NKX2-5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NK2 homeobox 5|This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 1482)
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Genes

350 genes differentially expressed following the NKX2-5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.81864
CHIT1 chitinase 1 (chitotriosidase) 2.81864
SUCNR1 succinate receptor 1 2.81864
PCDHB13 protocadherin beta 13 2.81864
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.81864
THSD8 thrombospondin type 1 domain containing 8 2.81864
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.81864
RNF17 ring finger protein 17 2.81864
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.81864
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.81864
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.81864
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.81864
PCDHB9 protocadherin beta 9 2.81864
MYCT1 myc target 1 2.81864
CD8B CD8b molecule 2.81864
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.81864
MMP20 matrix metallopeptidase 20 2.81864
SPHK1 sphingosine kinase 1 2.81864
RETN resistin 2.81864
ISL1 ISL LIM homeobox 1 2.81864
SAPCD1 suppressor APC domain containing 1 2.81864
HTRA4 HtrA serine peptidase 4 2.81864
MASP2 mannan-binding lectin serine peptidase 2 2.81864
TNIP3 TNFAIP3 interacting protein 3 2.77096
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.77096
CXCL2 chemokine (C-X-C motif) ligand 2 2.77096
GARIN6 golgi associated RAB2 interactor family member 6 2.77096
POSTN periostin, osteoblast specific factor 2.77096
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.77096
DIPK1C divergent protein kinase domain 1C 2.77096
TAL2 T-cell acute lymphocytic leukemia 2 2.77096
DIPK2B divergent protein kinase domain 2B 2.77096
KRT20 keratin 20, type I 2.77096
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.77096
IL5RA interleukin 5 receptor, alpha 2.77096
GJB5 gap junction protein, beta 5, 31.1kDa 2.77096
AADACL4 arylacetamide deacetylase-like 4 2.77096
DSG3 desmoglein 3 2.77096
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.77096
SIGLEC9 sialic acid binding Ig-like lectin 9 2.77096
PAEP progestagen-associated endometrial protein 2.77096
OCSTAMP osteoclast stimulatory transmembrane protein 2.77096
MAGED4 melanoma antigen family D4 2.77096
IL18R1 interleukin 18 receptor 1 2.77096
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.77096
PRR29 proline rich 29 2.77096
OIT3 oncoprotein induced transcript 3 2.77096
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.77096
HMX1 H6 family homeobox 1 2.77096
LUZP4 leucine zipper protein 4 2.77096
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.77096
ANKRD42-DT ANKRD42 divergent transcript 2.77096
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.77096
IZUMO4 IZUMO family member 4 2.77096
CLEC14A C-type lectin domain family 14, member A 2.77096
MRC1 mannose receptor, C type 1 2.77096
MEIOSIN meiosis initiator 2.77096
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.77096
KRT77 keratin 77, type II 2.77096
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.77096
STEAP4 STEAP family member 4 2.77096
SOX18 SRY (sex determining region Y)-box 18 2.77096
MILR1 mast cell immunoglobulin-like receptor 1 2.77096
RAB41 RAB41, member RAS oncogene family 2.77096
PCDHA3 protocadherin alpha 3 2.77096
RPS14 ribosomal protein S14 2.77096
DMP1 dentin matrix acidic phosphoprotein 1 2.77096
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.77096
TEDDM1 transmembrane epididymal protein 1 2.77096
PCDHB10 protocadherin beta 10 2.77096
TRIM67 tripartite motif containing 67 2.77096
VSX2 visual system homeobox 2 2.77096
CCR6 chemokine (C-C motif) receptor 6 2.77096
PAK1IP1 PAK1 interacting protein 1 2.77096
GDF6 growth differentiation factor 6 2.77096
LTK leukocyte receptor tyrosine kinase 2.77096
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.77096
GCSAM germinal center-associated, signaling and motility 2.77096
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.77096
ASB4 ankyrin repeat and SOCS box containing 4 2.77096
ATP13A5 ATPase type 13A5 2.77096
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.77096
GPX6 glutathione peroxidase 6 2.77096
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.77096
NSG2 neuronal vesicle trafficking associated 2 2.77096
PDIA2 protein disulfide isomerase family A, member 2 2.77096
