NKX2-6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NK2 homeobox 6 (NCBI Entrez Gene Database, 137814)
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Genes

247 genes differentially expressed following the NKX2-6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ASB9 ankyrin repeat and SOCS box containing 9 2.12769
SOWAHB sosondowah ankyrin repeat domain family member B 2.12769
CXCR6 chemokine (C-X-C motif) receptor 6 2.12769
CLEC2A C-type lectin domain family 2, member A 2.12769
TG thyroglobulin 2.12769
PPP5C protein phosphatase 5, catalytic subunit 2.12769
MSC musculin 2.12769
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.12769
SPDEF SAM pointed domain containing ETS transcription factor 2.12769
RINT1 RAD50 interactor 1 2.12769
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.12769
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.12769
KLHL41 kelch-like family member 41 2.12769
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.12769
LRRC61 leucine rich repeat containing 61 2.12769
MROH5 maestro heat-like repeat family member 5 2.12769
CAPS calcyphosine 2.12769
RTL9 retrotransposon Gag like 9 2.12769
ISM2 isthmin 2 2.12769
POTEI POTE ankyrin domain family, member I 2.12769
LY86 lymphocyte antigen 86 2.12769
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.09811
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.09811
PRODH2 proline dehydrogenase (oxidase) 2 2.09811
OSGIN1 oxidative stress induced growth inhibitor 1 2.09811
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.09811
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.09811
FBXL8 F-box and leucine-rich repeat protein 8 2.09811
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.09811
CELA2A chymotrypsin-like elastase family, member 2A 2.09811
IL22RA1 interleukin 22 receptor, alpha 1 2.09811
TRIM10 tripartite motif containing 10 2.09811
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.09811
PDZD9 PDZ domain containing 9 2.09811
GPR75-ASB3 GPR75-ASB3 readthrough 2.09811
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.09811
DLX4 distal-less homeobox 4 2.09811
POSTN periostin, osteoblast specific factor 2.09811
ADGB androglobin 2.09811
OTUD6A OTU deubiquitinase 6A 2.09811
SPRR1B small proline-rich protein 1B 2.09811
C11ORF87 chromosome 11 open reading frame 87 2.09811
SHTN1 shootin 1 2.09811
GPR21 G protein-coupled receptor 21 2.09811
OLIG1 oligodendrocyte transcription factor 1 2.09811
PLCH2 phospholipase C, eta 2 2.09811
PAX3 paired box 3 2.09811
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.09811
PRL prolactin 2.09811
GJB5 gap junction protein, beta 5, 31.1kDa 2.09811
GSTM5 glutathione S-transferase mu 5 2.09811
GJB2 gap junction protein, beta 2, 26kDa 2.09811
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.09811
PARVB parvin, beta 2.09811
NFASC neurofascin 2.09811
LTB4R2 leukotriene B4 receptor 2 2.09811
KRT80 keratin 80, type II 2.09811
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.09811
TMPRSS3 transmembrane protease, serine 3 2.09811
ADRB1 adrenoceptor beta 1 2.09811
LOC107986837 uncharacterized LOC107986837 2.09811
MCHR2 melanin-concentrating hormone receptor 2 2.09811
GBP2 guanylate binding protein 2, interferon-inducible 2.09811
TEX50 testis expressed 50 2.09811
DUT-AS1 DUT antisense RNA 1 2.09811
ZNF593OS ZNF593 opposite strand 2.09811
CTXND1 cortexin domain containing 1 2.09811
SPAAR small regulatory polypeptide of amino acid response 2.09811
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.09811
ALDOB aldolase B, fructose-bisphosphate 2.09811
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 2.09811
SHISA8 shisa family member 8 2.09811
ASB7 ankyrin repeat and SOCS box containing 7 2.09811
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.09811
GZMM granzyme M (lymphocyte met-ase 1) 2.09811
SACS sacsin molecular chaperone 2.09811
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.09811
MSX1 msh homeobox 1 2.09811
CLDN2 claudin 2 2.09811
LIPF lipase, gastric 2.09811
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.09811
