NKX2-8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
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Genes

370 genes differentially expressed following the NKX2-8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HCRTR1 hypocretin (orexin) receptor 1 3.93177
ARSH arylsulfatase family, member H 3.93177
YPEL4 yippee-like 4 (Drosophila) 3.93177
NWD2 NACHT and WD repeat domain containing 2 3.93177
KLK14 kallikrein-related peptidase 14 3.93177
RERGL RERG/RAS-like 3.93177
PDZD9 PDZ domain containing 9 3.93177
GDF6 growth differentiation factor 6 3.93177
MUC16 mucin 16, cell surface associated 3.93177
MEIKIN meiotic kinetochore factor 3.93177
TMEM179 transmembrane protein 179 3.93177
CREG2 cellular repressor of E1A-stimulated genes 2 3.93177
TMED6 transmembrane emp24 protein transport domain containing 6 3.93177
LIX1 Lix1 homolog (chicken) 3.93177
GOLGA6A golgin A6 family, member A 3.93177
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.93177
FGD2 FYVE, RhoGEF and PH domain containing 2 3.93177
APOD apolipoprotein D 3.93177
CFAP100 cilia and flagella associated protein 100 3.93177
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.93177
CNR2 cannabinoid receptor 2 (macrophage) 3.93177
RBBP8NL RBBP8 N-terminal like 3.93177
CFAP126 cilia and flagella associated protein 126 3.93177
RHEX regulator of hemoglobinization and erythroid cell expansion 3.93177
TMEM238L transmembrane protein 238 like 3.93177
CDH22 cadherin 22, type 2 3.93177
PCDHGB4 protocadherin gamma subfamily B, 4 3.93177
RNASE7 ribonuclease, RNase A family, 7 3.93177
MOG myelin oligodendrocyte glycoprotein 3.93177
GARIN1A golgi associated RAB2 interactor 1A 3.93177
LYPD5 LY6/PLAUR domain containing 5 3.93177
SYT5 synaptotagmin V 3.93177
TRIM74 tripartite motif containing 74 3.79801
FOXD1 forkhead box D1 3.79801
TRIM73 tripartite motif containing 73 3.79801
GPR22 G protein-coupled receptor 22 3.79801
NEU4 sialidase 4 3.79801
IFI27 interferon, alpha-inducible protein 27 3.79801
GRXCR2 glutaredoxin, cysteine rich 2 3.79801
ASB17 ankyrin repeat and SOCS box containing 17 3.79801
BMP8B bone morphogenetic protein 8b 3.79801
APOA5 apolipoprotein A-V 3.79801
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.79801
CCL5 chemokine (C-C motif) ligand 5 3.79801
TMEM151A transmembrane protein 151A 3.79801
MMP20 matrix metallopeptidase 20 3.79801
CRISP2 cysteine-rich secretory protein 2 3.79801
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.79801
THRSP thyroid hormone responsive 3.79801
CD34 CD34 molecule 3.79801
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.79801
EPHB3 EPH receptor B3 3.79801
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.79801
STEAP4 STEAP family member 4 3.79801
HES2 hes family bHLH transcription factor 2 3.79801
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.79801
ETV2 ets variant 2 3.79801
LGALS4 lectin, galactoside-binding, soluble, 4 3.79801
SYCE3 synaptonemal complex central element protein 3 3.79801
PSCA prostate stem cell antigen 3.79801
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.79801
C1ORF141 chromosome 1 open reading frame 141 3.79801
SNAI2 snail family zinc finger 2 3.79801
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.79801
RAPSN receptor-associated protein of the synapse 3.79801
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.79801
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.79801
ATXN7L2 ataxin 7-like 2 3.79801
SPMIP1 sperm microtubule inner protein 1 3.79801
