NKX3-1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NK3 homeobox 1|This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 4824)
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Genes

304 genes differentially expressed following the NKX3-1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 2.65747
OXER1 oxoeicosanoid (OXE) receptor 1 2.65747
CELA1 chymotrypsin-like elastase family, member 1 2.65747
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.65747
PRELP proline/arginine-rich end leucine-rich repeat protein 2.65747
MOGAT3 monoacylglycerol O-acyltransferase 3 2.65747
UBQLNL ubiquilin-like 2.65747
GMFG glia maturation factor, gamma 2.65747
CRYGN crystallin, gamma N 2.65747
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.65747
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.65747
GRAP2 GRB2-related adaptor protein 2 2.65747
CYS1 cystin 1 2.65747
C9ORF64 chromosome 9 open reading frame 64 2.65747
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.65747
ANKRD53 ankyrin repeat domain 53 2.65747
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.65747
TMSB15C thymosin beta 15C 2.65747
CLEC14A C-type lectin domain family 14, member A 2.65747
LINC02798 long intergenic non-protein coding RNA 2798 2.65747
PVRIG poliovirus receptor related immunoglobulin domain containing 2.65747
CCN6 cellular communication network factor 6 2.65747
ITK IL2-inducible T-cell kinase 2.65747
SIGLEC15 sialic acid binding Ig-like lectin 15 2.65747
H1-6 H1.6 linker histone, cluster member 2.65747
TUBB6 tubulin, beta 6 class V 2.61714
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.58826
DNASE1L2 deoxyribonuclease I-like 2 2.58826
AKR1C2 aldo-keto reductase family 1, member C2 2.58826
PRICKLE4 prickle homolog 4 (Drosophila) 2.58826
ZNF99 zinc finger protein 99 2.58826
GPR55 G protein-coupled receptor 55 2.58826
IGFL4 IGF-like family member 4 2.58826
GJA3 gap junction protein, alpha 3, 46kDa 2.58826
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.58826
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.58826
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.58826
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 2.58826
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.58826
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.58826
IL2RA interleukin 2 receptor, alpha 2.58826
LBX2 ladybird homeobox 2 2.58826
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.58826
BRICD5 BRICHOS domain containing 5 2.58826
S100A5 S100 calcium binding protein A5 2.58826
SYCE3 synaptonemal complex central element protein 3 2.58826
CRH corticotropin releasing hormone 2.58826
CD68 CD68 molecule 2.58826
TMEM217 transmembrane protein 217 2.58826
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.58826
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.58826
SMIM8 small integral membrane protein 8 2.58826
NCKAP1L NCK-associated protein 1-like 2.58826
TUBB1 tubulin, beta 1 class VI 2.58826
ESX1 ESX homeobox 1 2.58826
FETUB fetuin B 2.58826
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.58826
FAM153A family with sequence similarity 153, member A 2.58826
ACER1 alkaline ceramidase 1 2.58826
SPI1 Spi-1 proto-oncogene 2.58826
STX11 syntaxin 11 2.58826
SRGN serglycin 2.58826
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.58826
LMNTD1 lamin tail domain containing 1 2.58826
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.58826
PAPOLA poly(A) polymerase alpha 2.58826
CXCL13 chemokine (C-X-C motif) ligand 13 2.58826
DEFB108B defensin, beta 108B 2.58826
IRF2-DT IRF2 divergent transcript 2.58826
H4C12 H4 clustered histone 12 2.58826
IHO1 interactor of HORMAD1 1 2.58826
TEX13D TEX13 family member D 2.58826
MAJIN membrane anchored junction protein 2.58826
GARIN1A golgi associated RAB2 interactor 1A 2.58826
NIBAN3 niban apoptosis regulator 3 2.58826
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.58826
LY6H lymphocyte antigen 6 complex, locus H 2.58826
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.58826
MYH15 myosin, heavy chain 15 2.58826
ADGRG1 adhesion G protein-coupled receptor G1 2.58826
IL5 interleukin 5 2.58826
GOLGA7B golgin A7 family, member B 2.58826
IRF5 interferon regulatory factor 5 2.58826
DTHD1 death domain containing 1 2.58826
IL12RB1 interleukin 12 receptor, beta 1 2.58826
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.58826
CREB3L3 cAMP responsive element binding protein 3-like 3 2.58826
LSP1 lymphocyte-specific protein 1 2.58826
SOAT2 sterol O-acyltransferase 2 2.58826
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.58826
GDF6 growth differentiation factor 6 2.58826
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.58826
PGA3 pepsinogen 3, group I (pepsinogen A) 2.58826
FOXI2 forkhead box I2 2.58826
ARMS2 age-related maculopathy susceptibility 2 2.58826
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.58826
SPATA31H1 SPATA31 subfamily H member 1 2.58826
GPR150 G protein-coupled receptor 150 2.58826
CD5L CD5 molecule-like 2.58826
CALHM1 calcium homeostasis modulator 1 2.58826
