NHLH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nescient helix loop helix 1|The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002] (NCBI Entrez Gene Database, 4807)
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Genes

345 genes differentially expressed following the NHLH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 2.53444
SH2D6 SH2 domain containing 6 2.53444
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.53444
PAX6 paired box 6 2.53444
APOA2 apolipoprotein A-II 2.53444
FAM156B family with sequence similarity 156, member B 2.53444
ASB12 ankyrin repeat and SOCS box containing 12 2.53444
GYPB glycophorin B (MNS blood group) 2.53444
TRIM74 tripartite motif containing 74 2.53444
ANKRD34A ankyrin repeat domain 34A 2.53444
CXCL9 chemokine (C-X-C motif) ligand 9 2.53444
UMOD uromodulin 2.53444
AMTN amelotin 2.53444
TM4SF20 transmembrane 4 L six family member 20 2.53444
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.53444
FAM180A family with sequence similarity 180, member A 2.53444
ZNF492 zinc finger protein 492 2.53444
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.53444
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.53444
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.53444
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.53444
FABP1 fatty acid binding protein 1, liver 2.53444
TMEM244 transmembrane protein 244 2.53444
PKP1 plakophilin 1 2.53444
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.53444
GADL1 glutamate decarboxylase-like 1 2.53444
TPSD1 tryptase delta 1 2.53444
ETV7 ets variant 7 2.53444
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.53444
SPACA7 sperm acrosome associated 7 2.53444
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.53444
NMUR2 neuromedin U receptor 2 2.53444
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.53444
TLDC2 TBC/LysM-associated domain containing 2 2.53444
WFDC11 WAP four-disulfide core domain 11 2.53444
TSSK1B testis-specific serine kinase 1B 2.53444
ABRA actin binding Rho activating protein 2.53444
ANAPC13 anaphase promoting complex subunit 13 2.53444
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.53444
MUC22 mucin 22 2.53444
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.53444
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.53444
TDRD9 tudor domain containing 9 2.53444
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.53444
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.53444
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.53444
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.53444
RLN3 relaxin 3 2.53444
TCP11 t-complex 11, testis-specific 2.53444
S100A9 S100 calcium binding protein A9 2.53444
AREG amphiregulin 2.53444
SIX2 SIX homeobox 2 2.53444
KRABD1 KRAB domain containing 1 2.53444
CCER2 coiled-coil glutamate-rich protein 2 2.53444
ALX4 ALX homeobox 4 2.53444
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.53444
SRGN serglycin 2.53444
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.53444
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.53444
FCAMR Fc receptor, IgA, IgM, high affinity 2.53444
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.53444
GATA2 GATA binding protein 2 2.53444
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.53444
GPX5 glutathione peroxidase 5 2.53444
OTOF otoferlin 2.53444
ELOA2 elongin A2 2.53444
CATSPERH catsper channel auxiliary subunit eta 2.53444
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.53444
EPCIP exosomal polycystin 1 interacting protein 2.53444
LITAFD LITAF domain containing 2.53444
LOC124903372 uncharacterized LOC124903372 2.53444
ZNF593OS ZNF593 opposite strand 2.53444
H4C15 H4 clustered histone 15 2.53444
H4C14 H4 clustered histone 14 2.53444
ARMH2 armadillo like helical domain containing 2 2.53444
TMEM270 transmembrane protein 270 2.53444
SMCP sperm mitochondria-associated cysteine-rich protein 2.53444
MYO18B myosin XVIIIB 2.53444
GDF6 growth differentiation factor 6 2.53444
MAGEB3 melanoma antigen family B3 2.53444
VIT vitrin 2.53444
PCDHB13 protocadherin beta 13 2.53444
GGT5 gamma-glutamyltransferase 5 2.53444
HDC histidine decarboxylase 2.53444
