NLRP3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description NLR family, pyrin domain containing 3|This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 114548)
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Genes

347 genes differentially expressed following the NLRP3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NKAPL NFKB activating protein-like 3.13659
PROB1 proline-rich basic protein 1 3.13659
GJB1 gap junction protein, beta 1, 32kDa 3.13659
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.13659
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.13659
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.13659
NUGGC nuclear GTPase, germinal center associated 3.13659
ADAD2 adenosine deaminase domain containing 2 3.13659
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.13659
PECAM1 platelet/endothelial cell adhesion molecule 1 3.13659
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.13659
ADAMTSL5 ADAMTS-like 5 3.13659
GSTM5 glutathione S-transferase mu 5 3.13659
SIRPB2 signal-regulatory protein beta 2 3.13659
NCF1 neutrophil cytosolic factor 1 3.13659
PARP3 poly (ADP-ribose) polymerase family, member 3 3.13659
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.13659
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.13659
SLC26A7 solute carrier family 26 (anion exchanger), member 7 3.13659
HEATR9 HEAT repeat containing 9 3.13659
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.13659
MUC1 mucin 1, cell surface associated 3.13659
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.13659
SLC35G5 solute carrier family 35, member G5 3.13659
SOX14 SRY (sex determining region Y)-box 14 3.13659
CNTNAP4 contactin associated protein-like 4 3.13659
RGPD3 RANBP2-like and GRIP domain containing 3 3.13659
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.13659
TMC3 transmembrane channel-like 3 3.13659
LDHC lactate dehydrogenase C 3.13659
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.13659
ACY3 aminoacylase 3 3.13659
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.13659
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.13659
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.13659
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.13659
SNAI2 snail family zinc finger 2 3.13659
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.13659
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.13659
NPTX1 neuronal pentraxin I 3.13659
MYO1A myosin IA 3.13659
BMP3 bone morphogenetic protein 3 3.13659
TTLL2 tubulin tyrosine ligase-like family member 2 3.13659
DLX4 distal-less homeobox 4 3.13659
ZBTB37 zinc finger and BTB domain containing 37 3.13659
LGI1 leucine-rich, glioma inactivated 1 3.13659
COPZ2 coatomer protein complex, subunit zeta 2 3.13659
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.13659
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.13659
IL2RB interleukin 2 receptor, beta 3.13659
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 3.13659
MPL MPL proto-oncogene, thrombopoietin receptor 3.13659
PRDM12 PR domain containing 12 3.13659
MEIG1 meiosis/spermiogenesis associated 1 3.13659
ZC3H11C zinc finger CCCH-type containing 11C 3.13659
FIMP1 fertilization-influencing membrane protein 1 3.13659
PKD2L1 polycystic kidney disease 2-like 1 3.13659
MLN motilin 3.13659
TBC1D3L TBC1 domain family, member 3L 3.13659
C20ORF202 chromosome 20 open reading frame 202 3.13659
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 3.13659
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.13659
ASB9 ankyrin repeat and SOCS box containing 9 3.13659
DOK2 docking protein 2, 56kDa 3.13659
RTL1 retrotransposon-like 1 3.13659
CSAG3 CSAG family, member 3 3.13659
VN1R2 vomeronasal 1 receptor 2 3.13659
VN1R1 vomeronasal 1 receptor 1 3.13659
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.13659
NOTCH2NLB notch 2 N-terminal like B 3.13659
TMA7B translation machinery associated 7 homolog B 3.13659
H4C14 H4 clustered histone 14 3.13659
PPP1R2C PPP1R2C family member C 3.13659
PLAAT4 phospholipase A and acyltransferase 4 3.13659
PPP1R2B PPP1R2 family member B 3.13659
CCN3 cellular communication network factor 3 3.13659
H2BC1 H2B clustered histone 1 3.13659
GBP2 guanylate binding protein 2, interferon-inducible 3.13659
ZAR1 zygote arrest 1 3.13659
