NLRP1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description NLR family, pyrin domain containing 1|This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 22861)
External Link http://www.ncbi.nlm.nih.gov/gene/22861
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Genes

50 interacting proteins for NLRP1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6
APAF1 apoptotic peptidase activating factor 1
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
C1QA complement component 1, q subcomponent, A chain
C1QC complement component 1, q subcomponent, C chain
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CLU clusterin
CP ceruloplasmin (ferroxidase)
CUL3 cullin 3
DNTT DNA nucleotidylexotransferase
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERVK-10 endogenous retrovirus group K, member 10
FAM169A family with sequence similarity 169, member A
FGA fibrinogen alpha chain
FN1 fibronectin 1
HBA2 hemoglobin, alpha 2
IGKC immunoglobulin kappa constant
KIAA0754 KIAA0754
KRT1 keratin 1, type II
KRT16 keratin 16, type I
KRT9 keratin 9, type I
LECT1 leukocyte cell derived chemotaxin 1
MOCOS molybdenum cofactor sulfurase
NLRC4 NLR family, CARD domain containing 4
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
PDE4B phosphodiesterase 4B, cAMP-specific
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PYCARD PYD and CARD domain containing
PYDC2 pyrin domain containing 2
QDPR quinoid dihydropteridine reductase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RRP1B ribosomal RNA processing 1B
SACK1C scaffolding CK1 anchoring protein C
SAFB2 scaffold attachment factor B2
SERTAD3 SERTA domain containing 3
SETX senataxin
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPEF2 sperm flagellar 2
TNS3 tensin 3
TRIM68 tripartite motif containing 68
TTR transthyretin
TXNDC2 thioredoxin domain containing 2 (spermatozoa)