CD300LG CD300 molecule-like family member g 2.53444
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.53444
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.53444
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.53444
SRL sarcalumenin 2.53444
WNT11 wingless-type MMTV integration site family, member 11 2.53444
DAO D-amino-acid oxidase 2.53444
MAL mal, T-cell differentiation protein 2.53444
LRRC70 leucine rich repeat containing 70 2.53444
VCX3B variable charge, X-linked 3B 2.53444
CLEC17A C-type lectin domain family 17, member A 2.53444
TACR2 tachykinin receptor 2 2.53444
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.53444
PRR18 proline rich 18 2.53444
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.53444
ZNF257 zinc finger protein 257 2.53444
RUNX3 runt-related transcription factor 3 2.53444
CXCL16 chemokine (C-X-C motif) ligand 16 2.53444
ZMAT3 zinc finger, matrin-type 3 2.53444
ZNF703 zinc finger protein 703 2.53444
PCDHGA2 protocadherin gamma subfamily A, 2 2.53444
MUC16 mucin 16, cell surface associated 2.53444
IL19 interleukin 19 2.53444
IL1B interleukin 1, beta 2.53444
KISS1 KiSS-1 metastasis-suppressor 2.53444
SRRT serrate, RNA effector molecule 2.53444
CNGB3 cyclic nucleotide gated channel beta 3 2.53444
KLK11 kallikrein-related peptidase 11 2.53444
CATIP ciliogenesis associated TTC17 interacting protein 2.53444
MUC7 mucin 7, secreted 2.53444
TTC9B tetratricopeptide repeat domain 9B 2.53444
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.53444
APOC4 apolipoprotein C-IV 2.53444
GP9 glycoprotein IX (platelet) 2.53444
PLXNC1 plexin C1 2.53444
DQX1 DEAQ box RNA-dependent ATPase 1 2.53444
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.53444
RETNLB resistin like beta 2.53444
CRYBB2 crystallin, beta B2 2.53444
DUOX2 dual oxidase 2 2.53444
FAM163A family with sequence similarity 163, member A 2.53444
KLF2 Kruppel-like factor 2 2.53444
NIPAL4 NIPA-like domain containing 4 2.53444
SVOP SV2 related protein homolog (rat) 2.53444
SAMD7 sterile alpha motif domain containing 7 2.53444
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.53444
OTP orthopedia homeobox 2.53444
FAM151A family with sequence similarity 151, member A 2.53444
ETV3L ets variant 3-like 2.53444
SFTA2 surfactant associated 2 2.53444
ZNF831 zinc finger protein 831 2.53444
SNAP91 synaptosomal-associated protein, 91kDa 2.53444
EVI2A ecotropic viral integration site 2A 2.53444
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.53444
NLRP14 NLR family, pyrin domain containing 14 2.53444
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 2.53444
DEFB135 defensin, beta 135 2.53444
GSC2 goosecoid homeobox 2 2.53444
EPHA10 EPH receptor A10 2.53444
CTXN2 cortexin 2 2.53444
AICDA activation-induced cytidine deaminase 2.53444
TF transferrin 2.53444
DMRT1 doublesex and mab-3 related transcription factor 1 2.53444
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.53444
POGK pogo transposable element with KRAB domain 2.53444
PGR progesterone receptor 2.53444
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.53444
ORM2 orosomucoid 2 2.53444
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.53444
CD86 CD86 molecule 2.53444
FGF10 fibroblast growth factor 10 2.53444
NUTM2B NUT family member 2B 2.53444
TSPAN19 tetraspanin 19 2.53444
LRRC31 leucine rich repeat containing 31 2.53444
PHOSPHO1 phosphatase, orphan 1 2.53444
FCAR Fc fragment of IgA receptor 2.53444
TAS2R40 taste receptor, type 2, member 40 2.53444
CIB4 calcium and integrin binding family member 4 2.53444
HEPN1 hepatocellular carcinoma, down-regulated 1 2.53444
MAPK11 mitogen-activated protein kinase 11 2.53444
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.53444
CLCA1 chloride channel accessory 1 2.53444
AOC1 amine oxidase, copper containing 1 2.53444
CT55 cancer/testis antigen 55 2.53444
MRLN myoregulin 2.53444
MR1 major histocompatibility complex, class I-related 2.53444
CLIC1 chloride intracellular channel 1 2.53444
DMRTC1 DMRT-like family C1 2.53444
DAND5 DAN domain family member 5, BMP antagonist 2.53444
FNDC8 fibronectin type III domain containing 8 2.53444
PDCL2 phosducin-like 2 2.53444
