NNMT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nicotinamide N-methyltransferase|N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4837)
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Genes

312 genes differentially expressed following the NNMT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 4.27544
ARHGAP36 Rho GTPase activating protein 36 4.27544
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 4.27544
APOA2 apolipoprotein A-II 4.27544
RSPO3 R-spondin 3 4.27544
SCNN1G sodium channel, non voltage gated 1 gamma subunit 4.27544
TCAF2 TRPM8 channel-associated factor 2 4.27544
SPRR1B small proline-rich protein 1B 4.27544
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 4.27544
GUCY2F guanylate cyclase 2F, retinal 4.27544
MTTP microsomal triglyceride transfer protein 4.27544
AADACL4 arylacetamide deacetylase-like 4 4.27544
WT1 Wilms tumor 1 4.27544
SCGN secretagogin, EF-hand calcium binding protein 4.27544
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 4.27544
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 4.27544
FGL1 fibrinogen-like 1 4.27544
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 4.27544
PCDHB8 protocadherin beta 8 4.27544
MILR1 mast cell immunoglobulin-like receptor 1 4.27544
RUNDC3A RUN domain containing 3A 4.27544
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 4.27544
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 4.27544
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 4.27544
LGALS9 lectin, galactoside-binding, soluble, 9 4.27544
CRYAA crystallin, alpha A 4.27544
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 4.27544
FAM9C family with sequence similarity 9, member C 4.27544
ZC2HC1B zinc finger, C2HC-type containing 1B 4.27544
NEUROD4 neuronal differentiation 4 4.27544
AOC1 amine oxidase, copper containing 1 4.27544
RAB7B RAB7B, member RAS oncogene family 4.27544
C17ORF78 chromosome 17 open reading frame 78 4.27544
CSAG2 CSAG family, member 2 4.27544
CRYGA crystallin, gamma A 4.27544
HBD hemoglobin, delta 4.27544
PRSS36 protease, serine, 36 4.27544
ATP8B4 ATPase, class I, type 8B, member 4 4.27544
KIF2B kinesin family member 2B 4.27544
TCP11 t-complex 11, testis-specific 4.27544
DLL4 delta-like 4 (Drosophila) 4.27544
NPIPA8 nuclear pore complex interacting protein family, member A8 4.27544
MISP mitotic spindle positioning 4.27544
BRICD5 BRICHOS domain containing 5 4.27544
MUC22 mucin 22 4.27544
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 4.27544
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 4.27544
LOC124900192 uncharacterized LOC124900192 4.27544
YIPF7 Yip1 domain family, member 7 4.27544
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 4.27544
KRT86 keratin 86, type II 4.27544
IQCF3 IQ motif containing F3 4.27544
WNT16 wingless-type MMTV integration site family, member 16 4.27544
IMPG2 interphotoreceptor matrix proteoglycan 2 4.27544
MAGIX MAGI family member, X-linked 4.27544
CSAG1 chondrosarcoma associated gene 1 4.27544
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 4.27544
FYB1 FYN binding protein 1 4.27544
CPHXL2 cytoplasmic polyadenylated homeobox like 2 4.27544
RTL9 retrotransposon Gag like 9 4.27544
OR1R1 olfactory receptor family 1 subfamily R member 1 4.27544
NOTCH2NLB notch 2 N-terminal like B 4.27544
MYMK myomaker, myoblast fusion factor 4.27544
CPHXL cytoplasmic polyadenylated homeobox like 4.27544
CCDC197 coiled-coil domain containing 197 4.27544
TENT5D terminal nucleotidyltransferase 5D 4.27544
ATP5MGL ATP synthase membrane subunit g like 4.27544
GARIN1A golgi associated RAB2 interactor 1A 4.27544
CALHM5 calcium homeostasis modulator family member 5 4.27544
CCDC42 coiled-coil domain containing 42 4.27544
ROPN1 rhophilin associated tail protein 1 4.27544
CCR6 chemokine (C-C motif) receptor 6 4.27544
LGALS7B lectin, galactoside-binding, soluble, 7B 4.27544
