NKX2-1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NK2 homeobox 1|This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 7080)
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Genes

340 genes differentially expressed following the NKX2-1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFHR4 complement factor H-related 4 3.27229
BTC betacellulin 3.27229
TEX13B testis expressed 13B 3.27229
PCDHB7 protocadherin beta 7 3.27229
SLC35G5 solute carrier family 35, member G5 3.27229
KRT20 keratin 20, type I 3.27229
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.27229
TBX18 T-box 18 3.27229
DRICH1 aspartate-rich 1 3.27229
CXORF65 chromosome X open reading frame 65 3.27229
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.27229
TMEM176B transmembrane protein 176B 3.27229
NANOS2 nanos homolog 2 (Drosophila) 3.27229
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.27229
GJA5 gap junction protein, alpha 5, 40kDa 3.27229
SIX3 SIX homeobox 3 3.27229
SIX1 SIX homeobox 1 3.27229
SIX6 SIX homeobox 6 3.27229
SLFN11 schlafen family member 11 3.27229
COL20A1 collagen, type XX, alpha 1 3.27229
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.27229
EGFLAM EGF-like, fibronectin type III and laminin G domains 3.27229
VCX2 variable charge, X-linked 2 3.27229
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.27229
PAX3 paired box 3 3.27229
PAX5 paired box 5 3.27229
MEIKIN meiotic kinetochore factor 3.27229
CCDC38 coiled-coil domain containing 38 3.27229
COPZ2 coatomer protein complex, subunit zeta 2 3.27229
HEPHL1 hephaestin-like 1 3.27229
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.27229
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.27229
CPLX4 complexin 4 3.27229
CRYAA crystallin, alpha A 3.27229
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.27229
KIAA1755 KIAA1755 3.27229
LRRC10B leucine rich repeat containing 10B 3.27229
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.27229
TPSD1 tryptase delta 1 3.27229
OLIG3 oligodendrocyte transcription factor 3 3.27229
LRG1 leucine-rich alpha-2-glycoprotein 1 3.27229
ASB12 ankyrin repeat and SOCS box containing 12 3.27229
GYPB glycophorin B (MNS blood group) 3.27229
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.27229
CA1 carbonic anhydrase I 3.27229
ARSF arylsulfatase F 3.27229
TRIM74 tripartite motif containing 74 3.27229
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.27229
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.27229
KRTAP5-2 keratin associated protein 5-2 3.27229
SRL sarcalumenin 3.27229
CIMIP4 ciliary microtubule inner protein 4 3.27229
STING1 stimulator of interferon response cGAMP interactor 1 3.27229
SELE selectin E 3.27229
HAO2 hydroxyacid oxidase 2 (long chain) 3.27229
OPRM1 opioid receptor, mu 1 3.27229
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.27229
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.27229
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.27229
IGSF23 immunoglobulin superfamily, member 23 3.27229
MYPN myopalladin 3.27229
ZNF441 zinc finger protein 441 3.27229
VSIR V-set immunoregulatory receptor 3.27229
CCN5 cellular communication network factor 5 3.27229
DIPK2B divergent protein kinase domain 2B 3.27229
TEX53 testis expressed 53 3.27229
RPS21-DT RPS21 divergent transcript 3.27229
C1ORF232 chromosome 1 open reading frame 230 3.27229
SMIM35 small integral membrane protein 35 3.27229
MINDY4B MINDY family member 4B 3.27229
LHFPL7 LHFPL tetraspan subfamily member 7 3.27229
CPHXL cytoplasmic polyadenylated homeobox like 3.27229
CFAP206 cilia and flagella associated protein 206 3.27229
GARIN1A golgi associated RAB2 interactor 1A 3.27229
DUSP29 dual specificity phosphatase 29 3.27229
CNGA3 cyclic nucleotide gated channel alpha 3 3.27229
SMCP sperm mitochondria-associated cysteine-rich protein 3.27229
BBS12 Bardet-Biedl syndrome 12 3.27229
TACSTD2 tumor-associated calcium signal transducer 2 3.27229
GOLGA7B golgin A7 family, member B 3.27229
CXCL16 chemokine (C-X-C motif) ligand 16 3.27229
C10ORF62 chromosome 10 open reading frame 62 3.27229
GAS7 growth arrest-specific 7 3.27229
CD48 CD48 molecule 3.27229
NKX2-5 NK2 homeobox 5 3.27229
