NKX3-1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description NK3 homeobox 1|This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 4824)
External Link https://ncbi.nlm.nih.gov/gene/4824
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Genes

499 genes differentially expressed following the NKX3-1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
WDR7 WD repeat domain 7 0.026359
SSBP2 single-stranded DNA binding protein 2 0.0171976
RGS4 regulator of G-protein signaling 4 0.0162954
DPYD dihydropyrimidine dehydrogenase 0.0153415
MT1X metallothionein 1X 0.0151747
MT1G metallothionein 1G 0.013705
CA12 carbonic anhydrase XII 0.0134476
MT1H metallothionein 1H 0.0128907
MT1HL1 metallothionein 1H-like 1 0.0127716
PROS1 protein S (alpha) 0.0126816
ALCAM activated leukocyte cell adhesion molecule 0.0126779
MT1E metallothionein 1E 0.0126743
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0121461
MT1F metallothionein 1F 0.0120759
KRT14 keratin 14, type I 0.011966
EIF5A eukaryotic translation initiation factor 5A 0.011953
CDCA4 cell division cycle associated 4 0.011254
EVI2A ecotropic viral integration site 2A 0.0111106
XPO7 exportin 7 0.0110371
SCG5 secretogranin V 0.0104275
MT2A metallothionein 2A 0.0104175
NT5E 5'-nucleotidase, ecto (CD73) 0.01006
TXNL1 thioredoxin-like 1 0.00991023
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00988837
KRT5 keratin 5, type II 0.00986255
THBS2 thrombospondin 2 0.0098481
JCHAIN joining chain of multimeric IgA and IgM 0.00981847
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.00981345
PITX3 paired-like homeodomain 3 0.00972141
KRT15 keratin 15, type I 0.00969627
MME membrane metallo-endopeptidase 0.00967024
HDAC9 histone deacetylase 9 0.00966578
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0094282
HIST1H2AC histone cluster 1, H2ac 0.0093171
KRT23 keratin 23, type I 0.0093048
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.00928331
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.00905393
CA2 carbonic anhydrase II 0.00904065
GLUD1 glutamate dehydrogenase 1 0.00893151
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00891634
VTCN1 V-set domain containing T cell activation inhibitor 1 0.00890767
LY96 lymphocyte antigen 96 0.00889639
RPS27L ribosomal protein S27-like 0.00881098
CFB complement factor B 0.00861544
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00858124
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00840862
NARS1 asparaginyl-tRNA synthetase 1 0.0083987
SUSD4 sushi domain containing 4 0.00834393
COL3A1 collagen, type III, alpha 1 0.00831652
TCTA T-cell leukemia translocation altered 0.0082683
GSTO1 glutathione S-transferase omega 1 0.00825107
LPPR4 lipid phosphate phosphatase-related protein type 4 0.00824171
FXYD5 FXYD domain containing ion transport regulator 5 0.00823873
ARMCX2 armadillo repeat containing, X-linked 2 0.00811521
HTRA1 HtrA serine peptidase 1 0.00807844
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00805849
C1ORF54 chromosome 1 open reading frame 54 0.00804478
CLTB clathrin, light chain B 0.00804274
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.00803963
OXTR oxytocin receptor 0.00796022
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.00794567
PDZK1IP1 PDZK1 interacting protein 1 0.00794521
DOK5 docking protein 5 0.00792866
FGG fibrinogen gamma chain 0.0079277
CAPG capping protein (actin filament), gelsolin-like 0.00788097
DEFB1 defensin, beta 1 0.00787262
SLC66A2 solute carrier family 66 member 2 0.00787148
PF4 platelet factor 4 0.00785607
KLK10 kallikrein-related peptidase 10 0.00782096
THY1 Thy-1 cell surface antigen 0.00772741
TFPI2 tissue factor pathway inhibitor 2 0.0077258
FGF1 fibroblast growth factor 1 (acidic) 0.0077251
RGS10 regulator of G-protein signaling 10 0.00772329
RIPOR2 RHO family interacting cell polarization regulator 2 0.00770642
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00765088
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.00760723
SRGN serglycin 0.0075786
MZB1 marginal zone B and B1 cell-specific protein 0.00757272
SCGB2A1 secretoglobin, family 2A, member 1 0.00757035
XBP1 X-box binding protein 1 0.00756301
DCXR dicarbonyl/L-xylulose reductase 0.00755415
