| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | notch 1|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4851) |
| External Link | https://ncbi.nlm.nih.gov/gene/4851 |
| Similar Terms | |
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500 genes differentially expressed following the NOTCH1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| S100A8 | S100 calcium binding protein A8 | 0.0125947 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.011656 |
| LTF | lactotransferrin | 0.0114851 |
| HOPX | HOP homeobox | 0.0103064 |
| S100A9 | S100 calcium binding protein A9 | 0.0100071 |
| PERP | PERP, TP53 apoptosis effector | 0.00996419 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00936599 |
| LCN2 | lipocalin 2 | 0.00896223 |
| CST7 | cystatin F (leukocystatin) | 0.008844 |
| CSTA | cystatin A (stefin A) | 0.00866877 |
| S100A7 | S100 calcium binding protein A7 | 0.00866471 |
| CLIC3 | chloride intracellular channel 3 | 0.00841052 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00817447 |
| NXN | nucleoredoxin | 0.0079573 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.00770198 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 0.00756424 |
| TMSB15A | thymosin beta 15a | 0.00742917 |
| S100A14 | S100 calcium binding protein A14 | 0.00737428 |
| KRT7 | keratin 7, type II | 0.0073366 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00720652 |
| CALML5 | calmodulin-like 5 | 0.00706492 |
| DSP | desmoplakin | 0.00701206 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0068935 |
| PCNA | proliferating cell nuclear antigen | 0.00687427 |
| EZR | ezrin | 0.00685727 |
| EPCAM | epithelial cell adhesion molecule | 0.00684076 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00667728 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00660126 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.00657146 |
| MSLN | mesothelin | 0.0065101 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00650196 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00648701 |
| IL32 | interleukin 32 | 0.00646829 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 0.00639582 |
| CCNF | cyclin F | 0.0063775 |
| ANXA3 | annexin A3 | 0.00634245 |
| DEFB1 | defensin, beta 1 | 0.00611857 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0060958 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00606197 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.00606029 |
| S100A12 | S100 calcium binding protein A12 | 0.00603355 |
| AK4 | adenylate kinase 4 | 0.00595021 |
| GAL | galanin/GMAP prepropeptide | 0.00591745 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0058574 |
| TRIM16 | tripartite motif containing 16 | 0.00585558 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00581606 |
| GNLY | granulysin | 0.00577517 |
| KRT6A | keratin 6A, type II | 0.0057586 |
| VLDLR | very low density lipoprotein receptor | 0.00571811 |
| KRT5 | keratin 5, type II | 0.00569479 |
| PROM1 | prominin 1 | 0.00568749 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 0.00568734 |
| CAMP | cathelicidin antimicrobial peptide | 0.00566645 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00560812 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00554354 |
| MUC16 | mucin 16, cell surface associated | 0.00553992 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00553358 |
| MMP11 | matrix metallopeptidase 11 | 0.00552841 |
| XCL1 | chemokine (C motif) ligand 1 | 0.00549878 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00547782 |
| KRT16 | keratin 16, type I | 0.00547413 |
| ELANE | elastase, neutrophil expressed | 0.00546565 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.00541429 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00539096 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00536844 |
| HOXB2 | homeobox B2 | 0.00534692 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00532886 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00532804 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.00531793 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00531563 |
| GCH1 | GTP cyclohydrolase 1 | 0.00531131 |
| S100P | S100 calcium binding protein P | 0.00529301 |
| TMEM45A | transmembrane protein 45A | 0.00528707 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00528072 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00526585 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00526299 |
| NVL | nuclear VCP-like | 0.00525212 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00515709 |
| PPL | periplakin | 0.00514621 |
| NIT2 | nitrilase family, member 2 | 0.00513434 |
| TRIM29 | tripartite motif containing 29 | 0.00510334 |
| CTSV | cathepsin V | 0.00507417 |
| C1S | complement component 1, s subcomponent | 0.00504483 |
| MXRA7 | matrix-remodelling associated 7 | 0.00504032 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00503717 |
| CCDC85B | coiled-coil domain containing 85B | 0.0050145 |
| NKG7 | natural killer cell granule protein 7 | 0.00500473 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 0.00499183 |
| PXDN | peroxidasin | 0.00496733 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.00496069 |
| VPREB1 | pre-B lymphocyte 1 | 0.00494555 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00494127 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00492447 |
| GSDME | gasdermin E | 0.00492143 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00490874 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00488647 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 0.00487471 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | 0.00486366 |
