NKX2-4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
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Genes

266 genes differentially expressed following the NKX2-4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C22ORF42 chromosome 22 open reading frame 42 3.15422
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.15422
GCSAM germinal center-associated, signaling and motility 3.15422
LRRD1 leucine-rich repeats and death domain containing 1 3.15422
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.15422
TPPP tubulin polymerization promoting protein 3.15422
AVPR1B arginine vasopressin receptor 1B 3.15422
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.15422
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.15422
SLC46A3 solute carrier family 46, member 3 3.15422
GJC2 gap junction protein, gamma 2, 47kDa 3.15422
MEIG1 meiosis/spermiogenesis associated 1 3.15422
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.15422
R3HDML R3H domain containing-like 3.15422
ZNF831 zinc finger protein 831 3.15422
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.14555
SKOR2 SKI family transcriptional corepressor 2 3.14555
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.14555
GJB3 gap junction protein, beta 3, 31kDa 3.14555
RRAD Ras-related associated with diabetes 3.14555
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.14555
UPB1 ureidopropionase, beta 3.14555
PGBDF plakoglobin binding and degradation factor 3.14555
NANOS3 nanos homolog 3 (Drosophila) 3.14555
IGFL2 IGF-like family member 2 3.14555
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.14555
SLC25A41 solute carrier family 25, member 41 3.14555
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.14555
OLIG1 oligodendrocyte transcription factor 1 3.14555
FAM216B family with sequence similarity 216, member B 3.14555
HRG histidine-rich glycoprotein 3.14555
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.14555
FAM9B family with sequence similarity 9, member B 3.14555
HIC1 hypermethylated in cancer 1 3.14555
KCNU1 potassium channel, subfamily U, member 1 3.14555
SPACA5 sperm acrosome associated 5 3.14555
PRDM12 PR domain containing 12 3.14555
TAS2R19 taste receptor, type 2, member 19 3.14555
MISP mitotic spindle positioning 3.14555
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.14555
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.14555
C9ORF152 chromosome 9 open reading frame 152 3.14555
C3ORF22 chromosome 3 open reading frame 22 3.14555
FBLN7 fibulin 7 3.14555
TCAF2 TRPM8 channel-associated factor 2 3.14555
PARP3 poly (ADP-ribose) polymerase family, member 3 3.14555
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.14555
LRRC71 leucine rich repeat containing 71 3.14555
LRRC72 leucine rich repeat containing 72 3.14555
KRABD1 KRAB domain containing 1 3.14555
SMCP sperm mitochondria-associated cysteine-rich protein 3.14555
CCDC42 coiled-coil domain containing 42 3.14555
IMPG1 interphotoreceptor matrix proteoglycan 1 3.14555
TSPAN8 tetraspanin 8 3.14555
TMEM40 transmembrane protein 40 3.14555
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.14555
STMN4 stathmin-like 4 3.14555
OTOS otospiralin 3.14555
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 3.14555
FAM237B family with sequence similarity 237 member B 3.14555
SMIM35 small integral membrane protein 35 3.14555
SRARP steroid receptor associated and regulated protein 3.14555
LY6S-AS1 LY6S antisense RNA 1 3.14555
CIMIP2B ciliary microtubule inner protein 2B 3.14555
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.14555
SAA1 serum amyloid A1 3.14555
CD274 CD274 molecule 3.14555
TPBGL trophoblast glycoprotein-like 3.14555
CFHR3 complement factor H-related 3 3.14555
PDILT protein disulfide isomerase-like, testis expressed 3.14555
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.14555
PCDHA8 protocadherin alpha 8 3.14555
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.14555
C5ORF52 chromosome 5 open reading frame 52 3.14555
ZBTB16 zinc finger and BTB domain containing 16 3.14555
MAG myelin associated glycoprotein 3.14555
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.14555
C10ORF67 chromosome 10 open reading frame 67 3.14555
UROC1 urocanate hydratase 1 3.14555
MIP major intrinsic protein of lens fiber 3.14555
C1QL2 complement component 1, q subcomponent-like 2 3.14555
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.14555
