NOTCH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description notch 1|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4851)
Similar Terms
Downloads & Tools

Genes

333 genes differentially expressed following the NOTCH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SAPCD1 suppressor APC domain containing 1 2.9274
HNF4A hepatocyte nuclear factor 4, alpha 2.9274
DPRX divergent-paired related homeobox 2.9274
HBZ hemoglobin, zeta 2.9274
POU2F3 POU class 2 homeobox 3 2.9274
PKD2L1 polycystic kidney disease 2-like 1 2.9274
PRTN3 proteinase 3 2.9274
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.9274
CD53 CD53 molecule 2.9274
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.9274
PLA2G2C phospholipase A2, group IIC 2.9274
FOXP3 forkhead box P3 2.9274
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.9274
THSD8 thrombospondin type 1 domain containing 8 2.9274
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.9274
MAP3K7CL MAP3K7 C-terminal like 2.9274
MAJIN membrane anchored junction protein 2.9274
HAS1 hyaluronan synthase 1 2.9274
PCDH20 protocadherin 20 2.9274
S100B S100 calcium binding protein B 2.9274
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.9274
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.86416
WT1 Wilms tumor 1 2.86416
LRRC56 leucine rich repeat containing 56 2.86416
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.86416
GJA10 gap junction protein, alpha 10, 62kDa 2.86416
ZBTB42 zinc finger and BTB domain containing 42 2.86416
SGPP2 sphingosine-1-phosphate phosphatase 2 2.86416
SLC46A3 solute carrier family 46, member 3 2.86416
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.86416
ERV3-1 endogenous retrovirus group 3, member 1 2.86416
PON1 paraoxonase 1 2.86416
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.86416
OLAH oleoyl-ACP hydrolase 2.86416
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.86416
ABHD16B abhydrolase domain containing 16B 2.86416
CCNB3 cyclin B3 2.86416
PAX9 paired box 9 2.86416
CSMD3 CUB and Sushi multiple domains 3 2.86416
DOCK3 dedicator of cytokinesis 3 2.86416
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.86416
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.86416
VSTM2A V-set and transmembrane domain containing 2A 2.86416
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.86416
TRPC5OS TRPC5 opposite strand 2.86416
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.86416
CPLX1 complexin 1 2.86416
SPHK1 sphingosine kinase 1 2.86416
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.86416
PRR29 proline rich 29 2.86416
ADAT3 adenosine deaminase, tRNA-specific 3 2.86416
MEIKIN meiotic kinetochore factor 2.86416
SHCBP1L SHC SH2-domain binding protein 1-like 2.86416
TCAF2 TRPM8 channel-associated factor 2 2.86416
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.86416
C11ORF87 chromosome 11 open reading frame 87 2.86416
STRA8 stimulated by retinoic acid 8 2.86416
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.86416
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.86416
LCN15 lipocalin 15 2.86416
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.86416
ACVRL1 activin A receptor type II-like 1 2.86416
HES2 hes family bHLH transcription factor 2 2.86416
CIMIP2B ciliary microtubule inner protein 2B 2.86416
DUSP9 dual specificity phosphatase 9 2.86416
FMO2 flavin containing monooxygenase 2 (non-functional) 2.86416
FOXN4 forkhead box N4 2.86416
PDF peptide deformylase (mitochondrial) 2.86416
SMLR1 small leucine-rich protein 1 2.86416
IQCF1 IQ motif containing F1 2.86416
CSAG3 CSAG family, member 3 2.86416
PLEK2 pleckstrin 2 2.86416
SAMD15 sterile alpha motif domain containing 15 2.86416
VN1R2 vomeronasal 1 receptor 2 2.86416
GPR35 G protein-coupled receptor 35 2.86416
AANAT aralkylamine N-acetyltransferase 2.86416
C20ORF204 chromosome 20 open reading frame 204 2.86416
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.86416
TMEM225B transmembrane protein 225B 2.86416
DNAI7 dynein axonemal intermediate chain 7 2.86416