SLC46A2 solute carrier family 46, member 2 2.77096
ADGRE3 adhesion G protein-coupled receptor E3 2.77096
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.77096
MYOCOS myocilin opposite strand 2.77096
LRRC8E leucine rich repeat containing 8 family, member E 2.77096
GPR52 G protein-coupled receptor 52 2.77096
TMEM275 transmembrane protein 275 2.77096
PNMA8B PNMA family member 8B 2.77096
SPATS1 spermatogenesis associated, serine-rich 1 2.77096
HRH1 histamine receptor H1 2.77096
GJA5 gap junction protein, alpha 5, 40kDa 2.77096
CFHR4 complement factor H-related 4 2.77096
PIGR polymeric immunoglobulin receptor 2.77096
RNF150 ring finger protein 150 2.77096
FAM153A family with sequence similarity 153, member A 2.77096
XAGE3 X antigen family, member 3 2.77096
NT5C1B 5'-nucleotidase, cytosolic IB 2.77096
POU4F1 POU class 4 homeobox 1 2.77096
KRT3 keratin 3, type II 2.77096
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.77096
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.77096
FEZF2 FEZ family zinc finger 2 2.77096
SPRN shadow of prion protein homolog (zebrafish) 2.77096
TSPAN32 tetraspanin 32 2.77096
ARHGAP40 Rho GTPase activating protein 40 2.77096
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.77096
PRR15L proline rich 15-like 2.77096
C9ORF57 chromosome 9 open reading frame 57 2.77096
ACKR2 atypical chemokine receptor 2 2.77096
NUTM2F NUT family member 2F 2.77096
NUTM2D NUT family member 2D 2.77096
CARNS1 carnosine synthase 1 2.77096
IL18RAP interleukin 18 receptor accessory protein 2.77096
ERICH3 glutamate-rich 3 2.77096
LCNL1 lipocalin-like 1 2.77096
RGSL1 regulator of G-protein signaling like 1 2.77096
PRSS33 protease, serine, 33 2.77096
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.77096
KLK7 kallikrein-related peptidase 7 2.77096
NCR3 natural cytotoxicity triggering receptor 3 2.77096
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.77096
TEX19 testis expressed 19 2.77096
ART1 ADP-ribosyltransferase 1 2.77096
VWA3B von Willebrand factor A domain containing 3B 2.77096
LYPD5 LY6/PLAUR domain containing 5 2.77096
FIBIN fin bud initiation factor homolog (zebrafish) 2.77096
TRIM50 tripartite motif containing 50 2.77096
NIPAL4 NIPA-like domain containing 4 2.77096
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.77096
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.77096
PCP2 Purkinje cell protein 2 2.77096
SPATA31A1 SPATA31 subfamily A, member 1 2.77096
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.77096
CHRM1 cholinergic receptor, muscarinic 1 2.77096
RHAG Rh-associated glycoprotein 2.77096
TGM5 transglutaminase 5 2.77096
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.77096
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.77096
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.77096
PITX3 paired-like homeodomain 3 2.77096
APOA5 apolipoprotein A-V 2.77096
OSR2 odd-skipped related transciption factor 2 2.77096
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.77096
PLA2G1B phospholipase A2, group IB (pancreas) 2.77096
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.77096
C4BPA complement component 4 binding protein, alpha 2.77096
PHACTR3 phosphatase and actin regulator 3 2.77096
LRRC74A leucine rich repeat containing 74A 2.77096
CD86 CD86 molecule 2.77096
CLCF1 cardiotrophin-like cytokine factor 1 2.77096
LEP leptin 2.77096
LRRC74B leucine rich repeat containing 74B 2.77096
CCDC83 coiled-coil domain containing 83 2.77096
C5ORF46 chromosome 5 open reading frame 46 2.77096
MARCO macrophage receptor with collagenous structure 2.77096
IL23R interleukin 23 receptor 2.77096
PRSS21 protease, serine, 21 (testisin) 2.77096
STOML3 stomatin (EPB72)-like 3 2.77096
HSF2 heat shock transcription factor 2 2.73095
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.69571
KHK ketohexokinase (fructokinase) 2.68009
SPNS2 spinster homolog 2 (Drosophila) 2.6713
ILDR2 immunoglobulin-like domain containing receptor 2 2.6713
TMEM215 transmembrane protein 215 2.6713
PLCZ1 phospholipase C, zeta 1 2.6713
REEP5 receptor accessory protein 5 2.6681
SVIP small VCP/p97-interacting protein 2.64774
ZBED8 zinc finger, BED-type containing 8 2.63836
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.62222
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.6129
FAM43A family with sequence similarity 43, member A 2.56855
