NPAS2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neuronal PAS domain protein 2|The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4862)
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Genes

312 genes differentially expressed following the NPAS2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLFN11 schlafen family member 11 2.47334
OSR2 odd-skipped related transciption factor 2 2.47334
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.47334
ARHGAP36 Rho GTPase activating protein 36 2.47334
OLIG3 oligodendrocyte transcription factor 3 2.47334
XCL1 chemokine (C motif) ligand 1 2.47334
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.47334
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.47334
ASPA aspartoacylase 2.47334
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.47334
CNTNAP4 contactin associated protein-like 4 2.47334
WNT3A wingless-type MMTV integration site family, member 3A 2.47334
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.47334
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.47334
GPR55 G protein-coupled receptor 55 2.47334
CAMP cathelicidin antimicrobial peptide 2.47334
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 2.47334
PCDHB7 protocadherin beta 7 2.47334
FOXA2 forkhead box A2 2.47334
FOXA1 forkhead box A1 2.47334
NUGGC nuclear GTPase, germinal center associated 2.47334
TAL2 T-cell acute lymphocytic leukemia 2 2.47334
SP7 Sp7 transcription factor 2.47334
OXT oxytocin/neurophysin I prepropeptide 2.47334
AVP arginine vasopressin 2.47334
PRDM13 PR domain containing 13 2.47334
BMP3 bone morphogenetic protein 3 2.47334
ASGR2 asialoglycoprotein receptor 2 2.47334
TMC8 transmembrane channel-like 8 2.47334
LUZP4 leucine zipper protein 4 2.47334
ETV2 ets variant 2 2.47334
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 2.47334
HBZ hemoglobin, zeta 2.47334
PNOC prepronociceptin 2.47334
RFPL3 ret finger protein-like 3 2.47334
MGARP mitochondria-localized glutamic acid-rich protein 2.47334
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.47334
SMIM9 small integral membrane protein 9 2.47334
CELA1 chymotrypsin-like elastase family, member 1 2.47334
OCSTAMP osteoclast stimulatory transmembrane protein 2.47334
TMEM191B transmembrane protein 191B 2.47334
ADAT1 adenosine deaminase, tRNA-specific 1 2.47334
TPPP tubulin polymerization promoting protein 2.47334
FOLR1 folate receptor 1 (adult) 2.47334
TEKTL1 tektin like 1 2.47334
RAG1 recombination activating gene 1 2.47334
HTRA4 HtrA serine peptidase 4 2.47334
TCERG1L transcription elongation regulator 1-like 2.47334
STX11 syntaxin 11 2.47334
SRGN serglycin 2.47334
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.47334
GATA3 GATA binding protein 3 2.47334
DYNAP dynactin associated protein 2.47334
C3AR1 complement component 3a receptor 1 2.47334
OTOS otospiralin 2.47334
STYXL2 serine/threonine/tyrosine interacting like 2 2.47334
C3ORF85 chromosome 3 open reading frame 85 2.47334
CFAP97D2 CFAP97 domain containing 2 2.47334
CFAP141 cilia and flagella associated protein 141 2.47334
PCARE photoreceptor cilium actin regulator 2.47334
CFAP100 cilia and flagella associated protein 100 2.47334
CCDC198 coiled-coil domain containing 198 2.47334
LORICRIN loricrin cornified envelope precursor protein 2.47334
LOC112694756 uncharaterized LOC112694756 2.47334
HNF1B HNF1 homeobox B 2.47334
LGSN lengsin, lens protein with glutamine synthetase domain 2.47334
TAS1R1 taste receptor, type 1, member 1 2.47334
CCR6 chemokine (C-C motif) receptor 6 2.47334
GATA6 GATA binding protein 6 2.47334
CLDN9 claudin 9 2.47334
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.47334
GDA guanine deaminase 2.47334
PVRIG poliovirus receptor related immunoglobulin domain containing 2.47334
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.47334
PLVAP plasmalemma vesicle associated protein 2.47334
IL31RA interleukin 31 receptor A 2.47334
