NOD1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nucleotide-binding oligomerization domain containing 1|This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 10392)
External Link http://www.ncbi.nlm.nih.gov/gene/10392
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Genes

50 interacting proteins for NOD1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CACYBP calcyclin binding protein
CARD6 caspase recruitment domain family, member 6
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDC37 cell division cycle 37
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
COPS6 COP9 signalosome subunit 6
CYLD cylindromatosis (turban tumor syndrome)
FKBP5 FK506 binding protein 5
FKBPL FK506 binding protein like
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GPS1 G protein pathway suppressor 1
HNF1A HNF1 homeobox A
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ITCH itchy E3 ubiquitin protein ligase
MAGED1 melanoma antigen family D1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MLF2 myeloid leukemia factor 2
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NUDCD3 NudC domain containing 3
OLFM4 olfactomedin 4
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGES3 prostaglandin E synthase 3 (cytosolic)
RIPK2 receptor-interacting serine-threonine kinase 2
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
SOX8 SRY (sex determining region Y)-box 8
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF4 TNF receptor-associated factor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase