NOTCH4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description notch 4|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4855)
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Genes

332 genes differentially expressed following the NOTCH4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 2.99792
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.99792
ASPA aspartoacylase 2.99792
MFAP5 microfibrillar associated protein 5 2.99792
GIMAP4 GTPase, IMAP family member 4 2.99792
PECAM1 platelet/endothelial cell adhesion molecule 1 2.99792
FHL5 four and a half LIM domains 5 2.99792
BIRC3 baculoviral IAP repeat containing 3 2.99792
PTGFR prostaglandin F receptor (FP) 2.99792
CXCL2 chemokine (C-X-C motif) ligand 2 2.99792
XCL2 chemokine (C motif) ligand 2 2.99792
LRG1 leucine-rich alpha-2-glycoprotein 1 2.99792
CEP295NL CEP295 N-terminal like 2.99792
PON1 paraoxonase 1 2.99792
RAX retina and anterior neural fold homeobox 2.99792
HGD homogentisate 1,2-dioxygenase 2.99792
KRT24 keratin 24, type I 2.99792
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.99792
IQCJ IQ motif containing J 2.99792
CLEC19A C-type lectin domain family 19, member A 2.99792
SH2D6 SH2 domain containing 6 2.99792
FFAR4 free fatty acid receptor 4 2.99792
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.99792
ZNF556 zinc finger protein 556 2.99792
LOC105378220 macrophage receptor MARCO-like 2.99792
STEAP4 STEAP family member 4 2.99792
SPAG6 sperm associated antigen 6 2.99792
ZNF804B zinc finger protein 804B 2.99792
EMCN endomucin 2.99792
LEP leptin 2.99792
PCDHGA11 protocadherin gamma subfamily A, 11 2.99792
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.99792
CD33 CD33 molecule 2.99792
OIT3 oncoprotein induced transcript 3 2.99792
ETV7 ets variant 7 2.99792
HMX3 H6 family homeobox 3 2.99792
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.99792
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.99792
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.99792
CELA1 chymotrypsin-like elastase family, member 1 2.99792
CD68 CD68 molecule 2.99792
OC90 otoconin 90 2.99792
S100A1 S100 calcium binding protein A1 2.99792
COL15A1 collagen, type XV, alpha 1 2.99792
FAM216B family with sequence similarity 216, member B 2.99792
MMRN1 multimerin 1 2.99792
PRELP proline/arginine-rich end leucine-rich repeat protein 2.99792
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.99792
AVPR1A arginine vasopressin receptor 1A 2.99792
TAS2R60 taste receptor, type 2, member 60 2.99792
ADGRG7 adhesion G protein-coupled receptor G7 2.99792
SPATA31C1 SPATA31 subfamily C, member 1 2.99792
FAM220A family with sequence similarity 220, member A 2.99792
TBC1D3B TBC1 domain family, member 3B 2.99792
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.99792
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.99792
BDKRB1 bradykinin receptor B1 2.99792
TMOD4 tropomodulin 4 (muscle) 2.99792
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.99792
PHF24 PHD finger protein 24 2.99792
DRC11L dynein regulatory complex subunit 11 like 2.99792
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.99792
ZNF475 zinc finger protein 475 2.99792
CPNE8-AS1 CPNE8 antisense RNA 1 2.99792
SMIM43 small integral membrane protein 43 2.99792
GARIN5B golgi associated RAB2 interactor family member 5B 2.99792
PLPP4 phospholipid phosphatase 4 2.99792
MAB21L4 mab-21 like 4 2.99792
DEPP1 DEPP autophagy regulator 1 2.99792
GCSAM germinal center-associated, signaling and motility 2.99792
CCDC42 coiled-coil domain containing 42 2.99792
IL31RA interleukin 31 receptor A 2.99792
CCDC17 coiled-coil domain containing 17 2.99792
TMIE transmembrane inner ear 2.99792
PCDHB13 protocadherin beta 13 2.99792
NKX2-2 NK2 homeobox 2 2.99792
USH1G Usher syndrome 1G (autosomal recessive) 2.99792
LHCGR luteinizing hormone/choriogonadotropin receptor 2.99792
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.99792
NPPB natriuretic peptide B 2.99792
C3ORF80 chromosome 3 open reading frame 80 2.99792
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.99792