APOF apolipoprotein F 2.53444
TCF21 transcription factor 21 2.53444
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.50049
ADCY1 adenylate cyclase 1 (brain) 2.48554
DMBX1 diencephalon/mesencephalon homeobox 1 2.46877
PRUNE1 prune exopolyphosphatase 1 2.46877
ARL5C ADP-ribosylation factor-like 5C 2.46877
ICAM5 intercellular adhesion molecule 5, telencephalin 2.46359
BHMT betaine--homocysteine S-methyltransferase 2.46359
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.46359
NOD2 nucleotide-binding oligomerization domain containing 2 2.40439
DES desmin 2.38367
DISC1 disrupted in schizophrenia 1 2.3813
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.36892
ZXDB zinc finger, X-linked, duplicated B 2.3518
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J 2.3518
TMEM215 transmembrane protein 215 2.32056
SYNE4 spectrin repeat containing, nuclear envelope family member 4 2.30095
FMNL1 formin-like 1 2.28707
HARBI1 harbinger transposase derived 1 2.28707
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 2.27166
KICS2 KICSTOR subunit 2 2.26744
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.25111
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.25111
CCDC88C coiled-coil domain containing 88C 2.2505
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.24749
ZNF552 zinc finger protein 552 2.24077
WDR86 WD repeat domain 86 2.22116
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.21953
TRUB1 TruB pseudouridine (psi) synthase family member 1 2.21409
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.21248
AKAP12 A kinase (PRKA) anchor protein 12 2.21193
EID1 EP300 interacting inhibitor of differentiation 1 2.20857
MAGEF1 melanoma antigen family F1 2.17202
BCL7B B-cell CLL/lymphoma 7B 2.17202
ADARB1 adenosine deaminase, RNA-specific, B1 2.1681
SPAG17 sperm associated antigen 17 2.13975
SF3B6 splicing factor 3b, subunit 6, 14kDa 2.13975
GPS1 G protein pathway suppressor 1 2.1388
CCDC125 coiled-coil domain containing 125 2.13322
FCHO2 FCH domain only 2 2.1317
SF1 splicing factor 1 2.12848
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.1132
KCTD9 potassium channel tetramerization domain containing 9 2.10984
MED14 mediator complex subunit 14 2.10984
DSC2 desmocollin 2 2.10587
XRRA1 X-ray radiation resistance associated 1 2.05546
BRMS1L breast cancer metastasis-suppressor 1-like 2.04816
ZNF599 zinc finger protein 599 2.04805
TLN2 talin 2 2.04802
MRPS24 mitochondrial ribosomal protein S24 2.04324
CSNK1D casein kinase 1, delta 2.03355
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.03355
SETD1A SET domain containing 1A 2.01937
GSTO2 glutathione S-transferase omega 2 2.00997
NRL neural retina leucine zipper 2.00997
ERI1 exoribonuclease 1 2.00483
ERCC3 excision repair cross-complementation group 3 2.00429
RBL1 retinoblastoma-like 1 2.00429

decreased expression

Symbol Name Standardized Value
ASB16 ankyrin repeat and SOCS box containing 16 -2.53444
IL18R1 interleukin 18 receptor 1 -2.53444
CFAP99 cilia and flagella associated protein 99 -2.53444
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.53444
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.53444
FOSL2 FOS-like antigen 2 -2.53444
CKM creatine kinase, muscle -2.53444
AGBL4 ATP/GTP binding protein-like 4 -2.53444
SYTL5 synaptotagmin-like 5 -2.53444
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.53444
ITPKA inositol-trisphosphate 3-kinase A -2.53444
GPER1 G protein-coupled estrogen receptor 1 -2.53444
PAOX polyamine oxidase (exo-N4-amino) -2.53444
MYO6 myosin VI -2.53444
OVOL2 ovo-like zinc finger 2 -2.53444
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.53444
DPF3 D4, zinc and double PHD fingers, family 3 -2.53444
INTS7 integrator complex subunit 7 -2.53444
WNK2 WNK lysine deficient protein kinase 2 -2.53444
ASPA aspartoacylase -2.53444
SFXN3 sideroflexin 3 -2.53444
CSTL1 cystatin-like 1 -2.53444
LMO1 LIM domain only 1 (rhombotin 1) -2.53444
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.53444
OSR2 odd-skipped related transciption factor 2 -2.53444
C8ORF48 chromosome 8 open reading frame 48 -2.53444
ZBTB42 zinc finger and BTB domain containing 42 -2.53444
