NKX3-2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NK3 homeobox 2|This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 579)
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Genes

331 genes differentially expressed following the NKX3-2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.25469
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.25469
DSG3 desmoglein 3 3.25469
CD300A CD300a molecule 3.25469
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 3.25469
OLFM4 olfactomedin 4 3.25469
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.25469
GPR22 G protein-coupled receptor 22 3.25469
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.25469
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.25469
LRRC56 leucine rich repeat containing 56 3.25469
NRAP nebulin-related anchoring protein 3.25469
IL5RA interleukin 5 receptor, alpha 3.25469
HEATR9 HEAT repeat containing 9 3.25469
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.25469
SPATA31A6 SPATA31 subfamily A, member 6 3.25469
HCRTR1 hypocretin (orexin) receptor 1 3.25469
AKR1C2 aldo-keto reductase family 1, member C2 3.25469
TRIM10 tripartite motif containing 10 3.25469
PCDHB7 protocadherin beta 7 3.25469
CAPNS2 calpain, small subunit 2 3.25469
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.25469
SOWAHB sosondowah ankyrin repeat domain family member B 3.25469
GNRH2 gonadotropin-releasing hormone 2 3.25469
ABRA actin binding Rho activating protein 3.25469
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.25469
ANKRD30B ankyrin repeat domain 30B 3.25469
NPC1L1 NPC1-like 1 3.25469
ASCL3 achaete-scute family bHLH transcription factor 3 3.25469
AOC1 amine oxidase, copper containing 1 3.25469
MMP12 matrix metallopeptidase 12 3.25469
IFITM10 interferon induced transmembrane protein 10 3.25469
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.25469
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.25469
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.25469
BTBD16 BTB (POZ) domain containing 16 3.25469
MUC22 mucin 22 3.25469
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.25469
PTK6 protein tyrosine kinase 6 3.25469
ATOH7 atonal homolog 7 (Drosophila) 3.25469
MYO1A myosin IA 3.25469
MRC1 mannose receptor, C type 1 3.25469
CPLX1 complexin 1 3.25469
SPHK1 sphingosine kinase 1 3.25469
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.25469
FRMPD2 FERM and PDZ domain containing 2 3.25469
FAM90A12 family with sequence similarity 90 member A12 3.25469
ADRB1 adrenoceptor beta 1 3.25469
SELL selectin L 3.25469
HNF1A HNF1 homeobox A 3.25469
LTB lymphotoxin beta (TNF superfamily, member 3) 3.25469
PTH parathyroid hormone 3.25469
CLEC17A C-type lectin domain family 17, member A 3.25469
TACR2 tachykinin receptor 2 3.25469
TPTE transmembrane phosphatase with tensin homology 3.25469
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.25469
SPI1 Spi-1 proto-oncogene 3.25469
LDB3 LIM domain binding 3 3.25469
TMOD4 tropomodulin 4 (muscle) 3.25469
LOC124902436 talanin 3.25469
SRARP steroid receptor associated and regulated protein 3.25469
CFAP276 cilia and flagella associated protein 276 3.25469
GARIN1A golgi associated RAB2 interactor 1A 3.25469
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.25469
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 3.25469
FAM240B family with sequence similarity 240 member B 3.25469
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.25469
CES4A carboxylesterase 4A 3.25469
TLR8 toll-like receptor 8 3.25469
SCRT2 scratch family zinc finger 2 3.25469
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.25469
NDRG1 N-myc downstream regulated 1 3.25469
CFHR1 complement factor H-related 1 3.25469
LOC124905976 uncharacterized LOC124905976 3.25469
SOX1 SRY (sex determining region Y)-box 1 3.25469
NKAPL NFKB activating protein-like 3.25469
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.25469
UCN urocortin 3.25469
USP26 ubiquitin specific peptidase 26 3.25469
FAM3D family with sequence similarity 3, member D 3.25469
FPR3 formyl peptide receptor 3 3.25469