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 2.99792
IL16 interleukin 16 2.99792
FGFBP1 fibroblast growth factor binding protein 1 2.99792
OOSP1 oocyte secreted protein 1, pseudogene 2.99792
VCX3B variable charge, X-linked 3B 2.99792
PRR4 proline rich 4 (lacrimal) 2.99792
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.99792
PGC progastricsin (pepsinogen C) 2.99792
BHLHA9 basic helix-loop-helix family, member a9 2.99792
OVOL3 ovo-like zinc finger 3 2.99792
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.99792
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.99792
ARL13A ADP-ribosylation factor-like 13A 2.99792
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.99792
CST9 cystatin 9 (testatin) 2.99792
CPSF4L cleavage and polyadenylation specific factor 4-like 2.99792
CAPSL calcyphosine-like 2.99792
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.99792
CD28 CD28 molecule 2.99792
PSG3 pregnancy specific beta-1-glycoprotein 3 2.99792
EMX2 empty spiracles homeobox 2 2.99792
ARHGAP20 Rho GTPase activating protein 20 2.99792
ZNF132 zinc finger protein 132 2.99792
IER5L immediate early response 5-like 2.99792
CALML5 calmodulin-like 5 2.99792
MAGEB17 melanoma antigen family B17 2.99792
ONECUT3 one cut homeobox 3 2.99792
LYG2 lysozyme G-like 2 2.99792
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.99792
IL17REL interleukin 17 receptor E-like 2.99792
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.99792
ERICH6B glutamate-rich 6B 2.99792
PGR progesterone receptor 2.99792
FBXO40 F-box protein 40 2.99792
C20ORF144 chromosome 20 open reading frame 144 2.99792
SAMD9 sterile alpha motif domain containing 9 2.99792
PTHLH parathyroid hormone-like hormone 2.99792
ZC3H11D zinc finger CCCH-type containing 11D 2.99792
HLA-DOB major histocompatibility complex, class II, DO beta 2.99792
ITGA10 integrin, alpha 10 2.99792
AICDA activation-induced cytidine deaminase 2.99792
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.99792
MUC17 mucin 17, cell surface associated 2.99792
SOSTDC1 sclerostin domain containing 1 2.99792
NT5C1A 5'-nucleotidase, cytosolic IA 2.99792
TDRD10 tudor domain containing 10 2.99792
NPFFR1 neuropeptide FF receptor 1 2.99792
SPINK9 serine peptidase inhibitor, Kazal type 9 2.99792
CPA2 carboxypeptidase A2 (pancreatic) 2.99792
TREH trehalase (brush-border membrane glycoprotein) 2.99792
DMRT2 doublesex and mab-3 related transcription factor 2 2.99792
GPR150 G protein-coupled receptor 150 2.99792
ANKRD33 ankyrin repeat domain 33 2.99792
MMEL1 membrane metallo-endopeptidase-like 1 2.99792
LAMP5 lysosomal-associated membrane protein family, member 5 2.99792
SBSPON somatomedin B and thrombospondin, type 1 domain containing 2.99792
DUOXA1 dual oxidase maturation factor 1 2.99792
NONO non-POU domain containing, octamer-binding 2.99792
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.99792
SFTA2 surfactant associated 2 2.99792
CCDC170 coiled-coil domain containing 170 2.99792
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.99792
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.99792
CHMP3 charged multivesicular body protein 3 2.99792
TEX38 testis expressed 38 2.99792
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.99792
LRRC31 leucine rich repeat containing 31 2.99792
APOL6 apolipoprotein L, 6 2.99792
LRRC74A leucine rich repeat containing 74A 2.99792
BCAP31 B-cell receptor-associated protein 31 2.99792
APOA5 apolipoprotein A-V 2.99792
PRRX1 paired related homeobox 1 2.99792
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.99792
NUTM2B NUT family member 2B 2.99792
SMOX spermine oxidase 2.99792
PATE2 prostate and testis expressed 2 2.99792
KIF1B kinesin family member 1B 2.99792
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.99792
ITGA8 integrin, alpha 8 2.99792
NPAS4 neuronal PAS domain protein 4 2.99792
IL17B interleukin 17B 2.99792
PLA2G2C phospholipase A2, group IIC 2.99792
LAMB4 laminin, beta 4 2.99792
GLT6D1 glycosyltransferase 6 domain containing 1 2.99792
BTF3L4 basic transcription factor 3-like 4 2.97344