| ARG1 | arginase 1 | 0.00485573 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00483664 |
| HEBP2 | heme binding protein 2 | 0.00478527 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00478129 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.0047802 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.00477781 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00476758 |
| SPRR1B | small proline-rich protein 1B | 0.00474897 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00474256 |
| CDC45 | cell division cycle 45 | 0.00471568 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.00469835 |
| HOXB7 | homeobox B7 | 0.00465162 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00463994 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00457417 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00456447 |
| GPX1 | glutathione peroxidase 1 | 0.00455613 |
| PIR | pirin (iron-binding nuclear protein) | 0.00455204 |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 | 0.00454374 |
| HIST3H2A | histone cluster 3, H2a | 0.00450471 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00450186 |
| RAB25 | RAB25, member RAS oncogene family | 0.00449509 |
| CST6 | cystatin E/M | 0.00448725 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00445243 |
| CD48 | CD48 molecule | 0.00445091 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00444482 |
| KRT8 | keratin 8, type II | 0.00444253 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00443917 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 0.00443839 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00440635 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00440185 |
| CD69 | CD69 molecule | 0.00439934 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00439483 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00437181 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 0.00436787 |
| USP18 | ubiquitin specific peptidase 18 | 0.00436338 |
| FGF13 | fibroblast growth factor 13 | 0.00435827 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0043523 |
| CLDN10 | claudin 10 | 0.0043517 |
| STK10 | serine/threonine kinase 10 | 0.0043351 |
| HP | haptoglobin | 0.0043307 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.0043126 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00430558 |
| LUM | lumican | 0.00430288 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.00426661 |
| GLRX5 | glutaredoxin 5 | 0.00426332 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 0.00425399 |
| CDC20 | cell division cycle 20 | 0.00418192 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | 0.00416705 |
| FOLR1 | folate receptor 1 (adult) | 0.00415525 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00415181 |
| TADA2A | transcriptional adaptor 2A | 0.00415163 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00414615 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00412016 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00411496 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00411408 |
| HMGB3 | high mobility group box 3 | 0.00410794 |
| SOSTDC1 | sclerostin domain containing 1 | 0.00409143 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.00408992 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.00408788 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.00407971 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.0040731 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00407126 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.00407124 |
| DTX4 | deltex 4, E3 ubiquitin ligase | 0.00406835 |
| GSTT1 | glutathione S-transferase theta 1 | 0.00405287 |
| FGF9 | fibroblast growth factor 9 | 0.00404678 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.00402608 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00400798 |
| RAB38 | RAB38, member RAS oncogene family | 0.00398675 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | 0.0039815 |
| GOLGA8H | golgin A8 family, member H | 0.00397454 |
| ANO10 | anoctamin 10 | 0.00396006 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.00393004 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.00392921 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00392697 |
| RPS5 | ribosomal protein S5 | 0.00392468 |
| RAB3B | RAB3B, member RAS oncogene family | 0.00392376 |
| GYG1 | glycogenin 1 | 0.00391931 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00391263 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | 0.00391129 |
| ATP10A | ATPase, class V, type 10A | 0.00390648 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00390365 |
| CD53 | CD53 molecule | 0.0039001 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00389898 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.00387946 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00387789 |
| COCH | cochlin | 0.00387206 |
| ASRGL1 | asparaginase like 1 | 0.00387037 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.00386678 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.00384502 |
| NDUFB1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 0.00383984 |
| KLK8 | kallikrein-related peptidase 8 | 0.00383716 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00383238 |
| RPS27L | ribosomal protein S27-like | 0.00383082 |
| KRT6B | keratin 6B, type II | 0.00382502 |
| SHROOM2 | shroom family member 2 | 0.00382388 |
| TSPAN1 | tetraspanin 1 | 0.00382362 |
| SHFM1 | split hand/foot malformation (ectrodactyly) type 1 | 0.00382346 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00381824 |
| RGCC | regulator of cell cycle | 0.00381766 |
| BPI | bactericidal/permeability-increasing protein | 0.00380496 |