MEP1A meprin A, alpha (PABA peptide hydrolase) 3.27229
WEE2 WEE1 homolog 2 (S. pombe) 3.27229
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.27229
INSRR insulin receptor-related receptor 3.27229
NPFF neuropeptide FF-amide peptide precursor 3.27229
ACE2 angiotensin I converting enzyme 2 3.27229
NPIPB8 nuclear pore complex interacting protein family, member B8 3.27229
GDF9 growth differentiation factor 9 3.27229
PNPLA1 patatin-like phospholipase domain containing 1 3.27229
SETX senataxin 3.27229
PGA3 pepsinogen 3, group I (pepsinogen A) 3.27229
SAA2 serum amyloid A2 3.27229
CELA2A chymotrypsin-like elastase family, member 2A 3.27229
CDKN2A cyclin-dependent kinase inhibitor 2A 3.27229
CCR9 chemokine (C-C motif) receptor 9 3.27229
NKRF NFKB repressing factor 3.27229
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.27229
FAM209B family with sequence similarity 209, member B 3.27229
CRYBB3 crystallin, beta B3 3.27229
CLRN2 clarin 2 3.27229
CXCR6 chemokine (C-X-C motif) receptor 6 3.27229
GOLGA6B golgin A6 family, member B 3.27229
TDRD10 tudor domain containing 10 3.27229
CCDC27 coiled-coil domain containing 27 3.27229
PCDHGA4 protocadherin gamma subfamily A, 4 3.27229
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.27229
PRSS2 protease, serine, 2 (trypsin 2) 3.27229
ARR3 arrestin 3, retinal (X-arrestin) 3.27229
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.27229
PCDHGB1 protocadherin gamma subfamily B, 1 3.27229
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 3.27229
KRT3 keratin 3, type II 3.27229
LRRC46 leucine rich repeat containing 46 3.27229
IGFBP7 insulin-like growth factor binding protein 7 3.27229
GP5 glycoprotein V (platelet) 3.27229
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.27229
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.27229
KLHL1 kelch-like family member 1 3.27229
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.27229
SLC22A24 solute carrier family 22, member 24 3.27229
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.27229
TMPPE transmembrane protein with metallophosphoesterase domain 3.27229
MOBP myelin-associated oligodendrocyte basic protein 3.27229
EFCC1 EF-hand and coiled-coil domain containing 1 3.27229
TSPAN19 tetraspanin 19 3.27229
LMAN1L lectin, mannose-binding, 1 like 3.27229
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.27229
WNT10B wingless-type MMTV integration site family, member 10B 3.27229
LMX1B LIM homeobox transcription factor 1, beta 3.27229
LMX1A LIM homeobox transcription factor 1, alpha 3.27229
UBXN10 UBX domain protein 10 3.27229
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.27229
VAV1 vav 1 guanine nucleotide exchange factor 3.27229
LRRK2 leucine-rich repeat kinase 2 3.27229
FSHR follicle stimulating hormone receptor 3.27229
CTXN3 cortexin 3 3.27229
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 3.27229
IL9R interleukin 9 receptor 3.27229
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.27229
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.27229
SIGLEC15 sialic acid binding Ig-like lectin 15 3.27229
CRHBP corticotropin releasing hormone binding protein 3.27229
PHOX2A paired-like homeobox 2a 3.27229
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.27229
AREG amphiregulin 3.27229
ANGPTL5 angiopoietin-like 5 3.27229
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.27229
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.27229
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.27229
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.27229
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.27229
ANXA8 annexin A8 3.27229
CHAD chondroadherin 3.27229
SDSL serine dehydratase-like 3.27229
TGM5 transglutaminase 5 3.27229
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.27229
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.27229
CD3D CD3d molecule, delta (CD3-TCR complex) 3.27229
WFDC13 WAP four-disulfide core domain 13 3.27229
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.27229
POU3F3 POU class 3 homeobox 3 3.27229
BTBD16 BTB (POZ) domain containing 16 3.27229
ZNF679 zinc finger protein 679 3.27229