FBP1 fructose-1,6-bisphosphatase 1 0.00752152
XIC X chromosome inactivation center 0.0074924
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00748019
SCN3A sodium channel, voltage gated, type III alpha subunit 0.00744832
UROD uroporphyrinogen decarboxylase 0.00744592
PNMA8A PNMA family member 8A 0.00740478
PRKCI protein kinase C, iota 0.00738652
CIAO3 cytosolic iron-sulfur assembly component 3 0.007364
FGB fibrinogen beta chain 0.0073573
PDE8B phosphodiesterase 8B 0.00735515
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.00733246
RCAN1 regulator of calcineurin 1 0.00731772
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.00730497
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.00726726
C10ORF10 chromosome 10 open reading frame 10 0.00712572
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.00711939
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0071138
HK2 hexokinase 2 0.0071121
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.00711008
CALR calreticulin 0.00710536
ANXA1 annexin A1 0.00709299
ERAP1 endoplasmic reticulum aminopeptidase 1 0.00704596
TM9SF3 transmembrane 9 superfamily member 3 0.00701689
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.00698583
GDF15 growth differentiation factor 15 0.00695794
THBS1 thrombospondin 1 0.00694925
FECH ferrochelatase 0.00694419
AHNAK2 AHNAK nucleoprotein 2 0.00693808
ANPEP alanyl (membrane) aminopeptidase 0.0069363
RTP4 receptor (chemosensory) transporter protein 4 0.00693205
BPIFA1 BPI fold containing family A, member 1 0.00692946
GMFG glia maturation factor, gamma 0.00691219
IL2RG interleukin 2 receptor, gamma 0.00690142
OLFML3 olfactomedin-like 3 0.00687885
LDOC1 leucine zipper, down-regulated in cancer 1 0.00687131
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.00686787
ZFP36L2 ZFP36 ring finger protein-like 2 0.00681844
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.00680279
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.00675246
MICB MHC class I polypeptide-related sequence B 0.00672827
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.00672283
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.00671394
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.00671099
CRABP2 cellular retinoic acid binding protein 2 0.00670796
WASHC4 WASH complex subunit 4 0.00670673
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00668605
GPX1 glutathione peroxidase 1 0.00665903
CNN3 calponin 3, acidic 0.00662189
TRIM22 tripartite motif containing 22 0.00660035
ETV5 ets variant 5 0.00658104
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00654921
FCGBP Fc fragment of IgG binding protein 0.00652794
TMEM140 transmembrane protein 140 0.00652141
ZNF217 zinc finger protein 217 0.00650339
CXCL10 chemokine (C-X-C motif) ligand 10 0.00648985
MCUB mitochondrial calcium uniporter dominant negative subunit beta 0.00645704
KRT17 keratin 17, type I 0.00644631
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.00641017
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.0064061
TATDN2 TatD DNase domain containing 2 0.00639291
AK4 adenylate kinase 4 0.00639055
ICAM2 intercellular adhesion molecule 2 0.00635501
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.00634309
APOL1 apolipoprotein L, 1 0.00633477
WARS1 tryptophanyl-tRNA synthetase 1 0.00632819
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00629187
GRB7 growth factor receptor-bound protein 7 0.00628688
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00625228
SMCO4 single-pass membrane protein with coiled-coil domains 4 0.0062364
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.00623584
IQSEC1 IQ motif and Sec7 domain 1 0.00623579
VEGFC vascular endothelial growth factor C 0.00622732
NCAN neurocan 0.00622158
PLIN2 perilipin 2 0.00621617
MFAP3L microfibrillar-associated protein 3-like 0.00616234
ATP5MJ ATP synthase membrane subunit j 0.00616179
TUBB2A tubulin, beta 2A class IIa 0.00614554
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.00612821
CFI complement factor I 0.00611406
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.00608677
TCEA1 transcription elongation factor A (SII), 1 0.00607893
COPG1 coatomer protein complex, subunit gamma 1 0.00607345
