NOTCH2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description notch 2|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 4853)
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Genes

342 genes differentially expressed following the NOTCH2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLR5 toll-like receptor 5 3.191
COL20A1 collagen, type XX, alpha 1 3.191
ZACN zinc activated ligand-gated ion channel 3.191
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 3.191
SPINK4 serine peptidase inhibitor, Kazal type 4 3.191
SPINK6 serine peptidase inhibitor, Kazal type 6 3.191
PCDHB7 protocadherin beta 7 3.191
PKP1 plakophilin 1 3.191
HGD homogentisate 1,2-dioxygenase 3.191
GPR151 G protein-coupled receptor 151 3.191
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.191
GPR75 G protein-coupled receptor 75 3.191
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.191
C1ORF162 chromosome 1 open reading frame 162 3.191
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.191
AMHR2 anti-Mullerian hormone receptor, type II 3.191
CALCA calcitonin-related polypeptide alpha 3.191
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.191
CLDN2 claudin 2 3.191
RAB44 RAB44, member RAS oncogene family 3.191
IL12RB1 interleukin 12 receptor, beta 1 3.191
SYCP1 synaptonemal complex protein 1 3.191
HORMAD1 HORMA domain containing 1 3.191
PNMA5 paraneoplastic Ma antigen family member 5 3.191
CRYGN crystallin, gamma N 3.191
BHMT2 betaine--homocysteine S-methyltransferase 2 3.191
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 3.191
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.191
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.191
OIT3 oncoprotein induced transcript 3 3.191
OR56A5 olfactory receptor, family 56, subfamily A, member 5 3.191
STAP1 signal transducing adaptor family member 1 3.191
EMCN endomucin 3.191
OC90 otoconin 90 3.191
NEUROG3 neurogenin 3 3.191
SMIM5 small integral membrane protein 5 3.191
CXORF65 chromosome X open reading frame 65 3.191
TMEM191B transmembrane protein 191B 3.191
LRG1 leucine-rich alpha-2-glycoprotein 1 3.191
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.191
ADAD2 adenosine deaminase domain containing 2 3.191
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.191
POSTN periostin, osteoblast specific factor 3.191
HAS1 hyaluronan synthase 1 3.191
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.191
FGF3 fibroblast growth factor 3 3.191
MYH13 myosin, heavy chain 13, skeletal muscle 3.191
SPATA31F3 SPATA31 subfamily F member 3 3.191
RHEX regulator of hemoglobinization and erythroid cell expansion 3.191
H3-7 H3.7 histone (putative) 3.191
TMEM225B transmembrane protein 225B 3.191
DIPK1C divergent protein kinase domain 1C 3.191
SPACDR sperm acrosome developmental regulator 3.191
RTL9 retrotransposon Gag like 9 3.191
ACOD1 aconitate decarboxylase 1 3.191
FYB1 FYN binding protein 1 3.191
MT3 metallothionein 3 3.191
MCTS2 MCTS family member 2 3.191
SMIM45 small integral membrane protein 45 3.191
CD8B2 CD8b2 molecule 3.191
SPMIP7 sperm microtubule inner protein 7 3.191
DRC5 dynein regulatory complex subunit 5 3.191
SPATA31H1 SPATA31 subfamily H member 1 3.191
CIMIP2C ciliary microtubule inner protein 2C 3.191
EPCIP exosomal polycystin 1 interacting protein 3.191
WASL-DT WASL divergent transcript 3.191
LINC02268 long intergenic non-protein coding RNA 2268 3.191
CSP2 CS pseudogene 2 3.191
LINC02798 long intergenic non-protein coding RNA 2798 3.191
OR10H5 olfactory receptor, family 10, subfamily H, member 5 3.191
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 3.191
C15ORF62 chromosome 15 open reading frame 62 3.191
LRRN4CL LRRN4 C-terminal like 3.191
HNF1B HNF1 homeobox B 3.191
PCDHGC4 protocadherin gamma subfamily C, 4 3.191
EXOC3L4 exocyst complex component 3-like 4 3.191
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.191
CREB3L3 cAMP responsive element binding protein 3-like 3 3.191
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.191
ZAN zonadhesin (gene/pseudogene) 3.191
REP15 RAB15 effector protein 3.191
RASD1 RAS, dexamethasone-induced 1 3.191