SCIN scinderin 3.27229
PRSS55 protease, serine, 55 3.27229
RUFY4 RUN and FYVE domain containing 4 3.27229
SOST sclerostin 3.27229
EBI3 Epstein-Barr virus induced 3 3.27229
SMC1B structural maintenance of chromosomes 1B 3.14746
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 3.14746
RARS2 arginyl-tRNA synthetase 2, mitochondrial 3.02041
G0S2 G0/G1 switch 2 2.94644
GYPE glycophorin E (MNS blood group) 2.94644
EXD1 exonuclease 3'-5' domain containing 1 2.86657
ZFAND6 zinc finger, AN1-type domain 6 2.81239
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 2.78041
CRY1 cryptochrome circadian clock 1 2.76043
UBE2E3 ubiquitin-conjugating enzyme E2E 3 2.74396
NCDN neurochondrin 2.7366
RNASET2 ribonuclease T2 2.70648
ZNF706 zinc finger protein 706 2.70247
SEPTIN1 septin 1 2.56135
SYTL5 synaptotagmin-like 5 2.50687
BMP2K BMP2 inducible kinase 2.48646
RAD51AP2 RAD51 associated protein 2 2.44695
SOX21 SRY (sex determining region Y)-box 21 2.44695
ZNF304 zinc finger protein 304 2.40341
RNF167 ring finger protein 167 2.40225
ZFP30 ZFP30 zinc finger protein 2.39043
CPNE5 copine V 2.36162
ZNF595 zinc finger protein 595 2.34835
KLF2 Kruppel-like factor 2 2.3473
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.3473
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.34559
TMEM184A transmembrane protein 184A 2.3363
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 2.31473
PRPF38A pre-mRNA processing factor 38A 2.30426
MYOCOS myocilin opposite strand 2.28014
NPIPB15 nuclear pore complex interacting protein family, member B15 2.28014
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 2.27013
FAM229B family with sequence similarity 229, member B 2.26645
WAPL WAPL cohesin release factor 2.26588
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.24201
SRP54 signal recognition particle 54kDa 2.23463
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.22731
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 2.21505
NBPF19 neuroblastoma breakpoint family, member 19 2.21331
GSDMB gasdermin B 2.19862
SAPCD1 suppressor APC domain containing 1 2.19741
SH3BP2 SH3-domain binding protein 2 2.19741
ZFP3 ZFP3 zinc finger protein 2.19741
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.1963
ZNF853 zinc finger protein 853 2.19597
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.19597
ACSS2 acyl-CoA synthetase short-chain family member 2 2.14042
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.12196
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.11375
HSPA1L heat shock 70kDa protein 1-like 2.10117
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 2.10117
FGF4 fibroblast growth factor 4 2.10117
ZNF280B zinc finger protein 280B 2.10117
MDC1 mediator of DNA-damage checkpoint 1 2.10117
C11ORF86 chromosome 11 open reading frame 86 2.10117
SORBS2 sorbin and SH3 domain containing 2 2.09176
TRIM41 tripartite motif containing 41 2.08636
TLCD4 TLC domain containing 4 2.08609
PLA2G15 phospholipase A2, group XV 2.07901
MID1IP1 MID1 interacting protein 1 2.07408
SKP1 S-phase kinase-associated protein 1 2.06668
IL12RB2 interleukin 12 receptor, beta 2 2.05169
ZC3H10 zinc finger CCCH-type containing 10 2.05169
CHMP6 charged multivesicular body protein 6 2.05016
ZNF529 zinc finger protein 529 2.04966
LSM12 LSM12 homolog (S. cerevisiae) 2.04898
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.03463
SLC66A2 solute carrier family 66 member 2 2.03058
ZNF736 zinc finger protein 736 2.03052

decreased expression

Symbol Name Standardized Value
MAP3K4-AS1 MAP3K4 antisense RNA 1 -3.27229
APLN apelin -3.27229
NME5 NME/NM23 family member 5 -3.27229
HCRTR2 hypocretin (orexin) receptor 2 -3.27229
BIRC3 baculoviral IAP repeat containing 3 -3.27229
WDR5B WD repeat domain 5B -3.27229
PSCA prostate stem cell antigen -3.27229
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -3.27229
SPON2 spondin 2, extracellular matrix protein -3.27229
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.27229
ERN2 endoplasmic reticulum to nucleus signaling 2 -3.27229
GPRASP1 G protein-coupled receptor associated sorting protein 1 -3.27229
KCNK13 potassium channel, two pore domain subfamily K, member 13 -3.27229