R3HDM1 R3H domain containing 1 0.00607169
PLAUR plasminogen activator, urokinase receptor 0.0060592
PLPBP pyridoxal phosphate binding protein 0.00605679
MBD2 methyl-CpG binding domain protein 2 0.00604152
SPRED2 sprouty-related, EVH1 domain containing 2 0.00604076
SMYD2 SET and MYND domain containing 2 0.00603485
POU2AF1 POU class 2 associating factor 1 0.00602092
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00602007
SARS1 seryl-tRNA synthetase 1 0.00600195
ZMAT3 zinc finger, matrin-type 3 0.00599733
POSTN periostin, osteoblast specific factor 0.0059917
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.00598093
KLF10 Kruppel-like factor 10 0.00598028
LAMP5 lysosomal-associated membrane protein family, member 5 0.00597804
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.00597344
SELENOW selenoprotein W 0.00596178
BAMBI BMP and activin membrane-bound inhibitor 0.00595024
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.00594776
PBX3 pre-B-cell leukemia homeobox 3 0.00594571
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.0059365
BCAS2 breast carcinoma amplified sequence 2 0.0059354
SELL selectin L 0.00590978
DIPK1A divergent protein kinase domain 1A 0.00590837
GNAS GNAS complex locus 0.00590564
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.00590162
SLIRP SRA stem-loop interacting RNA binding protein 0.00589967
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00589276
MINPP1 multiple inositol-polyphosphate phosphatase 1 0.00589207
DUOX2 dual oxidase 2 0.00587931
ZNF395 zinc finger protein 395 0.00587478
KCTD12 potassium channel tetramerization domain containing 12 0.00587113
SCPEP1 serine carboxypeptidase 1 0.00585528
WWC1 WW and C2 domain containing 1 0.00584852
MAL mal, T-cell differentiation protein 0.00584315
PLAT plasminogen activator, tissue 0.00583869
FAM234B family with sequence similarity 234 member B 0.00582911
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.00582362
CLDN8 claudin 8 0.00581602
FHIT fragile histidine triad 0.00580754
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.00580112
CYBB cytochrome b-245, beta polypeptide 0.00580035
TP53I3 tumor protein p53 inducible protein 3 0.0057961
KDSR 3-ketodihydrosphingosine reductase 0.00579599
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.00578875
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.00578537
LAPTM5 lysosomal protein transmembrane 5 0.00578225
LST1 leukocyte specific transcript 1 0.00576962
COL5A1 collagen, type V, alpha 1 0.00575562
C9ORF16 chromosome 9 open reading frame 16 0.00575489
NCDN neurochondrin 0.0057499
CTSK cathepsin K 0.00574829
C3ORF14 chromosome 3 open reading frame 14 0.00574713
KLK7 kallikrein-related peptidase 7 0.00572582
FMO1 flavin containing monooxygenase 1 0.00571799
R3HDM4 R3H domain containing 4 0.00571274
PTPRO protein tyrosine phosphatase, receptor type, O 0.00570117
GLDC glycine dehydrogenase (decarboxylating) 0.00570024
UMOD uromodulin 0.00569111
JAG2 jagged 2 0.00568915
ADM adrenomedullin 0.00567554
COL5A2 collagen, type V, alpha 2 0.00565874
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.00564419
TCL1A T-cell leukemia/lymphoma 1A 0.00563235
MYOF myoferlin 0.00562421
DOCK10 dedicator of cytokinesis 10 0.00561227
CUTA cutA divalent cation tolerance homolog (E. coli) 0.00559763
PDGFC platelet derived growth factor C 0.00557463
EFNB3 ephrin-B3 0.00556506
VWA5A von Willebrand factor A domain containing 5A 0.00555819
FGA fibrinogen alpha chain 0.0055512
TRIM21 tripartite motif containing 21 0.0055444
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.00554211
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.00554024
PEG3 paternally expressed 3 0.00552584
KLK5 kallikrein-related peptidase 5 0.00551723
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.00550777
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0055068
GARS1 glycyl-tRNA synthetase 1 0.00548724
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.00548068
CAST calpastatin 0.0054787
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00547529
MXRA5 matrix-remodelling associated 5 0.00547288
TRIM8 tripartite motif containing 8 0.0054596
TADA2A transcriptional adaptor 2A 0.0054543
IRF1 interferon regulatory factor 1 0.00545236
