NOG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description noggin|The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9241)
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Genes

346 genes differentially expressed following the NOG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SRL sarcalumenin 2.7732
CCNB3 cyclin B3 2.7732
BLK BLK proto-oncogene, Src family tyrosine kinase 2.7732
DUSP15 dual specificity phosphatase 15 2.7732
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.7732
CORT cortistatin 2.7732
MTTP microsomal triglyceride transfer protein 2.7732
PAX6 paired box 6 2.7732
ASB12 ankyrin repeat and SOCS box containing 12 2.7732
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.7732
MUSK muscle, skeletal, receptor tyrosine kinase 2.7732
ENTHD1 ENTH domain containing 1 2.7732
SCN2B sodium channel, voltage gated, type II beta subunit 2.7732
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.7732
SBK3 SH3 domain binding kinase family, member 3 2.7732
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.7732
CSRP1 cysteine and glycine-rich protein 1 2.7732
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.7732
MAP3K7CL MAP3K7 C-terminal like 2.7732
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.7732
WDR87 WD repeat domain 87 2.7732
ZNF492 zinc finger protein 492 2.7732
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.7732
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.7732
SSTR2 somatostatin receptor 2 2.7732
GYPE glycophorin E (MNS blood group) 2.7732
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 2.7732
SPACA4 sperm acrosome associated 4 2.7732
RNF39 ring finger protein 39 2.7732
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.7732
HIC1 hypermethylated in cancer 1 2.7732
NWD1 NACHT and WD repeat domain containing 1 2.7732
FAM9B family with sequence similarity 9, member B 2.7732
KRTAP5-7 keratin associated protein 5-7 2.7732
PCDHGA11 protocadherin gamma subfamily A, 11 2.7732
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.7732
SPDEF SAM pointed domain containing ETS transcription factor 2.7732
WNT16 wingless-type MMTV integration site family, member 16 2.7732
TRPC5OS TRPC5 opposite strand 2.7732
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.7732
SLC9C2 solute carrier family 9, member C2 (putative) 2.7732
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.7732
BIRC3 baculoviral IAP repeat containing 3 2.7732
GUCY2F guanylate cyclase 2F, retinal 2.7732
TMEM217 transmembrane protein 217 2.7732
SPP2 secreted phosphoprotein 2, 24kDa 2.7732
PARP10 poly (ADP-ribose) polymerase family, member 10 2.7732
GLIS1 GLIS family zinc finger 1 2.7732
LRRC63 leucine rich repeat containing 63 2.7732
SETSIP SET-like protein 2.7732
NPR3 natriuretic peptide receptor 3 2.7732
SPMAP2L sperm microtubule associated protein 2 like 2.7732
CCDC9B coiled-coil domain containing 9B 2.7732
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.7732
TUBGCP4 tubulin, gamma complex associated protein 4 2.7732
MGAT4D MGAT4 family, member D 2.7732
MLN motilin 2.7732
LMNTD1 lamin tail domain containing 1 2.7732
TMPRSS7 transmembrane protease, serine 7 2.7732
ACSL5 acyl-CoA synthetase long-chain family member 5 2.7732
MYPN myopalladin 2.7732
DOK7 docking protein 7 2.7732
NIBAN3 niban apoptosis regulator 3 2.7732
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.7732
PMIS2 PMIS2 transmembrane protein 2.7732
LOC114841035 uncharacterized LOC114841035 2.7732
EPCIP exosomal polycystin 1 interacting protein 2.7732
KIF1C-AS1 KIF1C antisense RNA 1 2.7732
CIMAP1D CIMAP1 family member D 2.7732
INSYN1 inhibitory synaptic factor 1 2.7732
CTXND1 cortexin domain containing 1 2.7732
DNAAF6 dynein axonemal assembly factor 6 2.7732
MEIOSIN meiosis initiator 2.7732
H2BW2 H2B.W histone 2 2.7732
WDR97 WD repeat domain 97 2.7732
GCSAM germinal center-associated, signaling and motility 2.7732
WDR93 WD repeat domain 93 2.7732
ZAR1L zygote arrest 1-like 2.7732
SLC35D3 solute carrier family 35, member D3 2.7732
ACTL10 actin-like 10 2.7732
LIPC lipase, hepatic 2.7732
ATP13A4 ATPase type 13A4 2.7732
PVRIG poliovirus receptor related immunoglobulin domain containing 2.7732
PRH1-TAS2R14 PRH1-TAS2R14 readthrough 2.7732