MRPL53 mitochondrial ribosomal protein L53 -3.27229
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.27229
LOC124902436 talanin -3.27229
RNF227 ring finger protein 227 -3.27229
GOLGA6L7 golgin A6 family like 7 -3.27229
FMO5 flavin containing monooxygenase 5 -3.27229
S100B S100 calcium binding protein B -3.27229
CCR6 chemokine (C-C motif) receptor 6 -3.27229
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -3.27229
ZNF436 zinc finger protein 436 -3.27229
ZZZ3 zinc finger, ZZ-type containing 3 -3.27229
COL7A1 collagen, type VII, alpha 1 -3.27229
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.27229
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 -3.27229
GPATCH11 G patch domain containing 11 -3.27229
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -3.27229
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -3.27229
ACOX2 acyl-CoA oxidase 2, branched chain -3.27229
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -3.27229
TMEM31 transmembrane protein 31 -3.27229
ERICH6B glutamate-rich 6B -3.27229
C11ORF96 chromosome 11 open reading frame 96 -3.27229
ETNPPL ethanolamine-phosphate phospho-lyase -3.27229
KLF4 Kruppel-like factor 4 (gut) -3.27229
GP1BA glycoprotein Ib (platelet), alpha polypeptide -3.27229
CD52 CD52 molecule -3.27229
HCLS1 hematopoietic cell-specific Lyn substrate 1 -3.27229
CLEC4G C-type lectin domain family 4, member G -3.27229
GOLGA8R golgin A8 family, member R -3.27229
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 -3.22487
ANGEL1 angel homolog 1 (Drosophila) -3.20017
ACTA2 actin, alpha 2, smooth muscle, aorta -3.1749
BMS1 BMS1 ribosome biogenesis factor -2.97626
SLC60A1 solute carrier family 60 member 1 -2.95532
TBRG4 transforming growth factor beta regulator 4 -2.90169
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -2.90125
OXR1 oxidation resistance 1 -2.78041
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.71743
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.71743
SCX scleraxis basic helix-loop-helix transcription factor -2.70247
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.48948
LAG3 lymphocyte-activation gene 3 -2.45766
TNC tenascin C -2.45766
SPMIP2 sperm microtubule inner protein 2 -2.45766
MTMR4 myotubularin related protein 4 -2.45211
ELP2 elongator acetyltransferase complex subunit 2 -2.44867
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.44867
NUTM1 NUT midline carcinoma, family member 1 -2.41775
TTC16 tetratricopeptide repeat domain 16 -2.39043
CRYGS crystallin, gamma S -2.39043
TFF3 trefoil factor 3 (intestinal) -2.39043
SLITRK3 SLIT and NTRK-like family, member 3 -2.39043
CPLX1 complexin 1 -2.39043
CFAP90 cilia and flagella associated protein 90 -2.39043
PDZD7 PDZ domain containing 7 -2.39043
CNR1 cannabinoid receptor 1 (brain) -2.36622
SPATA2L spermatogenesis associated 2-like -2.36162
ICOSLG inducible T-cell co-stimulator ligand -2.3473
JOSD2 Josephin domain containing 2 -2.33682
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.33682
JRKL JRK-like -2.31269
FUNDC1 FUN14 domain containing 1 -2.31213
PCNX1 pecanex 1 -2.2908
SULF2 sulfatase 2 -2.27597
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.25009
JADE2 jade family PHD finger 2 -2.24201
RNF2 ring finger protein 2 -2.24201
RPIA ribose 5-phosphate isomerase A -2.23044
DENND1B DENN/MADD domain containing 1B -2.23044
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -2.20462
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.18665
ZNF286A zinc finger protein 286A -2.16291
FGD5 FYVE, RhoGEF and PH domain containing 5 -2.12634
PLCE1 phospholipase C, epsilon 1 -2.10485
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.10226
JPH4 junctophilin 4 -2.10051
SLC25A43 solute carrier family 25, member 43 -2.0773
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.05169
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -2.05169
ACVR1C activin A receptor, type IC -2.05016
C3ORF49 chromosome 3 open reading frame 49 -2.05016
NBEAL1 neurobeachin-like 1 -2.04385
UBQLN1 ubiquilin 1 -2.03698
GYS1 glycogen synthase 1 (muscle) -2.02769
MAST4 microtubule associated serine/threonine kinase family member 4 -2.02362