MUC6 mucin 6, oligomeric mucus/gel-forming -2.53444
MROH6 maestro heat-like repeat family member 6 -2.53444
SLC22A14 solute carrier family 22, member 14 -2.53444
CEP126 centrosomal protein 126kDa -2.53444
STK35 serine/threonine kinase 35 -2.53444
CNBD2 cyclic nucleotide binding domain containing 2 -2.53444
MTMR11 myotubularin related protein 11 -2.53444
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.53444
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -2.53444
TREH trehalase (brush-border membrane glycoprotein) -2.53444
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.53444
GPR146 G protein-coupled receptor 146 -2.53444
TAMALIN trafficking regulator and scaffold protein tamalin -2.53444
ADCY10 adenylate cyclase 10 (soluble) -2.53444
ESPNL espin-like -2.53444
H2BC13 H2B clustered histone 13 -2.53444
LRRN4 leucine rich repeat neuronal 4 -2.53444
PVALEF parvalbumin like EF-hand containing -2.53444
ZC3H11C zinc finger CCCH-type containing 11C -2.53444
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.53444
PTCH2 patched 2 -2.53444
ZNF112 zinc finger protein 112 -2.53444
ART1 ADP-ribosyltransferase 1 -2.53444
TYMS thymidylate synthetase -2.53444
MRPS11 mitochondrial ribosomal protein S11 -2.53444
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.53444
NPIPB8 nuclear pore complex interacting protein family, member B8 -2.53444
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.53444
CDK20 cyclin-dependent kinase 20 -2.53444
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.53444
PCDH12 protocadherin 12 -2.53444
BDKRB2 bradykinin receptor B2 -2.53444
TBC1D3L TBC1 domain family, member 3L -2.53444
CADM3 cell adhesion molecule 3 -2.53444
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.52374
ATXN2L ataxin 2-like -2.48554
DXO decapping exoribonuclease -2.46877
MIER1 mesoderm induction early response 1, transcriptional regulator -2.43279
MPPED1 metallophosphoesterase domain containing 1 -2.42486
MYLK4 myosin light chain kinase family, member 4 -2.42486
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -2.40439
TRAFD1 TRAF-type zinc finger domain containing 1 -2.38367
CTSV cathepsin V -2.36399
SLC35H1 solute carrier family 35 member H1 -2.35888
CCNE2 cyclin E2 -2.35591
PLD5 phospholipase D family, member 5 -2.35036
GLS glutaminase -2.35036
CHMP6 charged multivesicular body protein 6 -2.34999
ITSN2 intersectin 2 -2.34272
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.2922
AZU1 azurocidin 1 -2.28929
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.28327
NBPF20 neuroblastoma breakpoint family, member 20 -2.28327
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.26744
HMGB1 high mobility group box 1 -2.25828
C20ORF203 chromosome 20 open reading frame 203 -2.21564
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.21564
MOAP1 modulator of apoptosis 1 -2.21201
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.1908
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.18708
SP110 SP110 nuclear body protein -2.16991
PKNOX1 PBX/knotted 1 homeobox 1 -2.16375
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.16226
ACMSD aminocarboxymuconate semialdehyde decarboxylase -2.1317
EVI2B ecotropic viral integration site 2B -2.1317
SLC10A4 solute carrier family 10, member 4 -2.1317
ASMT acetylserotonin O-methyltransferase -2.1317
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -2.11359
ANKRD34B ankyrin repeat domain 34B -2.1132
SCAF1 SR-related CTD-associated factor 1 -2.10984
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.10984
LYG1 lysozyme G-like 1 -2.10587
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.08323
CENPVL3 centromere protein V like 3 -2.05955
STK17A serine/threonine kinase 17a -2.04324
MTM1 myotubularin 1 -2.03628
PPP1R13B protein phosphatase 1, regulatory subunit 13B -2.01937
CABIN1 calcineurin binding protein 1 -2.01931
SRSF4 serine/arginine-rich splicing factor 4 -2.01931
DBF4 DBF4 zinc finger -2.01349
USP43 ubiquitin specific peptidase 43 -2.00997
IREB2 iron-responsive element binding protein 2 -2.00889
TRIM25 tripartite motif containing 25 -2.00726
SFRP1 secreted frizzled-related protein 1 -2.00429