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.7732
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.7732
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.7732
WEE2 WEE1 homolog 2 (S. pombe) 2.7732
EDAR ectodysplasin A receptor 2.7732
CLEC3A C-type lectin domain family 3, member A 2.7732
CCR6 chemokine (C-C motif) receptor 6 2.7732
BLNK B-cell linker 2.7732
C7ORF57 chromosome 7 open reading frame 57 2.7732
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.7732
RASAL3 RAS protein activator like 3 2.7732
INSRR insulin receptor-related receptor 2.7732
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.7732
GZMM granzyme M (lymphocyte met-ase 1) 2.7732
DMBX1 diencephalon/mesencephalon homeobox 1 2.7732
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.7732
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.7732
HNF4A hepatocyte nuclear factor 4, alpha 2.7732
RHOJ ras homolog family member J 2.7732
CCDC27 coiled-coil domain containing 27 2.7732
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 2.7732
RSAD2 radical S-adenosyl methionine domain containing 2 2.7732
CLIC5 chloride intracellular channel 5 2.7732
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.7732
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.7732
FAM135B family with sequence similarity 135, member B 2.7732
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.7732
HCRT hypocretin (orexin) neuropeptide precursor 2.7732
PCDHGA3 protocadherin gamma subfamily A, 3 2.7732
CRHBP corticotropin releasing hormone binding protein 2.7732
C1ORF105 chromosome 1 open reading frame 105 2.7732
LGALS14 lectin, galactoside-binding, soluble, 14 2.7732
TCF21 transcription factor 21 2.7732
SOSTDC1 sclerostin domain containing 1 2.7732
DAW1 dynein assembly factor with WDR repeat domains 1 2.7732
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.7732
PCDHGB4 protocadherin gamma subfamily B, 4 2.7732
SPG11 spastic paraplegia 11 (autosomal recessive) 2.7732
TEX12 testis expressed 12 2.7732
BTNL2 butyrophilin-like 2 2.7732
IFITM5 interferon induced transmembrane protein 5 2.7732
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.7732
BPIFB4 BPI fold containing family B, member 4 2.7732
DRD5 dopamine receptor D5 2.7732
OSM oncostatin M 2.7732
CPA2 carboxypeptidase A2 (pancreatic) 2.7732
CBX8 chromobox homolog 8 2.7732
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.7732
BCO1 beta-carotene oxygenase 1 2.7732
MYADM myeloid-associated differentiation marker 2.7732
ARR3 arrestin 3, retinal (X-arrestin) 2.7732
ANKRD61 ankyrin repeat domain 61 2.7732
DGCR6 DiGeorge syndrome critical region gene 6 2.7732
OPRK1 opioid receptor, kappa 1 2.7732
EPGN epithelial mitogen 2.7732
KLK11 kallikrein-related peptidase 11 2.7732
PCP2 Purkinje cell protein 2 2.7732
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.7732
PDCD1 programmed cell death 1 2.7732
CALML5 calmodulin-like 5 2.7732
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.7732
C22ORF31 chromosome 22 open reading frame 31 2.7732
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.7732
GOLGA8J golgin A8 family, member J 2.7732
GRAP2 GRB2-related adaptor protein 2 2.7732
PADI6 peptidyl arginine deiminase, type VI 2.7732
GPR179 G protein-coupled receptor 179 2.7732
MEIOB meiosis specific with OB domains 2.7732
GOLGA8N golgin A8 family, member N 2.7732
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.7732
PHOX2A paired-like homeobox 2a 2.7732
NLRP7 NLR family, pyrin domain containing 7 2.7732
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.7732
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.7732
PITX2 paired-like homeodomain 2 2.7732
WFDC13 WAP four-disulfide core domain 13 2.7732
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.7732
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.7732
CASQ2 calsequestrin 2 (cardiac muscle) 2.7732
FZD1 frizzled class receptor 1 2.7732
PLA2G2C phospholipase A2, group IIC 2.7732
ALOX15B arachidonate 15-lipoxygenase, type B 2.7732
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.7732
POU3F2 POU class 3 homeobox 2 2.7732
LAMB3 laminin, beta 3 2.7732
PAGE2B P antigen family, member 2B 2.7732
NTSR1 neurotensin receptor 1 (high affinity) 2.7732
