| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | NLR family, pyrin domain containing 3|This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 114548) |
| External Link | https://ncbi.nlm.nih.gov/gene/114548 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the NLRP3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0168989 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0163094 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.0144079 |
| APOD | apolipoprotein D | 0.0140607 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.0131076 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.0130838 |
| MAP7 | microtubule-associated protein 7 | 0.0130455 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.0123706 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0115362 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.0106922 |
| PIP | prolactin-induced protein | 0.0104796 |
| XPO7 | exportin 7 | 0.0103456 |
| ADIRF | adipogenesis regulatory factor | 0.00988175 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00953293 |
| PTK2 | protein tyrosine kinase 2 | 0.00936229 |
| KRT14 | keratin 14, type I | 0.00933869 |
| MID1 | midline 1 | 0.00933579 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00919383 |
| FRZB | frizzled-related protein | 0.00915601 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00913402 |
| SYNM | synemin, intermediate filament protein | 0.00899274 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00896728 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00889153 |
| HOXC10 | homeobox C10 | 0.00885335 |
| TP63 | tumor protein p63 | 0.00859051 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.00852741 |
| NVL | nuclear VCP-like | 0.00841847 |
| RGS5 | regulator of G-protein signaling 5 | 0.00800935 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00798105 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.00793237 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.00773985 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 0.00769783 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.0076366 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.00758178 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00746309 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00745879 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00742837 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.00739859 |
| NAV2 | neuron navigator 2 | 0.00725976 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 0.00725551 |
| ASS1 | argininosuccinate synthase 1 | 0.00725183 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00721166 |
| PROM1 | prominin 1 | 0.00715784 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00707697 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00707195 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00706216 |
| PLXNA1 | plexin A1 | 0.00703786 |
| WIF1 | WNT inhibitory factor 1 | 0.007012 |
| SEPTIN10 | septin 10 | 0.00700535 |
| NOTCH2NL | notch 2 N-terminal like | 0.00698699 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00697742 |
| HMBOX1 | homeobox containing 1 | 0.00694634 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.00692726 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00689038 |
| HCRT | hypocretin (orexin) neuropeptide precursor | 0.00683627 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00682458 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00681733 |
| GOLGA8H | golgin A8 family, member H | 0.00680391 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.00675581 |
| PRTN3 | proteinase 3 | 0.00674811 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.00668211 |
| TGFB3 | transforming growth factor, beta 3 | 0.00664148 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | 0.00660846 |
| PHIP | pleckstrin homology domain interacting protein | 0.00658503 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.00656653 |
| RPL10 | ribosomal protein L10 | 0.00655804 |
| CHRDL1 | chordin-like 1 | 0.0065149 |
| SIK1 | salt-inducible kinase 1 | 0.00650021 |
| S100A11 | S100 calcium binding protein A11 | 0.00650017 |
| HIP1 | huntingtin interacting protein 1 | 0.00647314 |
| PNN | pinin, desmosome associated protein | 0.006448 |
| SETBP1 | SET binding protein 1 | 0.00635777 |
| SH3BP4 | SH3-domain binding protein 4 | 0.00632197 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0062792 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.00625392 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.00625251 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00623112 |
| ANOS1 | anosmin 1 | 0.00621764 |
| MBD1 | methyl-CpG binding domain protein 1 | 0.00621635 |
| NDNF | neuron-derived neurotrophic factor | 0.0062093 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | 0.0061937 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.00619248 |
| CAV2 | caveolin 2 | 0.00618255 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00618122 |
| PTN | pleiotrophin | 0.00617298 |
| JAG1 | jagged 1 | 0.00615573 |
| MYBPC1 | myosin binding protein C, slow type | 0.00614136 |
| NFASC | neurofascin | 0.00612796 |
| FERMT1 | fermitin family member 1 | 0.00612678 |
| VWF | von Willebrand factor | 0.00612268 |
| DIPK1A | divergent protein kinase domain 1A | 0.00604689 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00604553 |
| SASH1 | SAM and SH3 domain containing 1 | 0.00604321 |
| MCAM | melanoma cell adhesion molecule | 0.00604021 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | 0.00600001 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00599474 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00597941 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.00597016 |