| EVL | Enah/Vasp-like | 0.00379159 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.0037862 |
| CENPU | centromere protein U | 0.00378478 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00378238 |
| MZT2A | mitotic spindle organizing protein 2A | 0.00377382 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | 0.00377355 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | 0.00376916 |
| CDSN | corneodesmosin | 0.00376269 |
| SFN | stratifin | 0.00374252 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00374075 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.00374006 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00372662 |
| NDN | necdin, melanoma antigen (MAGE) family member | 0.00372331 |
| SPRR1A | small proline-rich protein 1A | 0.00370896 |
| COL1A2 | collagen, type I, alpha 2 | 0.00370876 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00370602 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.00370331 |
| CD52 | CD52 molecule | 0.0037016 |
| COG7 | component of oligomeric golgi complex 7 | 0.00370012 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00369472 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00369442 |
| INAVA | innate immunity activator | 0.00367184 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.00367166 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.00367093 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.00366342 |
| DNM1L | dynamin 1-like | 0.00365088 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00365034 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.00363564 |
| ATP5MF | ATP synthase membrane subunit f | 0.00363208 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00362728 |
| MOSPD1 | motile sperm domain containing 1 | 0.00362693 |
| TMEM246 | transmembrane protein 246 | 0.00362558 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.00362241 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00362209 |
| EDN3 | endothelin 3 | 0.00361684 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00361608 |
| ERLIN2 | ER lipid raft associated 2 | 0.00361434 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00360845 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.00359016 |
| BSPRY | B-box and SPRY domain containing | 0.00358627 |
| CALML3 | calmodulin-like 3 | 0.00358313 |
| MSMB | microseminoprotein, beta- | 0.00358214 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 0.00358032 |
| POP4 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) | 0.003577 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00357497 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00357103 |
| ACAA2 | acetyl-CoA acyltransferase 2 | 0.00357066 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.00356501 |
| FZD1 | frizzled class receptor 1 | 0.0035623 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.00355027 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.0035383 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0103652 |
| TSPAN7 | tetraspanin 7 | -0.00880374 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00845702 |
| CTSZ | cathepsin Z | -0.00833637 |
| PCDH9 | protocadherin 9 | -0.00812546 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00783737 |
| NOTCH1 | notch 1 | -0.00760681 |
| NUP85 | nucleoporin 85kDa | -0.0072368 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00722224 |
| PDGFD | platelet derived growth factor D | -0.00701786 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00699998 |
| TNC | tenascin C | -0.00682864 |
| EREG | epiregulin | -0.00671542 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00662257 |
| CAB39 | calcium binding protein 39 | -0.00660381 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00645151 |
| MEN1 | multiple endocrine neoplasia I | -0.00644904 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00638711 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00635557 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00633519 |
| EMP1 | epithelial membrane protein 1 | -0.00615034 |
| RGS5 | regulator of G-protein signaling 5 | -0.00612591 |
| BEX1 | brain expressed, X-linked 1 | -0.00611524 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00610783 |
| SIRT3 | sirtuin 3 | -0.00605192 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00600138 |
| CPE | carboxypeptidase E | -0.00598641 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00596575 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00590846 |
| QKI | QKI, KH domain containing, RNA binding | -0.00588229 |
| RTN2 | reticulon 2 | -0.00587334 |
| ZW10 | zw10 kinetochore protein | -0.00578111 |
| THBS4 | thrombospondin 4 | -0.00571412 |
| NELL1 | NEL-like 1 (chicken) | -0.00569892 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00568259 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.00567929 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00567358 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00565019 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00564294 |
| OLFM1 | olfactomedin 1 | -0.00562595 |
| VWF | von Willebrand factor | -0.00562443 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00561259 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00556217 |
| H1-0 | H1.0 linker histone | -0.00555843 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.00555155 |
| GPC3 | glypican 3 | -0.00549485 |
| NOTCH3 | notch 3 | -0.00549198 |
| MECOM | MDS1 and EVI1 complex locus | -0.00548943 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00547333 |
| RASA4 | RAS p21 protein activator 4 | -0.00547209 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00546536 |