PLXNC1 plexin C1 0.00544775

decreased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 -0.0327638
S100P S100 calcium binding protein P -0.0193696
AGR2 anterior gradient 2 -0.0167995
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0161924
TSPAN8 tetraspanin 8 -0.013975
HSPB8 heat shock 22kDa protein 8 -0.0128413
GPX3 glutathione peroxidase 3 -0.0123263
DES desmin -0.0121739
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0114094
ACKR3 atypical chemokine receptor 3 -0.0113853
SEPP1 selenoprotein P, plasma, 1 -0.0113631
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0111481
ACTA1 actin, alpha 1, skeletal muscle -0.0111379
BMP4 bone morphogenetic protein 4 -0.0107097
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0104904
PHACTR2 phosphatase and actin regulator 2 -0.0104523
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0102543
PERP PERP, TP53 apoptosis effector -0.0102281
YBX3 Y box binding protein 3 -0.0102192
TNIP1 TNFAIP3 interacting protein 1 -0.0101954
GSTA4 glutathione S-transferase alpha 4 -0.0100635
AKR1C1 aldo-keto reductase family 1, member C1 -0.0100287
AKR1C2 aldo-keto reductase family 1, member C2 -0.0098824
MFAP4 microfibrillar-associated protein 4 -0.0098664
SPARCL1 SPARC-like 1 (hevin) -0.00980957
ANXA3 annexin A3 -0.00978221
ACTC1 actin, alpha, cardiac muscle 1 -0.00975448
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00972823
TTN titin -0.00970414
TPD52L1 tumor protein D52-like 1 -0.00968316
PTCH1 patched 1 -0.00965244
CLU clusterin -0.0096437
CXCL5 chemokine (C-X-C motif) ligand 5 -0.00960948
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.00959266
AKR1C3 aldo-keto reductase family 1, member C3 -0.00950175
TBX3 T-box 3 -0.00946098
CST1 cystatin SN -0.00942289
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.00942038
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00936733
MYH11 myosin, heavy chain 11, smooth muscle -0.00934499
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.00925241
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0092412
ZDHHC11 zinc finger, DHHC-type containing 11 -0.00911779
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.00903312
MYO5C myosin VC -0.00892932
IL13RA2 interleukin 13 receptor, alpha 2 -0.00880848
GUSBP3 glucuronidase, beta pseudogene 3 -0.00879105
KAZN kazrin, periplakin interacting protein -0.00862533
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00849562
RAD23B RAD23 homolog B (S. cerevisiae) -0.0084838
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00846725
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0084507
FHL1 four and a half LIM domains 1 -0.00830157
AK1 adenylate kinase 1 -0.00829299
TNNC2 troponin C type 2 (fast) -0.00829067
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00827138
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.00826164
FGF13 fibroblast growth factor 13 -0.00824774
HOPX HOP homeobox -0.00824646
SI sucrase-isomaltase (alpha-glucosidase) -0.00820432
MID1 midline 1 -0.0081732
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.00815715
SRSF10 serine/arginine-rich splicing factor 10 -0.00807184
FOXF1 forkhead box F1 -0.00806709
SPRY2 sprouty homolog 2 (Drosophila) -0.00802709
TNNC1 troponin C type 1 (slow) -0.00802309
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.00801546
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.00800553
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -0.00799215
C8ORF4 chromosome 8 open reading frame 4 -0.00786356
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.00780111
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.00776301
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00775814
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -0.00772947
PROCR protein C receptor, endothelial -0.00769439
ELANE elastase, neutrophil expressed -0.00767581
NBPF10 neuroblastoma breakpoint family, member 10 -0.00766602
KIF5B kinesin family member 5B -0.00765428
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -0.0076474
LIMCH1 LIM and calponin homology domains 1 -0.00764054
CD99 CD99 molecule -0.00755757
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -0.00755061
KLHL41 kelch-like family member 41 -0.00753722