VEGFD vascular endothelial growth factor D 2.86416
DEPP1 DEPP autophagy regulator 1 2.86416
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.86416
KY kyphoscoliosis peptidase 2.86416
RAG1 recombination activating gene 1 2.86416
SERBP1 SERPINE1 mRNA binding protein 1 2.86416
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.86416
CLDN22 claudin 22 2.86416
CPNE5 copine V 2.86416
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.86416
HBA2 hemoglobin, alpha 2 2.86416
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.86416
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.86416
LY86 lymphocyte antigen 86 2.86416
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.86416
CHADL chondroadherin-like 2.86416
ASB15 ankyrin repeat and SOCS box containing 15 2.86416
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.86416
SLFN14 schlafen family member 14 2.86416
PRB2 proline-rich protein BstNI subfamily 2 2.86416
SPDYC speedy/RINGO cell cycle regulator family member C 2.86416
LSP1 lymphocyte-specific protein 1 2.86416
MIP major intrinsic protein of lens fiber 2.86416
TPTE transmembrane phosphatase with tensin homology 2.86416
IL4 interleukin 4 2.86416
NPNT nephronectin 2.86416
CBLN3 cerebellin 3 precursor 2.86416
MEOX1 mesenchyme homeobox 1 2.86416
PRB4 proline-rich protein BstNI subfamily 4 2.86416
DUXB double homeobox B 2.86416
EBF4 early B-cell factor 4 2.86416
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.86416
NPBWR1 neuropeptides B/W receptor 1 2.86416
EMP1 epithelial membrane protein 1 2.86416
FAM209B family with sequence similarity 209, member B 2.86416
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.86416
TEKT1 tektin 1 2.86416
CHI3L2 chitinase 3-like 2 2.86416
TIPE2 TNF alpha induced protein 8 like 2 2.86416
CNGB3 cyclic nucleotide gated channel beta 3 2.86416
EGR2 early growth response 2 2.86416
CALHM1 calcium homeostasis modulator 1 2.86416
OLFML1 olfactomedin-like 1 2.86416
MCCD1 mitochondrial coiled-coil domain 1 2.86416
MYF6 myogenic factor 6 (herculin) 2.86416
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.86416
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.86416
GPR12 G protein-coupled receptor 12 2.86416
DQX1 DEAQ box RNA-dependent ATPase 1 2.86416
KLHL6 kelch-like family member 6 2.86416
S100A14 S100 calcium binding protein A14 2.86416
C9ORF64 chromosome 9 open reading frame 64 2.86416
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.86416
ZFP90 ZFP90 zinc finger protein 2.86416
C20ORF144 chromosome 20 open reading frame 144 2.86416
HMGB4 high mobility group box 4 2.86416
NYX nyctalopin 2.86416
LGALS14 lectin, galactoside-binding, soluble, 14 2.86416
POU4F1 POU class 4 homeobox 1 2.86416
PCDHAC1 protocadherin alpha subfamily C, 1 2.86416
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.86416
MGP matrix Gla protein 2.86416
TTC22 tetratricopeptide repeat domain 22 2.86416
TMEM255A transmembrane protein 255A 2.86416
FOXN1 forkhead box N1 2.86416
CSDC2 cold shock domain containing C2, RNA binding 2.86416
BCL2L15 BCL2-like 15 2.86416
IGF2 insulin-like growth factor 2 2.86416
LIPJ lipase, family member J 2.86416
LRRC15 leucine rich repeat containing 15 2.86416
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.86416
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.86416
TRHR thyrotropin-releasing hormone receptor 2.86416
PDCD1LG2 programmed cell death 1 ligand 2 2.86416
PRSS33 protease, serine, 33 2.86416
NT5C1B 5'-nucleotidase, cytosolic IB 2.86416
ATP10B ATPase, class V, type 10B 2.86416
GOLGA8N golgin A8 family, member N 2.86416
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.86416
ANGPTL6 angiopoietin-like 6 2.86416
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.86416
ENHO energy homeostasis associated 2.86416
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.86416
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.86416
CIB3 calcium and integrin binding family member 3 2.86416
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.86416
CD8A CD8a molecule 2.86416