| ABAT | 4-aminobutyrate aminotransferase | -0.00545521 |
| GATA2 | GATA binding protein 2 | -0.00543409 |
| TGFB2 | transforming growth factor, beta 2 | -0.00542699 |
| FABP1 | fatty acid binding protein 1, liver | -0.00542381 |
| RTN4 | reticulon 4 | -0.00542364 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00536758 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00534036 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00533088 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00530319 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00529658 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00525811 |
| DMAC2L | distal membrane arm assembly component 2 like | -0.0051931 |
| A2M | alpha-2-macroglobulin | -0.00517924 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.00517303 |
| BAX | BCL2-associated X protein | -0.00516035 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00510367 |
| KIAA0355 | KIAA0355 | -0.00508248 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00507174 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.00503499 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0050277 |
| METTL7A | methyltransferase like 7A | -0.00502117 |
| GPSM2 | G-protein signaling modulator 2 | -0.00500291 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.00499355 |
| ITGA6 | integrin, alpha 6 | -0.00495752 |
| ADORA2B | adenosine A2b receptor | -0.00495713 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.00493969 |
| LEFTY1 | left-right determination factor 1 | -0.00491325 |
| LMNB1 | lamin B1 | -0.00489322 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00488586 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00488467 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00488451 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00487701 |
| PRR7 | proline rich 7 (synaptic) | -0.00487385 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00483869 |
| MMP7 | matrix metallopeptidase 7 | -0.00482943 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00481437 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00480945 |
| PCP4 | Purkinje cell protein 4 | -0.00479576 |
| HEY2 | hes-related family bHLH transcription factor with YRPW motif 2 | -0.00477354 |
| PCDH17 | protocadherin 17 | -0.00475043 |
| CCN2 | cellular communication network factor 2 | -0.00470395 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.00469347 |
| AREG | amphiregulin | -0.00468756 |
| CDK17 | cyclin-dependent kinase 17 | -0.00468142 |
| PF4 | platelet factor 4 | -0.0046664 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00462495 |
| OLFML2B | olfactomedin-like 2B | -0.0046129 |
| EPHB2 | EPH receptor B2 | -0.0046009 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.00459815 |
| EDNRB | endothelin receptor type B | -0.00459122 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0045909 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.0045892 |
| ZNF804A | zinc finger protein 804A | -0.00458659 |
| SCARB2 | scavenger receptor class B, member 2 | -0.0045652 |
| BRD4 | bromodomain containing 4 | -0.00455124 |
| DST | dystonin | -0.0045385 |
| SYBU | syntabulin (syntaxin-interacting) | -0.0045303 |
| RXRA | retinoid X receptor, alpha | -0.00452941 |
| ZBTB16 | zinc finger and BTB domain containing 16 | -0.00452684 |
| S1PR1 | sphingosine-1-phosphate receptor 1 | -0.00451859 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00450575 |
| SNX11 | sorting nexin 11 | -0.00450224 |
| MYBPC1 | myosin binding protein C, slow type | -0.00448416 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00441751 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00439892 |
| PLVAP | plasmalemma vesicle associated protein | -0.00439398 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00438186 |
| SLN | sarcolipin | -0.00438075 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | -0.00436113 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00433205 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00432029 |
| CAST | calpastatin | -0.00431998 |
| CHGB | chromogranin B | -0.00431921 |
| EXOSC4 | exosome component 4 | -0.00430853 |
| SNX7 | sorting nexin 7 | -0.00430196 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00429894 |
| CD1E | CD1e molecule | -0.00428599 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00426711 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | -0.00424299 |
| IL6ST | interleukin 6 signal transducer | -0.00424135 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00423612 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00423225 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00423143 |
| TPM4 | tropomyosin 4 | -0.0042294 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00419809 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00418807 |
| LPIN2 | lipin 2 | -0.00418068 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.00415421 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00413456 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00413187 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00411546 |
| PBX2P1 | pre-B-cell leukemia homeobox 2 pseudogene 1 | -0.00410493 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0041011 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00409361 |
| APH1A | APH1A gamma secretase subunit | -0.00409143 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00408567 |
| THBD | thrombomodulin | -0.00407375 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00406742 |
| KYNU | kynureninase | -0.00406494 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00405622 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00405498 |