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.58826
FAM163B family with sequence similarity 163, member B 2.58826
SMIM23 small integral membrane protein 23 2.58826
HHATL hedgehog acyltransferase-like 2.58826
CSTA cystatin A (stefin A) 2.58826
TP63 tumor protein p63 2.58826
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.58826
NIM1K NIM1 serine/threonine protein kinase 2.58826
KIAA1549 KIAA1549 2.58826
LRRC46 leucine rich repeat containing 46 2.58826
CCDC154 coiled-coil domain containing 154 2.58826
CPZ carboxypeptidase Z 2.58826
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.58826
DMBT1 deleted in malignant brain tumors 1 2.58826
TBC1D21 TBC1 domain family, member 21 2.58826
CDH19 cadherin 19, type 2 2.58826
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.58826
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.58826
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.58826
CSDC2 cold shock domain containing C2, RNA binding 2.58826
CD28 CD28 molecule 2.58826
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.58826
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.58826
CHIT1 chitinase 1 (chitotriosidase) 2.58826
C20ORF144 chromosome 20 open reading frame 144 2.58826
TIPE2 TNF alpha induced protein 8 like 2 2.58826
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.58826
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.58826
ILF3 interleukin enhancer binding factor 3, 90kDa 2.58826
C6ORF15 chromosome 6 open reading frame 15 2.58826
IL1A interleukin 1, alpha 2.58826
CCL19 chemokine (C-C motif) ligand 19 2.58826
MUC17 mucin 17, cell surface associated 2.58826
MUC13 mucin 13, cell surface associated 2.58826
NUTM2D NUT family member 2D 2.58826
POU3F2 POU class 3 homeobox 2 2.58826
DCST1 DC-STAMP domain containing 1 2.58826
KIF19 kinesin family member 19 2.58826
LPA lipoprotein, Lp(a) 2.58826
CDCP2 CUB domain containing protein 2 2.58826
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.58826
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.58826
ADAM20 ADAM metallopeptidase domain 20 2.58826
PRAP1 proline-rich acidic protein 1 2.58826
PTCRA pre T-cell antigen receptor alpha 2.58826
TEX36 testis expressed 36 2.58826
MNX1 motor neuron and pancreas homeobox 1 2.58826
FGF10 fibroblast growth factor 10 2.58826
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.58826
SPDEF SAM pointed domain containing ETS transcription factor 2.58826
POTEF POTE ankyrin domain family, member F 2.58826
LRRC74A leucine rich repeat containing 74A 2.58826
CLCA1 chloride channel accessory 1 2.58826
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.58826
LST1 leukocyte specific transcript 1 2.58826
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.57128
MFN1 mitofusin 1 2.53182
NT5M 5',3'-nucleotidase, mitochondrial 2.52837
ZNF587 zinc finger protein 587 2.51253
AGBL4 ATP/GTP binding protein-like 4 2.48637
ZNF470 zinc finger protein 470 2.48559
C11ORF71 chromosome 11 open reading frame 71 2.46962
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.44154
SPINK5 serine peptidase inhibitor, Kazal type 5 2.43869
ZFX zinc finger protein, X-linked 2.43626
ARL4A ADP-ribosylation factor-like 4A 2.43548
GTPBP2 GTP binding protein 2 2.43055
CPA6 carboxypeptidase A6 2.41202
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.40755
RRAGA Ras-related GTP binding A 2.40025
FAM167B family with sequence similarity 167, member B 2.37729
CNOT8 CCR4-NOT transcription complex, subunit 8 2.34382
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.30517
TERB1 telomere repeat binding bouquet formation protein 1 2.28903
TFB2M transcription factor B2, mitochondrial 2.28489
CCDC120 coiled-coil domain containing 120 2.27968
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.26107
ADD3 adducin 3 (gamma) 2.25907
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.24708
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.24398
PLN phospholamban 2.24231
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.24163
SCT secretin 2.23737
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.20578
KRIT1 KRIT1, ankyrin repeat containing 2.20578
TMEM269 transmembrane protein 269 2.20541
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.20541
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.20541
SEPTIN9 septin 9 2.20527
WDR77 WD repeat domain 77 2.20198
DOCK5 dedicator of cytokinesis 5 2.19676
ARHGAP32 Rho GTPase activating protein 32 2.15883
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.14804
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.14453
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 2.1441
TENM4 teneurin transmembrane protein 4 2.14042
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 2.13408
TAPT1 transmembrane anterior posterior transformation 1 2.13408
TMEM87B transmembrane protein 87B 2.13408
SLC10A3 solute carrier family 10, member 3 2.10548
AAGAB alpha- and gamma-adaptin binding protein 2.10548
GMPS guanine monphosphate synthase 2.10392
