NIK/NF-kappaB signaling Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). (Gene Ontology, GO_0038061)
External Link http://amigo.geneontology.org/amigo/term/GO_0038061
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Genes

33 genes participating in the NIK/NF-kappaB signaling biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CARD10 caspase recruitment domain family, member 10
CARD14 caspase recruitment domain family, member 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHUK conserved helix-loop-helix ubiquitous kinase
COPS8 COP9 signalosome subunit 8
CREBBP CREB binding protein
DICER1 dicer 1, ribonuclease type III
IRAK1 interleukin-1 receptor-associated kinase 1
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR3 toll-like receptor 3
TLR6 toll-like receptor 6
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
ZFP91 ZFP91 zinc finger protein