SCN10A sodium channel, voltage gated, type X alpha subunit 2.47334
SLC22A25 solute carrier family 22, member 25 2.47334
IL1RN interleukin 1 receptor antagonist 2.47334
RBM44 RNA binding motif protein 44 2.47334
UTS2 urotensin 2 2.47334
CCR3 chemokine (C-C motif) receptor 3 2.47334
PRR4 proline rich 4 (lacrimal) 2.47334
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.47334
SLC45A2 solute carrier family 45, member 2 2.47334
ZIC4 Zic family member 4 2.47334
TMPRSS11A transmembrane protease, serine 11A 2.47334
CLEC1B C-type lectin domain family 1, member B 2.47334
CTAGE9 CTAGE family, member 9 2.47334
GOLGA8R golgin A8 family, member R 2.47334
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.47334
KLF2 Kruppel-like factor 2 2.47334
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.47334
FKBP1C FK506 binding protein 1C 2.47334
NIPAL4 NIPA-like domain containing 4 2.47334
PAGE4 P antigen family, member 4 (prostate associated) 2.47334
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.47334
GP5 glycoprotein V (platelet) 2.47334
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.47334
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.47334
SLA2 Src-like-adaptor 2 2.47334
CH25H cholesterol 25-hydroxylase 2.47334
CFH complement factor H 2.47334
RGS13 regulator of G-protein signaling 13 2.47334
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.47334
EXTL1 exostosin-like glycosyltransferase 1 2.47334
CLEC4D C-type lectin domain family 4, member D 2.47334
TRIM55 tripartite motif containing 55 2.47334
KLHDC1 kelch domain containing 1 2.47334
ANKRD55 ankyrin repeat domain 55 2.47334
TPPP3 tubulin polymerization-promoting protein family member 3 2.47334
PRH2 proline-rich protein HaeIII subfamily 2 2.47334
CA5A carbonic anhydrase VA, mitochondrial 2.47334
LHX2 LIM homeobox 2 2.47334
CD27 CD27 molecule 2.47334
CDH26 cadherin 26 2.47334
EGR2 early growth response 2 2.47334
FBXO47 F-box protein 47 2.47334
C2CD4A C2 calcium-dependent domain containing 4A 2.47334
PCDHGA5 protocadherin gamma subfamily A, 5 2.47334
NUPR1 nuclear protein, transcriptional regulator, 1 2.47334
CCL17 chemokine (C-C motif) ligand 17 2.47334
TSNAXIP1 translin-associated factor X interacting protein 1 2.47334
TEKT2 tektin 2 (testicular) 2.47334
TEX19 testis expressed 19 2.47334
COL6A5 collagen, type VI, alpha 5 2.47334
GPR50 G protein-coupled receptor 50 2.47334
TCF21 transcription factor 21 2.47334
MIXL1 Mix paired-like homeobox 2.47334
BIN2 bridging integrator 2 2.47334
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.47334
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.47334
PADI4 peptidyl arginine deiminase, type IV 2.47334
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.47334
TAS2R46 taste receptor, type 2, member 46 2.47334
ANGPTL6 angiopoietin-like 6 2.47334
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.47334
RNF39 ring finger protein 39 2.47334
POPDC2 popeye domain containing 2 2.47334
FXYD4 FXYD domain containing ion transport regulator 4 2.47334
RHOJ ras homolog family member J 2.47334
NPR3 natriuretic peptide receptor 3 2.47334
RNASE6 ribonuclease, RNase A family, k6 2.47334
ITGAD integrin, alpha D 2.47334
NLRP14 NLR family, pyrin domain containing 14 2.47334
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.47334
GLT6D1 glycosyltransferase 6 domain containing 1 2.47334
CHAD chondroadherin 2.47334
MC5R melanocortin 5 receptor 2.47334
FGF18 fibroblast growth factor 18 2.47334
AGR2 anterior gradient 2 2.47334
CHRM1 cholinergic receptor, muscarinic 1 2.47334
PDCD1 programmed cell death 1 2.47334
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.47334
DENND6B DENN/MADD domain containing 6B 2.4466
CXCL3 chemokine (C-X-C motif) ligand 3 2.44248
KIF18B kinesin family member 18B 2.44248
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.44248
SYT14 synaptotagmin XIV 2.44248
MAGEH1 melanoma antigen family H1 2.43047