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.13659
CDKL4 cyclin-dependent kinase-like 4 3.13659
LRRC72 leucine rich repeat containing 72 3.13659
CD300E CD300e molecule 3.13659
FPR2 formyl peptide receptor 2 3.13659
TBX20 T-box 20 3.13659
SLC22A14 solute carrier family 22, member 14 3.13659
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.13659
CFHR3 complement factor H-related 3 3.13659
SIX3 SIX homeobox 3 3.13659
SIX2 SIX homeobox 2 3.13659
HLX H2.0-like homeobox 3.13659
AGTR1 angiotensin II receptor, type 1 3.13659
MYBPHL myosin binding protein H-like 3.13659
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.13659
TMEM229A transmembrane protein 229A 3.13659
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.13659
LRRC70 leucine rich repeat containing 70 3.13659
FMR1NB fragile X mental retardation 1 neighbor 3.13659
CDSN corneodesmosin 3.13659
TLR1 toll-like receptor 1 3.13659
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.13659
IL6 interleukin 6 3.13659
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.13659
ZIC4 Zic family member 4 3.13659
CXCL16 chemokine (C-X-C motif) ligand 16 3.13659
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.13659
ANXA10 annexin A10 3.13659
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.13659
RBP4 retinol binding protein 4, plasma 3.13659
LRRC32 leucine rich repeat containing 32 3.13659
ZNF541 zinc finger protein 541 3.13659
OTC ornithine carbamoyltransferase 3.13659
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.13659
GRK1 G protein-coupled receptor kinase 1 3.13659
HHATL hedgehog acyltransferase-like 3.13659
CDHR5 cadherin-related family member 5 3.13659
GOLGA6B golgin A6 family, member B 3.13659
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.13659
CPA3 carboxypeptidase A3 (mast cell) 3.13659
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.13659
C18ORF63 chromosome 18 open reading frame 63 3.13659
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.13659
VAX2 ventral anterior homeobox 2 3.13659
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.13659
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.13659
MYF6 myogenic factor 6 (herculin) 3.13659
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.13659
LMOD3 leiomodin 3 (fetal) 3.13659
IGFBP1 insulin-like growth factor binding protein 1 3.13659
RBMXL3 RNA binding motif protein, X-linked-like 3 3.13659
ERICH4 glutamate-rich 4 3.13659
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.13659
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.13659
DSC1 desmocollin 1 3.13659
COMP cartilage oligomeric matrix protein 3.13659
UBXN10 UBX domain protein 10 3.13659
CD28 CD28 molecule 3.13659
DCT dopachrome tautomerase 3.13659
IGSF10 immunoglobulin superfamily, member 10 3.13659
C1ORF105 chromosome 1 open reading frame 105 3.13659
MYADML2 myeloid-associated differentiation marker-like 2 3.13659
TYR tyrosinase 3.13659
POU4F3 POU class 4 homeobox 3 3.13659
HPGDS hematopoietic prostaglandin D synthase 3.13659
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.13659
CA5A carbonic anhydrase VA, mitochondrial 3.13659
CTSS cathepsin S 3.13659
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.13659
EGR2 early growth response 2 3.13659
SPATA9 spermatogenesis associated 9 3.13659
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.13659
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.13659
LY96 lymphocyte antigen 96 3.13659
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.13659
BCL2A1 BCL2-related protein A1 3.13659
DLX3 distal-less homeobox 3 3.13659
OTOP1 otopetrin 1 3.13659
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.13659
GCM2 glial cells missing homolog 2 (Drosophila) 3.13659
IL17B interleukin 17B 3.13659
ANGPTL6 angiopoietin-like 6 3.13659
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.13659
MSMP microseminoprotein, prostate associated 3.13659
A1CF APOBEC1 complementation factor 3.13659
ACSM5 acyl-CoA synthetase medium-chain family member 5 3.13659
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.13659
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.13659
LAMP5 lysosomal-associated membrane protein family, member 5 3.13659
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 3.13659
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.13659
CARNS1 carnosine synthase 1 3.13659