| ZNF160 | zinc finger protein 160 | 0.00596517 |
| NKX2-2 | NK2 homeobox 2 | 0.00593033 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00592016 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00591974 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.00591888 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.00591808 |
| AGR2 | anterior gradient 2 | 0.0058936 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00589326 |
| MYOF | myoferlin | 0.00589089 |
| COPA | coatomer protein complex, subunit alpha | 0.00587274 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00585522 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.00584969 |
| RASIP1 | Ras interacting protein 1 | 0.00582247 |
| RBM26 | RNA binding motif protein 26 | 0.00579665 |
| TTN | titin | 0.00578914 |
| PTCH1 | patched 1 | 0.00578788 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00577819 |
| PERP | PERP, TP53 apoptosis effector | 0.00577644 |
| RUNX3 | runt-related transcription factor 3 | 0.00574582 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.00572339 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00570965 |
| MGLL | monoglyceride lipase | 0.0057079 |
| DSC1 | desmocollin 1 | 0.00570048 |
| TBX3 | T-box 3 | 0.00569792 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 0.00569219 |
| NOTCH3 | notch 3 | 0.00568603 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00568478 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00568199 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.00567214 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00566327 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00565414 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.00565345 |
| AK1 | adenylate kinase 1 | 0.00562315 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.00559466 |
| PRRC2C | proline-rich coiled-coil 2C | 0.00559225 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00559161 |
| FAM160B2 | family with sequence similarity 160, member B2 | 0.00558905 |
| ELN | elastin | 0.00557748 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | 0.0055595 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00554099 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.00553637 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.00552086 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.00551472 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00550697 |
| TSPAN13 | tetraspanin 13 | 0.00550304 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00550031 |
| SRRT | serrate, RNA effector molecule | 0.00549877 |
| ANGPT2 | angiopoietin 2 | 0.00549509 |
| MELK | maternal embryonic leucine zipper kinase | 0.00549463 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.00548717 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.0054871 |
| CH25H | cholesterol 25-hydroxylase | 0.00548389 |
| DLG5 | discs, large homolog 5 (Drosophila) | 0.00547058 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00546674 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00546585 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.00546329 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.00546142 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00545178 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.00544972 |
| PLCE1 | phospholipase C, epsilon 1 | 0.00543734 |
| RND3 | Rho family GTPase 3 | 0.005433 |
| MYO1B | myosin IB | 0.0054323 |
| AZU1 | azurocidin 1 | 0.00541864 |
| TULP3 | tubby like protein 3 | 0.0054125 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | 0.00540153 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.00540133 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00538845 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00536832 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | 0.00535214 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00534923 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.00534385 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | 0.00534249 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.00532998 |
| WWC3 | WWC family member 3 | 0.0053233 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.00529589 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.0052915 |
| SYT17 | synaptotagmin XVII | 0.00529009 |
| MAOB | monoamine oxidase B | 0.00528874 |
| COL4A1 | collagen, type IV, alpha 1 | 0.00527757 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0052692 |
| SFTPB | surfactant protein B | 0.00526684 |
| RXRA | retinoid X receptor, alpha | 0.00526418 |
| IL27RA | interleukin 27 receptor, alpha | 0.0052601 |
| LAMC2 | laminin, gamma 2 | 0.00525646 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.00524951 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.00523434 |
| SPATA20 | spermatogenesis associated 20 | 0.00522544 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.00521969 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00521264 |
| NCOA6 | nuclear receptor coactivator 6 | 0.00518285 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.00518034 |
| RTN2 | reticulon 2 | 0.00517571 |
| PROS1 | protein S (alpha) | 0.00517078 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00516966 |
| FOXJ3 | forkhead box J3 | 0.00516488 |
| DUOX1 | dual oxidase 1 | 0.00516228 |
| CARD10 | caspase recruitment domain family, member 10 | 0.00514884 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.00514822 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00514244 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.00513077 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | 0.00512954 |
