| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/NOTCH_DN.V1_UP |
| Similar Terms | |
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369 genes differentially expressed following the NOTCH_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| ADAP1 | ArfGAP with dual PH domains 1 |
| ADGRG1 | adhesion G protein-coupled receptor G1 |
| AIM1L | absent in melanoma 1-like |
| AMPH | amphiphysin |
| ANGPT4 | angiopoietin 4 |
| ANGPTL7 | angiopoietin-like 7 |
| ANKH | ANKH inorganic pyrophosphate transport regulator |
| ANXA2P3 | annexin A2 pseudogene 3 |
| ASB9 | ankyrin repeat and SOCS box containing 9 |
| ATP1B2 | ATPase, Na+/K+ transporting, beta 2 polypeptide |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 |
| BARX2 | BARX homeobox 2 |
| BBS10 | Bardet-Biedl syndrome 10 |
| BHLHB9 | basic helix-loop-helix domain containing, class B, 9 |
| BTG2 | BTG family, member 2 |
| C1ORF106 | chromosome 1 open reading frame 106 |
| C6ORF15 | chromosome 6 open reading frame 15 |
| C8B | complement component 8, beta polypeptide |
| CA5B | carbonic anhydrase VB, mitochondrial |
| CALB1 | calbindin 1, 28kDa |
| CASKIN2 | CASK interacting protein 2 |
| CCNA1 | cyclin A1 |
| CDC37L1 | cell division cycle 37-like 1 |
| CDHR1 | cadherin-related family member 1 |
| CDHR2 | cadherin-related family member 2 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 |
| CDKL1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 |
| CIB2 | calcium and integrin binding family member 2 |
| CLDN16 | claudin 16 |
| CLMN | calmin (calponin-like, transmembrane) |
| CNTD2 | cyclin N-terminal domain containing 2 |
| COL4A1 | collagen, type IV, alpha 1 |
| CPA2 | carboxypeptidase A2 (pancreatic) |
| CPB1 | carboxypeptidase B1 (tissue) |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 |
| CRIP1 | cysteine-rich protein 1 (intestinal) |
| CRYGC | crystallin, gamma C |
| CRYM | crystallin, mu |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
| CTF1 | cardiotrophin 1 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 |
| DCLRE1A | DNA cross-link repair 1A |
| DGKE | diacylglycerol kinase, epsilon 64kDa |
| DGKI | diacylglycerol kinase, iota |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 |
| DPT | dermatopontin |
| EFNA3 | ephrin-A3 |
| EPN3 | epsin 3 |
| ESM1 | endothelial cell-specific molecule 1 |
| ETNPPL | ethanolamine-phosphate phospho-lyase |
| FAM215A | family with sequence similarity 215, member A (non-protein coding) |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 |
| FGF13 | fibroblast growth factor 13 |
| FGF16 | fibroblast growth factor 16 |
| FKBP9 | FK506 binding protein 9, 63 kDa |
| FLT3 | fms-related tyrosine kinase 3 |
| FOXP3 | forkhead box P3 |
| FYB | FYN binding protein |
| GABRR1 | gamma-aminobutyric acid (GABA) A receptor, rho 1 |
| GDNF | glial cell derived neurotrophic factor |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| GSN-AS1 | GSN antisense RNA 1 |
| GSTA3 | glutathione S-transferase alpha 3 |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa |
| GUCA1B | guanylate cyclase activator 1B (retina) |
| HABP4 | hyaluronan binding protein 4 |
| HHLA2 | HERV-H LTR-associating 2 |
| HMOX1 | heme oxygenase 1 |
| HPCAL4 | hippocalcin like 4 |
| HSPA1A | heat shock 70kDa protein 1A |
| HTN1 | histatin 1 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| INPP1 | inositol polyphosphate-1-phosphatase |
| IQCC | IQ motif containing C |
| ITPKC | inositol-trisphosphate 3-kinase C |
| KCND1 | potassium channel, voltage gated Shal related subfamily D, member 1 |
| KCNH2 | potassium channel, voltage gated eag related subfamily H, member 2 |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KIF13B | kinesin family member 13B |
| KLHL21 | kelch-like family member 21 |
| KLHL26 | kelch-like family member 26 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 |
| KRT18 | keratin 18, type I |
| KRT8P12 | keratin 8 pseudogene 12 |
| KSR1 | kinase suppressor of ras 1 |
| LCE2B | late cornified envelope 2B |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LHCGR | luteinizing hormone/choriogonadotropin receptor |