CCER2 coiled-coil glutamate-rich protein 2 3.79801
ACER1 alkaline ceramidase 1 3.79801
SPRR2F small proline-rich protein 2F 3.79801
PKD2L1 polycystic kidney disease 2-like 1 3.79801
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.79801
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 3.79801
FCMR Fc fragment of IgM receptor 3.79801
TBX10 T-box 10 3.79801
C3AR1 complement component 3a receptor 1 3.79801
NECTIN4 nectin cell adhesion molecule 4 3.79801
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.79801
TEKTL1 tektin like 1 3.79801
SPATA31F1 SPATA31 subfamily F member 1 3.79801
EPCIP exosomal polycystin 1 interacting protein 3.79801
H2BK1 H2B.K variant histone 1 3.79801
MYMK myomaker, myoblast fusion factor 3.79801
TEX13C TEX13 family member C 3.79801
CCDC190 coiled-coil domain containing 190 3.79801
TMEM271 transmembrane protein 271 3.79801
ZNF705D zinc finger protein 705D 3.79801
SAMD15 sterile alpha motif domain containing 15 3.79801
SASH3 SAM and SH3 domain containing 3 3.79801
LOC122455340 uncharacterized LOC122455340 3.79801
HHEX hematopoietically expressed homeobox 3.79801
FRMD7 FERM domain containing 7 3.79801
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 3.79801
TAS2R3 taste receptor, type 2, member 3 3.79801
FOLR1 folate receptor 1 (adult) 3.79801
FGF21 fibroblast growth factor 21 3.79801
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.79801
PCDHA3 protocadherin alpha 3 3.79801
DTHD1 death domain containing 1 3.79801
ITK IL2-inducible T-cell kinase 3.79801
BARX2 BARX homeobox 2 3.79801
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.79801
RASAL3 RAS protein activator like 3 3.79801
MIA melanoma inhibitory activity 3.79801
TLR8 toll-like receptor 8 3.79801
CKM creatine kinase, muscle 3.79801
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.79801
THPO thrombopoietin 3.79801
PGAM4 phosphoglycerate mutase family member 4 3.79801
IL17REL interleukin 17 receptor E-like 3.79801
LCN2 lipocalin 2 3.79801
HEMGN hemogen 3.79801
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.79801
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.79801
TBC1D28 TBC1 domain family, member 28 3.79801
GOLGA6C golgin A6 family, member C 3.79801
AKNAD1 AKNA domain containing 1 3.79801
SPATA4 spermatogenesis associated 4 3.79801
NUTM2B NUT family member 2B 3.79801
EPO erythropoietin 3.79801
CLEC4E C-type lectin domain family 4, member E 3.79801
TRIM50 tripartite motif containing 50 3.79801
AMER3 APC membrane recruitment protein 3 3.79801
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.79801
KIF4B kinesin family member 4B 3.79801
PRSS55 protease, serine, 55 3.79801
MRLN myoregulin 3.79801
LCT lactase 3.79801
KRT9 keratin 9, type I 3.79801
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.79801
LRCOL1 leucine rich colipase-like 1 3.79801
CDC20B cell division cycle 20B 3.79801
PCDHGB5 protocadherin gamma subfamily B, 5 3.79801
IL13RA2 interleukin 13 receptor, alpha 2 3.79801
PMP2 peripheral myelin protein 2 3.79801
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.79801
PIH1D2 PIH1 domain containing 2 3.79801
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.79801
PDCD1 programmed cell death 1 3.79801
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.79801
SUCNR1 succinate receptor 1 3.79801
NPAS4 neuronal PAS domain protein 4 3.79801
PXT1 peroxisomal, testis specific 1 3.79801
NT5C1B 5'-nucleotidase, cytosolic IB 3.79801
CA5A carbonic anhydrase VA, mitochondrial 3.79801
BPIFC BPI fold containing family C 3.79801
