NGF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nerve growth factor (beta polypeptide)|This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4803)
External Link http://www.ncbi.nlm.nih.gov/gene/4803
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Genes

76 interacting proteins for NGF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CHUK conserved helix-loop-helix ubiquitous kinase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYAB crystallin, alpha B
CYCS cytochrome c, somatic
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAL4 dynein, axonemal, light chain 4
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DYNLT1 dynein, light chain, Tctex-type 1
EHD4 EH-domain containing 4
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FURIN furin (paired basic amino acid cleaving enzyme)
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GRB2 growth factor receptor-bound protein 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KIDINS220 kinase D-interacting substrate, 220kDa
MAGED1 melanoma antigen family D1
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MMP7 matrix metallopeptidase 7
MYD88 myeloid differentiation primary response 88
NCSTN nicastrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLG plasminogen
PRDM4 PR domain containing 4
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOG ras homolog family member G
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
ROR1 receptor tyrosine kinase-like orphan receptor 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SORCS3 sortilin-related VPS10 domain containing receptor 3
SORT1 sortilin 1
SOS1 son of sevenless homolog 1 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)