NOTCH_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/NOTCH_DN.V1_UP
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Genes

369 genes differentially expressed following the NOTCH_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAP1 ArfGAP with dual PH domains 1
ADGRG1 adhesion G protein-coupled receptor G1
AIM1L absent in melanoma 1-like
AMPH amphiphysin
ANGPT4 angiopoietin 4
ANGPTL7 angiopoietin-like 7
ANKH ANKH inorganic pyrophosphate transport regulator
ANXA2P3 annexin A2 pseudogene 3
ASB9 ankyrin repeat and SOCS box containing 9
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BARX2 BARX homeobox 2
BBS10 Bardet-Biedl syndrome 10
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C6ORF15 chromosome 6 open reading frame 15
C8B complement component 8, beta polypeptide
CA5B carbonic anhydrase VB, mitochondrial
CALB1 calbindin 1, 28kDa
CASKIN2 CASK interacting protein 2
CCNA1 cyclin A1
CDC37L1 cell division cycle 37-like 1
CDHR1 cadherin-related family member 1
CDHR2 cadherin-related family member 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIB2 calcium and integrin binding family member 2
CLDN16 claudin 16
CLMN calmin (calponin-like, transmembrane)
CNTD2 cyclin N-terminal domain containing 2
COL4A1 collagen, type IV, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CPB1 carboxypeptidase B1 (tissue)
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRIP1 cysteine-rich protein 1 (intestinal)
CRYGC crystallin, gamma C
CRYM crystallin, mu
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTF1 cardiotrophin 1
DAAM2 dishevelled associated activator of morphogenesis 2
DCLRE1A DNA cross-link repair 1A
DGKE diacylglycerol kinase, epsilon 64kDa
DGKI diacylglycerol kinase, iota
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DPT dermatopontin
EFNA3 ephrin-A3
EPN3 epsin 3
ESM1 endothelial cell-specific molecule 1
ETNPPL ethanolamine-phosphate phospho-lyase
FAM215A family with sequence similarity 215, member A (non-protein coding)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF13 fibroblast growth factor 13
FGF16 fibroblast growth factor 16
FKBP9 FK506 binding protein 9, 63 kDa
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
FYB FYN binding protein
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GDNF glial cell derived neurotrophic factor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSN-AS1 GSN antisense RNA 1
GSTA3 glutathione S-transferase alpha 3
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCA1B guanylate cyclase activator 1B (retina)
HABP4 hyaluronan binding protein 4
HHLA2 HERV-H LTR-associating 2
HMOX1 heme oxygenase 1
HPCAL4 hippocalcin like 4
HSPA1A heat shock 70kDa protein 1A
HTN1 histatin 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INPP1 inositol polyphosphate-1-phosphatase
IQCC IQ motif containing C
ITPKC inositol-trisphosphate 3-kinase C
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF13B kinesin family member 13B
KLHL21 kelch-like family member 21
KLHL26 kelch-like family member 26
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT18 keratin 18, type I
KRT8P12 keratin 8 pseudogene 12
KSR1 kinase suppressor of ras 1
LCE2B late cornified envelope 2B
LDOC1 leucine zipper, down-regulated in cancer 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LINC01565 long intergenic non-protein coding RNA 1565
LMAN1 lectin, mannose-binding, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MEFV Mediterranean fever
MFSD6 major facilitator superfamily domain containing 6
MN1 meningioma (disrupted in balanced translocation) 1
MTG1 mitochondrial ribosome-associated GTPase 1
MYF5 myogenic factor 5
NAT6 N-acetyltransferase 6 (GCN5-related)
NEU2 sialidase 2 (cytosolic sialidase)
NEUROG3 neurogenin 3
NME5 NME/NM23 family member 5
NPTX1 neuronal pentraxin I
NPTXR neuronal pentraxin receptor
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NYNRIN NYN domain and retroviral integrase containing
OR10H3 olfactory receptor, family 10, subfamily H, member 3
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P3H3 prolyl 3-hydroxylase 3
PAIP2B poly(A) binding protein interacting protein 2B
PF4V1 platelet factor 4 variant 1
PGP phosphoglycolate phosphatase
PIAS3 protein inhibitor of activated STAT, 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKDREJ polycystin (PKD) family receptor for egg jelly
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PNPLA3 patatin-like phospholipase domain containing 3
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKG1 protein kinase, cGMP-dependent, type I
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS50 protease, serine, 50
RAB23 RAB23, member RAS oncogene family
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RANBP17 RAN binding protein 17
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RFPL1 ret finger protein-like 1
RGS2 regulator of G-protein signaling 2
RHCE Rh blood group, CcEe antigens
RNF39 ring finger protein 39
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRAD Ras-related associated with diabetes
RUNX2 runt-related transcription factor 2
S100A8 S100 calcium binding protein A8
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCTR secretin receptor
SDPR serum deprivation response
SETD1A SET domain containing 1A
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC30A10 solute carrier family 30, member 10
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SPTBN2 spectrin, beta, non-erythrocytic 2
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSH3 slingshot protein phosphatase 3
STARD8 StAR-related lipid transfer (START) domain containing 8
STAT2 signal transducer and activator of transcription 2, 113kDa
SYT12 synaptotagmin XII
TFDP3 transcription factor Dp family, member 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TLX1 T-cell leukemia homeobox 1
TMEM59L transmembrane protein 59-like
TMEM74B transmembrane protein 74B
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNNI3 troponin I type 3 (cardiac)
TNS1 tensin 1
TPPP tubulin polymerization promoting protein
TTC21B tetratricopeptide repeat domain 21B
