NOTCH2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description notch 2|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 4853)
External Link http://www.ncbi.nlm.nih.gov/gene/4853
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178 interacting proteins for NOTCH2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ALMS1 Alstrom syndrome protein 1
AMER1 APC membrane recruitment protein 1
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC5 anaphase promoting complex subunit 5
ANKRD28 ankyrin repeat domain 28
ANKRD44 ankyrin repeat domain 44
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASB14 ankyrin repeat and SOCS box containing 14
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG2 BCL2-associated athanogene 2
BAG5 BCL2-associated athanogene 5
CCDC77 coiled-coil domain containing 77
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCP110 centriolar coiled coil protein 110kDa
CENPJ centromere protein J
CEP192 centrosomal protein 192kDa
CEP295 centrosomal protein 295kDa
CEP72 centrosomal protein 72kDa
CEP85 centrosomal protein 85kDa
CEP89 centrosomal protein 89kDa
CGN cingulin
CIR1 corepressor interacting with RBPJ, 1
CNTN1 contactin 1
CNTROB centrobin, centrosomal BRCA2 interacting protein
CPVL carboxypeptidase, vitellogenic-like
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSPP1 centrosome and spindle pole associated protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYLD cylindromatosis (turban tumor syndrome)
DLL1 delta-like 1 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTX1 deltex 1, E3 ubiquitin ligase
EGFL7 EGF-like-domain, multiple 7
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERC1 ELKS/RAB6-interacting/CAST family member 1
FAM175B family with sequence similarity 175, member B
FAM193A family with sequence similarity 193, member A
FBF1 Fas (TNFRSF6) binding factor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FUBP3 far upstream element (FUSE) binding protein 3
FURIN furin (paired basic amino acid cleaving enzyme)
GIGYF1 GRB10 interacting GYF protein 1
GRIP1 glutamate receptor interacting protein 1
GSK3B glycogen synthase kinase 3 beta
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
INADL InaD-like (Drosophila)
JAG1 jagged 1
JAG2 jagged 2
KIAA0368 KIAA0368
KIAA1462 KIAA1462
KIAA1549 KIAA1549
KIAA1671 KIAA1671
KRI1 KRI1 homolog (S. cerevisiae)
LATS2 large tumor suppressor kinase 2
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LIMD1 LIM domains containing 1
LIN7C lin-7 homolog C (C. elegans)
LZTS2 leucine zipper, putative tumor suppressor 2
MAGED1 melanoma antigen family D1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MIA3 melanoma inhibitory activity family, member 3
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIB2 mindbomb E3 ubiquitin protein ligase 2
MIPOL1 mirror-image polydactyly 1
MOB1A MOB kinase activator 1A
MPDZ multiple PDZ domain protein
MPHOSPH9 M-phase phosphoprotein 9
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTMR3 myotubularin related protein 3
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCKAP5L NCK-associated protein 5-like
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEK4 NIMA-related kinase 4
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NIN ninein (GSK3B interacting protein)
NINL ninein-like
NME7 NME/NM23 family member 7
NOTCH1 notch 1
NUMB numb homolog (Drosophila)
NUP160 nucleoporin 160kDa
OFD1 oral-facial-digital syndrome 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PCM1 pericentriolar material 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDZD11 PDZ domain containing 11
PHLDB2 pleckstrin homology-like domain, family B, member 2
PKP4 plakophilin 4
PLAUR plasminogen activator, urokinase receptor
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP6C protein phosphatase 6, catalytic subunit
PPP6R1 protein phosphatase 6, regulatory subunit 1
PPP6R2 protein phosphatase 6, regulatory subunit 2
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB6A RAB6A, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RADIL Ras association and DIL domains
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBM15 RNA binding motif protein 15
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SDCCAG3 serologically defined colon cancer antigen 3
SEC16A SEC16 homolog A (S. cerevisiae)
SEC24C SEC24 family member C
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHKBP1 SH3KBP1 binding protein 1
SIN3A SIN3 transcription regulator family member A
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SNX18 sorting nexin 18
SORBS1 sorbin and SH3 domain containing 1
SPEN spen family transcriptional repressor
SPICE1 spindle and centriole associated protein 1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STXBP4 syntaxin binding protein 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCHP trichoplein, keratin filament binding
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TMED2 transmembrane emp24 domain trafficking protein 2
TNRC6B trinucleotide repeat containing 6B
TP53BP2 tumor protein p53 binding protein 2
TRIM27 tripartite motif containing 27
TRIM37 tripartite motif containing 37
TRIM41 tripartite motif containing 41
UBC ubiquitin C
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP10 ubiquitin specific peptidase 10
USP54 ubiquitin specific peptidase 54
ZNF8 zinc finger protein 8