| LINC01565 | long intergenic non-protein coding RNA 1565 |
| LMAN1 | lectin, mannose-binding, 1 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 |
| MEFV | Mediterranean fever |
| MFSD6 | major facilitator superfamily domain containing 6 |
| MN1 | meningioma (disrupted in balanced translocation) 1 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 |
| MYF5 | myogenic factor 5 |
| NAT6 | N-acetyltransferase 6 (GCN5-related) |
| NEU2 | sialidase 2 (cytosolic sialidase) |
| NEUROG3 | neurogenin 3 |
| NME5 | NME/NM23 family member 5 |
| NPTX1 | neuronal pentraxin I |
| NPTXR | neuronal pentraxin receptor |
| NPY6R | neuropeptide Y receptor Y6 (pseudogene) |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 |
| NYNRIN | NYN domain and retroviral integrase containing |
| OR10H3 | olfactory receptor, family 10, subfamily H, member 3 |
| P2RX3 | purinergic receptor P2X, ligand gated ion channel, 3 |
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 |
| P3H3 | prolyl 3-hydroxylase 3 |
| PAIP2B | poly(A) binding protein interacting protein 2B |
| PF4V1 | platelet factor 4 variant 1 |
| PGP | phosphoglycolate phosphatase |
| PIAS3 | protein inhibitor of activated STAT, 3 |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase |
| PKDREJ | polycystin (PKD) family receptor for egg jelly |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
| PNPLA3 | patatin-like phospholipase domain containing 3 |
| PPEF2 | protein phosphatase, EF-hand calcium binding domain 2 |
| PPP1R13L | protein phosphatase 1, regulatory subunit 13 like |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha |
| PRKG1 | protein kinase, cGMP-dependent, type I |
| PROC | protein C (inactivator of coagulation factors Va and VIIIa) |
| PRSS50 | protease, serine, 50 |
| RAB23 | RAB23, member RAS oncogene family |
| RAG1 | recombination activating gene 1 |
| RAG2 | recombination activating gene 2 |
| RANBP17 | RAN binding protein 17 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
| RDH5 | retinol dehydrogenase 5 (11-cis/9-cis) |
| RFPL1 | ret finger protein-like 1 |
| RGS2 | regulator of G-protein signaling 2 |
| RHCE | Rh blood group, CcEe antigens |
| RNF39 | ring finger protein 39 |
| RP2 | retinitis pigmentosa 2 (X-linked recessive) |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 |
| RRAD | Ras-related associated with diabetes |
| RUNX2 | runt-related transcription factor 2 |
| S100A8 | S100 calcium binding protein A8 |
| SCN8A | sodium channel, voltage gated, type VIII alpha subunit |
| SCTR | secretin receptor |
| SDPR | serum deprivation response |
| SETD1A | SET domain containing 1A |
| SLC17A9 | solute carrier family 17 (vesicular nucleotide transporter), member 9 |
| SLC30A10 | solute carrier family 30, member 10 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| SLC5A4 | solute carrier family 5 (glucose activated ion channel), member 4 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 |
| SLC9A7 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 |
| SPTBN2 | spectrin, beta, non-erythrocytic 2 |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 |
| SSH3 | slingshot protein phosphatase 3 |
| STARD8 | StAR-related lipid transfer (START) domain containing 8 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa |
| SYT12 | synaptotagmin XII |
| TFDP3 | transcription factor Dp family, member 3 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 |
| TGFBR1 | transforming growth factor, beta receptor 1 |
| TLX1 | T-cell leukemia homeobox 1 |
| TMEM59L | transmembrane protein 59-like |
| TMEM74B | transmembrane protein 74B |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 |
| TNNI3 | troponin I type 3 (cardiac) |
| TNS1 | tensin 1 |
| TPPP | tubulin polymerization promoting protein |
| TTC21B | tetratricopeptide repeat domain 21B |
| TUBBP5 | tubulin, beta pseudogene 5 |
| UPB1 | ureidopropionase, beta |
| WDR7 | WD repeat domain 7 |
| YBX2 | Y box binding protein 2 |