CDC14C cell division cycle 14C 2.86416
CD80 CD80 molecule 2.86416
AHSG alpha-2-HS-glycoprotein 2.86416
SOX30 SRY (sex determining region Y)-box 30 2.86416
TSPEAR thrombospondin-type laminin G domain and EAR repeats 2.86416
ERAP2 endoplasmic reticulum aminopeptidase 2 2.86416
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.86416
RNASE6 ribonuclease, RNase A family, k6 2.86416
FAM81B family with sequence similarity 81, member B 2.86416
SPDEF SAM pointed domain containing ETS transcription factor 2.86416
CD226 CD226 molecule 2.86416
ASCL5 achaete-scute family bHLH transcription factor 5 2.86416
TMEM88 transmembrane protein 88 2.86416
GH2 growth hormone 2 2.86416
FGF17 fibroblast growth factor 17 2.86416
SLC7A4 solute carrier family 7, member 4 2.86416
TECRL trans-2,3-enoyl-CoA reductase-like 2.86416
LRRC32 leucine rich repeat containing 32 2.86416
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.86416
C17ORF107 chromosome 17 open reading frame 107 2.86416
CYBB cytochrome b-245, beta polypeptide 2.86416
FZD1 frizzled class receptor 1 2.86416
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.86416
PCDHGB4 protocadherin gamma subfamily B, 4 2.86416
PCDHGB7 protocadherin gamma subfamily B, 7 2.86416
RBM34 RNA binding motif protein 34 2.79825
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.68939
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.68939
CLDN10 claudin 10 2.64558
PRH1 proline-rich protein HaeIII subfamily 1 2.64558
UBE4A ubiquitination factor E4A 2.63754
CSMD1 CUB and Sushi multiple domains 1 2.56743
GRAMD1C GRAM domain containing 1C 2.47478
PLSCR3 phospholipid scramblase 3 2.45715
COL4A4 collagen, type IV, alpha 4 2.44328
DAPK1 death-associated protein kinase 1 2.44328
LRRC4B leucine rich repeat containing 4B 2.44328
RUSC2 RUN and SH3 domain containing 2 2.4388
PFDN5 prefoldin subunit 5 2.43531
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.42714
IFI16 interferon, gamma-inducible protein 16 2.38261
MRPL57 mitochondrial ribosomal protein L57 2.36216
DENND6B DENN/MADD domain containing 6B 2.33188
TLR2 toll-like receptor 2 2.33188
TNNI1 troponin I type 1 (skeletal, slow) 2.33188
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.31233
TTK TTK protein kinase 2.29925
DNAI1 dynein, axonemal, intermediate chain 1 2.26264
H3C14 H3 clustered histone 14 2.26264
OPTN optineurin 2.25964
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.2162
CAT catalase 2.18775
EIF4A1 eukaryotic translation initiation factor 4A1 2.15877
KIF21B kinesin family member 21B 2.15055
EYA2 EYA transcriptional coactivator and phosphatase 2 2.15011
CCN1 cellular communication network factor 1 2.14824
H2BC21 H2B clustered histone 21 2.13368
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2.13368
SFPQ splicing factor proline/glutamine-rich 2.13368
NPHP4 nephronophthisis 4 2.13368
NLRC5 NLR family, CARD domain containing 5 2.13368
ADGRG6 adhesion G protein-coupled receptor G6 2.13368
TMSB4X thymosin beta 4, X-linked 2.12284
SESTD1 SEC14 and spectrin domains 1 2.10395
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.08374
CDCA2 cell division cycle associated 2 2.08374
TUG1 taurine up-regulated 1 (non-protein coding) 2.04837
SMIM29 small integral membrane protein 29 2.04008
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 2.02786
PMVK phosphomevalonate kinase 2.02786
MCL1 myeloid cell leukemia 1 2.0226
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2.02097
TC2N tandem C2 domains, nuclear 2.01989
ARHGAP4 Rho GTPase activating protein 4 2.01989
THAP4 THAP domain containing 4 2.01909
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.00376

decreased expression

Symbol Name Standardized Value
MBP myelin basic protein -2.9274
ZNF841 zinc finger protein 841 -2.9274
SOX21 SRY (sex determining region Y)-box 21 -2.9274
PWWP3B PWWP domain containing 3B -2.9274
SH3RF2 SH3 domain containing ring finger 2 -2.9274
POU2AF3 POU class 2 homeobox associating factor 3 -2.9274
GBA1 glucosylceramidase beta 1 -2.9274