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.25469
SIM2 single-minded family bHLH transcription factor 2 3.25469
GOLGA7B golgin A7 family, member B 3.25469
NPIPB9 nuclear pore complex interacting protein family, member B9 3.25469
WNT11 wingless-type MMTV integration site family, member 11 3.25469
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.25469
TRIM60 tripartite motif containing 60 3.25469
CLDN2 claudin 2 3.25469
OASL 2'-5'-oligoadenylate synthetase-like 3.25469
SECTM1 secreted and transmembrane 1 3.25469
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.25469
CCNO cyclin O 3.25469
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.25469
CDH19 cadherin 19, type 2 3.25469
CLEC4D C-type lectin domain family 4, member D 3.25469
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.25469
PSKH2 protein serine kinase H2 3.25469
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 3.25469
EMP1 epithelial membrane protein 1 3.25469
AGXT2 alanine--glyoxylate aminotransferase 2 3.25469
IFITM5 interferon induced transmembrane protein 5 3.25469
CPA2 carboxypeptidase A2 (pancreatic) 3.25469
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.25469
BPIFB1 BPI fold containing family B, member 1 3.25469
HHAT hedgehog acyltransferase 3.25469
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.25469
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.25469
GPR12 G protein-coupled receptor 12 3.25469
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 3.25469
ANKRD63 ankyrin repeat domain 63 3.25469
SCML4 sex comb on midleg-like 4 (Drosophila) 3.25469
MRPS18B mitochondrial ribosomal protein S18B 3.25469
COX7B2 cytochrome c oxidase subunit VIIb2 3.25469
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.25469
ORM1 orosomucoid 1 3.25469
IL21 interleukin 21 3.25469
ARHGAP40 Rho GTPase activating protein 40 3.25469
LAMB4 laminin, beta 4 3.25469
GOLGA8T golgin A8 family, member T 3.25469
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.25469
NR1D1 nuclear receptor subfamily 1, group D, member 1 3.25469
PHOX2A paired-like homeobox 2a 3.25469
CD24 CD24 molecule 3.25469
PSG3 pregnancy specific beta-1-glycoprotein 3 3.25469
PRSS38 protease, serine, 38 3.25469
C20ORF144 chromosome 20 open reading frame 144 3.25469
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.25469
ANKRD55 ankyrin repeat domain 55 3.25469
ARR3 arrestin 3, retinal (X-arrestin) 3.25469
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.25469
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.25469
GSTA1 glutathione S-transferase alpha 1 3.25469
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.25469
ITGA8 integrin, alpha 8 3.25469
GAL3ST2 galactose-3-O-sulfotransferase 2 3.25469
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.25469
DAND5 DAN domain family member 5, BMP antagonist 3.25469
EPO erythropoietin 3.25469
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.25469
CPZ carboxypeptidase Z 3.25469
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 3.25469
MAGEB17 melanoma antigen family B17 3.25469
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.25469
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.25469
PDCD1 programmed cell death 1 3.25469
AGR3 anterior gradient 3 3.25469
IL12A interleukin 12A 3.25469
CHRM4 cholinergic receptor, muscarinic 4 3.25469
GLT6D1 glycosyltransferase 6 domain containing 1 3.25469
APOL1 apolipoprotein L, 1 3.25469
CHRM1 cholinergic receptor, muscarinic 1 3.25469
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.25469
A3GALT2 alpha 1,3-galactosyltransferase 2 3.25469
IL17REL interleukin 17 receptor E-like 3.25469
MAGEA11 melanoma antigen family A11 3.25469
TICAM1 toll-like receptor adaptor molecule 1 3.2365
GAB3 GRB2-associated binding protein 3 3.2365
RNF180 ring finger protein 180 3.18323
AUNIP aurora kinase A and ninein interacting protein 3.00113
ITGB8 integrin, beta 8 2.9719
DAGLA diacylglycerol lipase, alpha 2.76687
GPNMB glycoprotein (transmembrane) nmb 2.75159
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.67488
STMP1 short transmembrane mitochondrial protein 1 2.59151