PADI6 peptidyl arginine deiminase, type VI 3.79801
PGR progesterone receptor 3.79801
TCAP titin-cap 3.79801
TAS2R46 taste receptor, type 2, member 46 3.79801
HMGB4 high mobility group box 4 3.79801
CXORF49C chromosome X open reading frame 49C 3.79801
SHISA3 shisa family member 3 3.79801
CLEC18A C-type lectin domain family 18, member A 3.79801
TRIML1 tripartite motif family-like 1 3.79801
GPR179 G protein-coupled receptor 179 3.79801
GOLGA8R golgin A8 family, member R 3.79801
STOML3 stomatin (EPB72)-like 3 3.79801
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.79801
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.79801
PCDHGA7 protocadherin gamma subfamily A, 7 3.79801
ITGB7 integrin, beta 7 3.79801
TIPE2 TNF alpha induced protein 8 like 2 3.79801
GATA5 GATA binding protein 5 3.79801
FBXO40 F-box protein 40 3.79801
SUN3 Sad1 and UNC84 domain containing 3 3.79801
CLCA1 chloride channel accessory 1 3.79801
CALR3 calreticulin 3 3.79801
IL9R interleukin 9 receptor 3.79801
APOL6 apolipoprotein L, 6 3.79801
GCM1 glial cells missing homolog 1 (Drosophila) 3.79801
ITPKA inositol-trisphosphate 3-kinase A 3.79801
CRHBP corticotropin releasing hormone binding protein 3.79801
LAMP5 lysosomal-associated membrane protein family, member 5 3.79801
FBXL22 F-box and leucine-rich repeat protein 22 3.69819
CNGB3 cyclic nucleotide gated channel beta 3 3.69819
RBM46 RNA binding motif protein 46 3.69819
RINL Ras and Rab interactor-like 3.35
HADH hydroxyacyl-CoA dehydrogenase 3.34406
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.16812
NIPSNAP3B nipsnap homolog 3B (C. elegans) 3.08625
SPATA12 spermatogenesis associated 12 2.97508
SMIM36 small integral membrane protein 36 2.97312
DPYSL2 dihydropyrimidinase-like 2 2.89634
HOMER1 homer scaffolding protein 1 2.84825
TBC1D31 TBC1 domain family, member 31 2.71175
OLFML3 olfactomedin-like 3 2.67626
MBP myelin basic protein 2.65129
MEI1 meiosis inhibitor 1 2.62826
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.62826
RHOV ras homolog family member V 2.62826
STX6 syntaxin 6 2.62826
IL33 interleukin 33 2.62826
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.60291
ARRB1 arrestin, beta 1 2.60291
PXDN peroxidasin 2.56937
RGPD8 RANBP2-like and GRIP domain containing 8 2.5352
SRRT serrate, RNA effector molecule 2.50891
CDK11B cyclin-dependent kinase 11B 2.48761
GPR137 G protein-coupled receptor 137 2.484
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.45979
DNER delta/notch-like EGF repeat containing 2.43334
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) 2.43265
STIM2 stromal interaction molecule 2 2.42192
CCDC47 coiled-coil domain containing 47 2.41298
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.4049
PMVK phosphomevalonate kinase 2.40175
INO80 INO80 complex subunit 2.40153
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.39625
ZNF396 zinc finger protein 396 2.39279
UHMK1 U2AF homology motif (UHM) kinase 1 2.38949
DSCAM Down syndrome cell adhesion molecule 2.37956
RGPD3 RANBP2-like and GRIP domain containing 3 2.37309
MYO9A myosin IXA 2.36491
DOC2A double C2-like domains, alpha 2.33538
STK17A serine/threonine kinase 17a 2.3187
TMEM25 transmembrane protein 25 2.30318
CCDC38 coiled-coil domain containing 38 2.30318
KANK2 KN motif and ankyrin repeat domains 2 2.30157
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.29223
TRIB3 tribbles pseudokinase 3 2.26144
AKIRIN2 akirin 2 2.23757
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 2.22272
PUSL1 pseudouridylate synthase-like 1 2.22146