CCR8 chemokine (C-C motif) receptor 8 3.14555
ACKR5 atypical chemokine receptor 5 3.14555
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.14555
LRRC46 leucine rich repeat containing 46 3.14555
MAGEA2B melanoma antigen family A2B 3.14555
TBX2 T-box 2 3.14555
EBF3 early B-cell factor 3 3.14555
MBOAT2 membrane bound O-acyltransferase domain containing 2 3.14555
GML glycosylphosphatidylinositol anchored molecule like 3.14555
HGFAC HGF activator 3.14555
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.14555
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.14555
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.14555
PRSS57 protease, serine, 57 3.14555
MC5R melanocortin 5 receptor 3.14555
BRDT bromodomain, testis-specific 3.14555
EPGN epithelial mitogen 3.14555
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.14555
TDRD10 tudor domain containing 10 3.14555
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.14555
POU2AF1 POU class 2 associating factor 1 3.14555
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.14555
GOLGA6A golgin A6 family, member A 3.14555
KLHL41 kelch-like family member 41 3.14555
TAS2R50 taste receptor, type 2, member 50 3.14555
CDHR5 cadherin-related family member 5 3.14555
ARR3 arrestin 3, retinal (X-arrestin) 3.14555
AQP8 aquaporin 8 3.14555
MCCD1 mitochondrial coiled-coil domain 1 3.14555
CERKL ceramide kinase-like 3.14555
NUTM2D NUT family member 2D 3.14555
SCN3A sodium channel, voltage gated, type III alpha subunit 3.14555
TGM7 transglutaminase 7 3.14555
TMEM156 transmembrane protein 156 3.14555
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.14555
FCAR Fc fragment of IgA receptor 3.14555
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.14555
ERICH6B glutamate-rich 6B 3.14555
GBX2 gastrulation brain homeobox 2 3.14555
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.14555
MB myoglobin 3.14555
NYX nyctalopin 3.14555
WDR26 WD repeat domain 26 3.14555
PATE2 prostate and testis expressed 2 3.14555
GH1 growth hormone 1 3.14555
CARNS1 carnosine synthase 1 3.14555
OTOP2 otopetrin 2 3.14555
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.14555
NR2E1 nuclear receptor subfamily 2, group E, member 1 3.14555
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.05957
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 2.92071
CRTC1 CREB regulated transcription coactivator 1 2.9125
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.80213
USPL1 ubiquitin specific peptidase like 1 2.80213
KIF20B kinesin family member 20B 2.7962
RIF1 replication timing regulatory factor 1 2.68938
NRIP3 nuclear receptor interacting protein 3 2.47785
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 2.47785
DPP6 dipeptidyl-peptidase 6 2.46882
EDA ectodysplasin A 2.40387
RNASEH2C ribonuclease H2, subunit C 2.37356
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.34986
EBI3 Epstein-Barr virus induced 3 2.32705
MYBPHL myosin binding protein H-like 2.32705
ENDOU endonuclease, polyU-specific 2.32705
OAZ3 ornithine decarboxylase antizyme 3 2.32705
TMEM238L transmembrane protein 238 like 2.32705
AQP3 aquaporin 3 (Gill blood group) 2.26728
ZNF830 zinc finger protein 830 2.2648
TMEM88 transmembrane protein 88 2.2648
BAHCC1 BAH domain and coiled-coil containing 1 2.2648
OXER1 oxoeicosanoid (OXE) receptor 1 2.2648
DPY19L1 dpy-19-like 1 (C. elegans) 2.2585
UBL7 ubiquitin-like 7 2.25771
GREB1L growth regulation by estrogen in breast cancer-like 2.22519
MOAP1 modulator of apoptosis 1 2.21295
BDNF brain-derived neurotrophic factor 2.20531
ZNF649 zinc finger protein 649 2.20531
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.19334
XYLT1 xylosyltransferase I 2.18032
PADI4 peptidyl arginine deiminase, type IV 2.13445
RPS23 ribosomal protein S23 2.12582
CEP131 centrosomal protein 131kDa 2.12116
SYN2 synapsin II 2.1211
EIF6 eukaryotic translation initiation factor 6 2.10533
ARFGEF3 ARFGEF family member 3 2.09972
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 2.08452
ZNF761 zinc finger protein 761 2.08318
NUCB2 nucleobindin 2 2.07598
ADH6 alcohol dehydrogenase 6 (class V) 2.06552
OPRM1 opioid receptor, mu 1 2.06552
AOC3 amine oxidase, copper containing 3 2.06552
CCDC92 coiled-coil domain containing 92 2.06552
PI15 peptidase inhibitor 15 2.06552
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.06493
XPC xeroderma pigmentosum, complementation group C 2.04929