PRB4 proline-rich protein BstNI subfamily 4 4.27544
REG4 regenerating islet-derived family, member 4 4.27544
SLC22A14 solute carrier family 22, member 14 4.27544
AKAP3 A kinase (PRKA) anchor protein 3 4.27544
GJA3 gap junction protein, alpha 3, 46kDa 4.27544
LY86 lymphocyte antigen 86 4.27544
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 4.27544
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4 4.27544
NHLRC4 NHL repeat containing 4 4.27544
TLR5 toll-like receptor 5 4.27544
CFAP52 cilia and flagella associated protein 52 4.27544
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 4.27544
TIMD4 T-cell immunoglobulin and mucin domain containing 4 4.27544
PGLYRP1 peptidoglycan recognition protein 1 4.27544
GLIPR1L2 GLI pathogenesis-related 1 like 2 4.27544
EXOC3L1 exocyst complex component 3-like 1 4.27544
EXOC3L4 exocyst complex component 3-like 4 4.27544
PRR18 proline rich 18 4.27544
CFAP45 cilia and flagella associated protein 45 4.27544
ALB albumin 4.27544
SVOP SV2 related protein homolog (rat) 4.27544
KLHL41 kelch-like family member 41 4.27544
KLF2 Kruppel-like factor 2 4.27544
PDCD1LG2 programmed cell death 1 ligand 2 4.27544
C2ORF66 chromosome 2 open reading frame 66 4.27544
NOX3 NADPH oxidase 3 4.27544
CTAGE9 CTAGE family, member 9 4.27544
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 4.27544
CRYBB3 crystallin, beta B3 4.27544
HHATL hedgehog acyltransferase-like 4.27544
MAB21L3 mab-21-like 3 (C. elegans) 4.27544
AQP8 aquaporin 8 4.27544
C11ORF97 chromosome 11 open reading frame 97 4.27544
BTNL8 butyrophilin-like 8 4.27544
CLEC1A C-type lectin domain family 1, member A 4.27544
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 4.27544
EFCAB9 EF-hand calcium binding domain 9 4.27544
GP2 glycoprotein 2 (zymogen granule membrane) 4.27544
ERICH6B glutamate-rich 6B 4.27544
CALHM1 calcium homeostasis modulator 1 4.27544
FSHR follicle stimulating hormone receptor 4.27544
PRR35 proline rich 35 4.27544
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 4.27544
DCDC2B doublecortin domain containing 2B 4.27544
EPHA5 EPH receptor A5 4.27544
GLRB glycine receptor, beta 4.27544
HRCT1 histidine rich carboxyl terminus 1 4.27544
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 4.27544
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 4.27544
IL1A interleukin 1, alpha 4.27544
MUC13 mucin 13, cell surface associated 4.27544
EVPLL envoplakin-like 4.27544
AGXT2 alanine--glyoxylate aminotransferase 2 4.27544
SNX31 sorting nexin 31 4.27544
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 4.27544
NT5DC4 5'-nucleotidase domain containing 4 4.27544
TRIM50 tripartite motif containing 50 4.27544
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 4.27544
MMP12 matrix metallopeptidase 12 4.27544
ACKR2 atypical chemokine receptor 2 4.27544
GH1 growth hormone 1 4.27544
GH2 growth hormone 2 4.27544
GRAPL GRB2-related adaptor protein-like 4.27544
SLC51B solute carrier family 51, beta subunit 4.27544
CFAP221 cilia and flagella associated protein 221 4.27544
GOLGA8J golgin A8 family, member J 4.27544
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 4.27544
PTPN7 protein tyrosine phosphatase, non-receptor type 7 4.27544
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 4.27544
OR10G3 olfactory receptor, family 10, subfamily G, member 3 4.27544
PF4V1 platelet factor 4 variant 1 4.27544
SSX3 synovial sarcoma, X breakpoint 3 4.27544
TTC24 tetratricopeptide repeat domain 24 4.27544
CXORF58 chromosome X open reading frame 58 4.27544
KRT15 keratin 15, type I 4.27544
MEPE matrix extracellular phosphoglycoprotein 4.27544
CRHBP corticotropin releasing hormone binding protein 4.27544
TMEM150B transmembrane protein 150B 4.27544
LRRN4 leucine rich repeat neuronal 4 4.27544
SMYD1 SET and MYND domain containing 1 4.27544
MYADML2 myeloid-associated differentiation marker-like 2 4.27544