GREB1L growth regulation by estrogen in breast cancer-like 2.2019
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.1611
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.15559
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.12779
MRO maestro 2.12779
CLIP3 CAP-GLY domain containing linker protein 3 2.12686
PHACTR1 phosphatase and actin regulator 1 2.12686
EIF1AX eukaryotic translation initiation factor 1A, X-linked 2.12071
FGF11 fibroblast growth factor 11 2.11185
CYSTM1 cysteine-rich transmembrane module containing 1 2.09715
NPB neuropeptide B 2.08867
PRSS27 protease, serine 27 2.08867
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.08446
MAPK3 mitogen-activated protein kinase 3 2.08446
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.08446
ECI2 enoyl-CoA delta isomerase 2 2.08113
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.08113
GATAD2A GATA zinc finger domain containing 2A 2.07316
TBCK TBC1 domain containing kinase 2.06463
ZNF664-RFLNA ZNF664-RFLNA readthrough 2.04385
CDH20 cadherin 20, type 2 2.04196
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.04135
PAPOLG poly(A) polymerase gamma 2.02742

decreased expression

Symbol Name Standardized Value
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -3.93177
SERF1A small EDRK-rich factor 1A (telomeric) -3.93177
WDR5B WD repeat domain 5B -3.93177
ATG4A autophagy related 4A, cysteine peptidase -3.93177
LBP lipopolysaccharide binding protein -3.93177
TULP2 tubby like protein 2 -3.93177
HPSE heparanase -3.93177
GYS2 glycogen synthase 2 (liver) -3.79801
PRSS22 protease, serine, 22 -3.79801
SLC9C2 solute carrier family 9, member C2 (putative) -3.79801
STAP1 signal transducing adaptor family member 1 -3.79801
MAGED4 melanoma antigen family D4 -3.79801
C8ORF74 chromosome 8 open reading frame 74 -3.79801
ATOH7 atonal homolog 7 (Drosophila) -3.79801
SPAG8 sperm associated antigen 8 -3.79801
ZBTB42 zinc finger and BTB domain containing 42 -3.79801
ETV7 ets variant 7 -3.79801
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -3.79801
CTXND1 cortexin domain containing 1 -3.79801
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.79801
GPAT3 glycerol-3-phosphate acyltransferase 3 -3.79801
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -3.79801
DDTL D-dopachrome tautomerase-like -3.79801
NPFF neuropeptide FF-amide peptide precursor -3.79801
MYH15 myosin, heavy chain 15 -3.79801
S1PR5 sphingosine-1-phosphate receptor 5 -3.79801
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -3.79801
SCRG1 stimulator of chondrogenesis 1 -3.79801
UPK3A uroplakin 3A -3.79801
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -3.79801
ZEB2 zinc finger E-box binding homeobox 2 -3.79801
DNASE1L2 deoxyribonuclease I-like 2 -3.79801
SYT15B synaptotagmin 15B -3.79801
ZBED6 zinc finger, BED-type containing 6 -3.79801
FCRLB Fc receptor-like B -3.79801
NPM2 nucleophosmin/nucleoplasmin 2 -3.79801
RAD21L1 RAD21-like 1 (S. pombe) -3.79801
RAD9B RAD9 homolog B (S. pombe) -3.79801
CHAD chondroadherin -3.79801
C11ORF96 chromosome 11 open reading frame 96 -3.79801
CLPSL1 colipase-like 1 -3.79801
SEZ6L seizure related 6 homolog (mouse)-like -3.79801
ERICH6B glutamate-rich 6B -3.79801
GOLGA8H golgin A8 family, member H -3.79801
CA7 carbonic anhydrase VII -3.79114
PGBD5 piggyBac transposable element derived 5 -3.58685
NKTR natural killer cell triggering receptor -3.55208
STAG3 stromal antigen 3 -3.16156
DEF6 differentially expressed in FDCP 6 homolog (mouse) -3.16039