CLGN calmegin -0.00752844
RNF146 ring finger protein 146 -0.00752684
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.00751501
FNBP1 formin binding protein 1 -0.00747221
CST3 cystatin C -0.00747217
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00745711
FABP4 fatty acid binding protein 4, adipocyte -0.00742028
OSR2 odd-skipped related transciption factor 2 -0.00739362
WSB1 WD repeat and SOCS box containing 1 -0.00737045
MN1 meningioma (disrupted in balanced translocation) 1 -0.00736889
MYOT myotilin -0.00729247
AMACR alpha-methylacyl-CoA racemase -0.00722661
CES1 carboxylesterase 1 -0.00722508
DST dystonin -0.00722361
PLCB4 phospholipase C, beta 4 -0.0071922
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -0.00718779
TSPAN4 tetraspanin 4 -0.00715578
ITM2A integral membrane protein 2A -0.00714671
MGP matrix Gla protein -0.00714668
RBPMS RNA binding protein with multiple splicing -0.00713371
ACE2 angiotensin I converting enzyme 2 -0.00712821
DKFZP586I1420 uncharacterized protein DKFZp586I1420 -0.007109
CADM1 cell adhesion molecule 1 -0.00710553
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.00709563
APOA1 apolipoprotein A-I -0.00707065
TBL1X transducin (beta)-like 1X-linked -0.00703967
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00701492
ARGLU1 arginine and glutamate rich 1 -0.00700959
HSPG2 heparan sulfate proteoglycan 2 -0.00700135
CST7 cystatin F (leukocystatin) -0.00698641
BTBD3 BTB (POZ) domain containing 3 -0.00697274
CA3 carbonic anhydrase III -0.00696206
S100A12 S100 calcium binding protein A12 -0.00696071
SVIL supervillin -0.00694493
CUX1 cut-like homeobox 1 -0.00692838
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.00689012
FBN2 fibrillin 2 -0.00687232
CPA3 carboxypeptidase A3 (mast cell) -0.00686911
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.00686712
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.00686519
GPM6A glycoprotein M6A -0.00685986
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -0.00684762
PLN phospholamban -0.00682636
CFD complement factor D (adipsin) -0.00681829
MYH2 myosin, heavy chain 2, skeletal muscle, adult -0.00681159
MB myoglobin -0.00680967
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00677122
CD46 CD46 molecule, complement regulatory protein -0.00672703
RNFT1 ring finger protein, transmembrane 1 -0.00672278
PRUNE2 prune homolog 2 (Drosophila) -0.00668526
CKM creatine kinase, muscle -0.00668392
FZD5 frizzled class receptor 5 -0.00668283
GDE1 glycerophosphodiester phosphodiesterase 1 -0.00668121
CST4 cystatin S -0.00666904
ELP1 elongator acetyltransferase complex subunit 1 -0.0066494
RHOBTB3 Rho-related BTB domain containing 3 -0.00664168
GLUL glutamate-ammonia ligase -0.00663551
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -0.0066348
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -0.00661982
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.00661949
KRT20 keratin 20, type I -0.00661483
KDM5D lysine (K)-specific demethylase 5D -0.00661363
C9ORF3 chromosome 9 open reading frame 3 -0.00661296
PON3 paraoxonase 3 -0.00660592
UCKL1 uridine-cytidine kinase 1-like 1 -0.00659118
SYPL1 synaptophysin-like 1 -0.00657648
SEPTIN10 septin 10 -0.00656735
NKTR natural killer cell triggering receptor -0.00656616
AUTS2 autism susceptibility candidate 2 -0.00655695
CXCL3 chemokine (C-X-C motif) ligand 3 -0.00654748
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -0.00654653
THBS4 thrombospondin 4 -0.0065442
PAGE4 P antigen family, member 4 (prostate associated) -0.00654344
ATXN1 ataxin 1 -0.0065407
RHOB ras homolog family member B -0.00653468
TMPRSS11E transmembrane protease, serine 11E -0.00653343
BMP2 bone morphogenetic protein 2 -0.00652476
RPL10 ribosomal protein L10 -0.00650981
PRKCZ protein kinase C, zeta -0.00649721
CEP350 centrosomal protein 350kDa -0.00647762
TFF1 trefoil factor 1 -0.00646047
MET MET proto-oncogene, receptor tyrosine kinase -0.00644886
MYLIP myosin regulatory light chain interacting protein -0.00644661
RESF1 retroelement silencing factor 1 -0.00643124
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.00641221
SRSF7 serine/arginine-rich splicing factor 7 -0.00640742
GRB14 growth factor receptor-bound protein 14 -0.00640356