KLHDC1 kelch domain containing 1 2.7732
CCDC78 coiled-coil domain containing 78 2.7732
TTC24 tetratricopeptide repeat domain 24 2.7732
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.7732
RNF222 ring finger protein 222 2.7732
APOL6 apolipoprotein L, 6 2.7732
EXPH5 exophilin 5 2.74269
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 2.74269
B9D2 B9 protein domain 2 2.7145
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.7145
ZMAT5 zinc finger, matrin-type 5 2.7145
PSD4 pleckstrin and Sec7 domain containing 4 2.7145
TAS2R30 taste receptor, type 2, member 30 2.7145
PROM2 prominin 2 2.7145
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.7145
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 2.7145
IRX3 iroquois homeobox 3 2.7145
MTRES1 mitochondrial transcription rescue factor 1 2.69281
TCF12 transcription factor 12 2.62816
ZNF329 zinc finger protein 329 2.62816
SYT6 synaptotagmin VI 2.60841
LIMK2 LIM domain kinase 2 2.59298
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.57247
CFAP53 cilia and flagella associated protein 53 2.57247
DAAM2 dishevelled associated activator of morphogenesis 2 2.56338
DPY19L2 dpy-19-like 2 (C. elegans) 2.56338
GASK1A golgi associated kinase 1A 2.54562
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.49582
LRRC8A leucine rich repeat containing 8 family, member A 2.46586
NPY1R neuropeptide Y receptor Y1 2.43523
PARG poly (ADP-ribose) glycohydrolase 2.42137
HEATR4 HEAT repeat containing 4 2.41936
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 2.40094
LRRC8C leucine rich repeat containing 8 family, member C 2.40094
LAMC1 laminin, gamma 1 (formerly LAMB2) 2.39754
CCDC32 coiled-coil domain containing 32 2.37509
TEX2 testis expressed 2 2.36531
ROR2 receptor tyrosine kinase-like orphan receptor 2 2.34766
DNAI3 dynein axonemal intermediate chain 3 2.33821
NF1 neurofibromin 1 2.33036
SMTNL1 smoothelin-like 1 2.31529
BRPF1 bromodomain and PHD finger containing, 1 2.30689
SNAP23 synaptosomal-associated protein, 23kDa 2.25444
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 2.24427
TCTN2 tectonic family member 2 2.24427
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2.24427
PYGO1 pygopus family PHD finger 1 2.24427
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.20974
RAD17 RAD17 homolog (S. pombe) 2.20754
LTA4H leukotriene A4 hydrolase 2.20264
ZNF620 zinc finger protein 620 2.20128
AFAP1 actin filament associated protein 1 2.19991
MAP6D1 MAP6 domain containing 1 2.18621
ADAM19 ADAM metallopeptidase domain 19 2.18621
ZSCAN10 zinc finger and SCAN domain containing 10 2.15323
MDFIC MyoD family inhibitor domain containing 2.14558
SLC38A1 solute carrier family 38, member 1 2.13637
INTS7 integrator complex subunit 7 2.12694
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 2.12271
PCDHA13 protocadherin alpha 13 2.11545
C1RL complement component 1, r subcomponent-like 2.10804
ABLIM1 actin binding LIM protein 1 2.08696
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.08577
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.0644
JAK2 Janus kinase 2 2.05081
NEK10 NIMA-related kinase 10 2.04489
METTL17 methyltransferase like 17 2.03024
RBM19 RNA binding motif protein 19 2.0286
RBKS ribokinase 2.02568
USP32 ubiquitin specific peptidase 32 2.02176
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 2.01728
FN3K fructosamine 3 kinase 2.01473
TRAF4 TNF receptor-associated factor 4 2.00689

decreased expression

Symbol Name Standardized Value
RAD54L RAD54-like (S. cerevisiae) -2.7732
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.7732
PKLR pyruvate kinase, liver and RBC -2.7732
TMEM102 transmembrane protein 102 -2.7732
ZNF324 zinc finger protein 324 -2.7732
SCX scleraxis basic helix-loop-helix transcription factor -2.7732
IL15 interleukin 15 -2.7732
IRAK4 interleukin-1 receptor-associated kinase 4 -2.7732
CTRL chymotrypsin-like -2.7732
RTKN2 rhotekin 2 -2.7732
FSTL5 follistatin-like 5 -2.7732
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.7732
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.7732
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.7732
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.74269