RANBP1 RAN binding protein 1 2.94206
FCSK fucose kinase 2.84623
TMEM79 transmembrane protein 79 2.84623
FAM167B family with sequence similarity 167, member B 2.723
AUTS2 autism susceptibility candidate 2 2.723
NUDC nudC nuclear distribution protein 2.71532
NPEPPS aminopeptidase puromycin sensitive 2.71161
RPS3A ribosomal protein S3A 2.69911
ARMC1 armadillo repeat containing 1 2.66556
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 2.61028
ATRAID all-trans retinoic acid-induced differentiation factor 2.60638
TBC1D3L TBC1 domain family, member 3L 2.55362
GOLGA6C golgin A6 family, member C 2.55362
CPT1C carnitine palmitoyltransferase 1C 2.5475
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.48575
LYN LYN proto-oncogene, Src family tyrosine kinase 2.48439
PGM2 phosphoglucomutase 2 2.36401
RPP40 ribonuclease P/MRP 40kDa subunit 2.35643
ZNF2 zinc finger protein 2 2.35083
SH3PXD2B SH3 and PX domains 2B 2.319
HACL2 2-hydroxyacyl-CoA lyase 2 2.30309
ALAS2 5'-aminolevulinate synthase 2 2.30272
RNASET2 ribonuclease T2 2.2992
FOXD1 forkhead box D1 2.28058
ZGPAT zinc finger, CCCH-type with G patch domain 2.2711
VBP1 von Hippel-Lindau binding protein 1 2.2663
CDHR3 cadherin-related family member 3 2.22958
FGD4 FYVE, RhoGEF and PH domain containing 4 2.22156
PEX3 peroxisomal biogenesis factor 3 2.2185
SCRIB scribbled planar cell polarity protein 2.20066
ABHD4 abhydrolase domain containing 4 2.18893
ZNF839 zinc finger protein 839 2.18893
DPY30 dpy-30 homolog (C. elegans) 2.18425
DMP1 dentin matrix acidic phosphoprotein 1 2.15223
STK25 serine/threonine kinase 25 2.14729
INTS6L integrator complex subunit 6 like 2.13705
PDE4DIP phosphodiesterase 4D interacting protein 2.13647
NOMO3 NODAL modulator 3 2.11739
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.11156
POC1A POC1 centriolar protein A 2.10622
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.08663
KIF2C kinesin family member 2C 2.08321
DTNA dystrobrevin, alpha 2.07848
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.07848
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.07682
TMEM276 transmembrane protein 276 2.07682
CKS1B CDC28 protein kinase regulatory subunit 1B 2.07591
LCMT2 leucine carboxyl methyltransferase 2 2.07591
PTPRD protein tyrosine phosphatase, receptor type, D 2.07591
ERLIN1 ER lipid raft associated 1 2.07146
SLC35H1 solute carrier family 35 member H1 2.07093
FBXO27 F-box protein 27 2.07051
CLDN12 claudin 12 2.05376
ZNF451 zinc finger protein 451 2.03865
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.037
KLF10 Kruppel-like factor 10 2.02346

decreased expression

Symbol Name Standardized Value
TNS1-AS1 TNS1 antisense RNA 1 -2.99792
FBLN7 fibulin 7 -2.99792
ARSA arylsulfatase A -2.99792
SUSD2 sushi domain containing 2 -2.99792
TTLL9 tubulin tyrosine ligase-like family member 9 -2.99792
SYCE3 synaptonemal complex central element protein 3 -2.99792
SPMIP6 sperm microtubule inner protein 6 -2.99792
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.99792
NPY neuropeptide Y -2.99792
CCDC87 coiled-coil domain containing 87 -2.99792
CYSRT1 cysteine-rich tail protein 1 -2.99792
FRMPD2 FERM and PDZ domain containing 2 -2.99792
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.99792
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.99792
THEM6 thioesterase superfamily member 6 -2.99792
ARHGAP31 Rho GTPase activating protein 31 -2.99792
DUSP10 dual specificity phosphatase 10 -2.99792
SPMIP3 sperm microtubule inner protein 3 -2.99792
PRRT1B proline rich transmembrane protein 1B -2.99792
INSYN1 inhibitory synaptic factor 1 -2.99792
PVALEF parvalbumin like EF-hand containing -2.99792
RIPOR1 RHO family interacting cell polarization regulator 1 -2.99792
SPATS1 spermatogenesis associated, serine-rich 1 -2.99792
PCDHGA9 protocadherin gamma subfamily A, 9 -2.99792
TMPRSS5 transmembrane protease, serine 5 -2.99792
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.99792
TMEM233 transmembrane protein 233 -2.99792
KLHL31 kelch-like family member 31 -2.99792
ACTL8 actin-like 8 -2.99792