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.191
VN1R5 vomeronasal 1 receptor 5 (gene/pseudogene) 3.191
SIM1 single-minded family bHLH transcription factor 1 3.191
RHCG Rh family, C glycoprotein 3.191
STX11 syntaxin 11 3.191
FMO3 flavin containing monooxygenase 3 3.191
TMPRSS4 transmembrane protease, serine 4 3.191
WDR64 WD repeat domain 64 3.191
TREX2 three prime repair exonuclease 2 3.191
SAG S-antigen; retina and pineal gland (arrestin) 3.191
MIP major intrinsic protein of lens fiber 3.191
FNDC9 fibronectin type III domain containing 9 3.191
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.191
FAM163A family with sequence similarity 163, member A 3.191
KLHL41 kelch-like family member 41 3.191
PRM1 protamine 1 3.191
ADAM7 ADAM metallopeptidase domain 7 3.191
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.191
C11ORF16 chromosome 11 open reading frame 16 3.191
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.191
CBX8 chromobox homolog 8 3.191
DRD2 dopamine receptor D2 3.191
CXCR2 chemokine (C-X-C motif) receptor 2 3.191
AQP7 aquaporin 7 3.191
LRRC46 leucine rich repeat containing 46 3.191
CCL24 chemokine (C-C motif) ligand 24 3.191
AKR1B15 aldo-keto reductase family 1, member B15 3.191
CLIC5 chloride intracellular channel 5 3.191
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.191
ZNF703 zinc finger protein 703 3.191
RGS11 regulator of G-protein signaling 11 3.191
HOXD3 homeobox D3 3.191
TESPA1 thymocyte expressed, positive selection associated 1 3.191
AQP8 aquaporin 8 3.191
PCDHGA2 protocadherin gamma subfamily A, 2 3.191
WNT7A wingless-type MMTV integration site family, member 7A 3.191
BCO1 beta-carotene oxygenase 1 3.191
CD28 CD28 molecule 3.191
CDH22 cadherin 22, type 2 3.191
HMGB4 high mobility group box 4 3.191
LGALS12 lectin, galactoside-binding, soluble, 12 3.191
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.191
FAIM2 Fas apoptotic inhibitory molecule 2 3.191
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.191
HLA-DMB major histocompatibility complex, class II, DM beta 3.191
GJC2 gap junction protein, gamma 2, 47kDa 3.191
GOLGA8M golgin A8 family, member M 3.191
PLCD4 phospholipase C, delta 4 3.191
PGR progesterone receptor 3.191
TIPE2 TNF alpha induced protein 8 like 2 3.191
RAB40AL RAB40A, member RAS oncogene family-like 3.191
LENEP lens epithelial protein 3.191
SVOP SV2 related protein homolog (rat) 3.191
IL9R interleukin 9 receptor 3.191
FGB fibrinogen beta chain 3.191
FGR FGR proto-oncogene, Src family tyrosine kinase 3.191
TG thyroglobulin 3.191
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.191
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.191
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.191
NGB neuroglobin 3.191
RUFY4 RUN and FYVE domain containing 4 3.191
HHIPL2 HHIP-like 2 3.191
LST1 leukocyte specific transcript 1 3.191
SLC7A4 solute carrier family 7, member 4 3.191
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.191
NUTM2F NUT family member 2F 3.191
PLGLB1 plasminogen-like B1 3.191
CARD6 caspase recruitment domain family, member 6 3.191
KRT15 keratin 15, type I 3.191
SHOX short stature homeobox 3.191
THEM5 thioesterase superfamily member 5 3.191
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.191
FBXO39 F-box protein 39 3.191
KRTAP4-1 keratin associated protein 4-1 3.191
TMEM184A transmembrane protein 184A 3.191
MORC1 MORC family CW-type zinc finger 1 3.191
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.191
C5ORF46 chromosome 5 open reading frame 46 3.191
ASCL1 achaete-scute family bHLH transcription factor 1 3.191
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.191
CLEC2A C-type lectin domain family 2, member A 3.191
CEPT1 choline/ethanolamine phosphotransferase 1 3.18147
SAPCD2 suppressor APC domain containing 2 3.04412
NCAPG non-SMC condensin I complex, subunit G 2.98706
ZNF761 zinc finger protein 761 2.77779
PTMS parathymosin 2.75681
MYO7A myosin VIIA 2.70897
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.6829
POMT1 protein-O-mannosyltransferase 1 2.65295
RPS17 ribosomal protein S17 2.59565