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.74269
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.74269
ARGFX arginine-fifty homeobox -2.74269
FLACC1 flagellum associated containing coiled-coil domains 1 -2.74269
IRX5 iroquois homeobox 5 -2.74269
LKAAEAR1 LKAAEAR motif containing 1 -2.74269
FGF9 fibroblast growth factor 9 -2.74269
CHD5 chromodomain helicase DNA binding protein 5 -2.74269
RPL28 ribosomal protein L28 -2.74269
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.74269
PCDHA3 protocadherin alpha 3 -2.74269
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.74269
WDR5B WD repeat domain 5B -2.74269
RUNX3 runt-related transcription factor 3 -2.74269
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.74269
ZNF324B zinc finger protein 324B -2.74269
ADH6 alcohol dehydrogenase 6 (class V) -2.74269
TBX20 T-box 20 -2.74269
BAIAP3 BAI1-associated protein 3 -2.74269
EFCAB8 EF-hand calcium binding domain 8 -2.74269
INMT indolethylamine N-methyltransferase -2.74269
KRT15 keratin 15, type I -2.74269
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.74269
ZPBP zona pellucida binding protein -2.74269
MAPK15 mitogen-activated protein kinase 15 -2.74269
AMIGO1 adhesion molecule with Ig-like domain 1 -2.74269
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -2.74269
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -2.74269
GOLGA8R golgin A8 family, member R -2.74269
ZNF600 zinc finger protein 600 -2.67615
CASR calcium-sensing receptor -2.67615
ACHE acetylcholinesterase (Yt blood group) -2.58684
TMEM91 transmembrane protein 91 -2.56988
GRM8 glutamate receptor, metabotropic 8 -2.5642
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -2.55262
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.53164
IL6ST interleukin 6 signal transducer -2.51192
EMC4 ER membrane protein complex subunit 4 -2.49849
CTSV cathepsin V -2.48604
SOX13 SRY (sex determining region Y)-box 13 -2.45868
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.43008
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.40094
DDB2 damage-specific DNA binding protein 2, 48kDa -2.39754
CGNL1 cingulin-like 1 -2.39754
CDK15 cyclin-dependent kinase 15 -2.3555
ADAP1 ArfGAP with dual PH domains 1 -2.34766
PAQR4 progestin and adipoQ receptor family member IV -2.34766
TFEB transcription factor EB -2.34766
MTMR4 myotubularin related protein 4 -2.33821
ZNF875 zinc finger protein 875 -2.3349
PIAS4 protein inhibitor of activated STAT, 4 -2.32069
NEMP1 nuclear envelope integral membrane protein 1 -2.29777
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) -2.25591
PEF1 penta-EF-hand domain containing 1 -2.24427
SLC60A2 solute carrier family 60 member 2 -2.23222
OBI1 ORC ubiquitin ligase 1 -2.23092
CBR4 carbonyl reductase 4 -2.20569
MACROD2 MACRO domain containing 2 -2.19354
E2F1 E2F transcription factor 1 -2.18713
PCP4 Purkinje cell protein 4 -2.18621
SPATA18 spermatogenesis associated 18 -2.18621
SMYD2 SET and MYND domain containing 2 -2.18458
BTN3A1 butyrophilin, subfamily 3, member A1 -2.15635
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.15269
GJC1 gap junction protein, gamma 1, 45kDa -2.14688
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.14558
IQCC IQ motif containing C -2.12694
FAM78A family with sequence similarity 78, member A -2.12694
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.12694
SPOUT1 SPOUT domain containing methyltransferase 1 -2.12185
SLC25A51 solute carrier family 25, member 51 -2.12089
SUB1 SUB1 homolog (S. cerevisiae) -2.11545
ZNF181 zinc finger protein 181 -2.11233
C2ORF69 chromosome 2 open reading frame 69 -2.10898
GLB1 galactosidase, beta 1 -2.10804
CEP70 centrosomal protein 70kDa -2.10076
GSR glutathione reductase -2.09464
GSS glutathione synthetase -2.07778
RAB11FIP2 RAB11 family interacting protein 2 (class I) -2.07778
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.06848
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.04236
CIC capicua transcriptional repressor -2.02929
RPL37 ribosomal protein L37 -2.02385
KLF15 Kruppel-like factor 15 -2.02385
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.01901
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.01393
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.00849