PDLIM5 PDZ and LIM domain 5 -0.00640233
CCL2 chemokine (C-C motif) ligand 2 -0.0063893
ANGPT1 angiopoietin 1 -0.00637621
CHRDL1 chordin-like 1 -0.00637584
CCL4 chemokine (C-C motif) ligand 4 -0.00635955
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.00635837
DIXDC1 DIX domain containing 1 -0.00634625
REG3A regenerating islet-derived 3 alpha -0.00631046
PRKCB protein kinase C, beta -0.00629691
PIR pirin (iron-binding nuclear protein) -0.0062844
SRSF1 serine/arginine-rich splicing factor 1 -0.00627811
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00626898
CAVIN2 caveolae associated protein 2 -0.00625956
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.00625687
DACH1 dachshund family transcription factor 1 -0.00625596
HOXA10 homeobox A10 -0.00625244
TGFBI transforming growth factor, beta-induced, 68kDa -0.00622766
MGST3 microsomal glutathione S-transferase 3 -0.00622335
TNNI2 troponin I type 2 (skeletal, fast) -0.00618965
IFNGR1 interferon gamma receptor 1 -0.00614974
CXCL6 chemokine (C-X-C motif) ligand 6 -0.00614898
PDZK1 PDZ domain containing 1 -0.00614822
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -0.00611901
HBB hemoglobin, beta -0.00609702
PMP22 peripheral myelin protein 22 -0.00609516
DUSP1 dual specificity phosphatase 1 -0.00609347
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -0.00609248
MYBPC1 myosin binding protein C, slow type -0.00608919
IL11 interleukin 11 -0.00607794
AKAP7 A kinase (PRKA) anchor protein 7 -0.00606475
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -0.00603465
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.00602387
SMPX small muscle protein, X-linked -0.0060173
CD34 CD34 molecule -0.00601376
KANK2 KN motif and ankyrin repeat domains 2 -0.00600711
PILRB paired immunoglobin-like type 2 receptor beta -0.00600681
PNISR PNN-interacting serine/arginine-rich protein -0.00600266
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.0059967
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00599279
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.00599076
MERTK MER proto-oncogene, tyrosine kinase -0.00597807
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.00594353
SPON1 spondin 1, extracellular matrix protein -0.0059343
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.00593224
BAG2 BCL2-associated athanogene 2 -0.00591489
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00591017
FXYD6 FXYD domain containing ion transport regulator 6 -0.00590942
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -0.0059009
APMAP adipocyte plasma membrane associated protein -0.00589031
TPM3 tropomyosin 3 -0.00588911
TAGLN transgelin -0.00587452
ANXA6 annexin A6 -0.00586705
FILIP1L filamin A interacting protein 1-like -0.00585388
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.00584893
RAB40B RAB40B, member RAS oncogene family -0.00583725
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.00583312
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00583168
MYBPC2 myosin binding protein C, fast type -0.005828
XCL1 chemokine (C motif) ligand 1 -0.00578754
PNN pinin, desmosome associated protein -0.00577844
ACTG2 actin, gamma 2, smooth muscle, enteric -0.00575651
NIT1 nitrilase 1 -0.0057235
CALML4 calmodulin-like 4 -0.0057014
TNC tenascin C -0.00570132
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -0.00569282
ACTN2 actinin, alpha 2 -0.00568919
PELO pelota homolog (Drosophila) -0.00568441
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.00567806
ACADVL acyl-CoA dehydrogenase, very long chain -0.00567738
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.00566484
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.00566428
LPP LIM domain containing preferred translocation partner in lipoma -0.00564998
ASPH aspartate beta-hydroxylase -0.00564697
BCLAF1 BCL2-associated transcription factor 1 -0.00563047
SLC38A1 solute carrier family 38, member 1 -0.00562702
PTK2 protein tyrosine kinase 2 -0.00562554
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.00562177
ARID1A AT rich interactive domain 1A (SWI-like) -0.00561044
ZBTB35 zinc finger and BTB domain containing 35 -0.00560045
ZBTB20 zinc finger and BTB domain containing 20 -0.00559469