XBP1 X-box binding protein 1 2.54308
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.53366
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 2.49565
SIGMAR1 sigma non-opioid intracellular receptor 1 2.47572
SH2D4A SH2 domain containing 4A 2.45672
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.45321
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 2.45321
CDH10 cadherin 10, type 2 (T2-cadherin) 2.43928
UQCRB ubiquinol-cytochrome c reductase binding protein 2.42548
CAB39 calcium binding protein 39 2.40209
KLHL14 kelch-like family member 14 2.39525
FNTA farnesyltransferase, CAAX box, alpha 2.38187
SWAP70 SWAP switching B-cell complex 70kDa subunit 2.3174
ETV5 ets variant 5 2.29349
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.28793
DGLUCY D-glutamate cyclase 2.28596
HLA-B major histocompatibility complex, class I, B 2.28502
OLAH oleoyl-ACP hydrolase 2.28059
SIX2 SIX homeobox 2 2.28059
SH2D3C SH2 domain containing 3C 2.26144
GPR183 G protein-coupled receptor 183 2.2577
EFCAB12 EF-hand calcium binding domain 12 2.2577
PCDHGB2 protocadherin gamma subfamily B, 2 2.2577
CIITA class II, major histocompatibility complex, transactivator 2.2577
AMBP alpha-1-microglobulin/bikunin precursor 2.2577
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.2577
IL17C interleukin 17C 2.2577
KLF11 Kruppel-like factor 11 2.25403
SND1 staphylococcal nuclease and tudor domain containing 1 2.2482
ZNF512 zinc finger protein 512 2.22403
TM9SF3 transmembrane 9 superfamily member 3 2.22342
TMED1 transmembrane emp24 protein transport domain containing 1 2.18071
RCE1 Ras converting CAAX endopeptidase 1 2.17294
CAAP1 caspase activity and apoptosis inhibitor 1 2.16249
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.15017
ATP5F1D ATP synthase F1 subunit delta 2.13664
CRELD1 cysteine-rich with EGF-like domains 1 2.11674
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.11644
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 2.10325
TMEM236 transmembrane protein 236 2.10325
HIPK1 homeodomain interacting protein kinase 1 2.09449
TCP1 t-complex 1 2.09326
LGI2 leucine-rich repeat LGI family, member 2 2.09099
LRRC37A2 leucine rich repeat containing 37, member A2 2.04655
KDR kinase insert domain receptor 2.04655
ZNF696 zinc finger protein 696 2.03275
NEXMIF neurite extension and migration factor 2.03224
TMEM14A transmembrane protein 14A 2.02264
WWP2 WW domain containing E3 ubiquitin protein ligase 2 2.0119
MORN4 MORN repeat containing 4 2.00648
CCDC149 coiled-coil domain containing 149 2.00196

decreased expression

Symbol Name Standardized Value
SPMIP2 sperm microtubule inner protein 2 -3.25469
HBA1 hemoglobin, alpha 1 -3.25469
CSMD3 CUB and Sushi multiple domains 3 -3.25469
UBE2U ubiquitin-conjugating enzyme E2U (putative) -3.25469
PCDH8 protocadherin 8 -3.25469
RPL3L ribosomal protein L3-like -3.25469
MGARP mitochondria-localized glutamic acid-rich protein -3.25469
ATP8B4 ATPase, class I, type 8B, member 4 -3.25469
TAS2R13 taste receptor, type 2, member 13 -3.25469
LDHC lactate dehydrogenase C -3.25469
SCIN scinderin -3.25469
EYA4 EYA transcriptional coactivator and phosphatase 4 -3.25469
CDCP1 CUB domain containing protein 1 -3.25469
CDAN1 codanin 1 -3.25469
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -3.25469
LMO1 LIM domain only 1 (rhombotin 1) -3.25469
ZFP57 ZFP57 zinc finger protein -3.25469
ZNF593OS ZNF593 opposite strand -3.25469
C1QTNF12 C1q and TNF related 12 -3.25469
PNMA8B PNMA family member 8B -3.25469
PHF24 PHD finger protein 24 -3.25469
GIPR gastric inhibitory polypeptide receptor -3.25469
RAB37 RAB37, member RAS oncogene family -3.25469
GATA4 GATA binding protein 4 -3.25469
LEKR1 leucine, glutamate and lysine rich 1 -3.25469
SAXO5 stabilizer of axonemal microtubules 5 -3.25469
OVOL3 ovo-like zinc finger 3 -3.25469
HNF4A hepatocyte nuclear factor 4, alpha -3.25469
NOTO notochord homeobox -3.25469
NUAK1 NUAK family, SNF1-like kinase, 1 -3.25469
IGFL4 IGF-like family member 4 -3.25469
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -3.25469
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -3.25469
