2 -0.0101443
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0100626
FBXO42 F-box protein 42 -0.00994383
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.00992493
BUB3 BUB3 mitotic checkpoint protein -0.00978906
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00976272
KIZ kizuna centrosomal protein -0.00975063
FUBP3 far upstream element (FUSE) binding protein 3 -0.00974816
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00972448
ALCAM activated leukocyte cell adhesion molecule -0.00970373
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.00965536
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.00953649
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.00953636
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.00940797
SH3YL1 SH3 and SYLF domain containing 1 -0.00932174
MSH4 mutS homolog 4 -0.00922859
YEATS2 YEATS domain containing 2 -0.00916472
HMGB2 high mobility group box 2 -0.00914505
SRP54 signal recognition particle 54kDa -0.00898639
FKBP10 FK506 binding protein 10, 65 kDa -0.00896571
SRP19 signal recognition particle 19kDa -0.00893489
CENPE centromere protein E, 312kDa -0.0089115
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.00886462
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.00884339
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.00875861
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.00872627
PRKX protein kinase, X-linked -0.00865075
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.00864427
NAV2 neuron navigator 2 -0.00864091
HIKESHI heat shock protein nuclear import factor hikeshi -0.00864052
ATP7B ATPase, Cu++ transporting, beta polypeptide -0.00863906
DPY19L3 dpy-19-like 3 (C. elegans) -0.00862026
ZFYVE9 zinc finger, FYVE domain containing 9 -0.00859161
DEPDC1 DEP domain containing 1 -0.00858328
MMP24OS MMP24 opposite strand -0.00857016
TMEM168 transmembrane protein 168 -0.00856595
CFAP251 cilia and flagella associated protein 251 -0.00854733
OXR1 oxidation resistance 1 -0.00854248
BABAM2 BRISC and BRCA1 A complex member 2 -0.00851222
MANBA mannosidase, beta A, lysosomal -0.00850964
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0084688
TARBP1 TAR (HIV-1) RNA binding protein 1 -0.00840341