GLT6D1 glycosyltransferase 6 domain containing 1 3.13659
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.13659
AMPD1 adenosine monophosphate deaminase 1 3.13659
DES desmin 3.13659
CD3D CD3d molecule, delta (CD3-TCR complex) 3.13659
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.13659
DYTN dystrotelin 3.13659
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.13659
TGM5 transglutaminase 5 3.13659
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.13659
PRSS54 protease, serine, 54 3.13659
PMP2 peripheral myelin protein 2 3.13659
PRC1 protein regulator of cytokinesis 1 3.12296
SETD7 SET domain containing (lysine methyltransferase) 7 3.09371
ATG9B autophagy related 9B 3.08163
NKD2 naked cuticle homolog 2 (Drosophila) 3.08163
PRKG1 protein kinase, cGMP-dependent, type I 2.97114
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 2.87047
GPC3 glypican 3 2.81686
CYTH2 cytohesin 2 2.78664
ZNF8 zinc finger protein 8 2.77459
NPC1 Niemann-Pick disease, type C1 2.75235
SART3 squamous cell carcinoma antigen recognized by T cells 3 2.7171
TPR translocated promoter region, nuclear basket protein 2.70841
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.68361
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.68361
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 2.65808
VAV3 vav 3 guanine nucleotide exchange factor 2.65019
CCNE2 cyclin E2 2.63782
KLHL22 kelch-like family member 22 2.62329
VMA22 vacuolar ATPase assembly factor VMA22 2.61865
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.61849
DENND2C DENN/MADD domain containing 2C 2.56453
ZNF703 zinc finger protein 703 2.55146
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.55146
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 2.54155
KAT14 lysine acetyltransferase 14 2.53929
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.52399
JAKMIP2 janus kinase and microtubule interacting protein 2 2.51101
RNF43 ring finger protein 43 2.51014
OPTC opticin 2.50826
NPIPB4 nuclear pore complex interacting protein family, member B4 2.50289
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 2.50289
PRB2 proline-rich protein BstNI subfamily 2 2.50221
ATOH8 atonal homolog 8 (Drosophila) 2.50221
RAD51D RAD51 paralog D 2.46657
TTLL7 tubulin tyrosine ligase-like family member 7 2.44623
SLC39A9 solute carrier family 39, member 9 2.43753
SLC10A7 solute carrier family 10, member 7 2.42927
GPR158 G protein-coupled receptor 158 2.37367
ZNF780B zinc finger protein 780B 2.32432
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 2.30963
ADAM28 ADAM metallopeptidase domain 28 2.29947
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.29933
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.27123
HAPLN4 hyaluronan and proteoglycan link protein 4 2.26129
RCAN1 regulator of calcineurin 1 2.24474
TMC7 transmembrane channel-like 7 2.23677
PNPLA5 patatin-like phospholipase domain containing 5 2.22383
NPB neuropeptide B 2.2099
FYB2 FYN binding protein 2 2.2099
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 2.2099
PRPH2 peripherin 2 (retinal degeneration, slow) 2.2099
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.2099
PTGR1 prostaglandin reductase 1 2.1885
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.16981
NOTCH2NLC notch 2 N-terminal like C 2.16834
FMNL1 formin-like 1 2.14066
MTCL1 microtubule crosslinking factor 1 2.13592
SLTM SAFB-like, transcription modulator 2.13193
C8ORF33 chromosome 8 open reading frame 33 2.12306
TMED3 transmembrane emp24 protein transport domain containing 3 2.12152
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.12004
PROKR2 prokineticin receptor 2 2.11814
KIAA2012 KIAA2012 2.11695
TTLL4 tubulin tyrosine ligase-like family member 4 2.10094
PLK2 polo-like kinase 2 2.10094
SLFNL1 schlafen-like 1 2.06535
CPEB4 cytoplasmic polyadenylation element binding protein 4 2.06
CCNG2 cyclin G2 2.05653
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.05124
FYCO1 FYVE and coiled-coil domain containing 1 2.04626
EFCAB14 EF-hand calcium binding domain 14 2.03279
DGCR6L DiGeorge syndrome critical region gene 6-like 2.03184
RORA RAR-related orphan receptor A 2.0292
GCLM glutamate-cysteine ligase, modifier subunit 2.02437
ZBTB7A zinc finger and BTB domain containing 7A 2.01533

decreased expression

Symbol Name Standardized Value
