NIK Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 14|This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9020)
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100 substrates of the kinase NIK from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TWIST1 twist family bHLH transcription factor 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
HIST1H2BB histone cluster 1, H2bb
MARCKSL1 MARCKS-like 1
SCAF1 SR-related CTD-associated factor 1
PLXNB1 plexin B1
SSTR5 somatostatin receptor 5
WNK1 WNK lysine deficient protein kinase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
ARHGAP35 Rho GTPase activating protein 35
TRA2A transformer 2 alpha homolog (Drosophila)
ATF1 activating transcription factor 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
SETD2 SET domain containing 2
DCLRE1C DNA cross-link repair 1C
MYL9 myosin, light chain 9, regulatory
CREB1 cAMP responsive element binding protein 1
IL2RA interleukin 2 receptor, alpha
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
LARP1 La ribonucleoprotein domain family, member 1
GANAB glucosidase, alpha; neutral AB
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
MYBPC3 myosin binding protein C, cardiac
ERBB2 erb-b2 receptor tyrosine kinase 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
MSX2 msh homeobox 2
TACSTD2 tumor-associated calcium signal transducer 2
S1PR1 sphingosine-1-phosphate receptor 1
RASAL3 RAS protein activator like 3
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
AIM1 absent in melanoma 1
FRMD4B FERM domain containing 4B
TRPC1 transient receptor potential cation channel, subfamily C, member 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
NEO1 neogenin 1
AKAP5 A kinase (PRKA) anchor protein 5
TNNI3 troponin I type 3 (cardiac)
BTK Bruton agammaglobulinemia tyrosine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
C11ORF30 chromosome 11 open reading frame 30
TOR4A torsin family 4, member A
EGFR epidermal growth factor receptor
RACGAP1 Rac GTPase activating protein 1
BAHD1 bromo adjacent homology domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SRSF2 serine/arginine-rich splicing factor 2
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PTPN14 protein tyrosine phosphatase, non-receptor type 14
ANKRD33B ankyrin repeat domain 33B
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
PRM2 protamine 2
RARA retinoic acid receptor, alpha
DUOX1 dual oxidase 1
GRK7 G protein-coupled receptor kinase 7
DAPK3 death-associated protein kinase 3
MAP3K11 mitogen-activated protein kinase kinase kinase 11
RGS18 regulator of G-protein signaling 18
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
DRD2 dopamine receptor D2
PHF2 PHD finger protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
KDM1A lysine (K)-specific demethylase 1A
SYT6 synaptotagmin VI
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
CYTH2 cytohesin 2
NLGN4X neuroligin 4, X-linked
PYGO2 pygopus family PHD finger 2
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
CHERP calcium homeostasis endoplasmic reticulum protein
AEBP2 AE binding protein 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
CDR2L cerebellar degeneration-related protein 2-like
FAM214B family with sequence similarity 214, member B
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
SYTL1 synaptotagmin-like 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
CDC25B cell division cycle 25B
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
PPP1R12A protein phosphatase 1, regulatory subunit 12A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
SETD1A SET domain containing 1A
FOXG1 forkhead box G1
NOLC1 nucleolar and coiled-body phosphoprotein 1
DGAT1 diacylglycerol O-acyltransferase 1
LIMK2 LIM domain kinase 2
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
SRRM2 serine/arginine repetitive matrix 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MORC3 MORC family CW-type zinc finger 3
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
JMJD6 jumonji domain containing 6
NGFR nerve growth factor receptor
CLK2 CDC-like kinase 2
CLK3 CDC-like kinase 3
KIF4A kinesin family member 4A
SF1 splicing factor 1
FXYD1 FXYD domain containing ion transport regulator 1