TMEM233 transmembrane protein 233 -2.86416
ZNF597 zinc finger protein 597 -2.86416
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.86416
COL19A1 collagen, type XIX, alpha 1 -2.86416
TRAM1L1 translocation associated membrane protein 1-like 1 -2.86416
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.86416
C1ORF146 chromosome 1 open reading frame 146 -2.86416
NLRP1 NLR family, pyrin domain containing 1 -2.86416
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.86416
ICAM5 intercellular adhesion molecule 5, telencephalin -2.86416
CYGB cytoglobin -2.86416
CCDC38 coiled-coil domain containing 38 -2.86416
RORC RAR-related orphan receptor C -2.86416
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.86416
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.86416
SPEF1 sperm flagellar 1 -2.86416
FBXO43 F-box protein 43 -2.86416
TF transferrin -2.86416
BHLHA15 basic helix-loop-helix family, member a15 -2.86416
GPR146 G protein-coupled receptor 146 -2.86416
EPHA8 EPH receptor A8 -2.86416
CCDC121 coiled-coil domain containing 121 -2.86416
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.86416
SPATC1 spermatogenesis and centriole associated 1 -2.86416
ENKUR enkurin, TRPC channel interacting protein -2.86416
STX19 syntaxin 19 -2.86416
KAT14 lysine acetyltransferase 14 -2.79093
ZC3H7B zinc finger CCCH-type containing 7B -2.77513
MYCBP MYC binding protein -2.76566
RPP14 ribonuclease P/MRP 14kDa subunit -2.7245
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.70523
TOR4A torsin family 4, member A -2.64558
PADI2 peptidyl arginine deiminase, type II -2.64558
SDF2L1 stromal cell-derived factor 2-like 1 -2.59543
JHY junctional cadherin complex regulator -2.55509
FAM227B family with sequence similarity 227, member B -2.5352
LOXL1 lysyl oxidase-like 1 -2.5135
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.50434
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.4604
ZC2HC1A zinc finger, C2HC-type containing 1A -2.43972
RUSF1 RUS family member 1 -2.3781
PIH1D1 PIH1 domain containing 1 -2.36418
VEGFB vascular endothelial growth factor B -2.34954
STK40 serine/threonine kinase 40 -2.31351
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.28806
ZIC5 Zic family member 5 -2.28088
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B -2.25901
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -2.24591
MRPS23 mitochondrial ribosomal protein S23 -2.2045
MTRES1 mitochondrial transcription rescue factor 1 -2.19672
ZNF888 zinc finger protein 888 -2.17725
CLDN7 claudin 7 -2.17725
CUL1 cullin 1 -2.17562
PLK5 polo-like kinase 5 -2.16806
NBPF10 neuroblastoma breakpoint family, member 10 -2.16806
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.16806
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.16806
DDHD2 DDHD domain containing 2 -2.15055
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.15011
ZNF181 zinc finger protein 181 -2.1481
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.1481
USP40 ubiquitin specific peptidase 40 -2.13368
RABL2B RAB, member of RAS oncogene family-like 2B -2.13368
ZNF107 zinc finger protein 107 -2.13368
ZNF644 zinc finger protein 644 -2.12906
TMEM126A transmembrane protein 126A -2.1243
ADGRA2 adhesion G protein-coupled receptor A2 -2.10591
RGS20 regulator of G-protein signaling 20 -2.10591
AKAP9 A kinase (PRKA) anchor protein 9 -2.09659
ZNF610 zinc finger protein 610 -2.08422
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.05809
TENM4 teneurin transmembrane protein 4 -2.05331
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -2.05088
UBFD1 ubiquitin family domain containing 1 -2.04018
ZNF628 zinc finger protein 628 -2.04018
SAP130 Sin3A-associated protein, 130kDa -2.03923
RETREG3 reticulophagy regulator family member 3 -2.0226
UBA3 ubiquitin-like modifier activating enzyme 3 -2.01909
GRB2 growth factor receptor-bound protein 2 -2.00873
MRPL9 mitochondrial ribosomal protein L9 -2.00873
RING1 ring finger protein 1 -2.00335
WDR75 WD repeat domain 75 -2.00277
TTC21A tetratricopeptide repeat domain 21A -2.00019