CDPF1 cysteine-rich, DPF motif domain containing 1 2.43047
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.43047
PCDHB10 protocadherin beta 10 2.43047
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.38344
KDR kinase insert domain receptor 2.37021
ANXA11 annexin A11 2.35753
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.35753
RHOT1 ras homolog family member T1 2.35311
HOOK3 hook microtubule-tethering protein 3 2.33988
COL8A2 collagen, type VIII, alpha 2 2.32996
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.32055
FAT3 FAT atypical cadherin 3 2.31556
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.31408
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.29683
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.28235
NHSL2 NHS-like 2 2.28235
ANGPTL4 angiopoietin-like 4 2.26928
HDAC9 histone deacetylase 9 2.25173
TBC1D17 TBC1 domain family, member 17 2.2494
CRYBG1 crystallin beta-gamma domain containing 1 2.22466
STC1 stanniocalcin 1 2.22466
MX1 MX dynamin-like GTPase 1 2.20025
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.18529
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 2.16227
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.16128
NSF N-ethylmaleimide-sensitive factor 2.13569
COL6A2 collagen, type VI, alpha 2 2.13569
MKRN1 makorin ring finger protein 1 2.12978
TRPM7 transient receptor potential cation channel, subfamily M, member 7 2.09822
MTERF1 mitochondrial transcription termination factor 1 2.08718
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2.08545
DOP1A DOP1 leucine zipper like protein A 2.07132
VCF2 VCP nuclear cofactor family member 2 2.07045
WLS wntless Wnt ligand secretion mediator 2.06609
DHPS deoxyhypusine synthase 2.06609
FNTA farnesyltransferase, CAAX box, alpha 2.06275
CLIP1 CAP-GLY domain containing linker protein 1 2.03156
SLC39A9 solute carrier family 39, member 9 2.0266
LOC107985101 uncharacterized LOC107985101 2.0266
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 2.02063
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.01305
HJURP Holliday junction recognition protein 2.01305
GIPC1 GIPC PDZ domain containing family, member 1 2.01305

decreased expression

Symbol Name Standardized Value
RPL3L ribosomal protein L3-like -2.47334
SPAG4 sperm associated antigen 4 -2.47334
ADPRH ADP-ribosylarginine hydrolase -2.47334
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.47334
CCDC25 coiled-coil domain containing 25 -2.47334
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -2.47334
ETNPPL ethanolamine-phosphate phospho-lyase -2.47334
KRTDAP keratinocyte differentiation-associated protein -2.47334
ZMAT2 zinc finger, matrin-type 2 -2.47334
TMEM144 transmembrane protein 144 -2.47334
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.47334
ATL1 atlastin GTPase 1 -2.47334
ZDHHC9 zinc finger, DHHC-type containing 9 -2.47334
DGAT2 diacylglycerol O-acyltransferase 2 -2.47334
SERF1A small EDRK-rich factor 1A (telomeric) -2.47334
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -2.47334
AUP1 ancient ubiquitous protein 1 -2.47334
PNPLA7 patatin-like phospholipase domain containing 7 -2.47334
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.47334
TENT4A terminal nucleotidyltransferase 4A -2.47334
NBPF26 neuroblastoma breakpoint family, member 26 -2.47334
SCN4B sodium channel, voltage gated, type IV beta subunit -2.47334
LINC02560 long intergenic non-protein coding RNA 2560 -2.47334
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.47334
RPS27L ribosomal protein S27-like -2.47334
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.47334
SLC60A1 solute carrier family 60 member 1 -2.47334
SFRP5 secreted frizzled-related protein 5 -2.47334
PCDHGA9 protocadherin gamma subfamily A, 9 -2.44248
PVALEF parvalbumin like EF-hand containing -2.44248
DUSP9 dual specificity phosphatase 9 -2.44248
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -2.44248