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -3.09517
CCDC137 coiled-coil domain containing 137 -3.09402
B9D2 B9 protein domain 2 -3.00586
F12 coagulation factor XII (Hageman factor) -2.97257
RNF150 ring finger protein 150 -2.95805
TPRN taperin -2.94746
GRHL3 grainyhead-like 3 (Drosophila) -2.75819
ZIC1 Zic family member 1 -2.75819
SYPL2 synaptophysin-like 2 -2.75819
VEZT vezatin, adherens junctions transmembrane protein -2.71351
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.68858
MRPL20 mitochondrial ribosomal protein L20 -2.66931
KIAA1958 KIAA1958 -2.66167
FAM234B family with sequence similarity 234 member B -2.64117
VIM vimentin -2.63746
ZNF837 zinc finger protein 837 -2.49057
BID BH3 interacting domain death agonist -2.48627
ADAMTSL1 ADAMTS-like 1 -2.48242
PGRMC1 progesterone receptor membrane component 1 -2.4731
ZNF764 zinc finger protein 764 -2.4644
CREB5 cAMP responsive element binding protein 5 -2.45968
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -2.43571
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.41704
ZNF507 zinc finger protein 507 -2.41704
RTP1 receptor (chemosensory) transporter protein 1 -2.40552
SLC22A14 solute carrier family 22, member 14 -2.40552
GSTP1 glutathione S-transferase pi 1 -2.40153
COA6 cytochrome c oxidase assembly factor 6 -2.40084
C19ORF47 chromosome 19 open reading frame 47 -2.39959
SORD sorbitol dehydrogenase -2.38949
TRAPPC2L trafficking protein particle complex 2-like -2.3757
NXT1 nuclear transport factor 2-like export factor 1 -2.3756
SLC25A35 solute carrier family 25, member 35 -2.36461
IFI35 interferon-induced protein 35 -2.3624
SPATA16 spermatogenesis associated 16 -2.35544
SFRP4 secreted frizzled-related protein 4 -2.35544
PHEX phosphate regulating endopeptidase homolog, X-linked -2.31708
NRK Nik related kinase -2.3053
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.30157
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.29976
RCAN2 regulator of calcineurin 2 -2.27696
ACTL6B actin-like 6B -2.27667
KASH5 KASH domain containing 5 -2.27667
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.25112
SLC61A1 solute carrier family 61 member 1 -2.25112
PIDD1 p53-induced death domain protein 1 -2.22897
MRPL15 mitochondrial ribosomal protein L15 -2.22195
RGS5 regulator of G-protein signaling 5 -2.2019
B3GLCT beta 3-glucosyltransferase -2.18415
CNOT11 CCR4-NOT transcription complex, subunit 11 -2.16804
RBSN rabenosyn, RAB effector -2.16804
MBD3 methyl-CpG binding domain protein 3 -2.15786
POM121C POM121 transmembrane nucleoporin C -2.15559
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.12779
PCGF5 polycomb group ring finger 5 -2.11012
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.10731
PLBD1 phospholipase B domain containing 1 -2.10258
HINT1 histidine triad nucleotide binding protein 1 -2.08446
STAMBPL1 STAM binding protein-like 1 -2.08113
DRC11 dynein regulatory complex subunit 11 -2.07105
CCND3 cyclin D3 -2.07105
RFTN1 raftlin, lipid raft linker 1 -2.06561
UVRAG UV radiation resistance associated -2.06463
CCNA2 cyclin A2 -2.05486
PEX5 peroxisomal biogenesis factor 5 -2.04475
BTBD17 BTB (POZ) domain containing 17 -2.04475
CFAP73 cilia and flagella associated protein 73 -2.04475
STARD9 StAR-related lipid transfer (START) domain containing 9 -2.02988
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.02964
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.02742
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.00448
PLXNA2 plexin A2 -2.00197