CRACR2A calcium release activated channel regulator 2A 2.09811
FOXI2 forkhead box I2 2.09811
GAPT GRB2-binding adaptor protein, transmembrane 2.09811
GATA3 GATA binding protein 3 2.09811
GATA6 GATA binding protein 6 2.09811
SYT10 synaptotagmin X 2.09811
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.09811
PLB1 phospholipase B1 2.09811
TACR2 tachykinin receptor 2 2.09811
CDKN2A cyclin-dependent kinase inhibitor 2A 2.09811
ACKR5 atypical chemokine receptor 5 2.09811
CPZ carboxypeptidase Z 2.09811
SCML4 sex comb on midleg-like 4 (Drosophila) 2.09811
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.09811
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.09811
ADAM2 ADAM metallopeptidase domain 2 2.09811
TPSB2 tryptase beta 2 (gene/pseudogene) 2.09811
TRADD TNFRSF1A-associated via death domain 2.09811
CPA3 carboxypeptidase A3 (mast cell) 2.09811
TREH trehalase (brush-border membrane glycoprotein) 2.09811
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.09811
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.09811
DYTN dystrotelin 2.09811
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.09811
MYF6 myogenic factor 6 (herculin) 2.09811
CNTF ciliary neurotrophic factor 2.09811
ERICH4 glutamate-rich 4 2.09811
GPR12 G protein-coupled receptor 12 2.09811
TNR tenascin R 2.09811
C11ORF91 chromosome 11 open reading frame 91 2.09811
BCL2L1 BCL2-like 1 2.09811
AGXT2 alanine--glyoxylate aminotransferase 2 2.09811
LOC102723971 beta-lactoglobulin-like 2.09811
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.09811
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.09811
CTRB1 chymotrypsinogen B1 2.09811
FLRT2 fibronectin leucine rich transmembrane protein 2 2.09811
LGALS12 lectin, galactoside-binding, soluble, 12 2.09811
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.09811
CLEC18B C-type lectin domain family 18, member B 2.09811
TRIML1 tripartite motif family-like 1 2.09811
CTSS cathepsin S 2.09811
LYZ lysozyme 2.09811
KISS1 KiSS-1 metastasis-suppressor 2.09811
COL6A5 collagen, type VI, alpha 5 2.09811
EGR2 early growth response 2 2.09811
KLK3 kallikrein-related peptidase 3 2.09811
ZC3H12D zinc finger CCCH-type containing 12D 2.09811
TPPP3 tubulin polymerization-promoting protein family member 3 2.09811
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.09811
SYNGR4 synaptogyrin 4 2.09811
PHACTR3 phosphatase and actin regulator 3 2.09811
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.09811
ZC2HC1B zinc finger, C2HC-type containing 1B 2.09811
PITX1 paired-like homeodomain 1 2.09811
PITX2 paired-like homeodomain 2 2.09811
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.09811
ZNF648 zinc finger protein 648 2.09811
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.09811
TMEM88 transmembrane protein 88 2.09811
PLA2G1B phospholipase A2, group IB (pancreas) 2.09811
OR4E2 olfactory receptor, family 4, subfamily E, member 2 2.09811
PCDHGA11 protocadherin gamma subfamily A, 11 2.09811
KIAA1755 KIAA1755 2.09811
PRDM12 PR domain containing 12 2.09811
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.09811
PBX4 pre-B-cell leukemia homeobox 4 2.09811
TCEAL5 transcription elongation factor A (SII)-like 5 2.09811
RXRG retinoid X receptor, gamma 2.09811
HIC1 hypermethylated in cancer 1 2.09811
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.09811
ZNF804B zinc finger protein 804B 2.09811
TRAF3IP3 TRAF3 interacting protein 3 2.09811
GREM1 gremlin 1, DAN family BMP antagonist 2.09811
POTEF POTE ankyrin domain family, member F 2.09811
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.09811
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.09811
WDFY4 WDFY family member 4 2.09811
TBC1D21 TBC1 domain family, member 21 2.09811
AGRP agouti related neuropeptide 2.09811
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.09811
TMEM181 transmembrane protein 181 2.09811
POTED POTE ankyrin domain family, member D 2.09811
GH1 growth hormone 1 2.09811
TEX35 testis expressed 35 2.09811