BMP8A bone morphogenetic protein 8a -3.13659
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -3.13659
AKAP14 A kinase (PRKA) anchor protein 14 -3.13659
PRSS53 protease, serine, 53 -3.13659
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -3.13659
ZBTB5 zinc finger and BTB domain containing 5 -3.13659
LMOD1 leiomodin 1 (smooth muscle) -3.12969
RBM28 RNA binding motif protein 28 -3.08604
CD68 CD68 molecule -2.97114
PRSS36 protease, serine, 36 -2.97114
PODNL1 podocan-like 1 -2.97114
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -2.97114
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) -2.97114
ASCL5 achaete-scute family bHLH transcription factor 5 -2.97114
FRMPD2 FERM and PDZ domain containing 2 -2.97114
ARRDC2 arrestin domain containing 2 -2.97114
FAM90A1 family with sequence similarity 90, member A1 -2.97114
UPB1 ureidopropionase, beta -2.97114
PRRT1B proline rich transmembrane protein 1B -2.97114
H4C12 H4 clustered histone 12 -2.97114
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -2.97114
CES4A carboxylesterase 4A -2.97114
PCDHGA9 protocadherin gamma subfamily A, 9 -2.97114
MROH5 maestro heat-like repeat family member 5 -2.97114
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -2.97114
CFAP45 cilia and flagella associated protein 45 -2.97114
PLIN4 perilipin 4 -2.97114
ST18 suppression of tumorigenicity 18, zinc finger -2.97114
SYTL5 synaptotagmin-like 5 -2.97114
CTAGE4 CTAGE family, member 4 -2.97114
MR1 major histocompatibility complex, class I-related -2.97114
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.97114
FBXO36 F-box protein 36 -2.97114
PLCD4 phospholipase C, delta 4 -2.97114
SPATA32 spermatogenesis associated 32 -2.97114
CD52 CD52 molecule -2.97114
CAMKV CaM kinase-like vesicle-associated -2.96467
ZNF567 zinc finger protein 567 -2.94462
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.93981
HK2 hexokinase 2 -2.76354
RAB11FIP2 RAB11 family interacting protein 2 (class I) -2.76221
CCDC14 coiled-coil domain containing 14 -2.66601
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.62774
SHB Src homology 2 domain containing adaptor protein B -2.555
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.54893
MYOM1 myomesin 1 -2.54876
THY1 Thy-1 cell surface antigen -2.51137
SUSD1 sushi domain containing 1 -2.51014
CDC45 cell division cycle 45 -2.50826
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.48098
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.47505
C1ORF202 chromosome 1 open reading frame 202 -2.47505
FSCN3 fascin actin-bundling protein 3, testicular -2.47505
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.4029
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -2.38404
CMYA5 cardiomyopathy associated 5 -2.31249
C5ORF24 chromosome 5 open reading frame 24 -2.2855
DHCR24 24-dehydrocholesterol reductase -2.28095
F10 coagulation factor X -2.27123
DORIP1 dopamine receptor interacting protein 1 -2.27123
RSL1D1 ribosomal L1 domain containing 1 -2.26129
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.26129
NIPAL3 NIPA-like domain containing 3 -2.23677
FDX2 ferredoxin 2 -2.20223
MEAK7 MTOR associated protein, eak-7 homolog -2.19305
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.19101
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.18443
POU5F1B POU class 5 homeobox 1B -2.18138
CD200R1L CD200 receptor 1-like -2.18067
NFYA nuclear transcription factor Y, alpha -2.15382
TEAD4 TEA domain family member 4 -2.15353
ACVR1C activin A receptor, type IC -2.13568
MTMR1 myotubularin related protein 1 -2.1316
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.11141
CD226 CD226 molecule -2.10787
MTERF4 mitochondrial transcription termination factor 4 -2.09999
ZNF185 zinc finger protein 185 (LIM domain) -2.09944
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.08574
PEX39 peroxisomal biogenesis factor 39 -2.08129
KIF2A kinesin heavy chain member 2A -2.06835
CCDC136 coiled-coil domain containing 136 -2.06107
KDM6B lysine (K)-specific demethylase 6B -2.05653
RILPL1 Rab interacting lysosomal protein-like 1 -2.04626
ABHD11 abhydrolase domain containing 11 -2.03707
ZNF737 zinc finger protein 737 -2.03184
PCDH9 protocadherin 9 -2.01533
PGM3 phosphoglucomutase 3 -2.01054
ZNF543 zinc finger protein 543 -2.00981
LRRC75A leucine rich repeat containing 75A -2.00981