EIF3I eukaryotic translation initiation factor 3, subunit I 2.07962
SCRN2 secernin 2 2.06081
EIF3H eukaryotic translation initiation factor 3, subunit H 2.05852
STARD3NL STARD3 N-terminal like 2.05844
PGK1 phosphoglycerate kinase 1 2.0357
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 2.03544
ATE1 arginyltransferase 1 2.00211

decreased expression

Symbol Name Standardized Value
CD177 CD177 molecule -2.65348
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.65348
RXRB retinoid X receptor, beta -2.65348
CHL1 cell adhesion molecule L1-like -2.65348
OPRL1 opiate receptor-like 1 -2.58826
QTMAN queuosine-tRNA mannosyltransferase -2.58826
CPB2 carboxypeptidase B2 (plasma) -2.58826
LONRF2 LON peptidase N-terminal domain and ring finger 2 -2.58826
C19ORF73 chromosome 19 open reading frame 73 -2.58826
HUNK hormonally up-regulated Neu-associated kinase -2.58826
C5AR2 complement component 5a receptor 2 -2.58826
TBC1D26 TBC1 domain family, member 26 -2.58826
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.58826
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.58826
STYXL2 serine/threonine/tyrosine interacting like 2 -2.58826
SPATS1 spermatogenesis associated, serine-rich 1 -2.58826
VN1R1 vomeronasal 1 receptor 1 -2.58826
DUSP9 dual specificity phosphatase 9 -2.58826
STPG1 sperm-tail PG-rich repeat containing 1 -2.58826
MTFR1L mitochondrial fission regulator 1-like -2.58826
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.58826
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 -2.58826
CATSPER3 cation channel, sperm associated 3 -2.58826
ATP13A4 ATPase type 13A4 -2.58826
CATSPERT catsper channel auxiliary subunit tau -2.58826
ZNF625 zinc finger protein 625 -2.58826
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.58826
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.58826
LOC728743 zinc finger protein pseudogene -2.58826
C2CD4B C2 calcium-dependent domain containing 4B -2.58826
PCDHGA7 protocadherin gamma subfamily A, 7 -2.58826
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.58826
EFCAB12 EF-hand calcium binding domain 12 -2.58826
CPA2 carboxypeptidase A2 (pancreatic) -2.58826
UPK1B uroplakin 1B -2.58826
SORBS3 sorbin and SH3 domain containing 3 -2.58826
OTP orthopedia homeobox -2.58826
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.58826
GAGE10 G antigen 10 -2.58826
TMEM161A transmembrane protein 161A -2.58514
MFSD6L major facilitator superfamily domain containing 6-like -2.57077
TMEM106C transmembrane protein 106C -2.52022
CIPC CLOCK-interacting pacemaker -2.48559
TLCD2 TLC domain containing 2 -2.46747
RHOT1 ras homolog family member T1 -2.43055
RCN2 reticulocalbin 2, EF-hand calcium binding domain -2.43055
GSS glutathione synthetase -2.41819
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.41395
LDB1 LIM domain binding 1 -2.36298
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -2.30517
MPZL1 myelin protein zero-like 1 -2.28239
TPRN taperin -2.26107
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.25522
TSPAN10 tetraspanin 10 -2.24929
KRTDAP keratinocyte differentiation-associated protein -2.22971
CCS copper chaperone for superoxide dismutase -2.19966
PRR14 proline rich 14 -2.19966
SFMBT2 Scm-like with four mbt domains 2 -2.1982
GRIK5 glutamate receptor, ionotropic, kainate 5 -2.17997
LAMC2 laminin, gamma 2 -2.17594
GRWD1 glutamate-rich WD repeat containing 1 -2.17594
DRAM2 DNA-damage regulated autophagy modulator 2 -2.17203
BAIAP2L1 BAI1-associated protein 2-like 1 -2.16846
ZNF517 zinc finger protein 517 -2.15537
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.15496
WDR59 WD repeat domain 59 -2.15496
PLAAT3 phospholipase A and acyltransferase 3 -2.15438
LIFR leukemia inhibitory factor receptor alpha -2.15081
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.14042
MAP2K2 mitogen-activated protein kinase kinase 2 -2.14023
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.14001
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -2.13408
DGUOK deoxyguanosine kinase -2.13408
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.13408
TENT5C terminal nucleotidyltransferase 5C -2.13408
HRH1 histamine receptor H1 -2.13408
CRTAC1 cartilage acidic protein 1 -2.13408
PHKA2 phosphorylase kinase, alpha 2 (liver) -2.13408
KIAA2012 KIAA2012 -2.09916
SMIM41 small integral membrane protein 41 -2.09811
KRCC1 lysine-rich coiled-coil 1 -2.08548
MTMR9 myotubularin related protein 9 -2.07962
THAP6 THAP domain containing 6 -2.07621
ZNF181 zinc finger protein 181 -2.07547
VCL vinculin -2.06724
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.06427
ZNF41 zinc finger protein 41 -2.06081
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.05467
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.03922
ORAI2 ORAI calcium release-activated calcium modulator 2 -2.0357
FAM219A family with sequence similarity 219, member A -2.03562
TMEM9 transmembrane protein 9 -2.01466
UNK unkempt family zinc finger -2.00905
UBL5 ubiquitin-like 5 -2.00905
SLC48A1 solute carrier family 48 (heme transporter), member 1 -2.00049