RORC RAR-related orphan receptor C 4.27544
GPR50 G protein-coupled receptor 50 4.27544
BARHL2 BarH-like homeobox 2 4.27544
PRND prion protein 2 (dublet) 4.27544
VAX1 ventral anterior homeobox 1 4.27544
FGR FGR proto-oncogene, Src family tyrosine kinase 4.24747
CFAP44 cilia and flagella associated protein 44 3.7906
ANLN anillin, actin binding protein 3.60441
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 3.47415
NALCN sodium leak channel, non selective 3.2531
CD38 CD38 molecule 3.23787
SMIM10 small integral membrane protein 10 3.23787
EVPL envoplakin 3.23787
BTG1 B-cell translocation gene 1, anti-proliferative 3.13722
PTPRM protein tyrosine phosphatase, receptor type, M 3.00608
SLC16A11 solute carrier family 16, member 11 2.91077
DAP death-associated protein 2.79115
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 2.7777
RPL32 ribosomal protein L32 2.73434
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.69446
STMN2 stathmin 2 2.63227
CXCL5 chemokine (C-X-C motif) ligand 5 2.60567
ASL argininosuccinate lyase 2.51812
FOXI3 forkhead box I3 2.48579
LHCGR luteinizing hormone/choriogonadotropin receptor 2.48579
GPR157 G protein-coupled receptor 157 2.47339
YJEFN3 YjeF N-terminal domain containing 3 2.46734
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.45561
GOLGA4 golgin A4 2.44719
GPX2 glutathione peroxidase 2 2.42975
CCDC196 coiled-coil domain containing 196 2.42975
KCNK6 potassium channel, two pore domain subfamily K, member 6 2.40119
TTC12 tetratricopeptide repeat domain 12 2.38728
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.3623
STK11 serine/threonine kinase 11 2.35923
AKAP11 A kinase (PRKA) anchor protein 11 2.34822
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.34161
PTK2B protein tyrosine kinase 2 beta 2.33387
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.32466
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 2.31895
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.31837
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.31549
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.31549
JPT2 Jupiter microtubule associated homolog 2 2.27122
MRPS26 mitochondrial ribosomal protein S26 2.26929
TK1 thymidine kinase 1, soluble 2.23465
PDAP1 PDGFA associated protein 1 2.22862
ZNF212 zinc finger protein 212 2.18884
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 2.18599
SAT2 spermidine/spermine N1-acetyltransferase family member 2 2.16403
PUSL1 pseudouridylate synthase-like 1 2.15652
TK2 thymidine kinase 2, mitochondrial 2.15436
MCL1 myeloid cell leukemia 1 2.10325
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.09776
KASH5 KASH domain containing 5 2.09776
OPCML opioid binding protein/cell adhesion molecule-like 2.07903
SH2D3A SH2 domain containing 3A 2.07524
PEX10 peroxisomal biogenesis factor 10 2.07126
TMEM26 transmembrane protein 26 2.06494
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.06494
MPI mannose phosphate isomerase 2.04497
KCNIP4 Kv channel interacting protein 4 2.02631
TMEM106A transmembrane protein 106A 2.02532

decreased expression

Symbol Name Standardized Value
SYNPO synaptopodin -4.27544
PTGR3 prostaglandin reductase 3 -4.27544
SAXO5 stabilizer of axonemal microtubules 5 -4.27544
DOK6 docking protein 6 -4.27544
MAPK11 mitogen-activated protein kinase 11 -4.24747
TPPP tubulin polymerization promoting protein -4.24747
ZBTB16 zinc finger and BTB domain containing 16 -4.24747
PRR22 proline rich 22 -4.24747
C10ORF90 chromosome 10 open reading frame 90 -4.24747
CNTNAP4 contactin associated protein-like 4 -4.24747
PPP1R3C protein phosphatase 1, regulatory subunit 3C -4.24747
FAM110D family with sequence similarity 110, member D -4.24747
IL17D interleukin 17D -4.24747
ZNF396 zinc finger protein 396 -4.24747
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -4.24747