| TAOK3 | TAO kinase 3 | -0.00404783 |
| MAOA | monoamine oxidase A | -0.00404561 |
| DEK | DEK proto-oncogene | -0.00404186 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.00403699 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00403676 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00401571 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00401558 |
| C9ORF3 | chromosome 9 open reading frame 3 | -0.00401175 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00400903 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00400697 |
| GLUL | glutamate-ammonia ligase | -0.00400033 |
| FAM131A | family with sequence similarity 131, member A | -0.00398913 |
| THY1 | Thy-1 cell surface antigen | -0.003977 |
| TLR4 | toll-like receptor 4 | -0.00397218 |
| EMC2 | ER membrane protein complex subunit 2 | -0.00397183 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | -0.00397013 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00396079 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00395647 |
| CD93 | CD93 molecule | -0.00394941 |
| TNNC2 | troponin C type 2 (fast) | -0.00394322 |
| BRD2 | bromodomain containing 2 | -0.00393894 |
| MMP3 | matrix metallopeptidase 3 | -0.00393808 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.00392454 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.00392046 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.00390897 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00389516 |
| PLAT | plasminogen activator, tissue | -0.00388114 |
| ENO3 | enolase 3 (beta, muscle) | -0.00388052 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00387912 |
| TBC1D31 | TBC1 domain family, member 31 | -0.0038778 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0038626 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.00386218 |
| VEGFA | vascular endothelial growth factor A | -0.00383436 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -0.00383378 |
| CALCRL | calcitonin receptor-like | -0.00383282 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00382973 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00380679 |
| DNMBP | dynamin binding protein | -0.00380227 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00380162 |
| MYOT | myotilin | -0.00379901 |
| ATXN2 | ataxin 2 | -0.00378347 |
| CAVIN2 | caveolae associated protein 2 | -0.00376846 |
| SACS | sacsin molecular chaperone | -0.00376755 |
| GLS | glutaminase | -0.00375204 |
| DUSP6 | dual specificity phosphatase 6 | -0.00374617 |
| FAM198B | family with sequence similarity 198, member B | -0.00373834 |
| SELP | selectin P (granule membrane protein 140kDa, antigen CD62) | -0.00373172 |
| EIF3J | eukaryotic translation initiation factor 3, subunit J | -0.00372559 |
| EGR2 | early growth response 2 | -0.00372499 |
| CNN3 | calponin 3, acidic | -0.00372492 |
| CANX | calnexin | -0.00371902 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.00371511 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0037108 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00371059 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | -0.00370928 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.00370709 |
| MEF2C | myocyte enhancer factor 2C | -0.00370314 |
| MRTFB | myocardin related transcription factor B | -0.00369172 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00368979 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.00368732 |
| EGR1 | early growth response 1 | -0.00367989 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00367459 |
| RAI14 | retinoic acid induced 14 | -0.00364341 |
| HOXD1 | homeobox D1 | -0.00364037 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.00364021 |
| PRSS3 | protease, serine, 3 | -0.00363894 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -0.0036214 |
| FYB1 | FYN binding protein 1 | -0.00361106 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.00360944 |
| AGO2 | argonaute RISC catalytic component 2 | -0.00359644 |
| JAG1 | jagged 1 | -0.00359299 |
| FNBP1 | formin binding protein 1 | -0.00359005 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00358717 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00358604 |
| SNX13 | sorting nexin 13 | -0.00358527 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.00358394 |
| SPATA5L1 | spermatogenesis associated 5-like 1 | -0.00357991 |
| BAG3 | BCL2-associated athanogene 3 | -0.00357573 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.00357095 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.00356532 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -0.00355723 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0035554 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | -0.00354648 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0035342 |
| CDC5L | cell division cycle 5-like | -0.00352084 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00351065 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00350708 |
| JAKMIP2 | janus kinase and microtubule interacting protein 2 | -0.00350237 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00350193 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00350035 |
| NUP153 | nucleoporin 153kDa | -0.00349905 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0034929 |
| IRS1 | insulin receptor substrate 1 | -0.00348964 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00348841 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00348501 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.00348327 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -0.0034772 |
| SPAG9 | sperm associated antigen 9 | -0.00347244 |
