NOTCH4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description notch 4|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4855)
External Link http://www.ncbi.nlm.nih.gov/gene/4855
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43 interacting proteins for NOTCH4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CIR1 corepressor interacting with RBPJ, 1
DLL4 delta-like 4 (Drosophila)
EGFL7 EGF-like-domain, multiple 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FURIN furin (paired basic amino acid cleaving enzyme)
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NRF1 nuclear respiratory factor 1
NUMB numb homolog (Drosophila)
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
RAB6A RAB6A, member RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TMED2 transmembrane emp24 domain trafficking protein 2
TP53 tumor protein p53
UBC ubiquitin C