NR4A2 nuclear receptor subfamily 4, group A, member 2 -4.24747
TLR2 toll-like receptor 2 -4.24747
MYL5 myosin, light chain 5, regulatory -4.24747
SMKR1 small lysine-rich protein 1 -4.24747
MEIS2 Meis homeobox 2 -4.24747
EFCAB12 EF-hand calcium binding domain 12 -4.24747
SPACA9 sperm acrosome associated 9 -4.24747
NECTIN4 nectin cell adhesion molecule 4 -4.24747
CD200R1 CD200 receptor 1 -4.24747
ROPN1L rhophilin associated tail protein 1-like -4.24747
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -4.24747
TRIM73 tripartite motif containing 73 -4.24747
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -4.24747
LTB lymphotoxin beta (TNF superfamily, member 3) -4.24747
MPPED1 metallophosphoesterase domain containing 1 -4.24747
FAM186B family with sequence similarity 186, member B -4.24747
PDE7B phosphodiesterase 7B -4.24747
PITPNM3 PITPNM family member 3 -4.14091
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -3.87894
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -3.60746
PRDM14 PR domain containing 14 -3.09254
PPP1R37 protein phosphatase 1, regulatory subunit 37 -3.04514
WDR5B WD repeat domain 5B -3.03502
ALS2CL ALS2 C-terminal like -3.03502
FRMD1 FERM domain containing 1 -3.03502
IGFBP3 insulin-like growth factor binding protein 3 -3.03502
RHBG Rh family, B glycoprotein (gene/pseudogene) -3.03502
SETD3 SET domain containing 3 -3.00518
ZNF587B zinc finger protein 587B -2.9845
ADORA2B adenosine A2b receptor -2.98418
TTC26 tetratricopeptide repeat domain 26 -2.92045
C10ORF95 chromosome 10 open reading frame 95 -2.92045
FAM177A1 family with sequence similarity 177, member A1 -2.91555
SCART1 scavenger receptor protein family member -2.91305
MYOZ1 myozenin 1 -2.91305
RBP5 retinol binding protein 5, cellular -2.91305
TRIM69 tripartite motif containing 69 -2.88287
SLC45A1 solute carrier family 45, member 1 -2.88287
CCDC81 coiled-coil domain containing 81 -2.86927
FOXH1 forkhead box H1 -2.83912
TLN2 talin 2 -2.83572
CDHR2 cadherin-related family member 2 -2.81448
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.81448
CCDC200 coiled-coil domain containing 200 -2.79265
KCTD13 potassium channel tetramerization domain containing 13 -2.79265
DEPDC5 DEP domain containing 5 -2.68792
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.56525
SH3GL1 SH3-domain GRB2-like 1 -2.52166
NRARP NOTCH-regulated ankyrin repeat protein -2.45723
ZNF157 zinc finger protein 157 -2.4206
ZNF25 zinc finger protein 25 -2.35217
GZF1 GDNF-inducible zinc finger protein 1 -2.31837
CETN3 centrin, EF-hand protein, 3 -2.30818
TCTA T-cell leukemia translocation altered -2.28806
BMP8A bone morphogenetic protein 8a -2.2754
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.27122
MASP2 mannan-binding lectin serine peptidase 2 -2.26929
SERTAD4 SERTA domain containing 4 -2.26632
TP53TG5 TP53 target 5 -2.26632
YEATS2 YEATS domain containing 2 -2.26632
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.26632
PCNT pericentrin -2.24589
CTTNBP2 cortactin binding protein 2 -2.24349
BICD2 bicaudal D homolog 2 (Drosophila) -2.24166
RECQL4 RecQ protein-like 4 -2.19567
CDKL4 cyclin-dependent kinase-like 4 -2.18884
CCDC18 coiled-coil domain containing 18 -2.1862
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.15652
MRPS14 mitochondrial ribosomal protein S14 -2.132
TMEM39B transmembrane protein 39B -2.12603
ERCC6 excision repair cross-complementation group 6 -2.12038
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.07822
RBM47 RNA binding motif protein 47 -2.0687
PLIN5 perilipin 5 -2.06494
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.05699
E2F7 E2F transcription factor 7 -2.04973
WNK1 WNK lysine deficient protein kinase 1 -2.04483
MDH1B malate dehydrogenase 1B, NAD (soluble) -2.04061
CIRSR corepressor of RBPJ and splicing regulator -2.01819
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 -2.00027