NODAL nodal growth differentiation factor 2.53553
H3C13 H3 clustered histone 13 2.49205
TSG101 tumor susceptibility 101 2.48643
IRGQ immunity-related GTPase family, Q 2.48478
HJURP Holliday junction recognition protein 2.48478
CTH cystathionine gamma-lyase 2.48337
PQBP1 polyglutamine binding protein 1 2.45219
ATG2A autophagy related 2A 2.42245
CANX calnexin 2.41825
USP54 ubiquitin specific peptidase 54 2.41516
ZNF589 zinc finger protein 589 2.41468
CCDC144A coiled-coil domain containing 144A 2.39935
MON1A MON1 secretory trafficking family member A 2.39658
ANO7 anoctamin 7 2.39567
CCDC24 coiled-coil domain containing 24 2.37205
CRACDL CRACD like 2.37178
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.37178
IHO1 interactor of HORMAD1 1 2.36207
PENK proenkephalin 2.36207
EIF4A2 eukaryotic translation initiation factor 4A2 2.36207
ADAM2 ADAM metallopeptidase domain 2 2.36207
CD5 CD5 molecule 2.36207
TCTN3 tectonic family member 3 2.36207
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.36207
PCOLCE procollagen C-endopeptidase enhancer 2.33536
COQ9 coenzyme Q9 2.3074
STOX1 storkhead box 1 2.26466
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.24234
LOC730098 uncharacterized LOC730098 2.2417
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.23958
RPN2 ribophorin II 2.23958
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.2366
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.2366
CIMAP2 ciliary microtubule associated protein 2 2.2366
SMIM36 small integral membrane protein 36 2.2366
JMJD7 jumonji domain containing 7 2.2366
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.2366
CORT cortistatin 2.2366
SLC41A3 solute carrier family 41, member 3 2.23478
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.17734
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 2.17734
ADCK1 aarF domain containing kinase 1 2.14282
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.14069
WDR25 WD repeat domain 25 2.11752
SIMC1 SUMO-interacting motifs containing 1 2.10748
CHD1 chromodomain helicase DNA binding protein 1 2.10703
SSBP4 single stranded DNA binding protein 4 2.06435
TMTC3 transmembrane and tetratricopeptide repeat containing 3 2.04156
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 2.04156
CACFD1 calcium channel flower domain containing 1 2.0311
MANBA mannosidase, beta A, lysosomal 2.0311
DPP4 dipeptidyl-peptidase 4 2.02967
UBAP1L ubiquitin associated protein 1-like 2.01383
RASGEF1A RasGEF domain family, member 1A 2.01172
DHCR24 24-dehydrocholesterol reductase 2.00203
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.00203

decreased expression

Symbol Name Standardized Value
CHL1 cell adhesion molecule L1-like -3.191
SARAF store-operated calcium entry-associated regulatory factor -3.191
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -3.191
ANGPT4 angiopoietin 4 -3.191
ZBTB47 zinc finger and BTB domain containing 47 -3.191
ZNF879 zinc finger protein 879 -3.191
NOTCH2 notch 2 -3.191
LSM11 LSM11, U7 small nuclear RNA associated -3.191
C8ORF74 chromosome 8 open reading frame 74 -3.18147
MEIKIN meiotic kinetochore factor -3.18147
TMEM121 transmembrane protein 121 -3.18147
TRPC5OS TRPC5 opposite strand -3.18147
CAPS calcyphosine -3.18147
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -3.18147
TMC2 transmembrane channel-like 2 -3.18147
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -3.18147
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -3.18147
ODAPH odontogenesis associated phosphoprotein -3.18147
KCNIP3 Kv channel interacting protein 3, calsenilin -3.18147
GCKR glucokinase (hexokinase 4) regulator -3.18147
GTSF1 gametocyte specific factor 1 -3.18147
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -3.18147
COL6A6 collagen, type VI, alpha 6 -3.18147
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.18147
FER1L6 fer-1-like family member 6 -3.18147
NAPSA napsin A aspartic peptidase -3.18147
SCG2 secretogranin II -3.18147
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -3.18147
GFAP glial fibrillary acidic protein -3.18147
TUBB1 tubulin, beta 1 class VI -3.18147
RSPO3 R-spondin 3 -3.18147