| REEP1 | receptor accessory protein 1 | 0.00512452 |
| ADAR | adenosine deaminase, RNA-specific | 0.00512282 |
| RBPMS | RNA binding protein with multiple splicing | 0.00511999 |
| CTBP2 | C-terminal binding protein 2 | 0.00511857 |
| TRIM29 | tripartite motif containing 29 | 0.0051147 |
| FASN | fatty acid synthase | 0.00510989 |
| ZNF638 | zinc finger protein 638 | 0.00510774 |
| TXLNA | taxilin alpha | 0.00510214 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00509193 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.00508441 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00507387 |
| SETD5 | SET domain containing 5 | 0.00507233 |
| CALML5 | calmodulin-like 5 | 0.00506496 |
| COL4A2 | collagen, type IV, alpha 2 | 0.00505699 |
| LONP2 | lon peptidase 2, peroxisomal | 0.00505201 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00504371 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00503311 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00503085 |
| PLA1A | phospholipase A1 member A | 0.0050077 |
| RGCC | regulator of cell cycle | 0.00495838 |
| DLX5 | distal-less homeobox 5 | 0.00495327 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.00495246 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.00495087 |
| BCL7B | B-cell CLL/lymphoma 7B | 0.00494138 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.00493165 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00492831 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00492573 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00490153 |
| PRKD2 | protein kinase D2 | 0.00489954 |
| RET | ret proto-oncogene | 0.00489348 |
| IER5 | immediate early response 5 | 0.00488864 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00487096 |
| POF1B | premature ovarian failure, 1B | 0.00487065 |
| XCL1 | chemokine (C motif) ligand 1 | 0.00485766 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.00484389 |
| PRC1 | protein regulator of cytokinesis 1 | 0.00483837 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.00483511 |
| MICALL2 | MICAL-like 2 | 0.00483111 |
| FAR2 | fatty acyl CoA reductase 2 | 0.0048244 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00481887 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 0.00481866 |
| SPEN | spen family transcriptional repressor | 0.00481714 |
| PDZD8 | PDZ domain containing 8 | 0.00481641 |
| FAM193A | family with sequence similarity 193, member A | 0.00481167 |
| FBXW12 | F-box and WD repeat domain containing 12 | 0.00480622 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.0047901 |
| OLFM1 | olfactomedin 1 | 0.0047888 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00478065 |
| BTG3 | BTG family, member 3 | 0.00477366 |
| SEPTIN2 | septin 2 | 0.00476419 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.00476408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | -0.0163984 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0161707 |
| PLBD1 | phospholipase B domain containing 1 | -0.0133838 |
| XIC | X chromosome inactivation center | -0.013267 |
| PITX1 | paired-like homeodomain 1 | -0.011938 |
| WDR7 | WD repeat domain 7 | -0.011417 |
| PCP4 | Purkinje cell protein 4 | -0.011287 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0111646 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.0110412 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0109464 |
| SELL | selectin L | -0.010811 |
| S100A9 | S100 calcium binding protein A9 | -0.00977318 |
| RGS4 | regulator of G-protein signaling 4 | -0.00973124 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0096997 |
| MAL | mal, T-cell differentiation protein | -0.00968009 |
| CCNA1 | cyclin A1 | -0.00945536 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.0093589 |
| LCN2 | lipocalin 2 | -0.00926989 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -0.00926605 |
| ADM | adrenomedullin | -0.00914619 |
| GLUL | glutamate-ammonia ligase | -0.00909705 |
| RNASE6 | ribonuclease, RNase A family, k6 | -0.00908603 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.00903084 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0088993 |
| PITX3 | paired-like homeodomain 3 | -0.00883658 |
| SYNGR3 | synaptogyrin 3 | -0.0087874 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00877122 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00868705 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00867604 |
| BMP4 | bone morphogenetic protein 4 | -0.00851213 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00841249 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00833445 |
| FGL2 | fibrinogen-like 2 | -0.00831423 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00827171 |
| LOX | lysyl oxidase | -0.00810962 |
| TXNL1 | thioredoxin-like 1 | -0.0080993 |
| CFI | complement factor I | -0.00807328 |
| RRAGA | Ras-related GTP binding A | -0.0079773 |
| HHEX | hematopoietically expressed homeobox | -0.00795658 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00793151 |
| LY96 | lymphocyte antigen 96 | -0.00786623 |
| CST3 | cystatin C | -0.00783786 |
| CHKB | choline kinase beta | -0.00782494 |
| AK4 | adenylate kinase 4 | -0.00782183 |
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 | -0.00774565 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00771626 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0077008 |