AKNAD1 AKNA domain containing 1 -3.25469
PCDHA13 protocadherin alpha 13 -3.25469
PLCD4 phospholipase C, delta 4 -3.25469
CAGE1 cancer antigen 1 -3.25469
SPINK9 serine peptidase inhibitor, Kazal type 9 -3.25469
EBF3 early B-cell factor 3 -3.25469
CLIC5 chloride intracellular channel 5 -3.25469
ANTKMT adenine nucleotide translocase lysine methyltransferase -3.25469
IGIP IgA-inducing protein -3.25469
NICN1 nicolin 1 -3.25469
DAW1 dynein assembly factor with WDR repeat domains 1 -3.25469
KCTD13 potassium channel tetramerization domain containing 13 -3.19561
C8ORF34 chromosome 8 open reading frame 34 -3.18323
PM20D1 peptidase M20 domain containing 1 -3.17014
PCDHGA8 protocadherin gamma subfamily A, 8 -3.17014
CD200R1L CD200 receptor 1-like -3.16014
PDZD7 PDZ domain containing 7 -2.99053
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.95961
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.8935
TMEM278 transmembrane protein 278 -2.8935
TARS1 threonyl-tRNA synthetase 1 -2.85685
SESN1 sestrin 1 -2.77935
ARL17A ADP-ribosylation factor-like 17A -2.74281
ARL4C ADP-ribosylation factor-like 4C -2.6756
F10 coagulation factor X -2.66208
AKAP13 A kinase (PRKA) anchor protein 13 -2.66208
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.61437
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.5515
HOMER1 homer scaffolding protein 1 -2.51169
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.49116
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.48283
CLEC2L C-type lectin domain family 2, member L -2.48283
SEC13 SEC13 homolog (S. cerevisiae) -2.47092
CDCA7 cell division cycle associated 7 -2.42548
HDAC9 histone deacetylase 9 -2.41966
SLC49A3 solute carrier family 49 member 3 -2.41966
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.38187
CLUL1 clusterin-like 1 (retinal) -2.35792
IGFBP3 insulin-like growth factor binding protein 3 -2.35792
RSL24D1 ribosomal L24 domain containing 1 -2.35792
LCTL lactase-like -2.35251
TMEM65 transmembrane protein 65 -2.3497
PITPNA phosphatidylinositol transfer protein, alpha -2.34414
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.28793
PDIK1L PDLIM1 interacting kinase 1 like -2.28368
JADE1 jade family PHD finger 1 -2.28089
BLTP3A bridge-like lipid transfer protein family member 3A -2.25915
C19ORF38 chromosome 19 open reading frame 38 -2.2577
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.25198
GCLC glutamate-cysteine ligase, catalytic subunit -2.22342
ADAM32 ADAM metallopeptidase domain 32 -2.21575
NAP1L1 nucleosome assembly protein 1-like 1 -2.21575
ZXDB zinc finger, X-linked, duplicated B -2.20179
ICMT isoprenylcysteine carboxyl methyltransferase -2.19758
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.18853
HMGN5 high mobility group nucleosome binding domain 5 -2.18689
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.18689
CA11 carbonic anhydrase XI -2.18657
TULP2 tubby like protein 2 -2.18358
NUBP2 nucleotide binding protein 2 -2.17497
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.16583
FGF4 fibroblast growth factor 4 -2.16249
YIPF4 Yip1 domain family, member 4 -2.15599
FGF2 fibroblast growth factor 2 (basic) -2.14525
ENTREP1 endosomal transmembrane epsin interactor 1 -2.12807
DISP3 dispatched RND transporter family member 3 -2.12114
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -2.10325
SMIM12 small integral membrane protein 12 -2.09665
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -2.09665
EHD2 EH-domain containing 2 -2.09262
RNF216 ring finger protein 216 -2.09262
RETREG3 reticulophagy regulator family member 3 -2.09262
TONSL tonsoku-like, DNA repair protein -2.07997
WDR47 WD repeat domain 47 -2.0706
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.05505
GCNA germ cell nuclear acidic peptidase -2.03454
ZNF211 zinc finger protein 211 -2.03224
C3ORF70 chromosome 3 open reading frame 70 -2.02081
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.0188
YPEL2 yippee-like 2 (Drosophila) -2.01719
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.01478
POGLUT3 protein O-glucosyltransferase 3 -2.00452