TUBBP5 tubulin, beta pseudogene 5
UPB1 ureidopropionase, beta
WDR7 WD repeat domain 7
YBX2 Y box binding protein 2
ZBBX zinc finger, B-box domain containing
ZNF112 zinc finger protein 112
ZNF230 zinc finger protein 230
ZNF507 zinc finger protein 507
ZNF671 zinc finger protein 671
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACADL acyl-CoA dehydrogenase, long chain
ACKR3 atypical chemokine receptor 3
ADCK4 aarF domain containing kinase 4
ADTRP androgen-dependent TFPI-regulating protein
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALLC allantoicase
AMOTL2 angiomotin like 2
ARHGAP6 Rho GTPase activating protein 6
ARSD arylsulfatase D
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
BAIAP2 BAI1-associated protein 2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCAS1 breast carcinoma amplified sequence 1
C3AR1 complement component 3a receptor 1
C3ORF18 chromosome 3 open reading frame 18
C9ORF3 chromosome 9 open reading frame 3
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CA8 carbonic anhydrase VIII
CAPN10 calpain 10
CCDC70 coiled-coil domain containing 70
CCDC81 coiled-coil domain containing 81
CCNK cyclin K
CD209 CD209 molecule
CD27 CD27 molecule
CD82 CD82 molecule
CEL carboxyl ester lipase
CHIA chitinase, acidic
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CLIC2 chloride intracellular channel 2
CLSTN3 calsyntenin 3
CNGB3 cyclic nucleotide gated channel beta 3
CPNE6 copine VI (neuronal)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRH corticotropin releasing hormone
CRHR2 corticotropin releasing hormone receptor 2
CRMP1 collapsin response mediator protein 1
CST1 cystatin SN
CXCR3 chemokine (C-X-C motif) receptor 3
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCLK2 doublecortin-like kinase 2
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DIO2 deiodinase, iodothyronine, type II
DLK1 delta-like 1 homolog (Drosophila)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOC2A double C2-like domains, alpha
DRAM1 DNA-damage regulated autophagy modulator 1
E2F2 E2F transcription factor 2
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
FAIM Fas apoptotic inhibitory molecule
FAT2 FAT atypical cadherin 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FMNL2 formin-like 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GGTLC1 gamma-glutamyltransferase light chain 1
GNAT3 guanine nucleotide binding protein, alpha transducing 3
GPR15 G protein-coupled receptor 15
GPR32 G protein-coupled receptor 32
GPR65 G protein-coupled receptor 65
GPR68 G protein-coupled receptor 68
GUCA2A guanylate cyclase activator 2A (guanylin)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCRT hypocretin (orexin) neuropeptide precursor
HES1 hes family bHLH transcription factor 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXA3 homeobox A3
HS1BP3 HCLS1 binding protein 3
ICOS inducible T-cell co-stimulator
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IL11 interleukin 11
IL26 interleukin 26
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
IPO8 importin 8
ITGA7 integrin, alpha 7
ITGA9 integrin, alpha 9
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF15 Kruppel-like factor 15
KLF2 Kruppel-like factor 2
KLHL12 kelch-like family member 12
KRT9 keratin 9, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LHX6 LIM homeobox 6
LMTK2 lemur tyrosine kinase 2
LOC57399 uncharacterized gastric protein ZA52P
LPAR6 lysophosphatidic acid receptor 6
LRP4 low density lipoprotein receptor-related protein 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene)
LZTFL1 leucine zipper transcription factor-like 1
MAGEC3 melanoma antigen family C3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK13 mitogen-activated protein kinase 13
MMP25 matrix metallopeptidase 25
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO1A myosin IA
MYO1D myosin ID
MYO1E myosin IE
MYO7B myosin VIIB
NID1 nidogen 1
NOTCH3 notch 3
NSUN6 NOP2/Sun domain family, member 6
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR2H1 olfactory receptor, family 2, subfamily H, member 1
ORAI2 ORAI calcium release-activated calcium modulator 2
ORM1 orosomucoid 1
PBOV1 prostate and breast cancer overexpressed 1
PGLYRP1 peptidoglycan recognition protein 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PKD2L1 polycystic kidney disease 2-like 1
PLAT plasminogen activator, tissue
POF1B premature ovarian failure, 1B
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIEL peptidylprolyl isomerase E-like pseudogene
PROL1 proline rich, lacrimal 1
PSPN persephin
PTCRA pre T-cell antigen receptor alpha
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHO rhodopsin
RPL39L ribosomal protein L39-like
SAMD4B sterile alpha motif domain containing 4B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SEMG2 semenogelin II
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHCBP1L SHC SH2-domain binding protein 1-like
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC45A2 solute carrier family 45, member 2
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SNED1 sushi, nidogen and EGF-like domains 1
SP140 SP140 nuclear body protein
SPANXC SPANX family, member C
SPRR2B small proline-rich protein 2B
SPRY4 sprouty homolog 4 (Drosophila)
SUSD4 sushi domain containing 4
TBC1D29 TBC1 domain family, member 29
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TM4SF20 transmembrane 4 L six family member 20
TMEM132A transmembrane protein 132A
TMEM92 transmembrane protein 92
TMPRSS6 transmembrane protease, serine 6
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRGV7 T cell receptor gamma variable 7 (pseudogene)
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBB2B tubulin, beta 2B class IIb
UTF1 undifferentiated embryonic cell transcription factor 1
VN1R1 vomeronasal 1 receptor 1
VNN2 vanin 2
VPREB3 pre-B lymphocyte 3
WIF1 WNT inhibitory factor 1
ZBTB16 zinc finger and BTB domain containing 16
ZC3H12A zinc finger CCCH-type containing 12A
ZFP37 ZFP37 zinc finger protein
ZNF221 zinc finger protein 221
ZNF74 zinc finger protein 74
ZSCAN5A zinc finger and SCAN domain containing 5A