| MMP9 | matrix metallopeptidase 9 | -0.00769968 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00768208 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00765809 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00762724 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00754101 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00753924 |
| CTSB | cathepsin B | -0.00752434 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00742253 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0073778 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00734979 |
| RGS10 | regulator of G-protein signaling 10 | -0.00732244 |
| LTF | lactotransferrin | -0.00730318 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00723618 |
| OLFM4 | olfactomedin 4 | -0.00720678 |
| TCL1A | T-cell leukemia/lymphoma 1A | -0.00719489 |
| FGG | fibrinogen gamma chain | -0.00718525 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.00717613 |
| FHIT | fragile histidine triad | -0.00716003 |
| VCAN | versican | -0.00713247 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00710125 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.00704376 |
| PEG3 | paternally expressed 3 | -0.00702447 |
| NMU | neuromedin U | -0.00701487 |
| H1-2 | H1.2 linker histone, cluster member | -0.00699729 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00698993 |
| LSP1 | lymphocyte-specific protein 1 | -0.00696659 |
| BLVRB | biliverdin reductase B | -0.00689659 |
| HIST3H2A | histone cluster 3, H2a | -0.00689485 |
| CLDN7 | claudin 7 | -0.00683691 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | -0.00682249 |
| GLOD4 | glyoxalase domain containing 4 | -0.00681511 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.00680674 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0067766 |
| ATP5MJ | ATP synthase membrane subunit j | -0.00676732 |
| PSAP | prosaposin | -0.00675946 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00672207 |
| RNF130 | ring finger protein 130 | -0.00668165 |
| IL7R | interleukin 7 receptor | -0.00666846 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00665835 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00664745 |
| BEX4 | brain expressed, X-linked 4 | -0.00663293 |
| AIF1 | allograft inflammatory factor 1 | -0.0066272 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.0066017 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.0066014 |
| TUBA1A | tubulin, alpha 1a | -0.00658918 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00656332 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00651069 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0064644 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0064403 |
| FYB1 | FYN binding protein 1 | -0.0064394 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.0064228 |
| S100A12 | S100 calcium binding protein A12 | -0.00641517 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.00639879 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | -0.00637797 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00636556 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | -0.00629392 |
| LMNB1 | lamin B1 | -0.00627187 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00625281 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.00621947 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.00621774 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00621099 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00620904 |
| DNTT | DNA nucleotidylexotransferase | -0.00618587 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | -0.00617386 |
| NFE2 | nuclear factor, erythroid 2 | -0.00617368 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00616837 |
| EVI2A | ecotropic viral integration site 2A | -0.0061624 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00614771 |
| TNFSF13 | tumor necrosis factor (ligand) superfamily, member 13 | -0.00612606 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00610117 |
| REG1A | regenerating islet-derived 1 alpha | -0.00607326 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00605003 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00604348 |
| GM2A | GM2 ganglioside activator | -0.00603974 |
| S100A7 | S100 calcium binding protein A7 | -0.00603208 |
| GNAS | GNAS complex locus | -0.00600763 |
| TUBB2A | tubulin, beta 2A class IIa | -0.0060057 |
| CLDN10 | claudin 10 | -0.00600549 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00598322 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.0059581 |
| LST1 | leukocyte specific transcript 1 | -0.00595754 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.00595683 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00595151 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0059466 |
| GOLGA7 | golgin A7 | -0.00594356 |
| ALB | albumin | -0.00593195 |
| STK38L | serine/threonine kinase 38 like | -0.00592733 |
| CD52 | CD52 molecule | -0.0059219 |
| BLNK | B-cell linker | -0.00591842 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00590816 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | -0.00590295 |
| CD86 | CD86 molecule | -0.00588759 |
| MT1G | metallothionein 1G | -0.00587836 |
| H1-10 | H1.10 linker histone | -0.00586251 |
| DUOX2 | dual oxidase 2 | -0.00585553 |
| CPQ | carboxypeptidase Q | -0.00585217 |
| FPR1 | formyl peptide receptor 1 | -0.00584486 |
| GCHFR | GTP cyclohydrolase I feedback regulator | -0.00583998 |
| TFF1 | trefoil factor 1 | -0.00583346 |
| IGSF6 | immunoglobulin superfamily, member 6 | -0.00582614 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | -0.00582378 |
| PNMA1 | paraneoplastic Ma antigen 1 | -0.00580566 |
| STX8 | syntaxin 8 | -0.0057804 |