| ZBBX | zinc finger, B-box domain containing |
| ZNF112 | zinc finger protein 112 |
| ZNF230 | zinc finger protein 230 |
| ZNF507 | zinc finger protein 507 |
| ZNF671 | zinc finger protein 671 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 |
| Symbol | Name |
|---|---|
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ABCB9 | ATP-binding cassette, sub-family B (MDR/TAP), member 9 |
| ACADL | acyl-CoA dehydrogenase, long chain |
| ACKR3 | atypical chemokine receptor 3 |
| ADCK4 | aarF domain containing kinase 4 |
| ADTRP | androgen-dependent TFPI-regulating protein |
| AIPL1 | aryl hydrocarbon receptor interacting protein-like 1 |
| ALLC | allantoicase |
| AMOTL2 | angiomotin like 2 |
| ARHGAP6 | Rho GTPase activating protein 6 |
| ARSD | arylsulfatase D |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 |
| BAIAP2 | BAI1-associated protein 2 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
| BCAS1 | breast carcinoma amplified sequence 1 |
| C3AR1 | complement component 3a receptor 1 |
| C3ORF18 | chromosome 3 open reading frame 18 |
| C9ORF3 | chromosome 9 open reading frame 3 |
| CA2 | carbonic anhydrase II |
| CA4 | carbonic anhydrase IV |
| CA8 | carbonic anhydrase VIII |
| CAPN10 | calpain 10 |
| CCDC70 | coiled-coil domain containing 70 |
| CCDC81 | coiled-coil domain containing 81 |
| CCNK | cyclin K |
| CD209 | CD209 molecule |
| CD27 | CD27 molecule |
| CD82 | CD82 molecule |
| CEL | carboxyl ester lipase |
| CHIA | chitinase, acidic |
| CHRND | cholinergic receptor, nicotinic, delta (muscle) |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 |
| CIDEB | cell death-inducing DFFA-like effector b |
| CLIC2 | chloride intracellular channel 2 |
| CLSTN3 | calsyntenin 3 |
| CNGB3 | cyclic nucleotide gated channel beta 3 |
| CPNE6 | copine VI (neuronal) |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 |
| CRH | corticotropin releasing hormone |
| CRHR2 | corticotropin releasing hormone receptor 2 |
| CRMP1 | collapsin response mediator protein 1 |
| CST1 | cystatin SN |
| CXCR3 | chemokine (C-X-C motif) receptor 3 |
| CYP4F2 | cytochrome P450, family 4, subfamily F, polypeptide 2 |
| CYP7B1 | cytochrome P450, family 7, subfamily B, polypeptide 1 |
| DCLK2 | doublecortin-like kinase 2 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 |
| DIO2 | deiodinase, iodothyronine, type II |
| DLK1 | delta-like 1 homolog (Drosophila) |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 |
| DOC2A | double C2-like domains, alpha |
| DRAM1 | DNA-damage regulated autophagy modulator 1 |
| E2F2 | E2F transcription factor 2 |
| EPB41L4A | erythrocyte membrane protein band 4.1 like 4A |
| FAIM | Fas apoptotic inhibitory molecule |
| FAT2 | FAT atypical cadherin 2 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 |
| FIGF | c-fos induced growth factor (vascular endothelial growth factor D) |
| FMNL2 | formin-like 2 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
| GABRG3 | gamma-aminobutyric acid (GABA) A receptor, gamma 3 |
| GGTLC1 | gamma-glutamyltransferase light chain 1 |
| GNAT3 | guanine nucleotide binding protein, alpha transducing 3 |
| GPR15 | G protein-coupled receptor 15 |
| GPR32 | G protein-coupled receptor 32 |
| GPR65 | G protein-coupled receptor 65 |
| GPR68 | G protein-coupled receptor 68 |
| GUCA2A | guanylate cyclase activator 2A (guanylin) |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| HCRT | hypocretin (orexin) neuropeptide precursor |
| HES1 | hes family bHLH transcription factor 1 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha |
| HOXA3 | homeobox A3 |
| HS1BP3 | HCLS1 binding protein 3 |
| ICOS | inducible T-cell co-stimulator |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IFI30 | interferon, gamma-inducible protein 30 |
| IGLC2 | immunoglobulin lambda constant 2 (Kern-Oz- marker) |
| IL11 | interleukin 11 |
| IL26 | interleukin 26 |
| IL7R | interleukin 7 receptor |
| INSM1 | insulinoma-associated 1 |
| IPO8 | importin 8 |
| ITGA7 | integrin, alpha 7 |
| ITGA9 | integrin, alpha 9 |