TMPRSS15 transmembrane protease, serine 15 2.09811
THEM5 thioesterase superfamily member 5 2.09811
SYTL4 synaptotagmin-like 4 2.09811
CD80 CD80 molecule 2.09811
ZC3H7B zinc finger CCCH-type containing 7B 2.08956
AIG1 androgen-induced 1 2.07543
COL28A1 collagen, type XXVIII, alpha 1 2.07224
RP1L1 retinitis pigmentosa 1-like 1 2.0715
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.05742
E2F5 E2F transcription factor 5, p130-binding 2.01302

decreased expression

Symbol Name Standardized Value
ZNF222 zinc finger protein 222 -2.12769
RCN2 reticulocalbin 2, EF-hand calcium binding domain -2.12769
SCO2 SCO2 cytochrome c oxidase assembly protein -2.12769
CCDC39 coiled-coil domain containing 39 -2.12769
PCDHGA7 protocadherin gamma subfamily A, 7 -2.12143
C11ORF52 chromosome 11 open reading frame 52 -2.11351
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.09811
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.09811
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.09811
CHADL chondroadherin-like -2.09811
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.09811
CD1D CD1d molecule -2.09811
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.09811
TPD52 tumor protein D52 -2.09811
C1ORF198 chromosome 1 open reading frame 198 -2.09811
NME5 NME/NM23 family member 5 -2.09811
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.09811
CEP104 centrosomal protein 104kDa -2.09811
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.09811
TEX101 testis expressed 101 -2.09811
THSD8 thrombospondin type 1 domain containing 8 -2.09811
CIMAP1D CIMAP1 family member D -2.09811
GARIN1A golgi associated RAB2 interactor 1A -2.09811
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -2.09811
INTS15 integrator complex subunit 15 -2.09811
SMIM38 small integral membrane protein 38 -2.09811
ACP3 acid phosphatase 3 -2.09811
MYG1 MYG1 exonuclease -2.09811
FAM185A family with sequence similarity 185, member A -2.09811
ACTA2 actin, alpha 2, smooth muscle, aorta -2.09811
F11R F11 receptor -2.09811
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -2.09811
NPFF neuropeptide FF-amide peptide precursor -2.09811
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.09811
NRF1 nuclear respiratory factor 1 -2.09811
CEP295NL CEP295 N-terminal like -2.09811
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.09811
OGFRL1 opioid growth factor receptor-like 1 -2.09811
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.09811
CXCR4 chemokine (C-X-C motif) receptor 4 -2.09811
C5ORF22 chromosome 5 open reading frame 22 -2.09811
EEF1G eukaryotic translation elongation factor 1 gamma -2.09811
HUS1B HUS1 checkpoint homolog b (S. pombe) -2.09811
FAM209B family with sequence similarity 209, member B -2.09811
MZB1 marginal zone B and B1 cell-specific protein -2.09811
IL3RA interleukin 3 receptor, alpha (low affinity) -2.09811
LRRC3 leucine rich repeat containing 3 -2.09811
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -2.09811
ABLIM3 actin binding LIM protein family, member 3 -2.09811
CCDC71 coiled-coil domain containing 71 -2.09811
TMEM107 transmembrane protein 107 -2.09811
FZD7 frizzled class receptor 7 -2.09811
MARVELD1 MARVEL domain containing 1 -2.09811
LMBRD2 LMBR1 domain containing 2 -2.09811
FGF8 fibroblast growth factor 8 (androgen-induced) -2.09811
S100A2 S100 calcium binding protein A2 -2.09811
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.09811
FANCD2OS FANCD2 opposite strand -2.09811
TTLL3 tubulin tyrosine ligase-like family member 3 -2.09811
ASCL3 achaete-scute family bHLH transcription factor 3 -2.09811
ZC3H8 zinc finger CCCH-type containing 8 -2.09811
ZNF324B zinc finger protein 324B -2.09811
C5AR1 complement component 5a receptor 1 -2.09811
HEPHL1 hephaestin-like 1 -2.09811
NOTCH4 notch 4 -2.04853
CFAP70 cilia and flagella associated protein 70 -2.04853
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.04853
LIF leukemia inhibitory factor -2.04853
RLN1 relaxin 1 -2.03931
FAM222A family with sequence similarity 222, member A -2.01302
PTS 6-pyruvoyltetrahydropterin synthase -2.00985