IQCJ IQ motif containing J -2.44248
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 -2.44248
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.44248
NPPC natriuretic peptide C -2.44248
ZNF446 zinc finger protein 446 -2.44248
TFEB transcription factor EB -2.44248
C1ORF162 chromosome 1 open reading frame 162 -2.44248
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.44248
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.44248
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.44248
MGAM maltase-glucoamylase -2.44248
HRH4 histamine receptor H4 -2.44248
CSF1 colony stimulating factor 1 (macrophage) -2.44248
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.44248
C10ORF90 chromosome 10 open reading frame 90 -2.44248
RIPPLY2 ripply transcriptional repressor 2 -2.44248
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.44248
KRT222 keratin 222, type II -2.44248
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.44248
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.44248
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.44248
CSPG4 chondroitin sulfate proteoglycan 4 -2.44248
SHOX2 short stature homeobox 2 -2.44248
EFCAB3 EF-hand calcium binding domain 3 -2.44248
CRYBB3 crystallin, beta B3 -2.44248
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -2.44248
MYO15A myosin XVA -2.44248
LPO lactoperoxidase -2.44248
OSER1 oxidative stress responsive serine-rich 1 -2.43047
C22ORF15 chromosome 22 open reading frame 15 -2.43047
ZNF225 zinc finger protein 225 -2.38693
CD7 CD7 molecule -2.38693
TNPO3 transportin 3 -2.38471
AAGAB alpha- and gamma-adaptin binding protein -2.3823
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.35332
RASGRP4 RAS guanyl releasing protein 4 -2.34147
OGDHL oxoglutarate dehydrogenase-like -2.34147
SAMD14 sterile alpha motif domain containing 14 -2.3115
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.30837
LYPD3 LY6/PLAUR domain containing 3 -2.30003
NUF2 NUF2, NDC80 kinetochore complex component -2.29215
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -2.26897
RPS20 ribosomal protein S20 -2.2616
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.24737
CCDC28B coiled-coil domain containing 28B -2.24737
CCPG1 cell cycle progression 1 -2.2378
EIF3E eukaryotic translation initiation factor 3, subunit E -2.22025
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.21207
ASB2 ankyrin repeat and SOCS box containing 2 -2.2038
DYNLRB1 dynein, light chain, roadblock-type 1 -2.2038
IL4I1 interleukin 4 induced 1 -2.18881
PRPH2 peripherin 2 (retinal degeneration, slow) -2.18881
HYAL1 hyaluronoglucosaminidase 1 -2.18881
ADH6 alcohol dehydrogenase 6 (class V) -2.18881
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -2.16227
OCA2 oculocutaneous albinism II -2.15324
GSE1 Gse1 coiled-coil protein -2.14766
FGF13 fibroblast growth factor 13 -2.1313
CIDEB cell death-inducing DFFA-like effector b -2.12273
EIF4B eukaryotic translation initiation factor 4B -2.08545
PNPLA3 patatin-like phospholipase domain containing 3 -2.07132
EIF1B eukaryotic translation initiation factor 1B -2.07045
CASP2 caspase 2, apoptosis-related cysteine peptidase -2.06494
HOMER1 homer scaffolding protein 1 -2.06275
PRMT2 protein arginine methyltransferase 2 -2.06275
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.05657
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.04937
UCKL1 uridine-cytidine kinase 1-like 1 -2.04487
RIPK2 receptor-interacting serine-threonine kinase 2 -2.03428
MTPAP mitochondrial poly(A) polymerase -2.03363
ZFR2 zinc finger RNA binding protein 2 -2.02242
SERP2 stress-associated endoplasmic reticulum protein family member 2 -2.02088
CRMP1 collapsin response mediator protein 1 -2.01305
NOTO notochord homeobox -2.00771
ZNF572 zinc finger protein 572 -2.00771
GRM8 glutamate receptor, metabotropic 8 -2.00771
ZNF93 zinc finger protein 93 -2.00476