| KCNA1 | potassium channel, voltage gated shaker related subfamily A, member 1 |
| KCNA5 | potassium channel, voltage gated shaker related subfamily A, member 5 |
| KCNE1 | potassium channel, voltage gated subfamily E regulatory beta subunit 1 |
| KCNN1 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 |
| KLF15 | Kruppel-like factor 15 |
| KLF2 | Kruppel-like factor 2 |
| KLHL12 | kelch-like family member 12 |
| KRT9 | keratin 9, type I |
| LGALS4 | lectin, galactoside-binding, soluble, 4 |
| LHX6 | LIM homeobox 6 |
| LMTK2 | lemur tyrosine kinase 2 |
| LOC57399 | uncharacterized gastric protein ZA52P |
| LPAR6 | lysophosphatidic acid receptor 6 |
| LRP4 | low density lipoprotein receptor-related protein 4 |
| LY6G6C | lymphocyte antigen 6 complex, locus G6C |
| LY6G6E | lymphocyte antigen 6 complex, locus G6E (pseudogene) |
| LZTFL1 | leucine zipper transcription factor-like 1 |
| MAGEC3 | melanoma antigen family C3 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 |
| MAPK13 | mitogen-activated protein kinase 13 |
| MMP25 | matrix metallopeptidase 25 |
| MRM1 | mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| MYO1A | myosin IA |
| MYO1D | myosin ID |
| MYO1E | myosin IE |
| MYO7B | myosin VIIB |
| NID1 | nidogen 1 |
| NOTCH3 | notch 3 |
| NSUN6 | NOP2/Sun domain family, member 6 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 |
| ORAI2 | ORAI calcium release-activated calcium modulator 2 |
| ORM1 | orosomucoid 1 |
| PBOV1 | prostate and breast cancer overexpressed 1 |
| PGLYRP1 | peptidoglycan recognition protein 1 |
| PHKG1 | phosphorylase kinase, gamma 1 (muscle) |
| PKD2L1 | polycystic kidney disease 2-like 1 |
| PLAT | plasminogen activator, tissue |
| POF1B | premature ovarian failure, 1B |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 |
| PPIEL | peptidylprolyl isomerase E-like pseudogene |
| PROL1 | proline rich, lacrimal 1 |
| PSPN | persephin |
| PTCRA | pre T-cell antigen receptor alpha |
| RAB3IL1 | RAB3A interacting protein (rabin3)-like 1 |
| RAMP2 | receptor (G protein-coupled) activity modifying protein 2 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 |
| RHO | rhodopsin |
| RPL39L | ribosomal protein L39-like |
| SAMD4B | sterile alpha motif domain containing 4B |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SELE | selectin E |
| SEMG2 | semenogelin II |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 |
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 |
| SHCBP1L | SHC SH2-domain binding protein 1-like |
| SLC28A3 | solute carrier family 28 (concentrative nucleoside transporter), member 3 |
| SLC45A2 | solute carrier family 45, member 2 |
| SLN | sarcolipin |
| SLPI | secretory leukocyte peptidase inhibitor |
| SNED1 | sushi, nidogen and EGF-like domains 1 |
| SP140 | SP140 nuclear body protein |
| SPANXC | SPANX family, member C |
| SPRR2B | small proline-rich protein 2B |
| SPRY4 | sprouty homolog 4 (Drosophila) |
| SUSD4 | sushi domain containing 4 |
| TBC1D29 | TBC1 domain family, member 29 |
| TBX3 | T-box 3 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TM4SF20 | transmembrane 4 L six family member 20 |
| TMEM132A | transmembrane protein 132A |
| TMEM92 | transmembrane protein 92 |
| TMPRSS6 | transmembrane protease, serine 6 |
| TNFRSF8 | tumor necrosis factor receptor superfamily, member 8 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TRGV7 | T cell receptor gamma variable 7 (pseudogene) |
| TRPC3 | transient receptor potential cation channel, subfamily C, member 3 |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 |
| TUBB2B | tubulin, beta 2B class IIb |
| UTF1 | undifferentiated embryonic cell transcription factor 1 |
| VN1R1 | vomeronasal 1 receptor 1 |
| VNN2 | vanin 2 |
| VPREB3 | pre-B lymphocyte 3 |
| WIF1 | WNT inhibitory factor 1 |
| ZBTB16 | zinc finger and BTB domain containing 16 |
| ZC3H12A | zinc finger CCCH-type containing 12A |
| ZFP37 | ZFP37 zinc finger protein |
| ZNF221 | zinc finger protein 221 |
| ZNF74 | zinc finger protein 74 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A |