DCXR dicarbonyl/L-xylulose reductase 2.52803
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.50057
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.46967
SHROOM4 shroom family member 4 2.46167
FTL ferritin, light polypeptide 2.39301
PTDSS1 phosphatidylserine synthase 1 2.38758
IFT140 intraflagellar transport 140 2.38653
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 2.38365
RPS19BP1 ribosomal protein S19 binding protein 1 2.38137
IRX1 iroquois homeobox 1 2.35835
DUSP1 dual specificity phosphatase 1 2.34989
TPD52L2 tumor protein D52-like 2 2.3182
PAX5 paired box 5 2.31308
CIB1 calcium and integrin binding 1 (calmyrin) 2.31242
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.29741
CAPN6 calpain 6 2.29581
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 2.28964
ADGRA2 adhesion G protein-coupled receptor A2 2.28777
RCCD1 RCC1 domain containing 1 2.2719
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.24731
RNF4 ring finger protein 4 2.22419
NAP1L3 nucleosome assembly protein 1-like 3 2.19991
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.18302
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.17975
NARS1 asparaginyl-tRNA synthetase 1 2.15759
NEFL neurofilament, light polypeptide 2.15521
POLR1C polymerase (RNA) I polypeptide C, 30kDa 2.1394
LMBR1L limb development membrane protein 1-like 2.11602
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.11602
MUS81 MUS81 structure-specific endonuclease subunit 2.11602
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.11399
FBXO31 F-box protein 31 2.11364
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.11146
PCDHGA6 protocadherin gamma subfamily A, 6 2.09511
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.09092
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.06476
SLC49A4 solute carrier family 49 member 4 2.06153
ZNF354B zinc finger protein 354B 2.06153
CCDC126 coiled-coil domain containing 126 2.05896
METTL27 methyltransferase like 27 2.0582
MIF4GD MIF4G domain containing 2.05384
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 2.05219
FANCE Fanconi anemia, complementation group E 2.05219
WASHC5 WASH complex subunit 5 2.05012
SHANK1 SH3 and multiple ankyrin repeat domains 1 2.04829
BRD3 bromodomain containing 3 2.03483
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.021
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.01198
ASB1 ankyrin repeat and SOCS box containing 1 2.00692
HCCS holocytochrome c synthase 2.00583
RADX RPA1 related single stranded DNA binding protein, X-linked 2.0003

decreased expression

Symbol Name Standardized Value
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.81864
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.81864
C5ORF58 chromosome 5 open reading frame 58 -2.81864
ECRG4 ECRG4 augurin precursor -2.81864
TACR2 tachykinin receptor 2 -2.81864
KYNU kynureninase -2.81864
CD80 CD80 molecule -2.77096
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.77096
NPSR1 neuropeptide S receptor 1 -2.77096
PDE7B phosphodiesterase 7B -2.77096
TMEM100 transmembrane protein 100 -2.77096
APLN apelin -2.77096
ZMYND15 zinc finger, MYND-type containing 15 -2.77096
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.77096
PTK6 protein tyrosine kinase 6 -2.77096
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.77096
CDR2 cerebellar degeneration-related protein 2, 62kDa -2.77096
GYS2 glycogen synthase 2 (liver) -2.77096
HBZ hemoglobin, zeta -2.77096
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.77096
TTLL2 tubulin tyrosine ligase-like family member 2 -2.77096
NWD2 NACHT and WD repeat domain containing 2 -2.77096
FIBCD1 fibrinogen C domain containing 1 -2.77096
NR4A3 nuclear receptor subfamily 4, group A, member 3 -2.77096
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.77096
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -2.77096
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.77096
RAI2 retinoic acid induced 2 -2.77096
IGFL4 IGF-like family member 4 -2.77096
SIAH3 siah E3 ubiquitin protein ligase family member 3 -2.77096
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.77096
FCMR Fc fragment of IgM receptor -2.77096
CRACD capping protein inhibiting regulator of actin dynamics -2.77096
SLC22A31 solute carrier family 22, member 31 -2.77096
H1-6 H1.6 linker histone, cluster member -2.77096