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.99792
CCDC62 coiled-coil domain containing 62 -2.99792
MMP3 matrix metallopeptidase 3 -2.99792
SPATA32 spermatogenesis associated 32 -2.99792
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.99792
CDH26 cadherin 26 -2.99792
ZNF426 zinc finger protein 426 -2.99792
NRIP2 nuclear receptor interacting protein 2 -2.99792
GLRB glycine receptor, beta -2.99792
GLB1L2 galactosidase, beta 1-like 2 -2.99792
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.99792
GAB3 GRB2-associated binding protein 3 -2.99792
ANKRD65 ankyrin repeat domain 65 -2.99792
CBX8 chromobox homolog 8 -2.99792
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.99792
TTC29 tetratricopeptide repeat domain 29 -2.99792
BCO1 beta-carotene oxygenase 1 -2.99792
SNX31 sorting nexin 31 -2.99792
ORM2 orosomucoid 2 -2.99792
TMEM221 transmembrane protein 221 -2.9552
ITLN2 intelectin 2 -2.71161
DYNLT5 dynein light chain Tctex-type family member 5 -2.71161
FAM222A family with sequence similarity 222, member A -2.71161
MCFD2 multiple coagulation factor deficiency 2 -2.67411
PTRH2 peptidyl-tRNA hydrolase 2 -2.66487
RGN regucalcin -2.66487
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -2.65613
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.63683
GATAD2B GATA zinc finger domain containing 2B -2.63403
GSTO2 glutathione S-transferase omega 2 -2.61389
DNAI1 dynein, axonemal, intermediate chain 1 -2.60638
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 -2.59088
IGSF6 immunoglobulin superfamily, member 6 -2.51634
PRRC2B proline-rich coiled-coil 2B -2.51634
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3 -2.51203
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.45974
MARVELD1 MARVEL domain containing 1 -2.43507
RSKR ribosomal protein S6 kinase related -2.42628
DHCR7 7-dehydrocholesterol reductase -2.39019
BEND6 BEN domain containing 6 -2.38528
CADM2 cell adhesion molecule 2 -2.36244
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -2.35589
LARP1 La ribonucleoprotein domain family, member 1 -2.33835
SPACA9 sperm acrosome associated 9 -2.33313
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -2.32449
TCF12 transcription factor 12 -2.319
ZDHHC16 zinc finger, DHHC-type containing 16 -2.31843
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.31526
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 -2.26447
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -2.22927
CCDC63 coiled-coil domain containing 63 -2.22156
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.21415
HIF3A hypoxia inducible factor 3, alpha subunit -2.21394
HSDL2 hydroxysteroid dehydrogenase like 2 -2.21394
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -2.20901
COL11A1 collagen, type XI, alpha 1 -2.203
TEX9 testis expressed 9 -2.203
CRPPA CDP-L-ribitol pyrophosphorylase A -2.18893
AP3M1 adaptor-related protein complex 3, mu 1 subunit -2.17724
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.16604
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.16378
ANKRD35 ankyrin repeat domain 35 -2.15131
SLC44A4 solute carrier family 44, member 4 -2.15124
EML2 echinoderm microtubule associated protein like 2 -2.13747
C10ORF95 chromosome 10 open reading frame 95 -2.09666
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.09014
HLTF helicase-like transcription factor -2.08663
TTF2 transcription termination factor, RNA polymerase II -2.07591
GARRE1 granule associated Rac and RHOG effector 1 -2.07093
KLHL24 kelch-like family member 24 -2.06041
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -2.05301
CEP63 centrosomal protein 63kDa -2.03998
ZNF442 zinc finger protein 442 -2.03865
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -2.03288
ZNF506 zinc finger protein 506 -2.02346
SENP5 SUMO1/sentrin specific peptidase 5 -2.02201
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.02201
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -2.01818
TTPAL tocopherol (alpha) transfer protein-like -2.01323
ZNF691 zinc finger protein 691 -2.01127