SLC23A3 solute carrier family 23, member 3 -3.18147
PARP15 poly (ADP-ribose) polymerase family, member 15 -3.18147
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -3.18147
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -3.18147
RIBC1 RIB43A domain with coiled-coils 1 -3.18147
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.18147
CREG2 cellular repressor of E1A-stimulated genes 2 -3.18147
SP100 SP100 nuclear antigen -3.18147
PTGDR prostaglandin D2 receptor (DP) -3.18147
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -3.18147
VTCN1 V-set domain containing T cell activation inhibitor 1 -3.18147
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.08804
COL6A3 collagen, type VI, alpha 3 -3.06755
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -3.06649
NRIP1 nuclear receptor interacting protein 1 -2.91495
KRTCAP3 keratinocyte associated protein 3 -2.85775
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.84095
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.80491
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.80491
PTGIS prostaglandin I2 (prostacyclin) synthase -2.74711
ARF4 ADP-ribosylation factor 4 -2.72778
RANBP3 RAN binding protein 3 -2.71704
UBXN1 UBX domain protein 1 -2.71614
NTNG1 netrin G1 -2.71233
FANCI Fanconi anemia, complementation group I -2.68369
SLC44A5 solute carrier family 44, member 5 -2.6829
EMC7 ER membrane protein complex subunit 7 -2.66847
NOTCH2NLA notch 2 N-terminal like A -2.65915
ATG2B autophagy related 2B -2.64909
PRKCI protein kinase C, iota -2.62373
UBE2B ubiquitin-conjugating enzyme E2B -2.617
IGFBPL1 insulin-like growth factor binding protein-like 1 -2.617
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B -2.60967
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.59601
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.59326
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.48478
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.47912
GPHA2 glycoprotein hormone alpha 2 -2.47912
KRABD2 KRAB domain containing 2 -2.45646
PTRH2 peptidyl-tRNA hydrolase 2 -2.41516
CCDC51 coiled-coil domain containing 51 -2.41468
CALR calreticulin -2.38861
CCDC102A coiled-coil domain containing 102A -2.37863
HPCAL1 hippocalcin-like 1 -2.35413
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.35413
QRICH1 glutamine-rich 1 -2.28001
ZMYM3 zinc finger, MYM-type 3 -2.26466
DRC8 dynein regulatory complex subunit 8 -2.26466
BCLAF1 BCL2-associated transcription factor 1 -2.26466
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) -2.26041
MAVS mitochondrial antiviral signaling protein -2.25723
PPP4C protein phosphatase 4, catalytic subunit -2.2366
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -2.23478
LCN10 lipocalin 10 -2.22707
MAGEA4 melanoma antigen family A4 -2.22707
DOCK3 dedicator of cytokinesis 3 -2.21126
C21ORF58 chromosome 21 open reading frame 58 -2.20519
TSSK6 testis-specific serine kinase 6 -2.20519
TMT1B thiol methyltransferase 1B -2.20519
SNX30 sorting nexin family member 30 -2.19569
RPL8 ribosomal protein L8 -2.18503
VWCE von Willebrand factor C and EGF domains -2.18006
MCM5 minichromosome maintenance complex component 5 -2.1746
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) -2.12067
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.11738
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -2.11212
TUBB2A tubulin, beta 2A class IIa -2.11212
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.11097
FBLN5 fibulin 5 -2.11097
LCT lactase -2.11097
KCTD21 potassium channel tetramerization domain containing 21 -2.11097
CALHM2 calcium homeostasis modulator 2 -2.10623
ONECUT2 one cut homeobox 2 -2.1051
PET117 PET117 homolog (S. cerevisiae) -2.05621
CRYAB crystallin, alpha B -2.04542
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.04156
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.04156
C16ORF89 chromosome 16 open reading frame 89 -2.03062
SFMBT1 Scm-like with four mbt domains 1 -2.02896
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -2.01383
MTX3 metaxin 3 -2.01172
SP1 Sp1 transcription factor -2.00559