| PFDN6 | prefoldin subunit 6 | -0.00576877 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.00573358 |
| NDN | necdin, melanoma antigen (MAGE) family member | -0.00573202 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0057209 |
| ARRB2 | arrestin, beta 2 | -0.00571834 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00566688 |
| MT1H | metallothionein 1H | -0.00564909 |
| LY86 | lymphocyte antigen 86 | -0.00563327 |
| PLIN2 | perilipin 2 | -0.00563106 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | -0.00562001 |
| CD48 | CD48 molecule | -0.00560562 |
| ANXA6 | annexin A6 | -0.00559686 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00558248 |
| FAM162A | family with sequence similarity 162, member A | -0.00558127 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00557748 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00557642 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.0055628 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00555628 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.0055372 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0055345 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00552586 |
| CHPT1 | choline phosphotransferase 1 | -0.00551931 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00549791 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | -0.00549755 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00549008 |
| KRT15 | keratin 15, type I | -0.00548338 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.0054822 |
| CPE | carboxypeptidase E | -0.00546239 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00545517 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00544476 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.00544132 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00543137 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00541869 |
| MAT2B | methionine adenosyltransferase II, beta | -0.005407 |
| COMMD10 | COMM domain containing 10 | -0.00534251 |
| EIF1B | eukaryotic translation initiation factor 1B | -0.00533958 |
| H1-0 | H1.0 linker histone | -0.00532683 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00532058 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.00530496 |
| MT1X | metallothionein 1X | -0.00530214 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00530117 |
| LYRM4 | LYR motif containing 4 | -0.00529563 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.00529197 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.00527539 |
| HP | haptoglobin | -0.00527022 |
| RNF167 | ring finger protein 167 | -0.00525637 |
| MRPL40 | mitochondrial ribosomal protein L40 | -0.00525497 |
| LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | -0.00525026 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00523812 |
| MT1HL1 | metallothionein 1H-like 1 | -0.00523791 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00523687 |
| GPX1 | glutathione peroxidase 1 | -0.00523013 |
| RGS2 | regulator of G-protein signaling 2 | -0.00521659 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.00521329 |
| ACTN1 | actinin, alpha 1 | -0.00519474 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.00518596 |
| EAPP | E2F-associated phosphoprotein | -0.00515838 |
| ADORA2B | adenosine A2b receptor | -0.00515736 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00513685 |
| ATF3 | activating transcription factor 3 | -0.00512847 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | -0.00512723 |
| CD53 | CD53 molecule | -0.00510901 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00510801 |
| ZNF277 | zinc finger protein 277 | -0.0051031 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00510163 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00509801 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | -0.00509752 |
| CLEC4A | C-type lectin domain family 4, member A | -0.00508422 |
| GUK1 | guanylate kinase 1 | -0.00506546 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.00505994 |
| COPS4 | COP9 signalosome subunit 4 | -0.00503899 |
| RHOB | ras homolog family member B | -0.00503888 |
| GTPBP8 | GTP-binding protein 8 (putative) | -0.00503564 |
| MT2A | metallothionein 2A | -0.0050129 |
| TPD52L1 | tumor protein D52-like 1 | -0.0050117 |
| WASHC4 | WASH complex subunit 4 | -0.00500851 |
| PRMT1 | protein arginine methyltransferase 1 | -0.00500179 |
| MBD2 | methyl-CpG binding domain protein 2 | -0.00500097 |
| CD9 | CD9 molecule | -0.00499939 |
| VAMP5 | vesicle-associated membrane protein 5 | -0.00498918 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00498581 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.00497044 |
| MT1E | metallothionein 1E | -0.00496978 |
| KLF2 | Kruppel-like factor 2 | -0.0049669 |
| NPC2 | Niemann-Pick disease, type C2 | -0.00493835 |
| HIST1H2AJ | histone cluster 1, H2aj | -0.00493676 |
| SST | somatostatin | -0.00493596 |
| KIAA0226L | KIAA0226-like | -0.00492708 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00490523 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.00488886 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00488187 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00487648 |
| RPL26L1 | ribosomal protein L26-like 1 | -0.00487213 |
| TSPAN5 | tetraspanin 5 | -0.00486363 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0048627 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00484946 |
| MMP12 | matrix metallopeptidase 12 | -0.00484772 |
| ISOC2 | isochorismatase domain containing 2 | -0.00484673 |
| TMEM126B | transmembrane protein 126B | -0.00484449 |
| TMEM14B | transmembrane protein 14B | -0.00484361 |