PAAF1 proteasomal ATPase-associated factor 1 2.03555
SLC68A1 solute carrier family 68 member 1 2.02797
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.02533
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 2.01556
NINL ninein-like 2.00854
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2.00524

decreased expression

Symbol Name Standardized Value
LOXHD1 lipoxygenase homology domains 1 -3.15422
ANXA1 annexin A1 -3.15422
FOXJ1 forkhead box J1 -3.15422
MMP19 matrix metallopeptidase 19 -3.15422
CHADL chondroadherin-like -3.15422
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -3.15422
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -3.14555
XK X-linked Kx blood group -3.14555
TMPRSS15 transmembrane protease, serine 15 -3.14555
PCDHB4 protocadherin beta 4 -3.14555
EYS eyes shut homolog (Drosophila) -3.14555
SLC25A45 solute carrier family 25, member 45 -3.14555
MTTP microsomal triglyceride transfer protein -3.14555
EMCN endomucin -3.14555
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -3.14555
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.14555
MYCT1 myc target 1 -3.14555
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -3.14555
IZUMO1 izumo sperm-egg fusion 1 -3.14555
ACTL8 actin-like 8 -3.14555
LGSN lengsin, lens protein with glutamine synthetase domain -3.14555
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -3.14555
SPATS1 spermatogenesis associated, serine-rich 1 -3.14555
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -3.14555
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -3.14555
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.14555
SCNN1D sodium channel, non voltage gated 1 delta subunit -3.14555
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -3.14555
UBE2M ubiquitin-conjugating enzyme E2M -3.14555
BTK Bruton agammaglobulinemia tyrosine kinase -3.14555
ARL5C ADP-ribosylation factor-like 5C -3.14555
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -3.14555
PCDHB12 protocadherin beta 12 -3.14555
CDC20B cell division cycle 20B -3.14555
IL21R interleukin 21 receptor -3.14555
LEF1 lymphoid enhancer-binding factor 1 -3.14555
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -3.14555
OAF OAF homolog (Drosophila) -3.10445
WSCD2 WSC domain containing 2 -3.02166
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.99102
ADAMTSL2 ADAMTS-like 2 -2.88579
CATSPER2 cation channel, sperm associated 2 -2.79146
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.79146
RPL9 ribosomal protein L9 -2.79146
ARSI arylsulfatase family, member I -2.70439
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -2.70439
GALT galactose-1-phosphate uridylyltransferase -2.68503
CCDC86 coiled-coil domain containing 86 -2.6268
SOCS3 suppressor of cytokine signaling 3 -2.50738
TRAF3IP2 TRAF3 interacting protein 2 -2.45634
PEA15 phosphoprotein enriched in astrocytes 15 -2.38105
CHKB choline kinase beta -2.3437
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.26773
CCNH cyclin H -2.2648
PTPRR protein tyrosine phosphatase, receptor type, R -2.22975
PLGLB1 plasminogen-like B1 -2.22519
C17ORF113 chromosome 17 open reading frame 113 -2.22519
KCNRG potassium channel regulator -2.22519
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.21128
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.20531
GPR22 G protein-coupled receptor 22 -2.20531
GRM2 glutamate receptor, metabotropic 2 -2.19027
CFAP100 cilia and flagella associated protein 100 -2.19027
FADS3 fatty acid desaturase 3 -2.16695
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.16695
LAMA2 laminin, alpha 2 -2.13092
TM6SF2 transmembrane 6 superfamily member 2 -2.12116
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.1211
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.1207
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.11981
MISP3 MISP family member 3 -2.11981
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.10469
DMWD dystrophia myotonica, WD repeat containing -2.07836
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.06621
COL5A1 collagen, type V, alpha 1 -2.06529
FBXL19 F-box and leucine-rich repeat protein 19 -2.06529
GPX4 glutathione peroxidase 4 -2.04188
SESN2 sestrin 2 -2.02797
BOK BCL2-related ovarian killer -2.02533
LINGO1 leucine rich repeat and Ig domain containing 1 -2.01556
ADAM11 ADAM metallopeptidase domain 11 -2.00773
PRR14 proline rich 14 -2.00524