NOTCH3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description notch 3|This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4854)
External Link http://www.ncbi.nlm.nih.gov/gene/4854
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171 interacting proteins for NOTCH3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADGRF5 adhesion G protein-coupled receptor F5
AFG3L2 AFG3-like AAA ATPase 2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHCTF1 AT hook containing transcription factor 1
AKAP8 A kinase (PRKA) anchor protein 8
ALB albumin
ALPI alkaline phosphatase, intestinal
ANKRD28 ankyrin repeat domain 28
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ATAD3A ATPase family, AAA domain containing 3A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC9 coiled-coil domain containing 9
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHUK conserved helix-loop-helix ubiquitous kinase
CIR1 corepressor interacting with RBPJ, 1
CLASP1 cytoplasmic linker associated protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CSNK2B casein kinase 2, beta polypeptide
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DHCR7 7-dehydrocholesterol reductase
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLL1 delta-like 1 (Drosophila)
DOCK8 dedicator of cytokinesis 8
E2F3 E2F transcription factor 3
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFTUD2 elongation factor Tu GTP binding domain containing 2
EGFL7 EGF-like-domain, multiple 7
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FBLN1 fibulin 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FURIN furin (paired basic amino acid cleaving enzyme)
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GSK3B glycogen synthase kinase 3 beta
GTPBP2 GTP binding protein 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HELLS helicase, lymphoid-specific
HLTF helicase-like transcription factor
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
IMMT inner membrane protein, mitochondrial
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INTS3 integrator complex subunit 3
INTS5 integrator complex subunit 5
INTS6 integrator complex subunit 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
JAG2 jagged 2
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KDM1A lysine (K)-specific demethylase 1A
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT9 keratin 9, type I
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LBR lamin B receptor
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LMNA lamin A/C
LRP1 low density lipoprotein receptor-related protein 1
LRPPRC leucine-rich pentatricopeptide repeat containing
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MATR3 matrin 3
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
MYO1B myosin IB
MYO1C myosin IC
MYO6 myosin VI
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPG non-SMC condensin I complex, subunit G
NCK1 NCK adaptor protein 1
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH1 notch 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
NUMB numb homolog (Drosophila)
NUP205 nucleoporin 205kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
PARP1 poly (ADP-ribose) polymerase 1
PCLO piccolo presynaptic cytomatrix protein
PGAP1 post-GPI attachment to proteins 1
PMM1 phosphomannomutase 1
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
POLG polymerase (DNA directed), gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PTCRA pre T-cell antigen receptor alpha
RAB13 RAB13, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RBSN rabenosyn, RAB effector
RFC1 replication factor C (activator 1) 1, 145kDa
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOT1 ras homolog family member T1
RHOT2 ras homolog family member T2
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SFMBT1 Scm-like with four mbt domains 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SNW1 SNW domain containing 1
SP1 Sp1 transcription factor
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STRAP serine/threonine kinase receptor associated protein
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUN2 Sad1 and UNC84 domain containing 2
TCERG1 transcription elongation regulator 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TECR trans-2,3-enoyl-CoA reductase
TFRC transferrin receptor
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM33 transmembrane protein 33
TNXB tenascin XB
TRIM23 tripartite motif containing 23
TRIM28 tripartite motif containing 28
TRRAP transformation/transcription domain-associated protein
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
WRN Werner syndrome, RecQ helicase-like
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBED4 zinc finger, BED-type containing 4
ZC3H11A zinc finger CCCH-type containing 11A
ZNF148 zinc finger protein 148
ZNF300 zinc finger protein 300