HPGDS hematopoietic prostaglandin D synthase -2.77096
CNRIP1 cannabinoid receptor interacting protein 1 -2.77096
SYT15B synaptotagmin 15B -2.77096
UNC5C unc-5 homolog C (C. elegans) -2.77096
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.77096
C4ORF50 chromosome 4 open reading frame 50 -2.77096
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.77096
SIX1 SIX homeobox 1 -2.77096
RPS21-DT RPS21 divergent transcript -2.77096
RAD21L1 RAD21-like 1 (S. pombe) -2.77096
EFCAB9 EF-hand calcium binding domain 9 -2.77096
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.77096
ALG10B ALG10B, alpha-1,2-glucosyltransferase -2.77096
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.77096
VCX3B variable charge, X-linked 3B -2.77096
GPR83 G protein-coupled receptor 83 -2.77096
KIAA1755 KIAA1755 -2.77096
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.77096
CREB1 cAMP responsive element binding protein 1 -2.73997
PNMA3 paraneoplastic Ma antigen 3 -2.671
IL15RA interleukin 15 receptor, alpha -2.65349
VPS35L VPS35 endosomal protein sorting factor like -2.60476
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.58632
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.58632
C17ORF99 chromosome 17 open reading frame 99 -2.54708
CRACDL CRACD like -2.54708
ATAD2 ATPase family, AAA domain containing 2 -2.52168
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -2.52168
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.51728
NCOA3 nuclear receptor coactivator 3 -2.50057
MAP7D1 MAP7 domain containing 1 -2.48504
ZBTB20 zinc finger and BTB domain containing 20 -2.47932
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.41109
PACS1 phosphofurin acidic cluster sorting protein 1 -2.38504
MX2 MX dynamin-like GTPase 2 -2.38504
CCNE2 cyclin E2 -2.37661
KLHL11 kelch-like family member 11 -2.37661
SPEN spen family transcriptional repressor -2.3688
ZNF543 zinc finger protein 543 -2.32781
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.32249
MCU mitochondrial calcium uniporter -2.3135
JHY junctional cadherin complex regulator -2.3135
TENM1 teneurin transmembrane protein 1 -2.31242
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.30592
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.29581
GFM1 G elongation factor, mitochondrial 1 -2.29581
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -2.28973
COBL cordon-bleu WH2 repeat protein -2.28686
TPST1 tyrosylprotein sulfotransferase 1 -2.24731
CNIH2 cornichon family AMPA receptor auxiliary protein 2 -2.23729
FBXO4 F-box protein 4 -2.23398
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.23194
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -2.22419
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.21887
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -2.21887
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.21779
TRIM14 tripartite motif containing 14 -2.19991
CCDC158 coiled-coil domain containing 158 -2.19556
PIH1D2 PIH1 domain containing 2 -2.19556
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.16972
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.16146
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -2.16
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.15521
ICA1 islet cell autoantigen 1, 69kDa -2.1326
CCDC61 coiled-coil domain containing 61 -2.11602
NMB neuromedin B -2.11146
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.1114
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.10447
PACRG PARK2 co-regulated -2.09886
UBXN1 UBX domain protein 1 -2.09124
NIFK nucleolar protein interacting with the FHA domain of MKI67 -2.09062
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.06817
PRPF38A pre-mRNA processing factor 38A -2.06817
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -2.06423
EXT1 exostosin glycosyltransferase 1 -2.06176
EFS embryonal Fyn-associated substrate -2.05844
ENG endoglin -2.0582
INTS6 integrator complex subunit 6 -2.05219
ZNF551 zinc finger protein 551 -2.05219
TADA1 transcriptional adaptor 1 -2.03739
NSRP1 nuclear speckle splicing regulatory protein 1 -2.03588
CRYGB crystallin, gamma B -2.03483
SMC4 structural maintenance of chromosomes 4 -2.02098
CCDC88A coiled-coil domain containing 88A -2.00583
HAUS5 HAUS augmin-like complex, subunit 5 -2.00583
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.00373
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.0003